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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for esrrd+esrrga_esrrb_esrra+esrrgb

Z-value: 2.49

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Transcription factors associated with esrrd+esrrga_esrrb_esrra+esrrgb

Gene Symbol Gene ID Gene Info
ENSDARG00000004861 estrogen-related receptor gamma a
ENSDARG00000015064 estrogen-related receptor delta
ENSDARG00000100847 estrogen-related receptor beta
ENSDARG00000011696 estrogen-related receptor gamma b
ENSDARG00000069266 estrogen-related receptor alpha

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
esrrgbdr11_v1_chr20_-_46808870_46808870-0.806.3e-05Click!
esrrbdr11_v1_chr17_-_29902187_299021870.771.6e-04Click!
esrrddr11_v1_chr18_-_48992363_489923630.735.2e-04Click!
esrradr11_v1_chr21_+_26620867_266208670.351.6e-01Click!

Activity profile of esrrd+esrrga_esrrb_esrra+esrrgb motif

Sorted Z-values of esrrd+esrrga_esrrb_esrra+esrrgb motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_39568290 8.69 ENSDART00000020741
aldolase a, fructose-bisphosphate, a
chr22_+_25720725 8.24 ENSDART00000150778
si:dkeyp-98a7.8
chr16_-_17197546 7.02 ENSDART00000139939
ENSDART00000135146
ENSDART00000063800
ENSDART00000163606
glyceraldehyde-3-phosphate dehydrogenase
chr17_-_26610814 6.05 ENSDART00000133402
ENSDART00000016608
mitochondrial ribosomal protein L57
chr16_-_46578523 5.99 ENSDART00000131061
si:dkey-152b24.6
chr8_-_52715911 5.95 ENSDART00000168241
tubulin, beta 2b
chr22_+_26853254 5.82 ENSDART00000182487
transmembrane protein 186
chr21_+_5080789 5.11 ENSDART00000024199
ATP synthase F1 subunit alpha
chr3_+_1182315 5.08 ENSDART00000055430
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6
chr23_+_44611864 5.05 ENSDART00000145905
ENSDART00000132361
enolase 3, (beta, muscle)
chr12_-_25201576 4.68 ENSDART00000077188
cytochrome c oxidase subunit VIIa polypeptide 3
chr11_+_18175893 4.67 ENSDART00000177625
zgc:173545
chr18_-_39636348 4.55 ENSDART00000129828
cytochrome P450, family 19, subfamily A, polypeptide 1a
chr6_-_10835849 4.43 ENSDART00000005903
ENSDART00000135065
ATP synthase membrane subunit c locus 3b
chr7_+_38716048 4.43 ENSDART00000024590
synaptotagmin XIII
chr21_+_37411547 4.32 ENSDART00000076320
mitochondrial ribosomal protein S17
chr7_+_22293894 4.14 ENSDART00000056790
transmembrane protein 256
chr11_+_18037729 3.99 ENSDART00000111624
zgc:175135
chr5_-_57820873 3.93 ENSDART00000089961
salt-inducible kinase 2a
chr11_+_18053333 3.87 ENSDART00000075750
zgc:175135
chr8_+_39760258 3.78 ENSDART00000037914
cytochrome c oxidase subunit VIa polypeptide 1
chr14_+_32852388 3.75 ENSDART00000166351
NFKB repressing factor
chr16_-_4546965 3.62 ENSDART00000060594
mitochondrial ribosomal protein L51
chr3_+_24207243 3.55 ENSDART00000023454
ENSDART00000136400
adenylosuccinate lyase
chr6_-_33878665 3.47 ENSDART00000129916
transmembrane protein 69
chr3_-_13599482 3.46 ENSDART00000166639
Tu translation elongation factor, mitochondrial
chr3_-_34724879 3.45 ENSDART00000177021
thyroid hormone receptor alpha a
chr6_+_52235441 3.41 ENSDART00000056319
cytochrome c oxidase subunit VIc
chr16_-_4547193 3.38 ENSDART00000097540
mitochondrial ribosomal protein L51
chr5_-_1076431 3.38 ENSDART00000168336
si:zfos-128g4.1
chr11_+_18130300 3.35 ENSDART00000169146
zgc:175135
chr21_-_22681534 3.33 ENSDART00000159233
grass carp reovirus (GCRV)-induced gene 2f
chr11_+_18157260 3.30 ENSDART00000144659
zgc:173545
chr3_+_3454610 3.28 ENSDART00000024900
zgc:165453
chr3_+_58167288 3.27 ENSDART00000155874
ENSDART00000010395
ubiquinol-cytochrome c reductase core protein 2a
chr3_-_60142530 3.24 ENSDART00000153247
si:ch211-120g10.1
chr1_+_580642 3.06 ENSDART00000147633
mitochondrial ribosomal protein L39
chr20_-_16171297 2.83 ENSDART00000012476
cytochrome c oxidase assembly factor 7
chr5_-_57879138 2.81 ENSDART00000145959
salt-inducible kinase 2a
chr21_+_39197628 2.80 ENSDART00000113607
carboxypeptidase D, b
chr16_-_5721386 2.72 ENSDART00000136655
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3
chr12_-_47648538 2.58 ENSDART00000108477
fumarate hydratase
chr14_-_35892767 2.52 ENSDART00000052648
transmembrane protein 144b
chr18_+_30508729 2.48 ENSDART00000185140
cytochrome c oxidase subunit IV isoform 1
chr16_-_50229193 2.48 ENSDART00000161782
ENSDART00000010081
electron-transfer-flavoprotein, beta polypeptide
chr10_-_16065185 2.42 ENSDART00000187266
si:dkey-184a18.5
chr13_-_18195942 2.34 ENSDART00000079902
solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16
chr24_-_23974559 2.29 ENSDART00000080510
ENSDART00000135242
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4
chr12_+_48395693 2.25 ENSDART00000180362
stearoyl-CoA desaturase (delta-9-desaturase)
chr22_-_21150845 2.24 ENSDART00000027345
transmembrane protein 59-like
chr6_+_9952678 2.23 ENSDART00000019325
cytochrome P450, family 20, subfamily A, polypeptide 1
chr6_+_22337081 2.20 ENSDART00000128047
ENSDART00000138930
ubiquinol-cytochrome c reductase core protein 1
chr1_+_24557414 2.11 ENSDART00000076519
dCTP pyrophosphatase 1
chr21_-_28640316 2.08 ENSDART00000128237
neuregulin 2a
chr5_-_37886063 2.08 ENSDART00000131378
ENSDART00000132152
si:ch211-139a5.9
chr8_+_45338073 2.04 ENSDART00000185024
poly(A) binding protein, cytoplasmic 1-like
chr21_+_27336550 2.02 ENSDART00000139634
dipeptidyl-peptidase 3
chr13_-_36418921 2.02 ENSDART00000135804
ddb1 and cul4 associated factor 5
chr22_-_26865361 2.00 ENSDART00000182504
heme oxygenase 2a
chr19_-_5103141 1.99 ENSDART00000150952
triosephosphate isomerase 1a
chr7_-_28549361 1.96 ENSDART00000173918
ENSDART00000054368
ENSDART00000113313
suppression of tumorigenicity 5
chr7_+_48805534 1.92 ENSDART00000145375
ENSDART00000148744
carnitine palmitoyltransferase 1Aa (liver)
chr23_+_19198244 1.88 ENSDART00000047015
coiled-coil domain containing 115
chr11_+_13207898 1.87 ENSDART00000060310
ATP synthase F1 subunit beta
chr5_+_37729207 1.84 ENSDART00000184378
CDC42 effector protein (Rho GTPase binding) 2
chr18_+_30507839 1.83 ENSDART00000026866
cytochrome c oxidase subunit IV isoform 1
chr7_+_48805725 1.81 ENSDART00000166543
carnitine palmitoyltransferase 1Aa (liver)
chr10_+_7671260 1.80 ENSDART00000157608
family with sequence similarity 136, member A
chr19_+_1465004 1.76 ENSDART00000159157

chr25_+_16116740 1.76 ENSDART00000139778
fatty acyl CoA reductase 1
chr19_-_5103313 1.75 ENSDART00000037007
triosephosphate isomerase 1a
chr21_+_15704556 1.73 ENSDART00000024858
ENSDART00000146909
coiled-coil-helix-coiled-coil-helix domain containing 10
chr13_-_15082024 1.72 ENSDART00000157482
sideroflexin 5a
chr12_-_45238759 1.70 ENSDART00000154859
tripartite motif containing 65
chr5_+_61738276 1.70 ENSDART00000186256
RAS like family 10 member B
chr19_-_7291733 1.64 ENSDART00000015559
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr2_+_30249977 1.63 ENSDART00000109160
ENSDART00000135171
transmembrane protein 70
chr22_-_15720347 1.63 ENSDART00000105692
mitochondrial ribosomal protein L54
chr17_-_38778826 1.58 ENSDART00000168182
ENSDART00000124041
ENSDART00000136921
D-glutamate cyclase
chr22_-_7050 1.56 ENSDART00000127829
ATPase family, AAA domain containing 3
chr12_+_28799988 1.55 ENSDART00000022724
pyridoxamine 5'-phosphate oxidase
chr1_-_55262763 1.55 ENSDART00000152769
si:ch211-286b5.4
chr13_-_9311253 1.54 ENSDART00000058056
mitochondrial ribosomal protein S26
chr22_+_24215007 1.53 ENSDART00000162227
glutaredoxin 2
chr1_+_12335816 1.53 ENSDART00000067086
N-acetylneuraminic acid synthase a
chr21_+_5882300 1.52 ENSDART00000165065
ubiquinol-cytochrome c reductase, complex III subunit X
chr1_-_55248496 1.51 ENSDART00000098615
nanos homolog 3
chr21_+_11885404 1.51 ENSDART00000092015
DDB1 and CUL4 associated factor 12
chr9_-_27717006 1.49 ENSDART00000146860
general transcription factor IIE, polypeptide 1, alpha
chr13_+_15800742 1.48 ENSDART00000146234
apoptogenic 1, mitochondrial
chr16_+_33938227 1.46 ENSDART00000166254
GPN-loop GTPase 2
chr17_-_1703259 1.45 ENSDART00000156489
x globin
chr10_-_18463934 1.43 ENSDART00000133116
ENSDART00000113422
si:dkey-28o19.1
chr8_-_49495584 1.40 ENSDART00000141691
opsin 7, group member d
chr2_+_44545912 1.40 ENSDART00000155362
si:dkeyp-94h10.5
chr15_-_21692630 1.39 ENSDART00000039865
succinate dehydrogenase complex, subunit D, integral membrane protein b
chr2_-_1227221 1.39 ENSDART00000130897
ATP binding cassette subfamily F member 3
chr14_-_17575764 1.38 ENSDART00000123145
ring finger protein 4
chr1_+_26467071 1.35 ENSDART00000112329
ENSDART00000159318
ENSDART00000193833
ENSDART00000011809
USO1 vesicle transport factor
chr5_+_50879545 1.33 ENSDART00000128402
nucleolar protein 6 (RNA-associated)
chr17_+_15213496 1.33 ENSDART00000058351
ENSDART00000131663
glucosamine-phosphate N-acetyltransferase 1
chr21_+_39432248 1.32 ENSDART00000179938
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1b
chr9_+_7909490 1.31 ENSDART00000133063
ENSDART00000109288
myosin XVI
chr14_+_1240419 1.31 ENSDART00000181248
adenosine deaminase domain containing 1 (testis-specific)
chr2_-_56649883 1.31 ENSDART00000191786
glutathione peroxidase 4b
chr15_-_1484795 1.30 ENSDART00000129356
si:dkeyp-97b10.3
chr14_-_35414559 1.29 ENSDART00000145033
ribonuclease H2, subunit C
chr11_+_14057605 1.28 ENSDART00000166262
glutamate receptor, ionotropic, N-methyl-D-aspartate 3Bb
chr14_+_1240235 1.27 ENSDART00000127477
adenosine deaminase domain containing 1 (testis-specific)
chr13_-_330004 1.26 ENSDART00000093149
DEAD (Asp-Glu-Ala-Asp) box helicase 21
chr7_-_41915312 1.26 ENSDART00000159869
DnaJ (Hsp40) homolog, subfamily A, member 2
chr6_+_50381665 1.25 ENSDART00000141128
cytochrome c-1
chr9_-_29844596 1.24 ENSDART00000138574
interleukin 1 receptor accessory protein-like 1a
chr21_-_5879897 1.23 ENSDART00000184034
ribosomal protein L35
chr23_-_20002459 1.23 ENSDART00000163396
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
chr7_+_40094081 1.21 ENSDART00000186054
si:ch73-174h16.4
chr3_-_32337653 1.21 ENSDART00000156918
ENSDART00000156551
si:dkey-16p21.8
chr22_+_33362552 1.20 ENSDART00000101580
nicolin 1
chr10_+_45128375 1.19 ENSDART00000164805
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2
chr19_-_44065581 1.19 ENSDART00000006338
mitochondrial transcription termination factor 3
chr19_+_20163826 1.16 ENSDART00000090942
ENSDART00000134650
coiled-coil domain containing 126
chr15_-_1485086 1.15 ENSDART00000191651
si:dkeyp-97b10.3
chr19_+_28187480 1.14 ENSDART00000183825
iroquois homeobox 4b
chr8_+_37749263 1.13 ENSDART00000108556
ENSDART00000147942
nucleophosmin/nucleoplasmin, 2a
chr15_+_34592215 1.13 ENSDART00000099776
tetraspanin 13a
chr3_-_32590164 1.12 ENSDART00000151151
tetraspanin 4b
chr1_-_46862190 1.12 ENSDART00000145167
1-acylglycerol-3-phosphate O-acyltransferase 3
chr22_-_9860792 1.08 ENSDART00000155908
si:dkey-253d23.2
chr15_+_20801253 1.07 ENSDART00000179387
aldehyde dehydrogenase 3 family, member A1
chr13_-_12660318 1.06 ENSDART00000008498
alcohol dehydrogenase 8a
chr25_+_25124684 1.04 ENSDART00000167542
lactate dehydrogenase A4
chr13_-_38039871 1.04 ENSDART00000140645

chr22_-_9861531 1.03 ENSDART00000193197
si:dkey-253d23.2
chr24_+_26140855 1.02 ENSDART00000139017
teleost multiple tissue opsin b
chr5_-_20491198 0.99 ENSDART00000183051
ENSDART00000144232
FIC domain containing
chr15_-_25365570 0.99 ENSDART00000152754
clustered mitochondria (cluA/CLU1) homolog a
chr14_+_38878482 0.99 ENSDART00000043317
translocase of inner mitochondrial membrane 8 homolog A (yeast)
chr14_+_1240604 0.98 ENSDART00000188258
adenosine deaminase domain containing 1 (testis-specific)
chr23_+_9560991 0.96 ENSDART00000081433
ENSDART00000131594
ENSDART00000130069
ENSDART00000138601
adhesion regulating molecule 1
chr6_+_59944488 0.96 ENSDART00000161158
nuclear fragile X mental retardation protein interacting protein 1
chr11_-_45429199 0.94 ENSDART00000173111
replication factor C (activator 1) 4
chr6_+_50381347 0.94 ENSDART00000055504
cytochrome c-1
chr7_-_8344243 0.93 ENSDART00000149510
coagulation factor XIII, A1 polypeptide b
chr23_+_9560797 0.93 ENSDART00000180014
adhesion regulating molecule 1
chr10_-_32558917 0.92 ENSDART00000128888
ENSDART00000143301
monoacylglycerol O-acyltransferase 2
chr17_-_33289304 0.92 ENSDART00000135118
ENSDART00000040346
EFR3 homolog Ba (S. cerevisiae)
chr1_-_17569793 0.92 ENSDART00000125125
acyl-CoA synthetase long chain family member 1a
chr7_+_21275152 0.91 ENSDART00000173612
serine (or cysteine) peptidase inhibitor, clade H, member 2
chr3_+_26814030 0.90 ENSDART00000180128
suppressor of cytokine signaling 1a
chr8_+_38564942 0.90 ENSDART00000085371
riboflavin kinase
chr25_+_17870799 0.90 ENSDART00000136797
BTB (POZ) domain containing 10a
chr16_-_12512568 0.89 ENSDART00000055161
ENSDART00000160906
cytochrome c oxidase subunit VIb polypeptide 2
chr13_-_18105278 0.89 ENSDART00000090475
WASH complex subunit 2C
chr24_-_6024466 0.89 ENSDART00000040865
prenyl (decaprenyl) diphosphate synthase, subunit 1
chr9_+_31075896 0.88 ENSDART00000188042
citrate lyase beta like
chr3_+_39566999 0.87 ENSDART00000146867
aldolase a, fructose-bisphosphate, a
chr20_-_3290791 0.87 ENSDART00000146870
si:ch1073-412h12.3
chr5_-_26566435 0.87 ENSDART00000146070
ARVCF, delta catenin family member b
chr6_+_29707129 0.87 ENSDART00000023549
ENSDART00000164849
prohibitin 2b
chr19_+_19976990 0.87 ENSDART00000052627
neuropeptide VF precursor
chr7_+_20524064 0.86 ENSDART00000052917
solute carrier family 3 (amino acid transporter heavy chain), member 2a
chr10_-_7671219 0.85 ENSDART00000159330
prenylcysteine oxidase 1
chr23_+_2906031 0.85 ENSDART00000109304
c23h20orf24 homolog (H. sapiens)
chr2_-_44971551 0.85 ENSDART00000018818
mitochondrial E3 ubiquitin protein ligase 1a
chr12_-_290782 0.84 ENSDART00000152527
ENSDART00000105694
ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
chr5_+_69780493 0.84 ENSDART00000154507
si:ch211-275j6.5
chr20_+_43942278 0.84 ENSDART00000100571
chloride intracellular channel 5b
chr2_+_26060528 0.84 ENSDART00000058111
glutamate receptor, ionotropic, N-methyl-D-aspartate 3Ba
chr22_+_10201826 0.84 ENSDART00000006513
ENSDART00000132641
pyruvate dehydrogenase E1 beta subunit
chr9_+_27379014 0.83 ENSDART00000167366
toll-like receptor 20, tandem duplicate 4
chr7_-_19600181 0.83 ENSDART00000100757
oxidase (cytochrome c) assembly 1-like
chr11_+_15890984 0.82 ENSDART00000158433
pantothenate kinase 4
chr23_+_42482137 0.82 ENSDART00000160199
cytochrome P450, family 2, subfamily AA, polypeptide 3
chr20_-_40758410 0.81 ENSDART00000183031
connexin 34.5
chr10_-_57270 0.81 ENSDART00000058411
holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
chr1_+_51221320 0.81 ENSDART00000138878
NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
chr18_+_44769027 0.81 ENSDART00000145190
ilvB (bacterial acetolactate synthase)-like
chr18_+_910992 0.80 ENSDART00000161206
ENSDART00000167229
pyruvate kinase M1/2a
chr25_+_36311333 0.80 ENSDART00000190174
histone cluster 1 H2A family member 2
chr16_+_38240027 0.78 ENSDART00000111081
prune exopolyphosphatase
chr16_+_20871021 0.77 ENSDART00000006429
3-hydroxyisobutyrate dehydrogenase b
chr11_-_11471857 0.77 ENSDART00000030103
keratin 94
chr4_-_6806632 0.77 ENSDART00000139242
interferon-related developmental regulator 1
chr25_-_35139520 0.76 ENSDART00000189008

chr10_+_2234283 0.76 ENSDART00000136363
contactin associated protein like 3
chr2_+_10006839 0.75 ENSDART00000160304
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3b
chr21_+_35328025 0.74 ENSDART00000136211
arginyl-tRNA synthetase
chr21_-_25250594 0.74 ENSDART00000163862
nuclear factor related to kappaB binding protein
chr14_-_28568107 0.71 ENSDART00000042850
ENSDART00000145502
preproinsulin b
chr8_+_17184602 0.71 ENSDART00000050228
ENSDART00000140531
DIM1 dimethyladenosine transferase 1-like (S. cerevisiae)
chr2_+_30032303 0.71 ENSDART00000151841
RNA binding motif protein 33b
chr13_-_44836727 0.71 ENSDART00000144385
si:dkeyp-2e4.3
chr6_+_19383267 0.70 ENSDART00000166549
melanin-concentrating hormone receptor 1a
chr24_-_21471389 0.70 ENSDART00000109848
ATPase phospholipid transporting 8A2
chr5_+_32924669 0.69 ENSDART00000085219
LIM domain only 4a
chr7_+_17120811 0.69 ENSDART00000147140
protein arginine methyltransferase 3
chr2_-_3045861 0.69 ENSDART00000105818
ENSDART00000187575
guanylate kinase 1a
chr20_+_16170848 0.69 ENSDART00000182115
zyg-11 homolog (C. elegans)
chr23_-_45568816 0.69 ENSDART00000076086
cytochrome P450, family 17, subfamily A, polypeptide 2
chr25_+_22730490 0.69 ENSDART00000149455
ATP-binding cassette, sub-family C (CFTR/MRP), member 8

Network of associatons between targets according to the STRING database.

First level regulatory network of esrrd+esrrga_esrrb_esrra+esrrgb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.6 GO:0030238 female sex determination(GO:0030237) male sex determination(GO:0030238)
1.3 3.8 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.9 3.7 GO:0019242 methylglyoxal biosynthetic process(GO:0019242) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.8 2.4 GO:0042364 water-soluble vitamin biosynthetic process(GO:0042364)
0.8 2.3 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.7 2.1 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.6 2.5 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.6 5.0 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.6 1.9 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.6 3.0 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.6 2.3 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.5 1.5 GO:0001113 DNA-templated transcriptional open complex formation(GO:0001112) transcriptional open complex formation at RNA polymerase II promoter(GO:0001113) protein-DNA complex remodeling(GO:0001120)
0.5 12.0 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.4 1.3 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.4 9.6 GO:0001966 thigmotaxis(GO:0001966)
0.4 4.1 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.4 5.2 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.4 3.5 GO:0006167 AMP biosynthetic process(GO:0006167)
0.4 1.5 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.4 3.6 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.3 3.4 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154)
0.3 1.4 GO:0048211 Golgi vesicle docking(GO:0048211)
0.3 2.0 GO:0006788 heme oxidation(GO:0006788)
0.3 1.3 GO:0051012 microtubule sliding(GO:0051012)
0.3 1.0 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.3 2.1 GO:0003222 ventricular trabecula myocardium morphogenesis(GO:0003222) trabecula formation(GO:0060343) heart trabecula formation(GO:0060347) skin epidermis development(GO:0098773)
0.3 1.2 GO:0061668 mitochondrial ribosome assembly(GO:0061668)
0.3 3.6 GO:0006382 adenosine to inosine editing(GO:0006382)
0.3 1.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.3 2.6 GO:0006108 malate metabolic process(GO:0006108)
0.2 0.9 GO:0045938 regulation of endocrine process(GO:0044060) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) endocrine hormone secretion(GO:0060986)
0.2 0.8 GO:0009097 isoleucine metabolic process(GO:0006549) isoleucine biosynthetic process(GO:0009097)
0.2 1.4 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.2 1.8 GO:0031274 pseudopodium organization(GO:0031268) pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.2 6.8 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.2 6.4 GO:0050821 protein stabilization(GO:0050821)
0.2 1.4 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.2 2.1 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.2 1.8 GO:0015746 tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.2 1.0 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.2 0.8 GO:0030328 prenylated protein catabolic process(GO:0030327) prenylcysteine catabolic process(GO:0030328) prenylcysteine metabolic process(GO:0030329)
0.2 0.8 GO:0032978 protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979) protein insertion into mitochondrial membrane(GO:0051204)
0.2 0.5 GO:0015990 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) electron transport coupled proton transport(GO:0015990)
0.2 8.4 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.2 1.1 GO:0046294 formaldehyde metabolic process(GO:0046292) formaldehyde catabolic process(GO:0046294)
0.2 0.9 GO:0060334 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.1 0.9 GO:0006574 valine catabolic process(GO:0006574)
0.1 1.0 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.1 0.5 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186) peptidyl-glutamine modification(GO:0018199)
0.1 0.5 GO:0051645 Golgi localization(GO:0051645) maintenance of centrosome location(GO:0051661)
0.1 1.9 GO:0043248 proteasome assembly(GO:0043248)
0.1 0.4 GO:0035773 insulin secretion involved in cellular response to glucose stimulus(GO:0035773) regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.1 1.4 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.1 0.7 GO:0008207 C21-steroid hormone metabolic process(GO:0008207)
0.1 0.3 GO:0009750 response to fructose(GO:0009750)
0.1 5.0 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.1 1.3 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.1 0.3 GO:0097676 histone H3-K4 trimethylation(GO:0080182) histone H3-K36 dimethylation(GO:0097676)
0.1 0.2 GO:0060283 negative regulation of oocyte development(GO:0060283)
0.1 2.0 GO:0060974 cell migration involved in heart formation(GO:0060974)
0.1 0.3 GO:0006089 lactate metabolic process(GO:0006089)
0.1 0.3 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 0.4 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.1 1.2 GO:0045920 negative regulation of exocytosis(GO:0045920)
0.1 1.2 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.1 0.6 GO:0051673 membrane disruption in other organism(GO:0051673)
0.1 0.8 GO:0060142 regulation of syncytium formation by plasma membrane fusion(GO:0060142)
0.1 0.2 GO:0048240 sperm capacitation(GO:0048240)
0.1 0.4 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143) protein urmylation(GO:0032447)
0.1 1.0 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.1 1.5 GO:0015671 oxygen transport(GO:0015671)
0.1 8.9 GO:0006979 response to oxidative stress(GO:0006979)
0.1 7.2 GO:0048545 response to steroid hormone(GO:0048545)
0.1 2.4 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.1 0.3 GO:0010481 epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.1 2.7 GO:0035336 long-chain fatty-acyl-CoA metabolic process(GO:0035336)
0.1 0.1 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
0.1 0.7 GO:0006797 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.1 0.5 GO:0046958 nonassociative learning(GO:0046958) habituation(GO:0046959)
0.1 1.2 GO:0006825 copper ion transport(GO:0006825)
0.1 0.2 GO:1903673 mitotic cytokinetic process(GO:1902410) mitotic cleavage furrow formation(GO:1903673)
0.1 1.3 GO:0006536 glutamate metabolic process(GO:0006536)
0.1 0.3 GO:0009052 pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.1 1.8 GO:0014866 skeletal myofibril assembly(GO:0014866)
0.1 0.2 GO:0002637 regulation of immunoglobulin production(GO:0002637) positive regulation of immunoglobulin production(GO:0002639)
0.1 0.8 GO:0018216 peptidyl-arginine methylation(GO:0018216)
0.1 0.8 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.1 0.2 GO:0021512 spinal cord anterior/posterior patterning(GO:0021512) cell proliferation involved in pronephros development(GO:0039015) cell proliferation involved in kidney development(GO:0072111)
0.1 0.2 GO:0006953 acute-phase response(GO:0006953)
0.1 0.2 GO:1901017 negative regulation of potassium ion transmembrane transporter activity(GO:1901017) negative regulation of potassium ion transmembrane transport(GO:1901380) negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.1 0.8 GO:0018195 peptidyl-arginine modification(GO:0018195)
0.1 0.8 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.7 GO:0035860 esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 0.2 GO:1903059 natural killer cell activation(GO:0030101) regulation of lipoprotein metabolic process(GO:0050746) regulation of protein lipidation(GO:1903059)
0.0 0.3 GO:0002753 cytoplasmic pattern recognition receptor signaling pathway(GO:0002753)
0.0 0.3 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 0.2 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.0 0.3 GO:0003272 endocardial cushion formation(GO:0003272) protein kinase D signaling(GO:0089700)
0.0 0.2 GO:1904667 negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.0 1.6 GO:0006119 oxidative phosphorylation(GO:0006119)
0.0 0.8 GO:0006415 translational termination(GO:0006415)
0.0 0.7 GO:0031167 rRNA methylation(GO:0031167)
0.0 0.1 GO:0038158 granulocyte colony-stimulating factor signaling pathway(GO:0038158)
0.0 0.4 GO:0035188 hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0 0.5 GO:0046314 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.0 0.2 GO:0070987 error-free translesion synthesis(GO:0070987)
0.0 0.3 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.0 0.4 GO:1901998 toxin transport(GO:1901998)
0.0 0.7 GO:0016203 muscle attachment(GO:0016203)
0.0 0.4 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.0 0.1 GO:0099625 regulation of membrane repolarization(GO:0060306) regulation of ventricular cardiac muscle cell membrane repolarization(GO:0060307) ventricular cardiac muscle cell action potential(GO:0086005) regulation of cardiac muscle cell membrane repolarization(GO:0099623) ventricular cardiac muscle cell membrane repolarization(GO:0099625) regulation of cardiac conduction(GO:1903779)
0.0 0.1 GO:0010755 regulation of plasminogen activation(GO:0010755)
0.0 0.2 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0 3.9 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.0 0.2 GO:0030728 ovulation(GO:0030728)
0.0 0.7 GO:0043507 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.0 0.1 GO:0099552 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
0.0 0.6 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 1.2 GO:0030851 granulocyte differentiation(GO:0030851)
0.0 0.2 GO:0043029 T cell homeostasis(GO:0043029)
0.0 0.4 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0 0.4 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.1 GO:0003250 cell proliferation involved in heart valve morphogenesis(GO:0003249) regulation of cell proliferation involved in heart valve morphogenesis(GO:0003250) endocardial cell development(GO:0060958) cell proliferation involved in heart valve development(GO:2000793)
0.0 0.1 GO:1901492 regulation of lymphangiogenesis(GO:1901490) positive regulation of lymphangiogenesis(GO:1901492)
0.0 1.5 GO:0007602 phototransduction(GO:0007602)
0.0 0.6 GO:0019319 hexose biosynthetic process(GO:0019319) monosaccharide biosynthetic process(GO:0046364)
0.0 0.4 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.0 0.2 GO:0035332 positive regulation of hippo signaling(GO:0035332)
0.0 0.1 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.0 0.9 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.5 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.4 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.6 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.4 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.0 0.6 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.0 1.3 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 0.2 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.0 0.2 GO:0006478 protein sulfation(GO:0006477) peptidyl-tyrosine sulfation(GO:0006478)
0.0 0.6 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.0 0.6 GO:0060030 dorsal convergence(GO:0060030)
0.0 0.4 GO:0009749 response to glucose(GO:0009749)
0.0 0.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.6 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.2 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.0 0.2 GO:0001840 neural plate development(GO:0001840)
0.0 1.2 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.2 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0 0.1 GO:0006102 isocitrate metabolic process(GO:0006102)
0.0 0.4 GO:0007007 inner mitochondrial membrane organization(GO:0007007)
0.0 0.2 GO:0045667 regulation of osteoblast differentiation(GO:0045667)
0.0 0.3 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.9 GO:0017144 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0 0.5 GO:0051014 actin filament severing(GO:0051014)
0.0 0.2 GO:0019233 sensory perception of pain(GO:0019233)
0.0 0.1 GO:0097241 hematopoietic stem cell migration to bone marrow(GO:0097241)
0.0 0.1 GO:0042249 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.0 0.2 GO:0032261 purine nucleotide salvage(GO:0032261) IMP salvage(GO:0032264)
0.0 0.8 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 0.6 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 0.5 GO:0061035 regulation of cartilage development(GO:0061035)
0.0 0.4 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 1.1 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 1.2 GO:0016051 carbohydrate biosynthetic process(GO:0016051)
0.0 0.4 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.3 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.7 GO:0006342 chromatin silencing(GO:0006342)
0.0 1.1 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.2 GO:0002027 regulation of heart rate(GO:0002027)
0.0 0.1 GO:0046461 neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.0 0.1 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.4 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.1 GO:0048855 adenohypophysis morphogenesis(GO:0048855)
0.0 0.0 GO:0045023 G0 to G1 transition(GO:0045023) regulation of G0 to G1 transition(GO:0070316) negative regulation of G0 to G1 transition(GO:0070317)
0.0 0.1 GO:2000036 regulation of stem cell population maintenance(GO:2000036)
0.0 0.0 GO:0048850 hypophysis morphogenesis(GO:0048850) diencephalon morphogenesis(GO:0048852)
0.0 1.0 GO:0006821 chloride transport(GO:0006821)
0.0 0.8 GO:0001666 response to hypoxia(GO:0001666) response to decreased oxygen levels(GO:0036293)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 7.4 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.6 8.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.6 5.0 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.6 3.0 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.4 1.3 GO:0034456 CURI complex(GO:0032545) UTP-C complex(GO:0034456)
0.4 3.6 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.3 2.4 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.3 1.3 GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex(GO:0008247)
0.3 1.3 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.3 21.6 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.3 4.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.3 1.5 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.3 0.8 GO:0005948 acetolactate synthase complex(GO:0005948)
0.2 7.6 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 1.0 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.2 1.9 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.2 3.0 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.1 0.4 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 5.1 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.1 2.3 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.1 0.9 GO:0005663 DNA replication factor C complex(GO:0005663)
0.1 3.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 0.5 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
0.1 0.3 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 5.5 GO:0032592 integral component of mitochondrial membrane(GO:0032592)
0.1 0.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.5 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.9 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.1 0.2 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.1 0.6 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 0.2 GO:0097189 apoptotic body(GO:0097189)
0.1 0.5 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.3 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.7 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 1.5 GO:0043186 P granule(GO:0043186)
0.0 1.6 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 4.3 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.2 GO:0017177 glucosidase II complex(GO:0017177)
0.0 1.8 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) anchored component of the cytoplasmic side of the plasma membrane(GO:0098753)
0.0 1.4 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.7 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510) clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.3 GO:0072487 MSL complex(GO:0072487)
0.0 0.5 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 5.1 GO:0005840 ribosome(GO:0005840)
0.0 0.2 GO:0001650 fibrillar center(GO:0001650)
0.0 0.5 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.7 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 8.4 GO:0005730 nucleolus(GO:0005730)
0.0 4.4 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.2 GO:0031526 brush border membrane(GO:0031526)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.6 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.3 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.3 GO:0005581 collagen trimer(GO:0005581)
0.0 1.1 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 1.5 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.3 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 1.7 GO:0005795 Golgi stack(GO:0005795)
0.0 0.1 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.5 GO:0005811 lipid particle(GO:0005811)
0.0 0.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 8.6 GO:0005739 mitochondrion(GO:0005739)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 0.3 GO:0030667 secretory granule membrane(GO:0030667)
0.0 18.6 GO:0005829 cytosol(GO:0005829)
0.0 0.9 GO:0034707 chloride channel complex(GO:0034707)
0.0 5.6 GO:0005874 microtubule(GO:0005874)
0.0 0.4 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.3 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.9 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 1.2 GO:0098858 actin-based cell projection(GO:0098858)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 2.7 GO:0030424 axon(GO:0030424)
0.0 0.4 GO:0005604 basement membrane(GO:0005604)
0.0 0.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 14.3 GO:0005615 extracellular space(GO:0005615)
0.0 0.1 GO:0043034 costamere(GO:0043034)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.2 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
1.3 5.1 GO:0070891 lipoteichoic acid binding(GO:0070891)
1.2 9.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.9 3.7 GO:0008929 triose-phosphate isomerase activity(GO:0004807) methylglyoxal synthase activity(GO:0008929)
0.9 3.5 GO:0016842 amidine-lyase activity(GO:0016842)
0.8 4.6 GO:0070330 aromatase activity(GO:0070330)
0.6 5.0 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.6 4.1 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.6 2.3 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.5 1.6 GO:0000104 succinate dehydrogenase activity(GO:0000104)
0.5 8.2 GO:0031726 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.5 2.4 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.4 1.2 GO:0050135 NAD(P)+ nucleosidase activity(GO:0050135)
0.4 2.1 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.3 2.0 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.3 3.6 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.3 1.9 GO:0061133 endopeptidase activator activity(GO:0061133)
0.3 1.5 GO:0004362 glutathione-disulfide reductase activity(GO:0004362)
0.3 0.9 GO:0047777 (3S)-citramalyl-CoA lyase activity(GO:0047777)
0.3 1.7 GO:0015142 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.3 7.7 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 0.8 GO:0003984 acetolactate synthase activity(GO:0003984)
0.3 1.8 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.2 1.2 GO:0016531 copper chaperone activity(GO:0016531)
0.2 0.7 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.2 2.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 0.7 GO:0030273 melanin-concentrating hormone receptor activity(GO:0030273)
0.2 0.9 GO:0008442 3-hydroxyisobutyrate dehydrogenase activity(GO:0008442)
0.2 1.1 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024) S-(hydroxymethyl)glutathione dehydrogenase activity(GO:0051903)
0.2 1.0 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.2 1.5 GO:0098809 nitrite reductase activity(GO:0098809)
0.2 0.6 GO:0048030 disaccharide binding(GO:0048030)
0.2 0.6 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.2 1.4 GO:0048039 ubiquinone binding(GO:0048039)
0.2 0.8 GO:0001735 prenylcysteine oxidase activity(GO:0001735)
0.2 1.2 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.2 1.3 GO:0004457 lactate dehydrogenase activity(GO:0004457)
0.2 0.5 GO:0001147 transcription termination site sequence-specific DNA binding(GO:0001147) transcription termination site DNA binding(GO:0001160)
0.1 2.0 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 2.3 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.7 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.1 0.7 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 0.7 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.1 0.5 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.1 0.8 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 3.8 GO:0009055 electron carrier activity(GO:0009055)
0.1 0.5 GO:0008887 glycerate kinase activity(GO:0008887)
0.1 0.6 GO:0030504 inorganic diphosphate transmembrane transporter activity(GO:0030504)
0.1 2.0 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 21.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 1.1 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.1 5.0 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 0.5 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.1 0.3 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.1 4.3 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.4 GO:0072570 ADP-D-ribose binding(GO:0072570) mono-ADP-D-ribose binding(GO:0072571)
0.1 1.3 GO:0070840 dynein complex binding(GO:0070840)
0.1 0.8 GO:0032977 membrane insertase activity(GO:0032977)
0.1 2.2 GO:0016411 acylglycerol O-acyltransferase activity(GO:0016411)
0.1 0.4 GO:0003844 1,4-alpha-glucan branching enzyme activity(GO:0003844)
0.1 0.3 GO:0004968 gonadotropin-releasing hormone receptor activity(GO:0004968)
0.1 0.9 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 0.8 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.1 0.8 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 0.9 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.1 4.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 1.5 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 0.5 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.1 0.8 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.1 1.6 GO:0010181 FMN binding(GO:0010181)
0.1 3.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 2.5 GO:0015144 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.1 0.7 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 0.7 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.1 0.3 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)
0.1 4.0 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 0.4 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.1 0.2 GO:0072591 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590) citrate-L-glutamate ligase activity(GO:0072591)
0.1 0.4 GO:0004966 galanin receptor activity(GO:0004966)
0.1 1.0 GO:0070566 adenylyltransferase activity(GO:0070566)
0.1 0.4 GO:0016421 CoA carboxylase activity(GO:0016421)
0.1 0.4 GO:0042936 dipeptide transporter activity(GO:0042936) dipeptide transmembrane transporter activity(GO:0071916)
0.1 1.0 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 0.4 GO:0043035 chromatin insulator sequence binding(GO:0043035)
0.0 0.8 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0 0.3 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)
0.0 0.3 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0 0.4 GO:0048038 quinone binding(GO:0048038)
0.0 0.6 GO:0002020 protease binding(GO:0002020)
0.0 0.2 GO:0010997 anaphase-promoting complex binding(GO:0010997) ubiquitin ligase activator activity(GO:1990757)
0.0 0.5 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.0 0.3 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.7 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.1 GO:0055105 ubiquitin-protein transferase inhibitor activity(GO:0055105)
0.0 1.0 GO:0008378 galactosyltransferase activity(GO:0008378)
0.0 0.2 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.2 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.9 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 0.6 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.4 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 3.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.6 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 2.7 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.3 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.0 0.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 1.5 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.7 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.1 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 1.6 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.2 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.2 GO:0070698 type I activin receptor binding(GO:0070698)
0.0 0.3 GO:0031995 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.0 6.9 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.1 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.1 GO:0005009 insulin-activated receptor activity(GO:0005009) insulin receptor substrate binding(GO:0043560)
0.0 1.3 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.2 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 0.2 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.0 0.2 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.4 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 1.8 GO:0003724 RNA helicase activity(GO:0003724)
0.0 3.6 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 0.3 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 2.7 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.2 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.0 0.2 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 1.1 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.0 0.2 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.5 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.2 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 3.0 GO:0020037 heme binding(GO:0020037)
0.0 0.3 GO:0030552 cAMP binding(GO:0030552)
0.0 0.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.1 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.0 0.1 GO:0016519 gastric inhibitory peptide receptor activity(GO:0016519)
0.0 0.3 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.1 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.0 0.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.0 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086)
0.0 0.7 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 1.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 5.0 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 1.2 GO:0045296 cadherin binding(GO:0045296)
0.0 0.1 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
0.0 0.3 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 0.3 GO:0004697 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698) calcium-dependent protein serine/threonine kinase activity(GO:0009931) calcium-dependent protein kinase activity(GO:0010857)
0.0 0.0 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.7 GO:0008146 sulfotransferase activity(GO:0008146)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.9 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 2.0 PID ARF 3PATHWAY Arf1 pathway
0.1 1.0 ST STAT3 PATHWAY STAT3 Pathway
0.1 3.1 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 0.7 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.9 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.3 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.9 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.4 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.8 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.9 PID ATR PATHWAY ATR signaling pathway
0.0 0.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.6 PID FOXO PATHWAY FoxO family signaling
0.0 0.6 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.2 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.4 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.2 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.4 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.5 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.2 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.1 PID PDGFRB PATHWAY PDGFR-beta signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 12.2 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.5 29.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.4 5.9 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.3 3.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.3 3.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.2 2.7 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 1.0 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 1.2 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 2.1 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.1 0.5 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.1 1.8 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 1.3 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 2.6 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.0 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.1 1.5 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.1 2.3 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.1 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.5 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.6 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.6 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.9 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.4 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 1.3 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.1 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.7 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.2 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.1 REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH Genes involved in NCAM signaling for neurite out-growth
0.0 0.2 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.2 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.2 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.5 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.1 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway