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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for e2f8

Z-value: 0.96

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Transcription factors associated with e2f8

Gene Symbol Gene ID Gene Info
e2f8
ENSDARG00000057323 E2F transcription factor 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
e2f8dr11_v1_chr7_-_16582187_16582187-0.961.2e-10Click!

Activity profile of e2f8 motif

Sorted Z-values of e2f8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_33220342 3.81 ENSDART00000100893
ENSDART00000113451
si:ch211-125e6.13
si:ch211-125e6.13
chr6_+_21005725 3.56 ENSDART00000041370
cx44.2
connexin 44.2
chr3_+_43086548 2.70 ENSDART00000163579
si:dkey-43p13.5
si:dkey-43p13.5
chr7_+_28724919 2.34 ENSDART00000011324
ccdc102a
coiled-coil domain containing 102A
chr6_-_33916756 2.29 ENSDART00000137447
ENSDART00000138488
nasp
nuclear autoantigenic sperm protein (histone-binding)
chr7_+_41812636 2.13 ENSDART00000174333
orc6
origin recognition complex, subunit 6
chr17_+_11372531 1.98 ENSDART00000130975
ENSDART00000149366
timm9
translocase of inner mitochondrial membrane 9 homolog
chr7_+_41812817 1.87 ENSDART00000174165
orc6
origin recognition complex, subunit 6
chr11_-_26576754 1.84 ENSDART00000191733
ENSDART00000002846
st3gal8
ST3 beta-galactoside alpha-2,3-sialyltransferase 8
chr7_+_41812190 1.79 ENSDART00000113732
ENSDART00000174137
orc6
origin recognition complex, subunit 6
chr1_-_18811517 1.74 ENSDART00000142026
si:dkey-167i21.2
si:dkey-167i21.2
chr7_+_24814866 1.64 ENSDART00000173581
si:ch211-226l4.6
si:ch211-226l4.6
chr20_+_13141408 1.64 ENSDART00000034098
dtl
denticleless E3 ubiquitin protein ligase homolog (Drosophila)
chr16_+_53278406 1.60 ENSDART00000010792
ptdss1a
phosphatidylserine synthase 1a
chr13_+_46941930 1.57 ENSDART00000056962
fbxo5
F-box protein 5
chr19_+_42660158 1.53 ENSDART00000018328
fbxl2
F-box and leucine-rich repeat protein 2
chr1_-_34450622 1.52 ENSDART00000083736
lmo7b
LIM domain 7b
chr1_-_38170997 1.52 ENSDART00000142811
hmgb2a
high mobility group box 2a
chr3_-_35865040 1.50 ENSDART00000102952
suz12a
SUZ12 polycomb repressive complex 2a subunit
chr19_+_40069524 1.48 ENSDART00000151365
ENSDART00000140926
zmym4
zinc finger, MYM-type 4
chr13_+_2894536 1.45 ENSDART00000183678
CABZ01087629.1

chr17_+_45009868 1.41 ENSDART00000085009
coq6
coenzyme Q6 monooxygenase
chr7_-_55648336 1.35 ENSDART00000147792
ENSDART00000135304
ENSDART00000131923
pabpn1l
poly(A) binding protein, nuclear 1-like (cytoplasmic)
chr16_-_39195318 1.34 ENSDART00000058546
ebag9
estrogen receptor binding site associated, antigen, 9
chr4_-_7869731 1.33 ENSDART00000067339
mcm10
minichromosome maintenance 10 replication initiation factor
chr19_-_2582858 1.32 ENSDART00000113829
cdca7b
cell division cycle associated 7b
chr16_+_33953644 1.28 ENSDART00000164447
ENSDART00000159969
arid1aa
AT rich interactive domain 1Aa (SWI-like)
chr13_+_30421472 1.28 ENSDART00000143569
zmiz1a
zinc finger, MIZ-type containing 1a
chr7_-_39360325 1.23 ENSDART00000098033
ENSDART00000173695
ENSDART00000173466
ENSDART00000173734
ambra1a
autophagy/beclin-1 regulator 1a
chr20_+_18703454 1.22 ENSDART00000152342
eif5
eukaryotic translation initiation factor 5
chr9_-_49964810 1.17 ENSDART00000167098
scn1a
sodium channel, voltage-gated, type I, alpha
chr1_-_24558838 1.16 ENSDART00000102522
gatb
glutamyl-tRNA(Gln) amidotransferase, subunit B
chr20_-_38827623 1.13 ENSDART00000153310
cad
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr10_+_10386435 1.12 ENSDART00000179214
ENSDART00000189799
ENSDART00000193875
sardh
sarcosine dehydrogenase
chr6_-_40071899 1.12 ENSDART00000034730
sec61a1
Sec61 translocon alpha 1 subunit
chr11_-_38554394 1.11 ENSDART00000102858
nucks1a
nuclear casein kinase and cyclin-dependent kinase substrate 1a
chr6_+_38896158 1.08 ENSDART00000029930
ENSDART00000131347
slc48a1b
solute carrier family 48 (heme transporter), member 1b
chr20_+_41859277 1.08 ENSDART00000061141
cep85l
centrosomal protein 85, like
chr3_-_26806032 1.08 ENSDART00000143710
pigq
phosphatidylinositol glycan anchor biosynthesis, class Q
chr3_-_49514874 1.03 ENSDART00000167179
asf1ba
anti-silencing function 1Ba histone chaperone
chr14_-_31465905 1.03 ENSDART00000173108
gpc3
glypican 3
chr20_+_53368611 1.03 ENSDART00000060432
cdc40
cell division cycle 40 homolog (S. cerevisiae)
chr5_-_37959874 1.02 ENSDART00000031719
mpzl2b
myelin protein zero-like 2b
chr3_+_17744339 1.01 ENSDART00000132622
znf385c
zinc finger protein 385C
chr5_-_30382925 1.00 ENSDART00000125381
gig2o
grass carp reovirus (GCRV)-induced gene 2o
chr23_-_29357764 1.00 ENSDART00000156512
si:ch211-129o18.4
si:ch211-129o18.4
chr11_+_24804556 0.98 ENSDART00000082761
ENSDART00000186283
adipor1a
adiponectin receptor 1a
chr23_+_29358188 0.97 ENSDART00000189242
tardbpl
TAR DNA binding protein, like
chr13_+_8255106 0.97 ENSDART00000080465
hells
helicase, lymphoid specific
chr13_-_18011168 0.96 ENSDART00000144813
march8
membrane-associated ring finger (C3HC4) 8
chr4_-_2380173 0.92 ENSDART00000177727
nap1l1
nucleosome assembly protein 1-like 1
chr14_+_49220026 0.91 ENSDART00000063643
ENSDART00000128744
rmnd5b
required for meiotic nuclear division 5 homolog B
chr7_+_71535045 0.91 ENSDART00000047069
tyms
thymidylate synthetase
chr22_-_4439311 0.91 ENSDART00000169317
uhrf1
ubiquitin-like with PHD and ring finger domains 1
chr5_-_16139600 0.91 ENSDART00000051644
coq5
coenzyme Q5, methyltransferase
chr7_-_41812015 0.90 ENSDART00000174058
vps35
vacuolar protein sorting 35 homolog (S. cerevisiae)
chr2_+_37424261 0.87 ENSDART00000132427
phc3
polyhomeotic homolog 3 (Drosophila)
chr4_-_73488406 0.87 ENSDART00000115002
si:ch73-266f23.1
si:ch73-266f23.1
chr23_+_39413163 0.85 ENSDART00000184254
src
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr21_-_11970199 0.84 ENSDART00000114524
nop56
NOP56 ribonucleoprotein homolog
chr2_+_6885852 0.84 ENSDART00000016607
rgs5b
regulator of G protein signaling 5b
chr2_+_9755422 0.84 ENSDART00000018524
pcyt1aa
phosphate cytidylyltransferase 1, choline, alpha a
chr11_-_11792766 0.83 ENSDART00000011657
cdc6
cell division cycle 6 homolog (S. cerevisiae)
chr23_+_10805188 0.83 ENSDART00000035693
ppp4r2a
protein phosphatase 4, regulatory subunit 2a
chr23_-_16981899 0.82 ENSDART00000125472
ENSDART00000142297
ENSDART00000143180
dnmt3bb.3
DNA (cytosine-5-)-methyltransferase beta, duplicate b.3
chr16_+_32184485 0.82 ENSDART00000084009
zufsp
zinc finger with UFM1-specific peptidase domain
chr20_+_27093042 0.79 ENSDART00000024595
ubr7
ubiquitin protein ligase E3 component n-recognin 7
chr20_-_38525467 0.76 ENSDART00000061417
si:ch211-245h14.1
si:ch211-245h14.1
chr7_+_26545911 0.76 ENSDART00000135313
tnk1
tyrosine kinase, non-receptor, 1
chr1_+_59142783 0.74 ENSDART00000152669
gpr108
G protein-coupled receptor 108
chr15_-_4596623 0.74 ENSDART00000132227
eif4h
eukaryotic translation initiation factor 4h
chr4_+_13953537 0.72 ENSDART00000133596
pphln1
periphilin 1
chr7_-_73854476 0.71 ENSDART00000186481
zgc:173552
zgc:173552
chr19_-_44064842 0.70 ENSDART00000151541
mterf3
mitochondrial transcription termination factor 3
chr22_-_26274177 0.70 ENSDART00000060978
wdr83
WD repeat domain containing 83
chr18_+_27571448 0.69 ENSDART00000147886
cd82b
CD82 molecule b
chr14_-_32631519 0.67 ENSDART00000167282
ENSDART00000052938
atp11c
ATPase phospholipid transporting 11C
chr12_+_21299338 0.64 ENSDART00000074540
ENSDART00000133188
ca10a
carbonic anhydrase Xa
chr3_+_52545400 0.64 ENSDART00000184183
slc27a1a
solute carrier family 27 (fatty acid transporter), member 1a
chr7_+_36898850 0.64 ENSDART00000113342
tox3
TOX high mobility group box family member 3
chr25_+_7532627 0.63 ENSDART00000187660
ptdss2
phosphatidylserine synthase 2
chr9_+_34380299 0.61 ENSDART00000131705
lamp1
lysosomal-associated membrane protein 1
chr7_+_26545502 0.60 ENSDART00000140528
tnk1
tyrosine kinase, non-receptor, 1
chr7_-_41812355 0.59 ENSDART00000016105
vps35
vacuolar protein sorting 35 homolog (S. cerevisiae)
chr21_-_27413294 0.59 ENSDART00000131646
slc29a2
solute carrier family 29 (equilibrative nucleoside transporter), member 2
chr6_-_18531760 0.54 ENSDART00000167167
utp6
UTP6, small subunit (SSU) processome component, homolog (yeast)
chr3_+_52545014 0.54 ENSDART00000018908
slc27a1a
solute carrier family 27 (fatty acid transporter), member 1a
chr15_-_37104165 0.52 ENSDART00000165867
zmp:0000001114
zmp:0000001114
chr18_-_35842554 0.51 ENSDART00000088488
opa3
optic atrophy 3
chr23_+_29357790 0.51 ENSDART00000139223
ENSDART00000141928
tardbpl
TAR DNA binding protein, like
chr15_+_23657051 0.51 ENSDART00000078336
klc3
kinesin light chain 3
chr22_+_8753365 0.50 ENSDART00000106086
si:dkey-182g1.2
si:dkey-182g1.2
chr1_+_37752171 0.50 ENSDART00000183247
ENSDART00000189756
ENSDART00000139448
GALNTL6
si:ch211-15e22.3
chr22_+_8753092 0.50 ENSDART00000140720
si:dkey-182g1.2
si:dkey-182g1.2
chr7_+_62320134 0.48 ENSDART00000012089
stim2b
stromal interaction molecule 2b
chr7_+_41421998 0.47 ENSDART00000083967
chpf2
chondroitin polymerizing factor 2
chr24_-_13349464 0.47 ENSDART00000134482
ENSDART00000139212
terf1
telomeric repeat binding factor (NIMA-interacting) 1
chr11_-_18017287 0.46 ENSDART00000155443
qrich1
glutamine-rich 1
chr11_-_18017918 0.46 ENSDART00000040171
qrich1
glutamine-rich 1
chr9_-_2892045 0.46 ENSDART00000137201
cdca7a
cell division cycle associated 7a
chr2_+_7818368 0.45 ENSDART00000007068
kcnmb2
potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr24_-_30843250 0.44 ENSDART00000162920
ptbp2a
polypyrimidine tract binding protein 2a
chr24_-_26945390 0.44 ENSDART00000123354
msl2b
male-specific lethal 2 homolog b (Drosophila)
chr24_-_13349802 0.43 ENSDART00000164729
terf1
telomeric repeat binding factor (NIMA-interacting) 1
chr17_+_9310259 0.43 ENSDART00000186158
ENSDART00000190329
NPAS3
neuronal PAS domain protein 3
chr25_-_35140746 0.41 ENSDART00000129969
si:ch211-113a14.19
si:ch211-113a14.19
chr13_+_48358467 0.41 ENSDART00000171080
ENSDART00000162531
msh6
mutS homolog 6 (E. coli)
chr8_-_2543327 0.41 ENSDART00000134115
si:ch211-51h9.6
si:ch211-51h9.6
chr11_-_18107447 0.40 ENSDART00000187376
qrich1
glutamine-rich 1
chr16_-_22775480 0.40 ENSDART00000141778
ENSDART00000145585
ENSDART00000125963
ENSDART00000127570
pbxip1b
pre-B-cell leukemia homeobox interacting protein 1b
chr11_+_3006124 0.40 ENSDART00000126071
cpne5b
copine Vb
chr1_+_6243906 0.39 ENSDART00000127329
gtf3c3
general transcription factor IIIC, polypeptide 3
chr10_+_573667 0.39 ENSDART00000110384
smad4a
SMAD family member 4a
chr18_+_35842933 0.39 ENSDART00000151587
ENSDART00000131121
ppp1r13l
protein phosphatase 1, regulatory subunit 13 like
chr1_+_44814322 0.39 ENSDART00000059227
ndufs8a
NADH dehydrogenase (ubiquinone) Fe-S protein 8a
chr5_+_13308139 0.38 ENSDART00000182189
ydjc
YdjC chitooligosaccharide deacetylase homolog
chr6_-_8466717 0.38 ENSDART00000151577
ENSDART00000151800
ENSDART00000151227
si:dkey-217d24.6
si:dkey-217d24.6
chr11_+_3005536 0.38 ENSDART00000174539
cpne5b
copine Vb
chr9_-_2892250 0.38 ENSDART00000140695
cdca7a
cell division cycle associated 7a
chr16_-_43011470 0.38 ENSDART00000131898
ENSDART00000142003
ENSDART00000017966
nudt17
nudix (nucleoside diphosphate linked moiety X)-type motif 17
chr12_+_17933775 0.37 ENSDART00000186047
ENSDART00000160586
trrap
transformation/transcription domain-associated protein
chr16_-_15988320 0.37 ENSDART00000160883
CABZ01060453.1

chr25_-_26753196 0.36 ENSDART00000155698
usp3
ubiquitin specific peptidase 3
chr7_+_69905307 0.36 ENSDART00000035907
sec24d
SEC24 homolog D, COPII coat complex component
chr3_+_14571813 0.35 ENSDART00000146728
ENSDART00000171731
znf653
zinc finger protein 653
chr19_-_32042105 0.35 ENSDART00000088358
znf704
zinc finger protein 704
chr25_-_35109536 0.33 ENSDART00000185229
CU302436.5

chr15_-_1651766 0.33 ENSDART00000127396
ppm1lb
protein phosphatase, Mg2+/Mn2+ dependent, 1Lb
chr2_-_25120197 0.32 ENSDART00000132549
pccb
propionyl CoA carboxylase, beta polypeptide
chr16_+_25116827 0.32 ENSDART00000163244
si:ch211-261d7.6
si:ch211-261d7.6
chr24_-_35561672 0.31 ENSDART00000058564
mcm4
minichromosome maintenance complex component 4
chr21_-_41818359 0.31 ENSDART00000046076
CU929230.1

chr25_-_35102781 0.30 ENSDART00000180881
ENSDART00000153747
si:dkey-108k21.24
si:dkey-108k21.24
chr23_+_20803270 0.30 ENSDART00000097381
zgc:154075
zgc:154075
chr7_+_66565930 0.30 ENSDART00000154597
tmem176l.3b
transmembrane protein 176l.3b
chr20_+_2732992 0.30 ENSDART00000152697
syncrip
synaptotagmin binding, cytoplasmic RNA interacting protein
chr25_-_35145920 0.29 ENSDART00000157137
si:dkey-261m9.19
si:dkey-261m9.19
chr5_-_20678300 0.29 ENSDART00000088639
wscd2
WSC domain containing 2
chr19_-_340347 0.29 ENSDART00000139924
golph3l
golgi phosphoprotein 3-like
chr13_+_26703922 0.29 ENSDART00000020946
fancl
Fanconi anemia, complementation group L
chr15_-_17618800 0.26 ENSDART00000157185
adamts15b
ADAM metallopeptidase with thrombospondin type 1 motif, 15b
chr17_-_36529016 0.25 ENSDART00000025019
colec11
collectin sub-family member 11
chr21_-_31252131 0.25 ENSDART00000121946
crcp
calcitonin gene-related peptide-receptor component protein
chr17_-_36529449 0.24 ENSDART00000187252
colec11
collectin sub-family member 11
chr19_-_340641 0.24 ENSDART00000183848
golph3l
golgi phosphoprotein 3-like
chr7_+_5956937 0.23 ENSDART00000170763
hist1h2a4
histone cluster 1 H2A family member 4
chr21_-_11655010 0.23 ENSDART00000144370
ENSDART00000139814
ENSDART00000139289
cast
calpastatin
chr7_+_28960518 0.22 ENSDART00000182903
ENSDART00000188250
ENSDART00000191830
dok4
docking protein 4
chr2_+_32016516 0.22 ENSDART00000135040
mycb
MYC proto-oncogene, bHLH transcription factor b
chr21_-_2360906 0.21 ENSDART00000171645
si:ch73-299h12.9
si:ch73-299h12.9
chr19_-_30359059 0.21 ENSDART00000103471
khdrbs1b
KH domain containing, RNA binding, signal transduction associated 1b
chr8_+_8196087 0.21 ENSDART00000026965
plxnb3
plexin B3
chr4_-_20027571 0.20 ENSDART00000003420
drd4-rs
dopamine receptor D4 related sequence
chr23_-_10137322 0.20 ENSDART00000142442
plxnb1a
plexin b1a
chr13_-_14929236 0.20 ENSDART00000020576
cdc25b
cell division cycle 25B
chr6_+_21062416 0.20 ENSDART00000141643
si:dkey-91f15.1
si:dkey-91f15.1
chr2_-_57378748 0.19 ENSDART00000149235
tcf3a
transcription factor 3a
chr15_+_5923851 0.19 ENSDART00000152520
ENSDART00000145827
ENSDART00000121529
sh3bgr
SH3 domain binding glutamate-rich protein
chr9_+_30294096 0.18 ENSDART00000026551
srpx
sushi-repeat containing protein, X-linked
chr7_-_73845736 0.18 ENSDART00000193414
zgc:173552
zgc:173552
chr23_+_1287910 0.18 ENSDART00000105287
utrn
utrophin
chr13_-_1423008 0.17 ENSDART00000110828
znf451
zinc finger protein 451
chr2_+_48074243 0.17 ENSDART00000056291
klf6b
Kruppel-like factor 6b
chr2_-_37874647 0.17 ENSDART00000039386
zgc:66427
zgc:66427
chr23_-_33738945 0.17 ENSDART00000136386
si:ch211-210c8.7
si:ch211-210c8.7
chr15_-_36055401 0.16 ENSDART00000154476
col4a4
collagen, type IV, alpha 4
chr17_-_47220934 0.15 ENSDART00000158740
alk
ALK receptor tyrosine kinase
chr25_+_35133404 0.15 ENSDART00000188505
hist1h2a2
histone cluster 1 H2A family member 2
chr18_+_39028417 0.14 ENSDART00000148428
myo5aa
myosin VAa
chr7_+_66565572 0.14 ENSDART00000180250
tmem176l.3b
transmembrane protein 176l.3b
chr21_+_11244068 0.13 ENSDART00000163432
arid6
AT-rich interaction domain 6
chr22_+_25590391 0.12 ENSDART00000178133
aars2
alanyl-tRNA synthetase 2, mitochondrial (putative)
chr12_+_34732262 0.12 ENSDART00000169634
si:dkey-21c1.8
si:dkey-21c1.8
chr24_-_11821505 0.12 ENSDART00000058992
gli3
GLI family zinc finger 3
chr15_-_14210382 0.12 ENSDART00000179599
CR925813.1

chr22_+_18349794 0.11 ENSDART00000186580
gatad2ab
GATA zinc finger domain containing 2Ab
chr1_-_28890028 0.11 ENSDART00000075500
poglut1
protein O-glucosyltransferase 1
chr15_+_6117502 0.11 ENSDART00000188293
PCP4 (1 of many)
Purkinje cell protein 4
chr5_-_64454459 0.10 ENSDART00000172321
ENSDART00000168030
brd3b
bromodomain containing 3b
chr17_-_8173380 0.10 ENSDART00000148520
syne1b
spectrin repeat containing, nuclear envelope 1b
chr4_-_16644708 0.10 ENSDART00000042307
sinhcaf
SIN3-HDAC complex associated factor
chr4_-_74062634 0.10 ENSDART00000105992
si:cabz01069012.2
si:cabz01069012.2
chr7_-_38634845 0.09 ENSDART00000173861
c1qtnf4
C1q and TNF related 4
chr8_-_44363596 0.09 ENSDART00000123658
si:busm1-228j01.4
si:busm1-228j01.4
chr4_-_74069252 0.09 ENSDART00000112802
si:cabz01069012.2
si:cabz01069012.2
chr23_+_21482571 0.09 ENSDART00000187368
si:dkey-1c11.1
si:dkey-1c11.1
chr9_+_23522656 0.09 ENSDART00000112295
cntnap5a
contactin associated protein-like 5a
chr7_+_29509255 0.08 ENSDART00000076172
si:dkey-182o15.5
si:dkey-182o15.5
chr15_-_17619306 0.08 ENSDART00000184011
adamts15b
ADAM metallopeptidase with thrombospondin type 1 motif, 15b
chr1_+_27052530 0.08 ENSDART00000184065
bnc2
basonuclin 2
chr18_-_34171280 0.08 ENSDART00000122321
slc33a1
solute carrier family 33 (acetyl-CoA transporter), member 1
chr18_-_34170918 0.08 ENSDART00000015079
slc33a1
solute carrier family 33 (acetyl-CoA transporter), member 1
chr2_-_54946834 0.07 ENSDART00000192280
CABZ01086574.1

chr4_-_58978527 0.07 ENSDART00000150408
si:ch211-64i20.5_2
si:ch211-64i20.5_2
chr8_+_45186989 0.07 ENSDART00000143861
si:ch211-220m6.4
si:ch211-220m6.4
chr19_-_3381422 0.07 ENSDART00000105146
edn1
endothelin 1
chr25_+_25464630 0.07 ENSDART00000150537
rassf7a
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7a
chr7_-_6362460 0.07 ENSDART00000129239
hist1h2a4
histone cluster 1 H2A family member 4
chr6_-_34008827 0.06 ENSDART00000191183
ENSDART00000003701
ENSDART00000192502
tie1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr9_-_22182396 0.06 ENSDART00000101809
crygm2d6
crystallin, gamma M2d6

Network of associatons between targets according to the STRING database.

First level regulatory network of e2f8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.3 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.4 1.6 GO:1904667 negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.4 1.1 GO:0021563 glossopharyngeal nerve development(GO:0021563)
0.4 1.1 GO:1901052 sarcosine metabolic process(GO:1901052)
0.3 3.4 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.3 0.9 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.3 0.8 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.2 1.0 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.2 1.6 GO:0072425 signal transduction involved in DNA integrity checkpoint(GO:0072401) signal transduction involved in DNA damage checkpoint(GO:0072422) signal transduction involved in G2 DNA damage checkpoint(GO:0072425)
0.2 1.0 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.2 1.9 GO:0044030 regulation of DNA methylation(GO:0044030)
0.2 0.7 GO:0061668 mitochondrial ribosome assembly(GO:0061668)
0.2 1.1 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.1 0.7 GO:0097355 protein localization to heterochromatin(GO:0097355)
0.1 4.8 GO:0006270 DNA replication initiation(GO:0006270)
0.1 1.0 GO:0060976 coronary vasculature development(GO:0060976)
0.1 0.4 GO:0019364 pyridine nucleotide catabolic process(GO:0019364) NAD catabolic process(GO:0019677) pyridine-containing compound catabolic process(GO:0072526)
0.1 0.4 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.1 2.3 GO:0006744 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1 1.1 GO:1901678 heme transport(GO:0015886) iron coordination entity transport(GO:1901678)
0.1 0.7 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.1 0.6 GO:0015864 uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
0.1 0.5 GO:0048194 Golgi vesicle budding(GO:0048194)
0.1 1.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.1 0.2 GO:0006290 somatic diversification of immune receptors via somatic mutation(GO:0002566) pyrimidine dimer repair(GO:0006290) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.1 0.5 GO:0005513 detection of calcium ion(GO:0005513)
0.1 0.5 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1 0.4 GO:1905097 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.1 0.6 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.1 0.4 GO:0051673 membrane disruption in other organism(GO:0051673)
0.0 0.3 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.2 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 1.3 GO:0043039 amino acid activation(GO:0043038) tRNA aminoacylation(GO:0043039)
0.0 1.4 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.4 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.9 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 2.7 GO:0048484 enteric nervous system development(GO:0048484)
0.0 0.2 GO:0045448 regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.0 0.5 GO:0019730 antimicrobial humoral response(GO:0019730)
0.0 1.1 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.2 GO:0097340 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.0 0.5 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 2.0 GO:0006119 oxidative phosphorylation(GO:0006119)
0.0 0.9 GO:0001878 response to yeast(GO:0001878)
0.0 1.5 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.8 GO:0048538 thymus development(GO:0048538)
0.0 1.5 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.4 GO:1902287 semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.0 0.1 GO:0060585 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 0.5 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.4 GO:0035675 neuromast hair cell development(GO:0035675)
0.0 0.4 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 0.2 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.2 GO:0060260 regulation of transcription initiation from RNA polymerase II promoter(GO:0060260) regulation of DNA-templated transcription, initiation(GO:2000142)
0.0 0.8 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.6 GO:0036269 swimming behavior(GO:0036269)
0.0 1.1 GO:0007626 locomotory behavior(GO:0007626)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.5 1.5 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.5 5.8 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.3 0.8 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.3 1.3 GO:0031298 replication fork protection complex(GO:0031298)
0.3 2.3 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.2 1.1 GO:0005784 Sec61 translocon complex(GO:0005784)
0.2 0.9 GO:0034657 GID complex(GO:0034657)
0.2 1.1 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.2 1.3 GO:0035060 brahma complex(GO:0035060)
0.1 0.8 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 0.2 GO:0032301 MutSalpha complex(GO:0032301)
0.1 0.5 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.1 0.4 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 0.9 GO:0000792 heterochromatin(GO:0000792)
0.1 0.4 GO:0072487 MSL complex(GO:0072487)
0.0 1.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.9 GO:0000784 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) nuclear chromosome, telomeric region(GO:0000784)
0.0 0.3 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.3 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.4 GO:0000124 SAGA complex(GO:0000124)
0.0 1.0 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 2.5 GO:0016459 myosin complex(GO:0016459)
0.0 0.4 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.4 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 6.0 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 1.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 1.0 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.2 GO:0005922 connexon complex(GO:0005922)
0.0 1.3 GO:0030141 secretory granule(GO:0030141)
0.0 1.0 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.2 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 1.1 GO:0000786 nucleosome(GO:0000786)
0.0 1.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.3 0.9 GO:0071532 ankyrin repeat binding(GO:0071532)
0.3 1.1 GO:0046997 oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.2 1.2 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.2 1.8 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.2 0.9 GO:0008169 C-methyltransferase activity(GO:0008169)
0.2 1.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.2 0.8 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.2 0.5 GO:0042806 fucose binding(GO:0042806)
0.2 1.1 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 1.1 GO:0015232 heme transporter activity(GO:0015232)
0.1 0.7 GO:0033592 RNA strand annealing activity(GO:0033592) RNA strand-exchange activity(GO:0034057)
0.1 1.2 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 0.2 GO:0032405 guanine/thymine mispair binding(GO:0032137) single base insertion or deletion binding(GO:0032138) single thymine insertion binding(GO:0032143) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357) mismatch repair complex binding(GO:0032404) MutLalpha complex binding(GO:0032405)
0.1 0.4 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 1.1 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.1 1.4 GO:0030515 snoRNA binding(GO:0030515)
0.1 0.8 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.1 1.6 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.5 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.1 0.5 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 0.8 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.1 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 1.3 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.2 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 1.0 GO:0042287 MHC protein binding(GO:0042287)
0.0 1.3 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.3 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.5 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.2 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 1.4 GO:0071949 FAD binding(GO:0071949)
0.0 1.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.6 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 1.1 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.3 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 1.0 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.4 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.5 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.1 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.4 GO:0003954 NADH dehydrogenase activity(GO:0003954)
0.0 0.1 GO:0035252 UDP-xylosyltransferase activity(GO:0035252)
0.0 0.2 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 2.9 GO:0042393 histone binding(GO:0042393)
0.0 0.2 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.2 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.2 GO:0008143 poly(A) binding(GO:0008143)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 ST STAT3 PATHWAY STAT3 Pathway
0.0 1.8 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.5 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.8 PID ATR PATHWAY ATR signaling pathway
0.0 0.3 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.9 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.7 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.4 PID P53 REGULATION PATHWAY p53 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.6 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 2.5 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 0.8 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 1.0 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.1 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 1.1 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 2.0 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.5 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.7 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.5 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.5 REACTOME KINESINS Genes involved in Kinesins
0.0 0.3 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 1.1 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.0 0.8 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.4 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 0.3 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.2 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.7 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.0 0.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.5 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.4 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 1.2 REACTOME TRANSLATION Genes involved in Translation