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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for fev+fli1a_erg_etv2
Z-value: 1.70
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Transcription factors associated with fev+fli1a_erg_etv2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSDARG00000009242 | FEV transcription factor, ETS family member | |
| ENSDARG00000054632 | Fli-1 proto-oncogene, ETS transcription factor a | |
| ENSDARG00000077304 | ETS transcription factor ERG | |
| ENSDARG00000053868 | ETS variant transcription factor 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| etv2 | dr11_v1_chr16_-_42013858_42013858 | 0.93 | 2.2e-08 | Click! |
| fli1a | dr11_v1_chr18_+_48428713_48428713 | 0.89 | 1.0e-06 | Click! |
| erg | dr11_v1_chr10_-_167782_167782 | -0.76 | 2.4e-04 | Click! |
| fev | dr11_v1_chr9_-_11549379_11549379 | 0.74 | 4.3e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_2993095 Show fit | 8.55 |
ENSDART00000152316
|
si:dkey-202c14.3 |
|
| chr5_+_42402536 Show fit | 6.76 |
ENSDART00000186754
|
|
|
| chr8_+_54284961 Show fit | 6.62 |
ENSDART00000122692
|
plexin D1 |
|
| chr3_+_24459709 Show fit | 6.61 |
ENSDART00000180976
|
chromobox homolog 6b |
|
| chr16_-_33930759 Show fit | 6.52 |
ENSDART00000177453
|
dynein, axonemal, light intermediate chain 1 |
|
| chr10_+_31222656 Show fit | 5.87 |
ENSDART00000140988
ENSDART00000143387 |
transmembrane protein 218 |
|
| chr9_-_48397702 Show fit | 5.82 |
ENSDART00000147169
|
zgc:172182 |
|
| chr21_+_28502340 Show fit | 5.79 |
ENSDART00000077897
ENSDART00000140229 |
OTU deubiquitinase, ubiquitin aldehyde binding 1a |
|
| chr14_+_81919 Show fit | 5.78 |
ENSDART00000171444
|
stromal antigen 3 |
|
| chr14_+_21007957 Show fit | 5.59 |
ENSDART00000162316
|
Pim proto-oncogene, serine/threonine kinase, related 194 |
Network of associatons between targets according to the STRING database.
First level regulatory network of fev+fli1a_erg_etv2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 87.2 | GO:0046777 | protein autophosphorylation(GO:0046777) |
| 0.1 | 11.2 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.3 | 9.3 | GO:0042073 | intraciliary transport(GO:0042073) |
| 0.6 | 8.7 | GO:0043248 | proteasome assembly(GO:0043248) |
| 1.0 | 8.0 | GO:0010826 | negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606) |
| 0.4 | 7.7 | GO:1902285 | semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287) |
| 0.3 | 7.1 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.1 | 6.5 | GO:0061515 | myeloid cell development(GO:0061515) |
| 0.7 | 6.4 | GO:0098787 | mRNA cleavage involved in mRNA processing(GO:0098787) pre-mRNA cleavage required for polyadenylation(GO:0098789) |
| 1.5 | 6.2 | GO:0009447 | polyamine catabolic process(GO:0006598) putrescine catabolic process(GO:0009447) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 21.0 | GO:0022626 | cytosolic ribosome(GO:0022626) |
| 0.4 | 19.4 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 15.3 | GO:0005929 | cilium(GO:0005929) |
| 0.8 | 13.4 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.1 | 12.5 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.2 | 11.8 | GO:0005814 | centriole(GO:0005814) |
| 0.3 | 11.0 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.4 | 7.7 | GO:0002116 | semaphorin receptor complex(GO:0002116) |
| 0.5 | 7.3 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.4 | 7.3 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 60.9 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.2 | 44.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.6 | 11.7 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.1 | 9.2 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 8.9 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 8.5 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.0 | 7.9 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 0.3 | 7.7 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 1.2 | 7.2 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.0 | 6.8 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 8.1 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 6.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 5.7 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.2 | 5.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 5.4 | PID E2F PATHWAY | E2F transcription factor network |
| 0.4 | 5.3 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.2 | 4.9 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 4.6 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 3.5 | PID RAC1 PATHWAY | RAC1 signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 21.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.4 | 18.9 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.3 | 14.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.3 | 6.3 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 5.8 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 5.4 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.2 | 4.9 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.3 | 4.8 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.3 | 4.3 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 3.8 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |