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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for fosb+fosl2+si:ch211-153j24.3
Z-value: 0.85
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Transcription factors associated with fosb+fosl2+si:ch211-153j24.3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| fosb | dr11_v1_chr18_+_36770166_36770166 | 0.91 | 1.5e-07 | Click! |
| fosl2 | dr11_v1_chr17_+_41302660_41302660 | 0.81 | 4.3e-05 | Click! |
| si:ch211-153j24.3 | dr11_v1_chr20_+_46560258_46560258 | 0.52 | 2.5e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_+_46382484 Show fit | 3.49 |
ENSDART00000024202
ENSDART00000142790 |
dynein assembly factor with WDR repeat domains 1 |
|
| chr12_-_212843 Show fit | 3.47 |
ENSDART00000083574
|
|
|
| chr11_-_24681292 Show fit | 3.30 |
ENSDART00000089601
|
olfactomedin-like 3b |
|
| chr10_+_31222656 Show fit | 2.48 |
ENSDART00000140988
ENSDART00000143387 |
transmembrane protein 218 |
|
| chr16_+_42829735 Show fit | 2.39 |
ENSDART00000014956
|
polymerase (RNA) III (DNA directed) polypeptide G like b |
|
| chr24_+_31361407 Show fit | 2.26 |
ENSDART00000162668
|
cAMP responsive element modulator b |
|
| chr10_+_31222433 Show fit | 1.93 |
ENSDART00000185080
|
transmembrane protein 218 |
|
| chr2_+_17524278 Show fit | 1.85 |
ENSDART00000165633
|
Pim proto-oncogene, serine/threonine kinase, related 196 |
|
| chr5_-_21888368 Show fit | 1.83 |
ENSDART00000020725
|
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 |
|
| chr3_-_61593274 Show fit | 1.73 |
ENSDART00000154132
ENSDART00000055071 |
neuronal pentraxin 2a |
Network of associatons between targets according to the STRING database.
First level regulatory network of fosb+fosl2+si:ch211-153j24.3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.7 | GO:0046777 | protein autophosphorylation(GO:0046777) |
| 0.1 | 3.8 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |
| 0.2 | 3.5 | GO:0060285 | cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285) |
| 0.2 | 2.3 | GO:0016973 | poly(A)+ mRNA export from nucleus(GO:0016973) |
| 0.1 | 2.1 | GO:0032482 | Rab protein signal transduction(GO:0032482) |
| 0.2 | 2.0 | GO:0097374 | sensory neuron axon guidance(GO:0097374) |
| 0.0 | 1.8 | GO:0051966 | regulation of synaptic transmission, glutamatergic(GO:0051966) |
| 0.1 | 1.6 | GO:0021999 | neural plate anterior/posterior regionalization(GO:0021999) |
| 0.2 | 1.5 | GO:0008343 | adult feeding behavior(GO:0008343) |
| 0.1 | 1.3 | GO:0035999 | tetrahydrofolate interconversion(GO:0035999) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.0 | GO:0005929 | cilium(GO:0005929) |
| 0.2 | 3.8 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.3 | 3.4 | GO:1990589 | ATF4-CREB1 transcription factor complex(GO:1990589) |
| 0.1 | 2.6 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.3 | 1.8 | GO:0016589 | NURF complex(GO:0016589) |
| 0.0 | 1.5 | GO:0030141 | secretory granule(GO:0030141) |
| 0.0 | 1.4 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.0 | 1.3 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.3 | 1.2 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.1 | 1.1 | GO:0030315 | T-tubule(GO:0030315) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.8 | GO:0004046 | aminoacylase activity(GO:0004046) |
| 0.0 | 2.3 | GO:0003724 | RNA helicase activity(GO:0003724) |
| 0.0 | 2.0 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.0 | 1.8 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 1.6 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.2 | 1.3 | GO:0004329 | formate-tetrahydrofolate ligase activity(GO:0004329) |
| 0.4 | 1.2 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.0 | 1.2 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 1.2 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.2 | 1.1 | GO:0016316 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 0.6 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.0 | 0.6 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.5 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.4 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.3 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 0.2 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 0.1 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 0.5 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.0 | 0.5 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 0.4 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.0 | 0.3 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 0.2 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.0 | 0.2 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.0 | 0.2 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 0.1 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.0 | 0.1 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |