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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for fosaa+fosab+fosl1a
Z-value: 2.48
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Transcription factors associated with fosaa+fosab+fosl1a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| fosl1a | dr11_v1_chr14_-_30747686_30747686 | -0.98 | 7.9e-13 | Click! |
| fosab | dr11_v1_chr20_-_46554440_46554440 | -0.83 | 1.9e-05 | Click! |
| fosaa | dr11_v1_chr17_-_50234004_50234004 | -0.78 | 1.3e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_60886984 Show fit | 23.85 |
ENSDART00000170974
|
phosphatidylinositol transfer protein, cytoplasmic 1 |
|
| chr2_-_17115256 Show fit | 9.50 |
ENSDART00000190488
|
PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae) |
|
| chr1_-_33647138 Show fit | 9.03 |
ENSDART00000142111
ENSDART00000015547 |
claudin g |
|
| chr11_+_29537756 Show fit | 8.83 |
ENSDART00000103388
|
wu:fi42e03 |
|
| chr17_-_6514962 Show fit | 7.85 |
ENSDART00000163514
|
DnaJ (Hsp40) homolog, subfamily C, member 5 gamma b |
|
| chr10_-_32877348 Show fit | 7.73 |
ENSDART00000018977
ENSDART00000133421 |
RAB guanine nucleotide exchange factor (GEF) 1 |
|
| chr18_+_45573416 Show fit | 7.30 |
ENSDART00000132184
ENSDART00000145288 |
kinesin family member C3 |
|
| chr24_+_10027902 Show fit | 7.03 |
ENSDART00000175961
ENSDART00000172773 |
si:ch211-146l10.8 |
|
| chr3_+_7808459 Show fit | 6.39 |
ENSDART00000162374
|
hook microtubule-tethering protein 2 |
|
| chr24_-_10006158 Show fit | 5.85 |
ENSDART00000106244
|
zgc:171750 |
Network of associatons between targets according to the STRING database.
First level regulatory network of fosaa+fosab+fosl1a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.0 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
| 1.2 | 14.1 | GO:0000002 | mitochondrial genome maintenance(GO:0000002) |
| 0.3 | 14.0 | GO:0032007 | negative regulation of TOR signaling(GO:0032007) |
| 0.4 | 13.8 | GO:0009648 | photoperiodism(GO:0009648) |
| 0.8 | 11.6 | GO:0060236 | regulation of mitotic spindle organization(GO:0060236) |
| 0.2 | 10.9 | GO:0031122 | cytoplasmic microtubule organization(GO:0031122) |
| 0.8 | 9.5 | GO:0000912 | assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837) |
| 0.5 | 9.3 | GO:0007032 | endosome organization(GO:0007032) |
| 1.0 | 9.1 | GO:0007080 | mitotic metaphase plate congression(GO:0007080) |
| 0.3 | 9.1 | GO:0031100 | organ regeneration(GO:0031100) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 18.2 | GO:0005657 | replication fork(GO:0005657) |
| 0.1 | 18.0 | GO:0005730 | nucleolus(GO:0005730) |
| 0.3 | 14.6 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 10.2 | GO:0005923 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 3.0 | 9.1 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.4 | 8.9 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.6 | 8.8 | GO:0034751 | aryl hydrocarbon receptor complex(GO:0034751) |
| 0.4 | 8.5 | GO:0005685 | U1 snRNP(GO:0005685) |
| 0.1 | 7.8 | GO:0005795 | Golgi stack(GO:0005795) |
| 1.2 | 7.5 | GO:0070695 | FHF complex(GO:0070695) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.9 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 2.8 | 14.1 | GO:0043139 | 5'-3' DNA helicase activity(GO:0043139) |
| 0.1 | 11.4 | GO:0042802 | identical protein binding(GO:0042802) |
| 0.3 | 11.2 | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) |
| 1.0 | 10.4 | GO:0035925 | AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.1 | 10.4 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.3 | 9.7 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.0 | 9.4 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.5 | 8.8 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.1 | 7.8 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 39.1 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.5 | 17.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.3 | 14.8 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.4 | 13.2 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.3 | 10.2 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.2 | 7.3 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 5.7 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.2 | 4.1 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.1 | 4.1 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.1 | 3.9 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 14.3 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.3 | 13.3 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 10.8 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.5 | 9.3 | REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE | Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle |
| 0.4 | 8.4 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.3 | 8.3 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.7 | 7.5 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.9 | 7.3 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.1 | 6.6 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.3 | 6.1 | REACTOME KINESINS | Genes involved in Kinesins |