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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for her6+her9

Z-value: 0.37

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Transcription factors associated with her6+her9

Gene Symbol Gene ID Gene Info
her6
ENSDARG00000006514 hairy-related 6
her9
ENSDARG00000056438 hairy-related 9
her6
ENSDARG00000111099 hairy-related 6
her9
ENSDARG00000115775 hairy-related 9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
her9dr11_v1_chr23_-_23401305_23401305-0.992.6e-14Click!
her6dr11_v1_chr6_-_36552844_36552844-0.897.3e-07Click!

Activity profile of her6+her9 motif

Sorted Z-values of her6+her9 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_2942900 0.99 ENSDART00000002622
oclna
occludin a
chr2_+_68789 0.95 ENSDART00000058569
cldn1
claudin 1
chr12_+_48340133 0.83 ENSDART00000152899
ENSDART00000153335
ENSDART00000054788
ddit4
DNA-damage-inducible transcript 4
chr9_+_500052 0.77 ENSDART00000166707
CU984600.1

chr4_-_77551860 0.73 ENSDART00000188176
AL935186.6

chr4_-_77563411 0.70 ENSDART00000186841
AL935186.8

chr20_-_16498991 0.66 ENSDART00000104137
ches1
checkpoint suppressor 1
chr18_+_3169579 0.65 ENSDART00000164724
ENSDART00000186340
ENSDART00000181247
ENSDART00000168056
pak1
p21 protein (Cdc42/Rac)-activated kinase 1
chr7_+_24528430 0.64 ENSDART00000133022
si:dkeyp-75h12.2
si:dkeyp-75h12.2
chr10_+_29138021 0.61 ENSDART00000025227
ENSDART00000123033
ENSDART00000034242
picalma
phosphatidylinositol binding clathrin assembly protein a
chr13_-_24826607 0.56 ENSDART00000087786
ENSDART00000186951
slka
STE20-like kinase a
chr13_+_7241170 0.56 ENSDART00000109434
aifm2
apoptosis-inducing factor, mitochondrion-associated, 2
chr15_-_1765098 0.51 ENSDART00000149980
ENSDART00000093074
bud23
BUD23, rRNA methyltransferase and ribosome maturation factor
chr23_+_36616717 0.51 ENSDART00000042701
ENSDART00000192980
pip4k2ca
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma a
chr1_+_49955869 0.51 ENSDART00000150517
gstcd
glutathione S-transferase, C-terminal domain containing
chr21_-_44731865 0.50 ENSDART00000013814
ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 homolog (human)
chr5_-_54395488 0.43 ENSDART00000160781
zmynd19
zinc finger, MYND-type containing 19
chr13_-_45022527 0.40 ENSDART00000159021
khdrbs1a
KH domain containing, RNA binding, signal transduction associated 1a
chr13_-_45022301 0.39 ENSDART00000183589
ENSDART00000125633
ENSDART00000074787
khdrbs1a
KH domain containing, RNA binding, signal transduction associated 1a
chr8_+_36509885 0.35 ENSDART00000109530
slc7a4
solute carrier family 7, member 4
chr5_-_12560569 0.33 ENSDART00000133587
wsb2
WD repeat and SOCS box containing 2
chr21_+_1647990 0.32 ENSDART00000148540
fech
ferrochelatase
chr20_-_40766387 0.30 ENSDART00000061173
hsdl1
hydroxysteroid dehydrogenase like 1
chr11_-_12800945 0.29 ENSDART00000191178
txlng
taxilin gamma
chr11_-_12801157 0.28 ENSDART00000103449
txlng
taxilin gamma
chr5_+_1965296 0.27 ENSDART00000156224
dhx33
DEAH (Asp-Glu-Ala-His) box polypeptide 33
chr18_+_41772474 0.24 ENSDART00000097547
trpc6b
transient receptor potential cation channel, subfamily C, member 6b
chr8_-_39977026 0.23 ENSDART00000141707
asphd2
aspartate beta-hydroxylase domain containing 2
chr13_+_35925490 0.22 ENSDART00000046115
mfsd2aa
major facilitator superfamily domain containing 2aa
chr20_-_6196989 0.22 ENSDART00000013343
b4galt6
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
chr7_+_17938128 0.22 ENSDART00000141044
mta2
metastasis associated 1 family, member 2
chr2_-_58257624 0.21 ENSDART00000098940
foxl2b
forkhead box L2b
chr14_-_32520295 0.20 ENSDART00000165463
atp11c
ATPase phospholipid transporting 11C
chr3_+_431208 0.17 ENSDART00000154296
ENSDART00000048733
si:ch73-308m11.1
si:dkey-167k11.5
si:ch73-308m11.1
si:dkey-167k11.5
chr7_+_31374383 0.16 ENSDART00000085505
ctdspl2b
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2b
chr14_-_41075262 0.12 ENSDART00000180518
drp2
dystrophin related protein 2
chr9_+_30213144 0.10 ENSDART00000139920
senp7a
SUMO1/sentrin specific peptidase 7a
chr5_+_35398745 0.10 ENSDART00000098010
ptger4b
prostaglandin E receptor 4 (subtype EP4) b
chr9_-_43538328 0.09 ENSDART00000140526
znf385b
zinc finger protein 385B
chr25_-_21280584 0.08 ENSDART00000143644
tmem60
transmembrane protein 60
chr1_-_52461322 0.08 ENSDART00000083836
si:ch211-217k17.7
si:ch211-217k17.7
chr3_-_58823762 0.08 ENSDART00000101253
luc7l3
LUC7-like 3 pre-mRNA splicing factor
chr1_+_37196106 0.08 ENSDART00000008756
ENSDART00000157503
ENSDART00000162971
ENSDART00000191004
ENSDART00000078206
ENSDART00000045111
dclk2a
doublecortin-like kinase 2a
chr22_-_193234 0.07 ENSDART00000131067
fbxo42
F-box protein 42
chr1_+_37195919 0.06 ENSDART00000159684
ENSDART00000172742
ENSDART00000158395
dclk2a
doublecortin-like kinase 2a
chr25_+_19954576 0.06 ENSDART00000149335
kcna1a
potassium voltage-gated channel, shaker-related subfamily, member 1a
chr17_-_3986236 0.05 ENSDART00000188794
ENSDART00000160830
PLCB1
si:ch1073-140o9.2
chr3_+_14641962 0.05 ENSDART00000091070
zgc:158403
zgc:158403
chr9_-_6624663 0.05 ENSDART00000092537
GPR45
si:dkeyp-118h3.5
chr20_-_5328637 0.04 ENSDART00000075974
ism2b
isthmin 2b
chr1_+_44390470 0.04 ENSDART00000100321
timm10
translocase of inner mitochondrial membrane 10 homolog (yeast)
chr23_-_6765653 0.03 ENSDART00000192310
FP102169.1

chr7_-_6438544 0.03 ENSDART00000173180
zgc:165555
zgc:165555
chr20_-_8304271 0.02 ENSDART00000179057
dab1a
Dab, reelin signal transducer, homolog 1a (Drosophila)
chr5_+_53479576 0.02 ENSDART00000099616
ENSDART00000169169
BX323994.1

chr14_-_2189889 0.02 ENSDART00000181557
ENSDART00000106707
pcdh2ab9
pcdh2ab11
protocadherin 2 alpha b 9
protocadherin 2 alpha b 11
chr25_+_27744293 0.01 ENSDART00000103519
ENSDART00000149456
wasla
Wiskott-Aldrich syndrome-like a
chr23_-_9919959 0.01 ENSDART00000127029
si:ch211-220i18.4
si:ch211-220i18.4
chr2_+_13069168 0.00 ENSDART00000192832
prkag2b
protein kinase, AMP-activated, gamma 2 non-catalytic subunit b
chr15_+_27387555 0.00 ENSDART00000018603
tbx4
T-box 4

Network of associatons between targets according to the STRING database.

First level regulatory network of her6+her9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.1 0.7 GO:0003232 bulbus arteriosus development(GO:0003232)
0.1 0.2 GO:0048496 maintenance of organ identity(GO:0048496)
0.1 0.2 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.0 0.3 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0 1.6 GO:0043297 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.0 0.1 GO:0006972 hyperosmotic response(GO:0006972)
0.0 0.6 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0 0.6 GO:0008637 apoptotic mitochondrial changes(GO:0008637)
0.0 0.7 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.3 GO:0043249 erythrocyte maturation(GO:0043249)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0098894 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.0 0.0 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 1.6 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.2 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0071889 14-3-3 protein binding(GO:0071889)
0.2 0.6 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.1 0.5 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 0.2 GO:0008489 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity(GO:0008489)
0.0 0.6 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.8 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.5 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.3 GO:0016229 steroid dehydrogenase activity(GO:0016229)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 0.9 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 0.6 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.8 PID MTOR 4PATHWAY mTOR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 0.7 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins