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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for gcm2

Z-value: 0.60

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Transcription factors associated with gcm2

Gene Symbol Gene ID Gene Info
gcm2
ENSDARG00000045413 glial cells missing transcription factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
gcm2dr11_v1_chr24_-_8831866_88319120.791.1e-04Click!

Activity profile of gcm2 motif

Sorted Z-values of gcm2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr25_+_1732838 1.52 ENSDART00000159555
ENSDART00000168161
FBLN1
fibulin 1
chr15_-_20939579 1.47 ENSDART00000152371
usp2a
ubiquitin specific peptidase 2a
chr5_-_34185115 1.29 ENSDART00000192771
fibcd1
fibrinogen C domain containing 1
chr2_-_32505091 1.24 ENSDART00000141884
ENSDART00000056639
faim2a
Fas apoptotic inhibitory molecule 2a
chr3_-_57425961 1.24 ENSDART00000033716
socs3a
suppressor of cytokine signaling 3a
chr21_-_43117327 1.20 ENSDART00000122352
p4ha2
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2
chr16_+_41517188 1.07 ENSDART00000049976
si:dkey-11p23.7
si:dkey-11p23.7
chr20_+_30725778 1.02 ENSDART00000062532
nhsl1b
NHS-like 1b
chr21_-_3452683 1.01 ENSDART00000009740
smad7
SMAD family member 7
chr1_-_20928772 1.00 ENSDART00000078277
msmo1
methylsterol monooxygenase 1
chr14_+_7140997 0.93 ENSDART00000170994
ENSDART00000129898
ctsf
cathepsin F
chr3_+_39759130 0.93 ENSDART00000185202
cacna1ha
calcium channel, voltage-dependent, T type, alpha 1H subunit a
chr6_+_9204099 0.91 ENSDART00000150167
ENSDART00000115394
tbx19
T-box 19
chr3_-_45298487 0.90 ENSDART00000102245
pdpk1a
3-phosphoinositide dependent protein kinase 1a
chr6_+_46258866 0.89 ENSDART00000134584
zgc:162324
zgc:162324
chr25_+_3328487 0.88 ENSDART00000181143
ldhbb
lactate dehydrogenase Bb
chr3_-_40202607 0.88 ENSDART00000074757
znf598
zinc finger protein 598
chr12_+_49125510 0.87 ENSDART00000185804
FO704607.1

chr17_+_53250802 0.83 ENSDART00000143819
VASH1
vasohibin 1
chr1_+_54043563 0.82 ENSDART00000149760
triobpa
TRIO and F-actin binding protein a
chr6_+_15762647 0.80 ENSDART00000127133
ENSDART00000128939
iqca1
IQ motif containing with AAA domain 1
chr13_+_31479814 0.79 ENSDART00000148112
lrrc9
leucine rich repeat containing 9
chr25_+_36336920 0.73 ENSDART00000073402
hist1h2a1
histone cluster 1 H2A family member1
chr1_-_51157660 0.73 ENSDART00000137172
jag1a
jagged 1a
chr16_+_25407021 0.71 ENSDART00000187489
ENSDART00000086333
jarid2a
jumonji, AT rich interactive domain 2a
chr20_-_14012859 0.71 ENSDART00000152429
si:ch211-22i13.2
si:ch211-22i13.2
chr23_+_40109353 0.68 ENSDART00000149249
ghrhrl
growth hormone releasing hormone receptor, like
chr7_-_74090168 0.68 ENSDART00000050528
tyrp1a
tyrosinase-related protein 1a
chr17_-_43665366 0.62 ENSDART00000127945
egr2a
early growth response 2a
chr5_-_23317477 0.61 ENSDART00000090171
nlgn3b
neuroligin 3b
chr18_-_21218851 0.61 ENSDART00000060160
calb2a
calbindin 2a
chr17_-_25563847 0.60 ENSDART00000040032
rtn4ip1
reticulon 4 interacting protein 1
chr16_+_12267672 0.59 ENSDART00000060037
zgc:92606
zgc:92606
chr19_+_56351 0.58 ENSDART00000168334
col14a1b
collagen, type XIV, alpha 1b
chr16_-_17258111 0.57 ENSDART00000079497
emg1
EMG1 N1-specific pseudouridine methyltransferase
chr6_+_39506043 0.57 ENSDART00000086260
CR388364.1

chr4_-_760560 0.55 ENSDART00000103601
agbl5
ATP/GTP binding protein-like 5
chr20_+_17739923 0.53 ENSDART00000024627
cdh2
cadherin 2, type 1, N-cadherin (neuronal)
chr16_+_3004422 0.52 ENSDART00000189969
CABZ01043952.1

chr10_-_25852517 0.52 ENSDART00000191551
trpc4a
transient receptor potential cation channel, subfamily C, member 4a
chr7_+_15266093 0.52 ENSDART00000124676
sv2ba
synaptic vesicle glycoprotein 2Ba
chr11_+_6010177 0.51 ENSDART00000170047
ENSDART00000022526
ENSDART00000161001
ENSDART00000188999
gtpbp3
GTP binding protein 3, mitochondrial
chr3_-_30061985 0.51 ENSDART00000189583
ppfia3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr3_+_32492467 0.50 ENSDART00000151329
trpm4a
transient receptor potential cation channel, subfamily M, member 4a
chr11_-_41132296 0.50 ENSDART00000162944
dnajc11b
DnaJ (Hsp40) homolog, subfamily C, member 11b
chr23_+_27652906 0.49 ENSDART00000077931
wnt1
wingless-type MMTV integration site family, member 1
chr17_+_443264 0.49 ENSDART00000159086
zgc:195050
zgc:195050
chr12_-_7824291 0.49 ENSDART00000148673
ENSDART00000149453
ank3b
ankyrin 3b
chr1_-_44940830 0.48 ENSDART00000097500
ENSDART00000134464
ENSDART00000137216
tmem176
transmembrane protein 176
chr10_-_302827 0.48 ENSDART00000157582
emsy
EMSY BRCA2-interacting transcriptional repressor
chr22_+_26703026 0.47 ENSDART00000158756
crebbpa
CREB binding protein a
chr16_-_27564256 0.47 ENSDART00000078297
zgc:153215
zgc:153215
chr4_+_11384891 0.46 ENSDART00000092381
ENSDART00000186577
ENSDART00000191054
ENSDART00000191584
pcloa
piccolo presynaptic cytomatrix protein a
chr3_+_6469754 0.46 ENSDART00000185809
NUP85 (1 of many)
nucleoporin 85
chr20_+_48100261 0.44 ENSDART00000158604
xkr5a
XK related 5a
chr1_-_54425791 0.44 ENSDART00000039911
pkd1a
polycystic kidney disease 1a
chr23_+_32011768 0.43 ENSDART00000053509
plagx
pleiomorphic adenoma gene X
chr6_+_39499623 0.43 ENSDART00000036057
si:ch211-173n18.3
si:ch211-173n18.3
chr22_+_26703518 0.43 ENSDART00000187997
ENSDART00000166775
crebbpa
CREB binding protein a
chr14_-_2602445 0.43 ENSDART00000166910
etf1a
eukaryotic translation termination factor 1a
chr1_-_51157454 0.42 ENSDART00000047851
jag1a
jagged 1a
chr10_+_4095917 0.42 ENSDART00000114533
mn1a
meningioma 1a
chr16_+_45571956 0.41 ENSDART00000143867
syngap1b
synaptic Ras GTPase activating protein 1b
chr24_-_26485098 0.41 ENSDART00000135496
ENSDART00000009609
ENSDART00000133782
ENSDART00000141029
ENSDART00000113739
eif5a
eukaryotic translation initiation factor 5A
chr1_+_34295925 0.41 ENSDART00000075584
kctd12.2
potassium channel tetramerisation domain containing 12.2
chr20_+_43648369 0.41 ENSDART00000187930
ENSDART00000017269
parp1
poly (ADP-ribose) polymerase 1
chr4_+_19127973 0.40 ENSDART00000136611
si:dkey-21o22.2
si:dkey-21o22.2
chr19_+_4892281 0.40 ENSDART00000150969
cdk12
cyclin-dependent kinase 12
chr20_-_52271262 0.39 ENSDART00000135463
rhpn1
rhophilin, Rho GTPase binding protein 1
chr19_-_8604429 0.38 ENSDART00000151165
trim46b
tripartite motif containing 46b
chr15_+_29123031 0.37 ENSDART00000133988
ENSDART00000060030
zgc:101731
zgc:101731
chr1_-_20911297 0.36 ENSDART00000078271
cpe
carboxypeptidase E
chr20_+_11731039 0.36 ENSDART00000152215
ENSDART00000152585
si:ch211-155o21.3
si:ch211-155o21.3
chr9_+_23770666 0.34 ENSDART00000182493
si:ch211-219a4.3
si:ch211-219a4.3
chr7_-_26306546 0.34 ENSDART00000140817
zgc:77439
zgc:77439
chr21_+_5993188 0.32 ENSDART00000048399
slc4a4b
solute carrier family 4 (sodium bicarbonate cotransporter), member 4b
chr18_-_3103827 0.32 ENSDART00000165048
aamdc
adipogenesis associated, Mth938 domain containing
chr10_+_7182423 0.31 ENSDART00000186788
psd3l
pleckstrin and Sec7 domain containing 3, like
chr19_-_47452874 0.31 ENSDART00000025931
tfap2e
transcription factor AP-2 epsilon
chr5_+_61476014 0.30 ENSDART00000050906
lrwd1
leucine-rich repeats and WD repeat domain containing 1
chr24_+_9003998 0.30 ENSDART00000179656
ENSDART00000191314
CR318624.2

chr7_-_20453661 0.29 ENSDART00000174001
ntn5
netrin 5
chr14_-_33177935 0.29 ENSDART00000180583
ENSDART00000078856
dlg3
discs, large homolog 3 (Drosophila)
chr17_-_26610814 0.29 ENSDART00000133402
ENSDART00000016608
mrpl57
mitochondrial ribosomal protein L57
chr2_-_13886842 0.28 ENSDART00000187203
CABZ01042417.1

chr14_-_413273 0.28 ENSDART00000163976
ENSDART00000179907
FAT4
FAT atypical cadherin 4
chr25_-_28443607 0.28 ENSDART00000157243
ptprz1a
protein tyrosine phosphatase, receptor-type, Z polypeptide 1a
chr25_-_21156678 0.28 ENSDART00000156257
wnk1a
WNK lysine deficient protein kinase 1a
chr16_-_22006996 0.28 ENSDART00000116114
si:dkey-71b5.7
si:dkey-71b5.7
chr3_-_9722603 0.26 ENSDART00000168234
crebbpb
CREB binding protein b
chr24_-_21258945 0.26 ENSDART00000111025
boc
BOC cell adhesion associated, oncogene regulated
chr1_+_5402476 0.26 ENSDART00000040204
tuba8l2
tubulin, alpha 8 like 2
chr17_-_35361322 0.26 ENSDART00000019617
rsad2
radical S-adenosyl methionine domain containing 2
chr19_+_12350069 0.26 ENSDART00000052240
psmg2
proteasome (prosome, macropain) assembly chaperone 2
chr15_-_14469704 0.26 ENSDART00000185077
numbl
numb homolog (Drosophila)-like
chr24_+_39614853 0.24 ENSDART00000165138
BX547934.2

chr9_-_3400727 0.24 ENSDART00000183979
ENSDART00000111386
dlx2a
distal-less homeobox 2a
chr5_+_69686368 0.24 ENSDART00000158237
znf1005
zinc finger protein 1005
chr25_-_18125769 0.23 ENSDART00000140484
kitlga
kit ligand a
chr1_+_2112726 0.23 ENSDART00000131714
ENSDART00000138396
mbnl2
muscleblind-like splicing regulator 2
chr11_-_41130239 0.23 ENSDART00000173268
dnajc11b
DnaJ (Hsp40) homolog, subfamily C, member 11b
chr10_-_39130839 0.22 ENSDART00000061274
ENSDART00000148648
rps25
ribosomal protein S25
chr8_-_27656765 0.22 ENSDART00000078491
mov10b.2
Moloney leukemia virus 10b, tandem duplicate 2
chr15_+_618081 0.22 ENSDART00000181518
si:ch211-210b2.1
si:ch211-210b2.1
chr10_-_5053589 0.22 ENSDART00000193579
tmem150c
transmembrane protein 150C
chr7_-_6355459 0.21 ENSDART00000172898
CU457819.1

chr25_+_36341356 0.21 ENSDART00000190100
CR354435.3

chr25_+_19541019 0.20 ENSDART00000141056
ENSDART00000027740
nedd1
neural precursor cell expressed, developmentally down-regulated 1
chr15_-_3976035 0.20 ENSDART00000168061
si:ch73-309g22.1
si:ch73-309g22.1
chr2_-_42871286 0.19 ENSDART00000087823
adcy8
adenylate cyclase 8 (brain)
chr25_-_36367523 0.19 ENSDART00000181344
CR354435.4

chr6_+_23010242 0.19 ENSDART00000113116
polg2
polymerase (DNA directed), gamma 2, accessory subunit
chr1_+_44941031 0.19 ENSDART00000141145
si:dkey-9i23.16
si:dkey-9i23.16
chr23_-_35649000 0.18 ENSDART00000053310
tmem18
transmembrane protein 18
chr14_-_5677979 0.18 ENSDART00000182156
tlx2
T cell leukemia homeobox 2
chr6_-_13308813 0.18 ENSDART00000065372
kcnj3b
potassium inwardly-rectifying channel, subfamily J, member 3b
chr15_-_41749364 0.18 ENSDART00000155464
ftr73
finTRIM family, member 73
chr14_+_2243 0.18 ENSDART00000191193
CYTL1
cytokine like 1
chr7_+_41314862 0.18 ENSDART00000185198
zgc:165532
zgc:165532
chr8_+_23711842 0.16 ENSDART00000128783
ppardb
peroxisome proliferator-activated receptor delta b
chr8_+_30797363 0.16 ENSDART00000077280
mmp11a
matrix metallopeptidase 11a
chr16_+_27564270 0.16 ENSDART00000140460
tmem67
transmembrane protein 67
chr21_+_25068215 0.15 ENSDART00000167523
ENSDART00000189259
dixdc1b
DIX domain containing 1b
chr17_+_45305645 0.15 ENSDART00000172488
capn3a
calpain 3a, (p94)
chr19_+_31183495 0.15 ENSDART00000088618
meox2b
mesenchyme homeobox 2b
chr6_+_41096058 0.14 ENSDART00000028373
fkbp5
FK506 binding protein 5
chr18_+_8346920 0.14 ENSDART00000083421
cpt1b
carnitine palmitoyltransferase 1B (muscle)
chr9_+_53637932 0.14 ENSDART00000188962
CABZ01084081.1

chr14_+_15543331 0.14 ENSDART00000167025
si:dkey-203a12.7
si:dkey-203a12.7
chr16_-_20312146 0.14 ENSDART00000134980
si:dkeyp-86h10.3
si:dkeyp-86h10.3
chr6_+_42818963 0.13 ENSDART00000184833
sema3fa
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa
chr16_-_383664 0.13 ENSDART00000051693
irx4a
iroquois homeobox 4a
chr22_+_5176255 0.13 ENSDART00000092647
cers1
ceramide synthase 1
chr22_-_5006801 0.12 ENSDART00000106166
rx1
retinal homeobox gene 1
chr6_+_42819337 0.12 ENSDART00000046498
sema3fa
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa
chr1_+_26445615 0.12 ENSDART00000180810
g3bp2
GTPase activating protein (SH3 domain) binding protein 2
chr20_+_26947800 0.11 ENSDART00000062066
si:dkey-177p2.6
si:dkey-177p2.6
chr14_-_15699528 0.11 ENSDART00000161123
neurl1b
neuralized E3 ubiquitin protein ligase 1B
chr24_-_6158933 0.11 ENSDART00000021609
gad2
glutamate decarboxylase 2
chr4_+_17310143 0.10 ENSDART00000004717
igf1
insulin-like growth factor 1
chr1_+_26444986 0.10 ENSDART00000046376
g3bp2
GTPase activating protein (SH3 domain) binding protein 2
chr22_+_5176693 0.10 ENSDART00000160927
cers1
ceramide synthase 1
chr21_+_3775551 0.10 ENSDART00000111699
tor1
torsin family 1
chr16_-_52646789 0.10 ENSDART00000035761
ubr5
ubiquitin protein ligase E3 component n-recognin 5
chr13_-_15986871 0.09 ENSDART00000189394
ikzf1
IKAROS family zinc finger 1 (Ikaros)
chr18_-_7539469 0.09 ENSDART00000101296
si:dkey-30c15.2
si:dkey-30c15.2
chr20_+_28434196 0.09 ENSDART00000034245
dpf3
D4, zinc and double PHD fingers, family 3
chr18_-_17399291 0.08 ENSDART00000192075
ENSDART00000060949
ENSDART00000188506
zfpm1
zinc finger protein, FOG family member 1
chr14_-_2217285 0.08 ENSDART00000157949
ENSDART00000166150
ENSDART00000054891
ENSDART00000183268
pcdh2ab2
pcdh2ab2
protocadherin 2 alpha b2
protocadherin 2 alpha b2
chr16_+_4133519 0.08 ENSDART00000174521
ENSDART00000175718
mtf1
metal-regulatory transcription factor 1
chr1_-_26293203 0.08 ENSDART00000180140
cxxc4
CXXC finger 4
chr14_+_18782610 0.08 ENSDART00000164468
si:ch211-111e20.1
si:ch211-111e20.1
chr1_-_26292897 0.07 ENSDART00000112899
ENSDART00000185410
cxxc4
CXXC finger 4
chr22_+_9922301 0.07 ENSDART00000105924
blf
bloody fingers
chr4_+_55758103 0.06 ENSDART00000185964
CT583728.23

chr8_+_49570884 0.06 ENSDART00000182117
ENSDART00000108613
rasef
RAS and EF-hand domain containing
chr11_+_29671661 0.06 ENSDART00000024318
ENSDART00000165024
rnf207a
ring finger protein 207a
chr20_-_54435287 0.06 ENSDART00000148632
yy1b
YY1 transcription factor b
chr17_+_51682429 0.05 ENSDART00000004379
nol10
nucleolar protein 10
chr6_-_46403475 0.05 ENSDART00000154148
camk1a
calcium/calmodulin-dependent protein kinase Ia
chr24_+_25069609 0.05 ENSDART00000115165
amer2
APC membrane recruitment protein 2
chr2_-_24270062 0.05 ENSDART00000192445
myh7
myosin heavy chain 7
chr8_+_43056153 0.04 ENSDART00000186377
prnpa
prion protein a
chr16_+_5678071 0.04 ENSDART00000011166
ENSDART00000134198
ENSDART00000131575
zgc:158689
zgc:158689
chr2_-_24269911 0.04 ENSDART00000099532
myh7
myosin heavy chain 7
chr5_-_61588998 0.04 ENSDART00000050912
pex12
peroxisomal biogenesis factor 12
chr25_+_35133404 0.04 ENSDART00000188505
hist1h2a2
histone cluster 1 H2A family member 2
chr5_+_66310495 0.04 ENSDART00000114532
malt1
MALT paracaspase 1
chr24_-_25787501 0.04 ENSDART00000015628
klhl24b
kelch-like family member 24b
chr7_-_73846995 0.04 ENSDART00000188079
FP236812.4

chr15_+_8335600 0.03 ENSDART00000190066
ENSDART00000152603
egln2
egl-9 family hypoxia-inducible factor 2
chr12_+_16168342 0.03 ENSDART00000079326
ENSDART00000170024
lrp2b
low density lipoprotein receptor-related protein 2b
chr12_-_46228023 0.03 ENSDART00000153455
si:ch211-226h7.6
si:ch211-226h7.6
chr17_-_35881841 0.02 ENSDART00000110040
sox11a
SRY (sex determining region Y)-box 11a
chr5_-_16274058 0.02 ENSDART00000090684
kremen1
kringle containing transmembrane protein 1
chr15_-_41458613 0.02 ENSDART00000141496
nlrc9
NLR family CARD domain containing 9
chr6_-_55354004 0.02 ENSDART00000165911
pcif1
PDX1 C-terminal inhibiting factor 1
chr17_+_8183393 0.01 ENSDART00000155957
tulp4b
tubby like protein 4b
chr18_-_17077419 0.01 ENSDART00000148714
il17c
interleukin 17c
chr10_+_7182168 0.01 ENSDART00000172766
psd3l
pleckstrin and Sec7 domain containing 3, like
chr3_+_46724528 0.01 ENSDART00000181358
pde4a
phosphodiesterase 4A, cAMP-specific
chr20_-_23842631 0.01 ENSDART00000153079
si:dkey-15j16.3
si:dkey-15j16.3
chr22_+_10759113 0.01 ENSDART00000045303
tmprss9
transmembrane protease, serine 9
chr21_+_21791799 0.01 ENSDART00000151759
neu3.1
sialidase 3 (membrane sialidase), tandem duplicate 1
chr1_+_45323400 0.01 ENSDART00000148906
ENSDART00000132366
emp1
epithelial membrane protein 1
chr4_+_7888047 0.00 ENSDART00000104676
camk1da
calcium/calmodulin-dependent protein kinase 1Da
chr13_-_44285793 0.00 ENSDART00000167383
CABZ01069436.1

Network of associatons between targets according to the STRING database.

First level regulatory network of gcm2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.2 1.1 GO:0045124 regulation of bone resorption(GO:0045124)
0.2 0.5 GO:0090247 hindbrain structural organization(GO:0021577) dorsal fin morphogenesis(GO:0035142) cell motility involved in somitogenic axis elongation(GO:0090247) cell migration involved in somitogenic axis elongation(GO:0090248)
0.2 0.5 GO:0002369 T cell cytokine production(GO:0002369)
0.2 1.2 GO:0048681 negative regulation of axon regeneration(GO:0048681) negative regulation of neuron projection regeneration(GO:0070571)
0.2 0.6 GO:1900271 regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271)
0.1 0.5 GO:0035608 protein deglutamylation(GO:0035608)
0.1 0.4 GO:0010712 regulation of collagen metabolic process(GO:0010712) regulation of collagen biosynthetic process(GO:0032965) regulation of multicellular organismal metabolic process(GO:0044246)
0.1 0.8 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 0.4 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.1 0.3 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.1 0.7 GO:0042438 melanin biosynthetic process(GO:0042438)
0.1 0.3 GO:0070199 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.1 1.2 GO:0019471 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.1 0.2 GO:0046532 regulation of photoreceptor cell differentiation(GO:0046532)
0.1 1.0 GO:0097475 motor neuron migration(GO:0097475)
0.1 0.4 GO:0045901 positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905)
0.1 1.1 GO:0030878 thyroid gland development(GO:0030878)
0.1 0.6 GO:0070475 rRNA base methylation(GO:0070475)
0.1 0.6 GO:0097090 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.1 0.9 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 0.7 GO:0042407 cristae formation(GO:0042407)
0.0 0.5 GO:1904071 presynaptic active zone assembly(GO:1904071)
0.0 0.5 GO:0035284 central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0 0.2 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.0 0.4 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0 0.1 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0 0.4 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.6 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0 0.2 GO:0051561 positive regulation of mitochondrial calcium ion concentration(GO:0051561)
0.0 0.4 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 1.0 GO:0016126 sterol biosynthetic process(GO:0016126)
0.0 0.2 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 0.5 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.1 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.0 0.2 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.0 0.1 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.5 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.1 GO:0071276 cellular response to cadmium ion(GO:0071276)
0.0 0.2 GO:0010887 negative regulation of cholesterol storage(GO:0010887)
0.0 0.3 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.0 0.3 GO:1903288 positive regulation of sodium ion transport(GO:0010765) positive regulation of sodium ion transmembrane transport(GO:1902307) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.0 0.3 GO:0043248 proteasome assembly(GO:0043248) chaperone-mediated protein complex assembly(GO:0051131)
0.0 1.0 GO:0050773 regulation of dendrite development(GO:0050773)
0.0 0.1 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.0 0.1 GO:1901315 negative regulation of histone ubiquitination(GO:0033183) regulation of protein K63-linked ubiquitination(GO:1900044) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) regulation of protein polyubiquitination(GO:1902914) negative regulation of protein polyubiquitination(GO:1902915)
0.0 0.9 GO:0001707 mesoderm formation(GO:0001707)
0.0 0.1 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.0 1.0 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.0 0.3 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.2 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.4 GO:0016082 synaptic vesicle priming(GO:0016082)
0.0 0.4 GO:0048854 brain morphogenesis(GO:0048854)
0.0 1.0 GO:0016573 histone acetylation(GO:0016573)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0018444 translation release factor complex(GO:0018444)
0.1 0.7 GO:0061617 MICOS complex(GO:0061617)
0.1 0.7 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 1.0 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.5 GO:0098982 GABA-ergic synapse(GO:0098982)
0.0 0.4 GO:0019908 cyclin/CDK positive transcription elongation factor complex(GO:0008024) nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.0 0.5 GO:0014704 intercalated disc(GO:0014704)
0.0 0.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.3 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.6 GO:0043195 terminal bouton(GO:0043195)
0.0 1.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 1.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.6 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.6 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.0 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.0 0.5 GO:0030496 midbody(GO:0030496)
0.0 1.0 GO:0000123 histone acetyltransferase complex(GO:0000123)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0000254 C-4 methylsterol oxidase activity(GO:0000254)
0.1 0.4 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.1 0.9 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 0.9 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.7 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.1 1.2 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.1 0.2 GO:0032574 5'-3' RNA helicase activity(GO:0032574)
0.1 0.7 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.1 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.1 1.0 GO:0070411 I-SMAD binding(GO:0070411)
0.0 1.1 GO:0005112 Notch binding(GO:0005112)
0.0 0.3 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 1.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.1 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.4 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 0.6 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.0 0.4 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.6 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.4 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.5 GO:0098882 structural constituent of presynaptic active zone(GO:0098882)
0.0 0.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.9 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.1 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 1.0 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 0.3 GO:0019869 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.0 0.3 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.1 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.5 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.0 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 0.2 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.5 GO:0005109 frizzled binding(GO:0005109)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.5 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.5 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 2.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.8 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.4 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 1.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.4 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.2 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.4 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.4 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.9 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation