ISMARA results: esrrd+esrrga_esrrb

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for esrrd+esrrga_esrrb_esrra+esrrgb

Z-value: 2.49

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Transcription factors associated with esrrd+esrrga_esrrb_esrra+esrrgb

Gene Symbol	Gene ID	Gene Info
esrrga NCBI UniProt	ENSDARG00000004861	estrogen-related receptor gamma a
esrrd NCBI UniProt	ENSDARG00000015064	estrogen-related receptor delta
esrrb NCBI UniProt	ENSDARG00000100847	estrogen-related receptor beta
esrrgb NCBI UniProt	ENSDARG00000011696	estrogen-related receptor gamma b
esrra NCBI UniProt	ENSDARG00000069266	estrogen-related receptor alpha

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
esrrgb	dr11_v1_chr20_-_46808870_46808870	-0.80	6.3e-05	Click!
esrrb	dr11_v1_chr17_-_29902187_29902187	0.77	1.6e-04	Click!
esrrd	dr11_v1_chr18_-_48992363_48992363	0.73	5.2e-04	Click!
esrra	dr11_v1_chr21_+_26620867_26620867	0.35	1.6e-01	Click!

Activity profile of esrrd+esrrga_esrrb_esrra+esrrgb motif

Sorted Z-values of esrrd+esrrga_esrrb_esrra+esrrgb motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_+_39568290 Show fit	8.69	ENSDART00000020741	aldoaa NCBI UniProt Show fit	aldolase a, fructose-bisphosphate, a
chr22_+_25720725 Show fit	8.24	ENSDART00000150778	si:dkeyp-98a7.8 NCBI UniProt Show fit	si:dkeyp-98a7.8
chr16_-_17197546 Show fit	7.02	ENSDART00000139939 ENSDART00000135146 ENSDART00000063800 ENSDART00000163606	gapdh NCBI UniProt Show fit	glyceraldehyde-3-phosphate dehydrogenase
chr17_-_26610814 Show fit	6.05	ENSDART00000133402 ENSDART00000016608	mrpl57 NCBI UniProt Show fit	mitochondrial ribosomal protein L57
chr16_-_46578523 Show fit	5.99	ENSDART00000131061	si:dkey-152b24.6 NCBI UniProt Show fit	si:dkey-152b24.6
chr8_-_52715911 Show fit	5.95	ENSDART00000168241	tubb2b NCBI UniProt Show fit	tubulin, beta 2b
chr22_+_26853254 Show fit	5.82	ENSDART00000182487	tmem186 NCBI UniProt Show fit	transmembrane protein 186
chr21_+_5080789 Show fit	5.11	ENSDART00000024199	atp5fa1 NCBI UniProt Show fit	ATP synthase F1 subunit alpha
chr3_+_1182315 Show fit	5.08	ENSDART00000055430	ndufa6 NCBI UniProt Show fit	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6
chr23_+_44611864 Show fit	5.05	ENSDART00000145905 ENSDART00000132361	eno3 NCBI UniProt Show fit	enolase 3, (beta, muscle)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of esrrd+esrrga_esrrb_esrra+esrrgb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	12.0	GO:0015985	energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.4	9.6	GO:0001966	thigmotaxis(GO:0001966)
0.1	8.9	GO:0006979	response to oxidative stress(GO:0006979)
0.2	8.4	GO:0070098	chemokine-mediated signaling pathway(GO:0070098)
0.1	7.2	GO:0048545	response to steroid hormone(GO:0048545)
0.2	6.8	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.2	6.4	GO:0050821	protein stabilization(GO:0050821)
0.4	5.2	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.6	5.0	GO:0032889	regulation of vacuole fusion, non-autophagic(GO:0032889)
0.1	5.0	GO:0014059	dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)

Showing 1 to 10 of 178 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	21.6	GO:0000313	organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.0	18.6	GO:0005829	cytosol(GO:0005829)
0.0	14.3	GO:0005615	extracellular space(GO:0005615)
0.0	8.6	GO:0005739	mitochondrion(GO:0005739)
0.0	8.4	GO:0005730	nucleolus(GO:0005730)
0.6	8.2	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)
0.2	7.6	GO:0030964	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
1.1	7.4	GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0	5.6	GO:0005874	microtubule(GO:0005874)
0.1	5.5	GO:0032592	integral component of mitochondrial membrane(GO:0032592)

Showing 1 to 10 of 80 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	21.6	GO:0003735	structural constituent of ribosome(GO:0003735)
1.2	9.6	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.5	8.2	GO:0031726	CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.3	7.7	GO:0015002	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
1.8	7.2	GO:0043891	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0	6.9	GO:0030246	carbohydrate binding(GO:0030246)
1.3	5.1	GO:0070891	lipoteichoic acid binding(GO:0070891)
0.6	5.0	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.1	5.0	GO:0001786	phosphatidylserine binding(GO:0001786)
0.0	5.0	GO:0061630	ubiquitin protein ligase activity(GO:0061630)

Showing 1 to 10 of 152 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.9	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.1	3.1	ST FAS SIGNALING PATHWAY	Fas Signaling Pathway
0.1	2.0	PID ARF 3PATHWAY	Arf1 pathway
0.0	1.9	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	1.0	ST STAT3 PATHWAY	STAT3 Pathway
0.0	0.9	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	0.9	PID ATR PATHWAY	ATR signaling pathway
0.0	0.8	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0	0.7	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	0.7	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks

Showing 1 to 10 of 23 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	29.9	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.6	12.2	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.4	5.9	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.3	3.5	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.3	3.2	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.2	2.7	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.1	2.6	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.1	2.3	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.1	2.1	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.1	1.8	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism

Showing 1 to 10 of 36 entries

Results for esrrd+esrrga_esrrb_esrra+esrrgb

Z-value: 2.49

Motif logo

Transcription factors associated with esrrd+esrrga_esrrb_esrra+esrrgb

Activity-expression correlation:

Activity profile of esrrd+esrrga_esrrb_esrra+esrrgb motif

Sorted Z-values of esrrd+esrrga_esrrb_esrra+esrrgb motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of esrrd+esrrga_esrrb_esrra+esrrgb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: