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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for e4f1+si:dkeyp-79b7.12
Z-value: 0.68
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Transcription factors associated with e4f1+si:dkeyp-79b7.12
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| e4f1 | dr11_v1_chr3_-_18737126_18737126 | 0.91 | 2.1e-07 | Click! |
| si:dkeyp-79b7.12 | dr11_v1_chr22_+_2207502_2207502 | 0.45 | 5.9e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_44801968 Show fit | 2.07 |
ENSDART00000161846
|
microtubule-associated protein 1 light chain 3 gamma |
|
| chr22_-_10541712 Show fit | 1.58 |
ENSDART00000013933
|
si:dkey-42i9.4 |
|
| chr10_-_44017642 Show fit | 1.54 |
ENSDART00000135240
ENSDART00000014669 |
acyl-CoA dehydrogenase short chain |
|
| chr17_+_25187226 Show fit | 1.53 |
ENSDART00000148431
|
CLN8, transmembrane ER and ERGIC protein |
|
| chr22_-_10541372 Show fit | 1.38 |
ENSDART00000179708
|
si:dkey-42i9.4 |
|
| chr7_-_26518086 Show fit | 1.30 |
ENSDART00000058913
|
eukaryotic translation initiation factor 4A1A |
|
| chr5_-_29531948 Show fit | 1.29 |
ENSDART00000098360
|
arrestin domain containing 1a |
|
| chr20_-_44576949 Show fit | 1.29 |
ENSDART00000148639
|
UBX domain protein 2A |
|
| chr2_+_9821757 Show fit | 1.28 |
ENSDART00000018408
ENSDART00000141227 ENSDART00000144681 ENSDART00000148227 |
annexin A13, like |
|
| chr5_+_44846434 Show fit | 1.27 |
ENSDART00000145299
ENSDART00000136521 |
KN motif and ankyrin repeat domains 1a |
Network of associatons between targets according to the STRING database.
First level regulatory network of e4f1+si:dkeyp-79b7.12
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.1 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.0 | 2.8 | GO:0045930 | negative regulation of mitotic cell cycle(GO:0045930) |
| 0.0 | 2.5 | GO:0032272 | negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272) |
| 0.0 | 1.9 | GO:0042752 | regulation of circadian rhythm(GO:0042752) |
| 0.2 | 1.8 | GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
| 0.6 | 1.7 | GO:0007008 | outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040) |
| 0.3 | 1.6 | GO:1990918 | double-strand break repair involved in meiotic recombination(GO:1990918) |
| 0.0 | 1.5 | GO:0055088 | lipid homeostasis(GO:0055088) |
| 0.1 | 1.3 | GO:0031468 | nuclear envelope reassembly(GO:0031468) |
| 0.0 | 1.3 | GO:0002183 | cytoplasmic translational initiation(GO:0002183) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.1 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 1.9 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.1 | 1.8 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.0 | 1.8 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.2 | 1.7 | GO:0001401 | mitochondrial sorting and assembly machinery complex(GO:0001401) |
| 0.0 | 1.6 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 1.2 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 1.1 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 0.9 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 0.8 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
| 0.0 | 2.5 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.1 | 1.8 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.0 | 1.6 | GO:0003678 | DNA helicase activity(GO:0003678) |
| 0.2 | 1.5 | GO:0046625 | sphingolipid binding(GO:0046625) ceramide binding(GO:0097001) |
| 0.1 | 1.5 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.3 | 1.3 | GO:1990756 | protein binding, bridging involved in substrate recognition for ubiquitination(GO:1990756) |
| 0.0 | 1.3 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 1.2 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.0 | 1.2 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 0.7 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.7 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 0.4 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 0.3 | PID ATM PATHWAY | ATM pathway |
| 0.0 | 0.1 | PID S1P S1P1 PATHWAY | S1P1 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 1.8 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 1.5 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.1 | 1.1 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 0.9 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.0 | 0.9 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.1 | 0.8 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 0.7 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 0.6 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.0 | 0.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |