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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for eomesa

Z-value: 1.39

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Transcription factors associated with eomesa

Gene Symbol Gene ID Gene Info
eomesa
ENSDARG00000006640 eomesodermin homolog a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
eomesadr11_v1_chr19_-_868187_8681870.617.3e-03Click!

Activity profile of eomesa motif

Sorted Z-values of eomesa motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_19596214 6.17 ENSDART00000183110
CABZ01059626.1

chr19_-_27564458 5.54 ENSDART00000123155
si:dkeyp-46h3.6
si:dkeyp-46h3.6
chr22_+_25704430 4.23 ENSDART00000143776
si:dkeyp-98a7.3
si:dkeyp-98a7.3
chr22_+_25687525 4.22 ENSDART00000135717
si:dkeyp-98a7.3
si:dkeyp-98a7.3
chr22_+_25681911 4.22 ENSDART00000113381
si:dkeyp-98a7.3
si:dkeyp-98a7.3
chr10_+_19595009 4.14 ENSDART00000112276
zgc:173837
zgc:173837
chr22_+_25693295 4.14 ENSDART00000123888
ENSDART00000150783
si:dkeyp-98a7.4
si:dkeyp-98a7.3
si:dkeyp-98a7.4
si:dkeyp-98a7.3
chr22_+_25715925 4.10 ENSDART00000150650
si:dkeyp-98a7.7
si:dkeyp-98a7.7
chr22_+_25753972 4.05 ENSDART00000188417
AL929192.2

chr22_+_25352530 3.97 ENSDART00000176742
ENSDART00000113186
si:dkey-240e12.6
si:dkey-240e12.6
chr22_+_25274712 3.79 ENSDART00000137341
BX950205.1

chr10_-_25217347 3.46 ENSDART00000036906
kpna7
karyopherin alpha 7 (importin alpha 8)
chr19_-_867071 2.96 ENSDART00000122257
eomesa
eomesodermin homolog a
chr22_+_25774750 2.76 ENSDART00000174421
AL929192.1

chr11_-_1550709 2.23 ENSDART00000110097
si:ch73-303b9.1
si:ch73-303b9.1
chr15_-_35112937 2.15 ENSDART00000154565
ENSDART00000099642
zgc:77118
zgc:77118
chr22_+_39096911 2.01 ENSDART00000157127
ENSDART00000153841
lmcd1
LIM and cysteine-rich domains 1
chr5_+_37749503 1.98 ENSDART00000148586
dpf2
D4, zinc and double PHD fingers family 2
chr15_-_45538773 1.80 ENSDART00000113494
MB21D2
Mab-21 domain containing 2
chr22_-_36690742 1.30 ENSDART00000017188
ENSDART00000124698
ncl
nucleolin
chr11_+_14312260 1.28 ENSDART00000102518
si:ch211-262i1.5
si:ch211-262i1.5
chr9_-_21238616 1.26 ENSDART00000191840
ENSDART00000189127
cox17
COX17 cytochrome c oxidase copper chaperone
chr7_+_27691647 1.22 ENSDART00000079091
cyp2r1
cytochrome P450, family 2, subfamily R, polypeptide 1
chr12_-_17424162 1.18 ENSDART00000079144
ENSDART00000079138
ptenb
phosphatase and tensin homolog B
chr3_+_59051503 1.16 ENSDART00000160767
rasd4
rasd family member 4
chr13_-_7031033 1.13 ENSDART00000193211
CABZ01061524.1

chr23_-_31648026 1.10 ENSDART00000133569
sgk1
serum/glucocorticoid regulated kinase 1
chr23_-_31647793 1.07 ENSDART00000145621
sgk1
serum/glucocorticoid regulated kinase 1
chr20_-_14665002 1.07 ENSDART00000152816
scrn2
secernin 2
chr23_+_37579107 1.05 ENSDART00000169376
plekhg5b
pleckstrin homology domain containing, family G (with RhoGef domain) member 5b
chr9_-_23824290 0.99 ENSDART00000059209
wdfy2
WD repeat and FYVE domain containing 2
chr12_-_25380028 0.97 ENSDART00000142674
zfp36l2
zinc finger protein 36, C3H type-like 2
chr10_-_8956973 0.97 ENSDART00000189564
mocs2
molybdenum cofactor synthesis 2
chr2_-_9607879 0.95 ENSDART00000056899
txndc12
thioredoxin domain containing 12 (endoplasmic reticulum)
chr1_-_40016058 0.90 ENSDART00000165373
cdk2ap2
cyclin-dependent kinase 2 associated protein 2
chr7_+_17716601 0.88 ENSDART00000173792
ENSDART00000080825
rtn3
reticulon 3
chr5_+_37379825 0.84 ENSDART00000171826
klhl13
kelch-like family member 13
chr19_-_81851 0.84 ENSDART00000172319
hnrnpr
heterogeneous nuclear ribonucleoprotein R
chr18_-_20444296 0.82 ENSDART00000132993
kif23
kinesin family member 23
chr13_-_280827 0.73 ENSDART00000144819
slc30a6
solute carrier family 30 (zinc transporter), member 6
chr13_-_280652 0.72 ENSDART00000193627
slc30a6
solute carrier family 30 (zinc transporter), member 6
chr5_-_67762434 0.68 ENSDART00000167301
b4galt4
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
chr21_-_14815952 0.67 ENSDART00000134278
ENSDART00000067004
phpt1
phosphohistidine phosphatase 1
chr5_-_41645058 0.67 ENSDART00000051092
riok2
RIO kinase 2 (yeast)
chr15_-_35126632 0.66 ENSDART00000187324
ENSDART00000037389
zgc:77118
zgc:55413
zgc:77118
zgc:55413
chr10_-_8956742 0.60 ENSDART00000150192
ENSDART00000149493
mocs2
molybdenum cofactor synthesis 2
chr22_-_9896180 0.60 ENSDART00000138343
znf990
zinc finger protein 990
chr1_-_40015782 0.57 ENSDART00000157425
ENSDART00000159238
cdk2ap2
cyclin-dependent kinase 2 associated protein 2
chr13_+_33703784 0.56 ENSDART00000173361
macrod2
MACRO domain containing 2
chr9_-_12885201 0.52 ENSDART00000124957
ankzf1
ankyrin repeat and zinc finger domain containing 1
chr16_+_25107344 0.50 ENSDART00000033211
zgc:66448
zgc:66448
chr7_+_21275152 0.50 ENSDART00000173612
serpinh2
serine (or cysteine) peptidase inhibitor, clade H, member 2
chr17_-_33416020 0.50 ENSDART00000140149
ccdc28a
coiled-coil domain containing 28A
chr25_-_23583101 0.47 ENSDART00000149107
ENSDART00000103704
ENSDART00000184903
nap1l4a
nucleosome assembly protein 1-like 4a
chr17_+_23554932 0.46 ENSDART00000135814
pank1a
pantothenate kinase 1a
chr17_-_33415740 0.45 ENSDART00000135218
ccdc28a
coiled-coil domain containing 28A
chr4_+_56833071 0.45 ENSDART00000157504
si:dkeyp-33c10.7
si:dkeyp-33c10.7
chr15_+_22448456 0.45 ENSDART00000040542
ENSDART00000190270
ENSDART00000185897
arhgef12a
Rho guanine nucleotide exchange factor (GEF) 12a
chr24_-_36196077 0.44 ENSDART00000154395
esco1
establishment of sister chromatid cohesion N-acetyltransferase 1
chr19_+_3849378 0.43 ENSDART00000166218
ENSDART00000159228
oscp1a
organic solute carrier partner 1a
chr18_+_6641542 0.42 ENSDART00000160379
c2cd5
C2 calcium-dependent domain containing 5
chr10_+_16225870 0.41 ENSDART00000164647
slc12a2
solute carrier family 12 (sodium/potassium/chloride transporter), member 2
chr10_+_16225553 0.40 ENSDART00000129844
slc12a2
solute carrier family 12 (sodium/potassium/chloride transporter), member 2
chr14_+_49231776 0.34 ENSDART00000169096
rmnd5b
required for meiotic nuclear division 5 homolog B
chr4_+_77948517 0.30 ENSDART00000149305
pacsin2
protein kinase C and casein kinase substrate in neurons 2
chr16_+_23947196 0.30 ENSDART00000103190
ENSDART00000132961
ENSDART00000147690
ENSDART00000142168
apoa4b.2
apolipoprotein A-IV b, tandem duplicate 2
chr1_-_8966046 0.28 ENSDART00000136198
socs1b
suppressor of cytokine signaling 1b
chr21_-_1742159 0.28 ENSDART00000151049
onecut2
one cut homeobox 2
chr23_+_24957008 0.28 ENSDART00000181069
nol9
nucleolar protein 9
chr4_-_77624155 0.28 ENSDART00000099761
si:ch211-250m6.7
si:ch211-250m6.7
chr22_-_18544701 0.25 ENSDART00000132156
cirbpb
cold inducible RNA binding protein b
chr1_-_56951369 0.24 ENSDART00000152294
si:ch211-1f22.2
si:ch211-1f22.2
chr1_+_29741843 0.24 ENSDART00000136066
raph1b
Ras association (RalGDS/AF-6) and pleckstrin homology domains 1b
chr20_-_46773258 0.24 ENSDART00000060653
si:ch211-57i17.5
si:ch211-57i17.5
chr16_+_4654333 0.24 ENSDART00000167665
LIN28A
si:ch1073-284b18.2
chr7_+_21887787 0.23 ENSDART00000162252
pop7
POP7 homolog, ribonuclease P/MRP subunit
chr13_-_51952020 0.23 ENSDART00000181079
LT631676.1

chr11_-_40504170 0.22 ENSDART00000165394
si:dkeyp-61b2.1
si:dkeyp-61b2.1
chr24_-_24060460 0.20 ENSDART00000142813
abcc13
ATP-binding cassette, sub-family C (CFTR/MRP), member 13
chr17_-_27048537 0.20 ENSDART00000050018
ENSDART00000193861
cnksr1
connector enhancer of kinase suppressor of Ras 1
chr15_-_1584137 0.20 ENSDART00000056772
trim59
tripartite motif containing 59
chr7_+_30493684 0.18 ENSDART00000027466
mindy2
MINDY lysine 48 deubiquitinase 2
chr5_+_13647288 0.18 ENSDART00000099660
ENSDART00000139199
h2afva
H2A histone family, member Va
chr1_+_45323142 0.17 ENSDART00000132210
emp1
epithelial membrane protein 1
chr3_+_16449490 0.15 ENSDART00000141467
kcnj12b
potassium inwardly-rectifying channel, subfamily J, member 12b
chr7_-_61845282 0.13 ENSDART00000182586
HTRA3
HtrA serine peptidase 3
chr4_+_10721795 0.13 ENSDART00000136000
ENSDART00000067253
stab2
stabilin 2
chr7_-_5396154 0.12 ENSDART00000172980
arhgef11
Rho guanine nucleotide exchange factor (GEF) 11
chr14_-_2361692 0.11 ENSDART00000167696
PCDHGC3 (1 of many)
si:ch73-233f7.4
chr2_-_32637592 0.10 ENSDART00000136353
si:dkeyp-73d8.8
si:dkeyp-73d8.8
chr22_+_19111444 0.10 ENSDART00000109655
fgf22
fibroblast growth factor 22
chr16_+_44314097 0.09 ENSDART00000148684
dpys
dihydropyrimidinase
chr4_-_18211 0.09 ENSDART00000171737
ptpn12
protein tyrosine phosphatase, non-receptor type 12
chr25_-_17367578 0.08 ENSDART00000064591
ENSDART00000110692
cyp2x6
cytochrome P450, family 2, subfamily X, polypeptide 6
chr4_+_77948970 0.08 ENSDART00000149636
pacsin2
protein kinase C and casein kinase substrate in neurons 2
chr1_+_45323400 0.07 ENSDART00000148906
ENSDART00000132366
emp1
epithelial membrane protein 1
chr2_-_13216269 0.07 ENSDART00000149947
bcl2b
BCL2, apoptosis regulator b
chr1_+_57142509 0.07 ENSDART00000146799
si:ch73-94k4.3
si:ch73-94k4.3
chr24_-_24060632 0.07 ENSDART00000090514
abcc13
ATP-binding cassette, sub-family C (CFTR/MRP), member 13
chr1_-_57129179 0.06 ENSDART00000157226
ENSDART00000152469
si:ch73-94k4.2
si:ch73-94k4.2
chr18_+_5618368 0.05 ENSDART00000159945
ulk3
unc-51 like kinase 3
chr7_-_69983462 0.05 ENSDART00000123380
KCNIP4
potassium voltage-gated channel interacting protein 4
chr10_+_26612321 0.05 ENSDART00000134322
fhl1b
four and a half LIM domains 1b
chr8_-_22965214 0.04 ENSDART00000148178
emilin3a
elastin microfibril interfacer 3a
chr20_-_35052464 0.04 ENSDART00000037195
kif26bb
kinesin family member 26Bb
chr22_-_6066867 0.03 ENSDART00000142383
si:dkey-19a16.1
si:dkey-19a16.1
chr18_-_50921002 0.02 ENSDART00000017053
ENSDART00000008696
cttn
cortactin
chr1_-_45042210 0.02 ENSDART00000073694
smu1b
SMU1, DNA replication regulator and spliceosomal factor b
chr19_+_2275019 0.01 ENSDART00000136138
itgb8
integrin, beta 8
chr11_-_13341051 0.01 ENSDART00000121872
mast3b
microtubule associated serine/threonine kinase 3b

Network of associatons between targets according to the STRING database.

First level regulatory network of eomesa

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:0060571 invagination involved in gastrulation with mouth forming second(GO:0055109) morphogenesis of an epithelial fold(GO:0060571)
0.3 3.5 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.2 1.2 GO:0031174 lifelong otolith mineralization(GO:0031174)
0.2 0.7 GO:0035971 peptidyl-histidine dephosphorylation(GO:0035971)
0.2 1.2 GO:0070640 vitamin D3 metabolic process(GO:0070640) cellular response to vitamin D(GO:0071305)
0.2 0.9 GO:0061687 detoxification of inorganic compound(GO:0061687)
0.2 1.6 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.1 0.4 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.8 GO:0040016 embryonic cleavage(GO:0040016)
0.1 1.3 GO:0009303 rRNA transcription(GO:0009303)
0.1 0.4 GO:0010828 positive regulation of glucose transport(GO:0010828)
0.1 0.8 GO:0048796 swim bladder maturation(GO:0048796) swim bladder inflation(GO:0048798)
0.1 0.3 GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448)
0.1 1.3 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) response to copper ion(GO:0046688) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 1.5 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.3 GO:0060330 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0 0.4 GO:0044854 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.0 0.5 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.1 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.0 0.2 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 1.1 GO:0043534 blood vessel endothelial cell migration(GO:0043534)
0.0 0.7 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 0.3 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.1 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.0 1.2 GO:0031101 fin regeneration(GO:0031101)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.1 2.0 GO:0071565 nBAF complex(GO:0071565)
0.1 0.3 GO:0034657 GID complex(GO:0034657)
0.1 0.7 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 1.2 GO:0016605 PML body(GO:0016605)
0.0 1.3 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 0.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.8 GO:0030139 endocytic vesicle(GO:0030139)
0.0 0.4 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.7 GO:0032580 Golgi cisterna membrane(GO:0032580)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0030366 molybdopterin synthase activity(GO:0030366)
0.3 1.2 GO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity(GO:0051717) phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.3 1.3 GO:0016531 copper chaperone activity(GO:0016531)
0.3 1.3 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.2 0.9 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.2 3.5 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.2 0.7 GO:0101006 protein histidine phosphatase activity(GO:0101006)
0.1 30.4 GO:0030246 carbohydrate binding(GO:0030246)
0.1 0.8 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.1 0.5 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 2.2 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 1.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.3 GO:0051731 polynucleotide 5'-hydroxyl-kinase activity(GO:0051731)
0.0 1.2 GO:0019003 GDP binding(GO:0019003)
0.0 0.7 GO:0008378 galactosyltransferase activity(GO:0008378)
0.0 1.3 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.2 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 2.5 GO:0042393 histone binding(GO:0042393)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 PID AURORA B PATHWAY Aurora B signaling
0.0 2.2 PID FOXO PATHWAY FoxO family signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.8 REACTOME KINESINS Genes involved in Kinesins
0.0 1.6 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.7 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 1.3 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.1 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.1 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.1 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.8 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides