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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for foxd2_foxd5
Z-value: 1.40
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Transcription factors associated with foxd2_foxd5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| foxd5 | dr11_v1_chr8_+_30452945_30452945 | 0.93 | 1.8e-08 | Click! |
| foxd2 | dr11_v1_chr8_+_19674369_19674369 | 0.80 | 6.6e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_8264751 Show fit | 8.96 |
ENSDART00000091628
|
coiled-coil domain containing 151 |
|
| chr5_+_67662430 Show fit | 6.88 |
ENSDART00000137700
ENSDART00000142586 |
si:dkey-70b23.2 |
|
| chr4_+_12013043 Show fit | 6.19 |
ENSDART00000130692
|
cryptochrome circadian clock 1aa |
|
| chr10_+_26973063 Show fit | 4.43 |
ENSDART00000143162
ENSDART00000186210 |
transmembrane 7 superfamily member 2 |
|
| chr10_+_26972755 Show fit | 4.43 |
ENSDART00000042162
|
transmembrane 7 superfamily member 2 |
|
| chr2_-_40191603 Show fit | 4.29 |
ENSDART00000180691
|
si:ch211-122l24.6 |
|
| chr14_-_4121052 Show fit | 4.05 |
ENSDART00000167074
|
interferon regulatory factor 2 |
|
| chr12_-_30583668 Show fit | 3.88 |
ENSDART00000153406
|
caspase 7, apoptosis-related cysteine peptidase |
|
| chr25_+_19149241 Show fit | 3.71 |
ENSDART00000184982
ENSDART00000067324 |
milk fat globule-EGF factor 8 protein b |
|
| chr24_+_26345427 Show fit | 3.35 |
ENSDART00000089756
|
leucine rich repeat containing 34 |
Network of associatons between targets according to the STRING database.
First level regulatory network of foxd2_foxd5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.9 | GO:1902653 | cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653) |
| 0.1 | 3.9 | GO:0097194 | execution phase of apoptosis(GO:0097194) |
| 0.2 | 3.3 | GO:0044154 | histone H3-K14 acetylation(GO:0044154) |
| 0.1 | 3.0 | GO:0015804 | neutral amino acid transport(GO:0015804) |
| 0.0 | 3.0 | GO:0007338 | single fertilization(GO:0007338) |
| 0.1 | 2.9 | GO:0006165 | nucleoside diphosphate phosphorylation(GO:0006165) |
| 0.3 | 2.8 | GO:0006611 | protein export from nucleus(GO:0006611) |
| 0.2 | 2.8 | GO:0046085 | adenosine metabolic process(GO:0046085) |
| 0.1 | 2.8 | GO:0048247 | lymphocyte chemotaxis(GO:0048247) |
| 0.0 | 2.7 | GO:0006914 | autophagy(GO:0006914) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.1 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.1 | 5.1 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.2 | 3.3 | GO:0070775 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
| 0.1 | 3.3 | GO:0043204 | perikaryon(GO:0043204) |
| 0.1 | 2.9 | GO:0005901 | caveola(GO:0005901) plasma membrane raft(GO:0044853) |
| 0.2 | 2.3 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.1 | 2.1 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 2.1 | GO:0014069 | postsynaptic density(GO:0014069) |
| 0.1 | 2.0 | GO:0043679 | axon terminus(GO:0043679) |
| 0.1 | 1.9 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.9 | GO:0016628 | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628) |
| 0.0 | 4.5 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.2 | 3.9 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.2 | 3.3 | GO:0010484 | H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994) |
| 0.1 | 3.0 | GO:0015175 | neutral amino acid transmembrane transporter activity(GO:0015175) |
| 0.1 | 2.8 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.1 | 2.4 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.1 | 2.4 | GO:0008253 | 5'-nucleotidase activity(GO:0008253) |
| 0.8 | 2.3 | GO:0000810 | diacylglycerol diphosphate phosphatase activity(GO:0000810) |
| 0.1 | 2.3 | GO:0005272 | sodium channel activity(GO:0005272) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.9 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 2.2 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 2.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 1.7 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 1.1 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 0.8 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 0.6 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.0 | 0.4 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.0 | 0.3 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 0.2 | PID ALK1 PATHWAY | ALK1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 8.9 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.4 | 6.6 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.4 | 3.9 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 2.3 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.2 | 2.2 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.0 | 2.0 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.1 | 1.7 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.1 | 1.6 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 1.2 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.2 | 1.0 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |