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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for fli1b
Z-value: 1.92
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Transcription factors associated with fli1b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| fli1b | dr11_v1_chr16_+_42018041_42018042 | -0.60 | 8.4e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_30117798 Show fit | 5.57 |
ENSDART00000135723
ENSDART00000000198 |
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6E |
|
| chr20_+_23947004 Show fit | 5.33 |
ENSDART00000144195
|
caspase 8 associated protein 2 |
|
| chr21_-_4793686 Show fit | 4.49 |
ENSDART00000158232
|
notch 1a |
|
| chr16_-_34195002 Show fit | 4.38 |
ENSDART00000054026
|
regulator of chromosome condensation 1 |
|
| chr19_+_10661520 Show fit | 4.12 |
ENSDART00000091813
ENSDART00000165653 |
argonaute RISC catalytic component 3b |
|
| chr23_-_10175898 Show fit | 4.07 |
ENSDART00000146185
|
keratin 5 |
|
| chr6_-_49547680 Show fit | 4.03 |
ENSDART00000169678
|
protein phosphatase 4, regulatory subunit 1-like |
|
| chr18_+_15271993 Show fit | 3.98 |
ENSDART00000099777
|
si:dkey-103i16.6 |
|
| chr3_+_43102010 Show fit | 3.94 |
ENSDART00000162096
|
mical-like 2a |
|
| chr24_-_2423791 Show fit | 3.81 |
ENSDART00000190402
|
ras responsive element binding protein 1a |
Network of associatons between targets according to the STRING database.
First level regulatory network of fli1b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.2 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.8 | 6.1 | GO:0003365 | establishment of cell polarity involved in ameboidal cell migration(GO:0003365) |
| 0.1 | 5.6 | GO:0001755 | neural crest cell migration(GO:0001755) |
| 0.2 | 5.5 | GO:0070936 | protein K48-linked ubiquitination(GO:0070936) |
| 0.4 | 5.4 | GO:0050732 | negative regulation of peptidyl-tyrosine phosphorylation(GO:0050732) negative regulation of protein tyrosine kinase activity(GO:0061099) |
| 0.2 | 5.4 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 0.1 | 5.4 | GO:0050708 | regulation of protein secretion(GO:0050708) |
| 0.2 | 5.3 | GO:0071230 | cellular response to amino acid stimulus(GO:0071230) |
| 1.3 | 5.2 | GO:0071788 | endoplasmic reticulum tubular network maintenance(GO:0071788) |
| 0.2 | 5.1 | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.8 | GO:0005923 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.2 | 8.0 | GO:0030496 | midbody(GO:0030496) |
| 0.5 | 7.0 | GO:0002102 | podosome(GO:0002102) |
| 0.5 | 6.2 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.0 | 5.5 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.1 | 5.4 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 5.2 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.0 | 5.1 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 4.9 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 4.8 | GO:0016607 | nuclear speck(GO:0016607) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.0 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.1 | 8.5 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 8.1 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.1 | 8.0 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.1 | 6.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 6.0 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 5.2 | GO:0042803 | protein homodimerization activity(GO:0042803) |
| 0.1 | 5.1 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.2 | 5.0 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 1.6 | 4.9 | GO:0004113 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.2 | 6.9 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.7 | 5.7 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.2 | 5.5 | PID ATM PATHWAY | ATM pathway |
| 0.2 | 5.2 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 4.8 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 4.5 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 4.4 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 3.4 | PID IFNG PATHWAY | IFN-gamma pathway |
| 0.1 | 3.2 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 9.0 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.4 | 7.1 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 7.0 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.3 | 5.5 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 4.8 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.2 | 4.7 | REACTOME TRAF6 MEDIATED NFKB ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
| 0.1 | 3.8 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 3.5 | REACTOME LATE PHASE OF HIV LIFE CYCLE | Genes involved in Late Phase of HIV Life Cycle |
| 0.3 | 3.0 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.3 | 3.0 | REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |