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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for egr3

Z-value: 0.35

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Transcription factors associated with egr3

Gene Symbol Gene ID Gene Info
egr3
ENSDARG00000089156 early growth response 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
egr3dr11_v1_chr8_+_50727220_50727220-0.116.7e-01Click!

Activity profile of egr3 motif

Sorted Z-values of egr3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_2584423 1.35 ENSDART00000013506
zp3.2
zona pellucida glycoprotein 3, tandem duplicate 2
chr22_-_10591876 0.60 ENSDART00000105846
si:dkey-42i9.8
si:dkey-42i9.8
chr2_+_59015878 0.56 ENSDART00000148816
ENSDART00000122795
si:ch1073-391i24.1
si:ch1073-391i24.1
chr17_+_46387086 0.55 ENSDART00000157079
si:dkey-206p8.1
si:dkey-206p8.1
chr16_-_47381519 0.54 ENSDART00000032188
ENSDART00000150136
si:dkey-256h2.1
si:dkey-256h2.1
chr2_+_16710889 0.51 ENSDART00000017852
ubxn7
UBX domain protein 7
chr7_+_46019780 0.51 ENSDART00000163991
ccne1
cyclin E1
chr12_-_990149 0.49 ENSDART00000054367
kdelr2b
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2b
chr13_+_35925490 0.44 ENSDART00000046115
mfsd2aa
major facilitator superfamily domain containing 2aa
chr1_+_12295142 0.43 ENSDART00000158595
gne
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
chr23_-_31645760 0.38 ENSDART00000035031
sgk1
serum/glucocorticoid regulated kinase 1
chr7_-_46019756 0.33 ENSDART00000162583
zgc:162297
zgc:162297
chr7_-_6364168 0.28 ENSDART00000173332
zgc:112234
zgc:112234
chr2_+_105748 0.27 ENSDART00000169601
CABZ01098670.1

chr11_+_1565806 0.27 ENSDART00000137479
mybl2b
v-myb avian myeloblastosis viral oncogene homolog-like 2b
chr19_-_48039400 0.26 ENSDART00000166748
ENSDART00000165921
csf3b
colony stimulating factor 3 (granulocyte) b
chr13_-_36141486 0.24 ENSDART00000044115
med6
mediator complex subunit 6
chr24_+_3328354 0.23 ENSDART00000147468
bdh1
3-hydroxybutyrate dehydrogenase, type 1
chr20_+_28803642 0.23 ENSDART00000188526
fntb
farnesyltransferase, CAAX box, beta
chr5_-_21030934 0.23 ENSDART00000133461
ENSDART00000098667
camk2b1
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1
chr7_+_55518519 0.23 ENSDART00000098476
ENSDART00000149915
cdt1
chromatin licensing and DNA replication factor 1
chr2_+_38924975 0.21 ENSDART00000109219
rem2
RAS (RAD and GEM)-like GTP binding 2
chr11_+_14049131 0.20 ENSDART00000172471
grin3bb
glutamate receptor, ionotropic, N-methyl-D-aspartate 3Bb
chr12_-_26537145 0.17 ENSDART00000138437
ENSDART00000163931
ENSDART00000132737
acsf2
acyl-CoA synthetase family member 2
chr12_-_37449396 0.16 ENSDART00000152951
cdc42ep4b
CDC42 effector protein (Rho GTPase binding) 4b
chr23_-_29556844 0.15 ENSDART00000138021
rbp7a
retinol binding protein 7a, cellular
chr8_+_6576940 0.15 ENSDART00000138135
vsig8b
V-set and immunoglobulin domain containing 8b
chr5_+_29831235 0.14 ENSDART00000109660
f11r.1
F11 receptor, tandem duplicate 1
chr4_-_73587205 0.14 ENSDART00000150837
znf1015
zinc finger protein 1015
chr3_-_11624694 0.14 ENSDART00000127157
hlfa
hepatic leukemia factor a
chr16_-_12512568 0.13 ENSDART00000055161
ENSDART00000160906
cox6b2
cytochrome c oxidase subunit VIb polypeptide 2
chr8_-_4618653 0.13 ENSDART00000025535
sept5a
septin 5a
chr5_+_6617401 0.11 ENSDART00000060532
zgc:110796
zgc:110796
chr20_+_27712714 0.11 ENSDART00000008306
zbtb1
zinc finger and BTB domain containing 1
chr2_+_35880600 0.11 ENSDART00000004277
lamc1
laminin, gamma 1
chr19_+_5480327 0.10 ENSDART00000148794
jupb
junction plakoglobin b
chr3_+_22984098 0.10 ENSDART00000043190
lsm12a
LSM12 homolog a
chr18_+_3169579 0.10 ENSDART00000164724
ENSDART00000186340
ENSDART00000181247
ENSDART00000168056
pak1
p21 protein (Cdc42/Rac)-activated kinase 1
chr15_+_9294620 0.09 ENSDART00000133588
ENSDART00000140009
slc37a4a
solute carrier family 37 (glucose-6-phosphate transporter), member 4a
chr21_-_217589 0.09 ENSDART00000185017
CZQB01146713.1

chr3_-_7106678 0.08 ENSDART00000175293
ENSDART00000187732
ENSDART00000158652
zgc:113102
BX005085.2
zgc:113102

chr4_+_63484571 0.07 ENSDART00000169518
ENSDART00000168681
si:dkey-11d20.1
si:dkey-11d20.1
chr2_+_23062085 0.07 ENSDART00000153745
csnk1g2a
casein kinase 1, gamma 2a
chr13_-_49666615 0.06 ENSDART00000148083
tomm20a
translocase of outer mitochondrial membrane 20
chr24_-_39354829 0.06 ENSDART00000169108
kcnj12a
potassium inwardly-rectifying channel, subfamily J, member 12a
chr3_-_49504023 0.06 ENSDART00000168108
prkacaa
protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
chr13_-_31166544 0.05 ENSDART00000146250
ENSDART00000132129
ENSDART00000139591
mapk8a
mitogen-activated protein kinase 8a
chr9_-_30363770 0.05 ENSDART00000147030
sytl5
synaptotagmin-like 5
chr1_-_48922273 0.05 ENSDART00000150254
si:ch211-112b1.2
si:ch211-112b1.2
chr23_+_804119 0.04 ENSDART00000148163
frmd4bb
FERM domain containing 4Bb
chr15_-_14038227 0.04 ENSDART00000139068
zgc:114130
zgc:114130
chr11_-_2594045 0.04 ENSDART00000114079
nab2
NGFI-A binding protein 2 (EGR1 binding protein 2)
chr4_+_30785713 0.03 ENSDART00000165945
si:dkey-178j11.5
si:dkey-178j11.5
chr17_+_48164536 0.02 ENSDART00000161750
ENSDART00000156923
plekhd1
pleckstrin homology domain containing, family D (with coiled-coil domains) member 1
chr15_-_16121496 0.02 ENSDART00000128624
sgk494a
uncharacterized serine/threonine-protein kinase SgK494a
chr21_-_24865217 0.02 ENSDART00000101136
igsf9bb
immunoglobulin superfamily, member 9Bb
chr22_+_9806867 0.02 ENSDART00000137182
ENSDART00000106103
si:ch211-236g6.1
si:ch211-236g6.1
chr20_+_13894123 0.01 ENSDART00000007744
slc30a1a
solute carrier family 30 (zinc transporter), member 1a
chr22_+_1806235 0.01 ENSDART00000158966
znf1168
zinc finger protein 1168
chr21_-_24865454 0.01 ENSDART00000142907
igsf9bb
immunoglobulin superfamily, member 9Bb
chr3_-_38918697 0.01 ENSDART00000145630
si:dkey-106c17.2
si:dkey-106c17.2
chr9_-_48036 0.01 ENSDART00000165230
ENSDART00000171335
map4k4
mitogen-activated protein kinase kinase kinase kinase 4
chr12_-_44016898 0.00 ENSDART00000175304
si:dkey-201i2.4
si:dkey-201i2.4

Network of associatons between targets according to the STRING database.

First level regulatory network of egr3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0042998 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.1 0.4 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.1 1.4 GO:0007339 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.1 0.5 GO:0006621 protein retention in ER lumen(GO:0006621)
0.1 0.2 GO:0018343 protein farnesylation(GO:0018343)
0.0 0.4 GO:0006047 UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.0 0.1 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.2 GO:0031269 pseudopodium organization(GO:0031268) pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.1 GO:0003232 bulbus arteriosus development(GO:0003232)
0.0 0.2 GO:0000076 DNA replication checkpoint(GO:0000076)
0.0 0.3 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.2 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.1 0.2 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.0 0.2 GO:0070847 core mediator complex(GO:0070847)
0.0 0.5 GO:0030663 COPI-coated vesicle membrane(GO:0030663)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0046923 ER retention sequence binding(GO:0046923)
0.1 0.4 GO:0009384 UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761) N-acylmannosamine kinase activity(GO:0009384)
0.1 0.6 GO:0071253 connexin binding(GO:0071253)
0.1 1.4 GO:0035804 structural constituent of egg coat(GO:0035804)
0.1 0.5 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.1 0.2 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.1 0.2 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 0.2 GO:0031956 medium-chain fatty acid-CoA ligase activity(GO:0031956) butyrate-CoA ligase activity(GO:0047760)
0.0 0.1 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.1 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.2 GO:0004972 NMDA glutamate receptor activity(GO:0004972)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.1 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway