ISMARA results: ebf3a-1+si:ch211-51e8.2

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for ebf3a-1+si:ch211-51e8.2

Z-value: 1.02

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Transcription factors associated with ebf3a-1+si:ch211-51e8.2

Gene Symbol	Gene ID	Gene Info
si_ch211-51e8.2 NCBI UniProt	ENSDARG00000092635	si_ch211-51e8.2
ebf3a-1 NCBI UniProt	ENSDARG00000099849	EBF transcription factor 1a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ebf3a	dr11_v1_chr14_+_35237613_35237613	0.16	5.2e-01	Click!
EBF1 (1 of many)	dr11_v1_chr21_-_33995213_33995213	-0.01	9.6e-01	Click!

Activity profile of ebf3a-1+si:ch211-51e8.2 motif

Sorted Z-values of ebf3a-1+si:ch211-51e8.2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_-_8208464 Show fit	6.43	ENSDART00000161283	pimr203 NCBI UniProt Show fit	Pim proto-oncogene, serine/threonine kinase, related 203
chr22_+_36914636 Show fit	3.59	ENSDART00000150948	pimr205 NCBI UniProt Show fit	Pim proto-oncogene, serine/threonine kinase, related 205
chr4_+_37992753 Show fit	3.46	ENSDART00000193890	CR759843.2 NCBI UniProt Show fit
chr6_-_8264751 Show fit	2.68	ENSDART00000091628	ccdc151 NCBI UniProt Show fit	coiled-coil domain containing 151
chr4_+_15819728 Show fit	2.52	ENSDART00000101613	lrguk NCBI UniProt Show fit	leucine-rich repeats and guanylate kinase domain containing
chr18_-_21177674 Show fit	2.38	ENSDART00000060175	si:dkey-12e7.4 NCBI UniProt Show fit	si:dkey-12e7.4
chr11_-_8271374 Show fit	2.36	ENSDART00000168253	pimr202 NCBI UniProt Show fit	Pim proto-oncogene, serine/threonine kinase, related 202
chr14_-_858985 Show fit	2.22	ENSDART00000148687 ENSDART00000149375	slc34a1a NCBI UniProt Show fit	solute carrier family 34 (type II sodium/phosphate cotransporter), member 1a
chr11_-_8288925 Show fit	1.88	ENSDART00000168524	pimr202 NCBI UniProt Show fit	Pim proto-oncogene, serine/threonine kinase, related 202
chr22_-_36934040 Show fit	1.84	ENSDART00000151666	pimr206 NCBI UniProt Show fit	Pim proto-oncogene, serine/threonine kinase, related 206

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ebf3a-1+si:ch211-51e8.2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	17.7	GO:0046777	protein autophosphorylation(GO:0046777)
0.4	2.2	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
0.0	1.8	GO:0060395	SMAD protein signal transduction(GO:0060395)
0.0	1.7	GO:0051259	protein oligomerization(GO:0051259)
0.3	1.4	GO:0031446	regulation of twitch skeletal muscle contraction(GO:0014724) regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) negative regulation of striated muscle contraction(GO:0045988) relaxation of skeletal muscle(GO:0090076)
0.1	1.3	GO:0030431	sleep(GO:0030431)
0.1	1.3	GO:0021884	forebrain neuron development(GO:0021884)
0.1	1.2	GO:1904071	presynaptic active zone assembly(GO:1904071)
0.1	1.1	GO:0016199	axon midline choice point recognition(GO:0016199)
0.1	1.1	GO:0015721	bile acid and bile salt transport(GO:0015721)

Showing 1 to 10 of 48 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.2	GO:0005903	brush border(GO:0005903)
0.1	1.7	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.3	1.4	GO:0031673	H zone(GO:0031673)
0.0	1.4	GO:0005882	intermediate filament(GO:0005882)
0.1	1.2	GO:0098982	GABA-ergic synapse(GO:0098982)
0.0	0.9	GO:0071144	SMAD2-SMAD3 protein complex(GO:0071144)
0.0	0.7	GO:0031680	G-protein beta/gamma-subunit complex(GO:0031680)
0.0	0.7	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.0	0.7	GO:0005639	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.1	0.6	GO:0042788	polysomal ribosome(GO:0042788)

Showing 1 to 10 of 19 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	17.8	GO:0004674	protein serine/threonine kinase activity(GO:0004674)
0.2	3.1	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.5	2.5	GO:0004385	guanylate kinase activity(GO:0004385)
0.4	2.2	GO:0005436	sodium:phosphate symporter activity(GO:0005436)
0.0	1.9	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)
0.0	1.9	GO:0008080	N-acetyltransferase activity(GO:0008080)
0.0	1.3	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
0.1	1.2	GO:0098882	structural constituent of presynaptic active zone(GO:0098882)
0.2	1.1	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.0	1.1	GO:0098632	protein binding involved in cell-cell adhesion(GO:0098632)

Showing 1 to 10 of 41 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.2	SIG CHEMOTAXIS	Genes related to chemotaxis
0.1	0.9	PID ALK2 PATHWAY	ALK2 signaling events
0.1	0.7	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	0.7	PID CONE PATHWAY	Visual signal transduction: Cones
0.0	0.5	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.3	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.3	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	0.2	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.

Showing 1 to 8 of 8 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.4	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	1.1	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.1	0.9	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.9	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	0.8	REACTOME KINESINS	Genes involved in Kinesins
0.0	0.7	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0	0.6	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.5	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.3	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0	0.3	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1

Showing 1 to 10 of 13 entries

Results for ebf3a-1+si:ch211-51e8.2

Z-value: 1.02

Motif logo

Transcription factors associated with ebf3a-1+si:ch211-51e8.2

Activity-expression correlation:

Activity profile of ebf3a-1+si:ch211-51e8.2 motif

Sorted Z-values of ebf3a-1+si:ch211-51e8.2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ebf3a-1+si:ch211-51e8.2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: