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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for glis2a+glis2b

Z-value: 0.31

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Transcription factors associated with glis2a+glis2b

Gene Symbol Gene ID Gene Info
glis2a
ENSDARG00000078388 GLIS family zinc finger 2a
glis2b
ENSDARG00000100232 GLIS family zinc finger 2b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
glis2bdr11_v1_chr3_+_12334509_123345090.361.5e-01Click!
glis2adr11_v1_chr22_-_26558166_26558166-0.214.0e-01Click!

Activity profile of glis2a+glis2b motif

Sorted Z-values of glis2a+glis2b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_10338554 1.11 ENSDART00000186936
cobll1a
cordon-bleu WH2 repeat protein-like 1a
chr17_-_4245311 1.02 ENSDART00000055379
gdf3
growth differentiation factor 3
chr6_-_7769178 0.85 ENSDART00000191701
ENSDART00000149823
myh9a
myosin, heavy chain 9a, non-muscle
chr12_+_22672323 0.81 ENSDART00000123808
ENSDART00000159864
cdca9
cell division cycle associated 9
chr17_-_4245902 0.79 ENSDART00000151851
gdf3
growth differentiation factor 3
chr25_+_30196039 0.72 ENSDART00000005299
hsd17b12a
hydroxysteroid (17-beta) dehydrogenase 12a
chr3_-_33113879 0.68 ENSDART00000044677
rarab
retinoic acid receptor, alpha b
chr4_-_1776352 0.62 ENSDART00000123089
dnajc2
DnaJ (Hsp40) homolog, subfamily C, member 2
chr2_-_49031303 0.61 ENSDART00000143471
cdc34b
cell division cycle 34 homolog (S. cerevisiae) b
chr2_+_51783120 0.58 ENSDART00000177559
crygn1
crystallin, gamma N1
chr25_-_997894 0.57 ENSDART00000169011
znf609a
zinc finger protein 609a
chr3_+_40409100 0.47 ENSDART00000103486
tnrc18
trinucleotide repeat containing 18
chr7_-_24838857 0.42 ENSDART00000179766
ENSDART00000180892
fam113
family with sequence similarity 113
chr25_+_16912243 0.41 ENSDART00000186579
zgc:77158
zgc:77158
chr5_+_25760112 0.41 ENSDART00000088011
ENSDART00000182046
tmem2
transmembrane protein 2
chr19_+_15443540 0.36 ENSDART00000193355
lin28a
lin-28 homolog A (C. elegans)
chr23_+_43668756 0.35 ENSDART00000112598
otud4
OTU deubiquitinase 4
chr23_-_31060350 0.34 ENSDART00000145598
ENSDART00000191491
si:ch211-197l9.5
si:ch211-197l9.5
chr12_-_41619257 0.34 ENSDART00000162967
dpysl4
dihydropyrimidinase-like 4
chr15_+_518092 0.33 ENSDART00000154594
pcsk7
proprotein convertase subtilisin/kexin type 7
chr13_+_1928361 0.31 ENSDART00000164764
hmgcll1
3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1
chr1_+_15258641 0.31 ENSDART00000033018
pi4k2b
phosphatidylinositol 4-kinase type 2 beta
chr10_-_1961576 0.30 ENSDART00000042441
tdgf1
teratocarcinoma-derived growth factor 1
chr8_-_20914829 0.29 ENSDART00000025356
haus5
HAUS augmin-like complex, subunit 5
chr6_+_38845848 0.26 ENSDART00000184907
stk35l
serine/threonine kinase 35, like
chr23_-_36934944 0.26 ENSDART00000109976
ENSDART00000162179
acap3a
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3a
chr6_+_38845697 0.23 ENSDART00000053187
stk35l
serine/threonine kinase 35, like
chr2_-_9744081 0.22 ENSDART00000097732
dvl3a
dishevelled segment polarity protein 3a
chr2_+_24867534 0.20 ENSDART00000158050
rab3aa
RAB3A, member RAS oncogene family, a
chr13_+_39208542 0.20 ENSDART00000147971
fam135a
family with sequence similarity 135, member A
chr24_-_32582378 0.16 ENSDART00000066590
rdh12l
retinol dehydrogenase 12, like
chr5_+_38886499 0.16 ENSDART00000076845
fras1
Fraser extracellular matrix complex subunit 1
chr3_+_21189766 0.14 ENSDART00000078807
zgc:123295
zgc:123295
chr4_-_4756349 0.11 ENSDART00000057507
ssbp1
single-stranded DNA binding protein 1
chr13_-_24880525 0.11 ENSDART00000136624
kat6b
K(lysine) acetyltransferase 6B
chr6_+_37625787 0.10 ENSDART00000065122
tubgcp5
tubulin, gamma complex associated protein 5
chr24_-_35707552 0.09 ENSDART00000165199
mapre2
microtubule-associated protein, RP/EB family, member 2
chr19_-_42928979 0.09 ENSDART00000086659
cyhr1
cysteine/histidine-rich 1
chr4_-_59152337 0.09 ENSDART00000156770
znf1149
zinc finger protein 1149
chr7_+_11390462 0.08 ENSDART00000114383
tlnrd1
talin rod domain containing 1
chr23_+_39481537 0.07 ENSDART00000187222
mical1
microtubule associated monooxygenase, calponin and LIM domain containing 1
chr19_-_36640677 0.05 ENSDART00000189743
csmd2
CUB and Sushi multiple domains 2
chr9_+_20781047 0.04 ENSDART00000139174
fam46c
family with sequence similarity 46, member C
chr19_-_48336535 0.04 ENSDART00000162752
si:ch73-359m17.6
si:ch73-359m17.6
chr23_-_26536055 0.03 ENSDART00000182719
si:dkey-205h13.2
si:dkey-205h13.2
chr22_-_18116635 0.03 ENSDART00000005724
ncanb
neurocan b
chr3_-_58078522 0.02 ENSDART00000154775
si:ch211-256e16.8
si:ch211-256e16.8
chr7_-_19642417 0.02 ENSDART00000160936
si:ch211-212k18.4
si:ch211-212k18.4
chr24_+_25471196 0.02 ENSDART00000066625
smpx
small muscle protein, X-linked
chr20_+_38285671 0.02 ENSDART00000061432
ccl38a.4
chemokine (C-C motif) ligand 38, duplicate 4
chr5_-_71995108 0.02 ENSDART00000124587
fam78ab
family with sequence similarity 78, member Ab
chr18_+_17151916 0.01 ENSDART00000175488
trhr2
thyrotropin releasing hormone receptor 2
chr9_+_54158387 0.01 ENSDART00000171315
ENSDART00000180570
TLR8
toll like receptor 8
chr10_+_21701568 0.01 ENSDART00000090748
pcdh1g9
protocadherin 1 gamma 9
chr2_+_13722116 0.00 ENSDART00000155015
zbtb41
zinc finger and BTB domain containing 41
chr16_-_26435431 0.00 ENSDART00000187526
megf8
multiple EGF-like-domains 8
chr17_-_44968177 0.00 ENSDART00000075510
ngb
neuroglobin

Network of associatons between targets according to the STRING database.

First level regulatory network of glis2a+glis2b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:1900145 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.2 0.8 GO:0072103 renal system vasculature morphogenesis(GO:0061438) kidney vasculature morphogenesis(GO:0061439) glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104)
0.1 0.3 GO:0090008 hypoblast development(GO:0090008)
0.1 0.7 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 0.4 GO:2000660 regulation of interleukin-1-mediated signaling pathway(GO:2000659) negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.1 0.3 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.1 0.2 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.1 0.7 GO:0003139 secondary heart field specification(GO:0003139)
0.0 0.1 GO:0051096 regulation of helicase activity(GO:0051095) positive regulation of helicase activity(GO:0051096)
0.0 0.2 GO:0090179 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.0 0.1 GO:0019417 sulfur oxidation(GO:0019417)
0.0 0.3 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.0 0.3 GO:0007032 endosome organization(GO:0007032)
0.0 0.1 GO:1904825 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.3 GO:0070652 HAUS complex(GO:0070652)
0.0 0.1 GO:0008274 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0 0.1 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.1 0.3 GO:0004419 hydroxymethylglutaryl-CoA lyase activity(GO:0004419)
0.1 1.1 GO:0003785 actin monomer binding(GO:0003785)
0.1 0.4 GO:0015154 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 0.3 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.3 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.3 GO:0070697 activin receptor binding(GO:0070697)
0.0 0.4 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.8 GO:0008083 growth factor activity(GO:0008083)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.1 NABA SECRETED FACTORS Genes encoding secreted soluble factors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.3 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.3 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane