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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for elf2a+elf2b
Z-value: 3.53
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Transcription factors associated with elf2a+elf2b
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSDARG00000019459 | E74-like factor 2a (ets domain transcription factor) | |
| ENSDARG00000079626 | E74-like factor 2b (ets domain transcription factor) | |
| ENSDARG00000117064 | E74-like factor 2b (ets domain transcription factor) |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| elf2a | dr11_v1_chr14_-_46070802_46070802 | -0.86 | 3.8e-06 | Click! |
| elf2b | dr11_v1_chr1_-_13964284_13964284 | -0.68 | 1.9e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_44363195 Show fit | 10.28 |
ENSDART00000161744
|
lysine methyltransferase 5Aa |
|
| chr20_-_23253630 Show fit | 9.41 |
ENSDART00000103365
|
OCIA domain containing 1 |
|
| chr9_+_2041535 Show fit | 8.28 |
ENSDART00000093187
|
limb and neural patterns a |
|
| chr5_+_3891485 Show fit | 8.15 |
ENSDART00000129329
ENSDART00000091711 |
RPA interacting protein |
|
| chr12_-_3840664 Show fit | 8.15 |
ENSDART00000160967
|
TAO kinase 2b |
|
| chr9_+_426392 Show fit | 7.60 |
ENSDART00000172515
|
basic leucine zipper and W2 domains 1b |
|
| chr1_-_34447515 Show fit | 7.57 |
ENSDART00000143048
|
LIM domain 7b |
|
| chr1_+_54737353 Show fit | 7.40 |
ENSDART00000130675
ENSDART00000162075 |
phosphatidylinositol 4-kinase type 2 alpha |
|
| chr15_+_24737599 Show fit | 7.29 |
ENSDART00000078024
|
v-crk avian sarcoma virus CT10 oncogene homolog |
|
| chr14_-_26482096 Show fit | 7.18 |
ENSDART00000187280
|
SMAD family member 5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of elf2a+elf2b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 51.2 | GO:0000398 | RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 0.2 | 25.2 | GO:0006401 | RNA catabolic process(GO:0006401) |
| 0.8 | 17.8 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.9 | 17.4 | GO:0007032 | endosome organization(GO:0007032) |
| 0.2 | 14.5 | GO:0006400 | tRNA modification(GO:0006400) |
| 0.5 | 14.3 | GO:1903845 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845) |
| 0.7 | 13.8 | GO:0032885 | regulation of polysaccharide biosynthetic process(GO:0032885) |
| 0.5 | 13.6 | GO:0006303 | double-strand break repair via nonhomologous end joining(GO:0006303) |
| 0.7 | 13.1 | GO:1901663 | ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663) |
| 0.2 | 13.0 | GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 25.8 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 25.7 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.2 | 20.3 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.1 | 19.4 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.1 | 15.9 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.9 | 15.4 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.2 | 14.9 | GO:0098791 | Golgi subcompartment(GO:0098791) |
| 0.1 | 14.1 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 14.0 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.0 | 12.7 | GO:0030425 | dendrite(GO:0030425) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 23.7 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.1 | 23.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.3 | 20.5 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.1 | 18.6 | GO:0035091 | phosphatidylinositol binding(GO:0035091) |
| 0.0 | 18.0 | GO:0008289 | lipid binding(GO:0008289) |
| 4.1 | 16.4 | GO:0004534 | 5'-3' exoribonuclease activity(GO:0004534) |
| 0.7 | 16.2 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 1.0 | 15.4 | GO:2001069 | glycogen binding(GO:2001069) |
| 0.2 | 15.1 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 15.0 | GO:0030695 | GTPase regulator activity(GO:0030695) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 18.8 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.4 | 18.4 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.5 | 11.0 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.2 | 10.7 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 1.1 | 8.9 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.5 | 8.0 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.4 | 7.4 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.2 | 7.4 | PID FOXO PATHWAY | FoxO family signaling |
| 0.4 | 7.3 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.4 | 6.6 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 18.9 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.6 | 17.8 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 1.3 | 11.9 | REACTOME ARMS MEDIATED ACTIVATION | Genes involved in ARMS-mediated activation |
| 0.3 | 11.8 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 11.7 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.7 | 10.6 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.3 | 9.8 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.4 | 9.6 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.5 | 9.5 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.4 | 8.5 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |