ISMARA results: gata1a+gata2b

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for gata1a+gata2b

Z-value: 0.18

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Transcription factors associated with gata1a+gata2b

Gene Symbol	Gene ID	Gene Info
gata2b NCBI UniProt	ENSDARG00000009094	GATA binding protein 2b
gata1a NCBI UniProt	ENSDARG00000013477	GATA binding protein 1a
gata1a NCBI UniProt	ENSDARG00000117116	GATA binding protein 1a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
gata1a	dr11_v1_chr11_-_25418856_25418856	-0.81	4.2e-05	Click!
gata2b	dr11_v1_chr6_+_40794015_40794015	0.45	6.0e-02	Click!

Activity profile of gata1a+gata2b motif

Sorted Z-values of gata1a+gata2b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_-_35532937 Show fit	0.33	ENSDART00000193209	ctps1b NCBI UniProt Show fit	CTP synthase 1b
chr22_+_21398508 Show fit	0.33	ENSDART00000089408 ENSDART00000186091	shdb NCBI UniProt Show fit	Src homology 2 domain containing transforming protein D, b
chr18_+_3169579 Show fit	0.26	ENSDART00000164724 ENSDART00000186340 ENSDART00000181247 ENSDART00000168056	pak1 NCBI UniProt Show fit	p21 protein (Cdc42/Rac)-activated kinase 1
chr10_+_42589391 Show fit	0.21	ENSDART00000067689 ENSDART00000075259	fgfr1b NCBI UniProt Show fit	fibroblast growth factor receptor 1b
chr11_-_40457325 Show fit	0.19	ENSDART00000128442	tnfrsf1b NCBI UniProt Show fit	tumor necrosis factor receptor superfamily, member 1B
chr8_-_6825588 Show fit	0.18	ENSDART00000135834	dock5 NCBI UniProt Show fit	dedicator of cytokinesis 5
chr10_-_31175744 Show fit	0.17	ENSDART00000191728	pknox2 NCBI UniProt Show fit	pbx/knotted 1 homeobox 2
chr4_-_2380173 Show fit	0.12	ENSDART00000177727	nap1l1 NCBI UniProt Show fit	nucleosome assembly protein 1-like 1
chr19_-_32710922 Show fit	0.07	ENSDART00000004034	hpca NCBI UniProt Show fit	hippocalcin
chr22_-_16270462 Show fit	0.07	ENSDART00000105681	cdc14ab NCBI UniProt Show fit	cell division cycle 14Ab

Showing 1 to 10 of 17 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of gata1a+gata2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0044210	'de novo' CTP biosynthetic process(GO:0044210)
0.0	0.3	GO:0003232	bulbus arteriosus development(GO:0003232)
0.0	0.2	GO:1901534	positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)

Showing 1 to 3 of 3 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0097268	cytoophidium(GO:0097268)
0.0	0.1	GO:1902636	kinociliary basal body(GO:1902636)

Showing 1 to 2 of 2 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0003883	CTP synthase activity(GO:0003883)
0.1	0.3	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.2	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)

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Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	PID S1P S1P2 PATHWAY	S1P2 pathway
0.0	0.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Showing 1 to 2 of 2 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway

Showing 1 to 1 of 1 entries

Results for gata1a+gata2b

Z-value: 0.18

Motif logo

Transcription factors associated with gata1a+gata2b

Activity-expression correlation:

Activity profile of gata1a+gata2b motif

Sorted Z-values of gata1a+gata2b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of gata1a+gata2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: