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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for hic1

Z-value: 0.27

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Transcription factors associated with hic1

Gene Symbol Gene ID Gene Info
hic1
ENSDARG00000055493 hypermethylated in cancer 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hic1dr11_v1_chr15_+_25683069_256830690.635.1e-03Click!

Activity profile of hic1 motif

Sorted Z-values of hic1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_20916251 0.87 ENSDART00000134053
usp2a
ubiquitin specific peptidase 2a
chr3_-_61592417 0.78 ENSDART00000155082
nptx2a
neuronal pentraxin 2a
chr5_+_62723233 0.77 ENSDART00000183718
nanos2
nanos homolog 2
chr15_-_18138607 0.59 ENSDART00000176690
CR385077.1

chr13_-_37519774 0.52 ENSDART00000141420
ENSDART00000185478
sgpp1
sphingosine-1-phosphate phosphatase 1
chr8_+_35172594 0.49 ENSDART00000177146
BX897670.1

chr21_-_45878872 0.48 ENSDART00000029763
sap30l
sap30-like
chr16_+_50006145 0.45 ENSDART00000049375
ube2e2
ubiquitin-conjugating enzyme E2E 2
chr1_+_135903 0.41 ENSDART00000124837
f10
coagulation factor X
chr17_-_8976307 0.28 ENSDART00000092113
zranb1b
zinc finger, RAN-binding domain containing 1b
chr14_+_49602 0.22 ENSDART00000035581
OTOP1
otopetrin 1
chr5_-_52784152 0.21 ENSDART00000169307
fam189a2
family with sequence similarity 189, member A2
chr14_-_21064199 0.19 ENSDART00000172099
si:dkey-74k8.3
si:dkey-74k8.3
chr4_-_55728559 0.16 ENSDART00000186201
CT583728.14

chr14_-_21063977 0.15 ENSDART00000164373
si:dkey-74k8.3
si:dkey-74k8.3
chr4_+_90048 0.14 ENSDART00000166440
lrp6
low density lipoprotein receptor-related protein 6
chr1_-_59571758 0.14 ENSDART00000193546
ENSDART00000167087
wfikkn1
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr10_+_23088 0.14 ENSDART00000022840
riox2
ribosomal oxygenase 2
chr4_+_55778679 0.13 ENSDART00000183009
CT583728.19

chr4_+_55794876 0.13 ENSDART00000189043
CT583728.17

chr4_+_55810436 0.13 ENSDART00000182875
CT583728.16

chr14_+_52369262 0.13 ENSDART00000169352
ENSDART00000157833
igfbp7
insulin-like growth factor binding protein 7
chr4_-_68568233 0.12 ENSDART00000184284
BX548011.1

chr4_-_797831 0.11 ENSDART00000158970
ENSDART00000170012
mapre3b
microtubule-associated protein, RP/EB family, member 3b
chr1_+_45839927 0.10 ENSDART00000148086
ENSDART00000180413
ENSDART00000048191
ENSDART00000179047
map2k7
mitogen-activated protein kinase kinase 7
chr7_-_24995631 0.08 ENSDART00000173955
ENSDART00000173791
rcor2
REST corepressor 2
chr4_-_68831753 0.08 ENSDART00000189170
si:dkey-264f17.1
si:dkey-264f17.1
chr3_-_56896702 0.07 ENSDART00000023265
ush1ga
Usher syndrome 1Ga (autosomal recessive)
chr14_-_34044369 0.06 ENSDART00000149396
ENSDART00000123607
ENSDART00000190746
cyfip2
cytoplasmic FMR1 interacting protein 2
chr19_-_19505167 0.06 ENSDART00000160582
creb5a
cAMP responsive element binding protein 5a
chr23_+_45611649 0.06 ENSDART00000169521
dclk2b
doublecortin-like kinase 2b
chr9_-_849069 0.05 ENSDART00000136091
c1ql2
complement component 1, q subcomponent-like 2
chr23_+_14590767 0.05 ENSDART00000143675
si:rp71-79p20.2
si:rp71-79p20.2
chr1_+_10720294 0.04 ENSDART00000139387
atp1b1b
ATPase Na+/K+ transporting subunit beta 1b
chr10_-_21484065 0.04 ENSDART00000064545
fgf18b
fibroblast growth factor 18b
chr9_-_14992730 0.03 ENSDART00000137117
pard3bb
par-3 family cell polarity regulator beta b
chr20_-_18915376 0.02 ENSDART00000063725
xkr6b
XK, Kell blood group complex subunit-related family, member 6b
chr9_+_7358749 0.02 ENSDART00000081660
ihha
Indian hedgehog homolog a
chr6_-_1874664 0.01 ENSDART00000007972
dlgap4b
discs, large (Drosophila) homolog-associated protein 4b
chr12_-_54375 0.01 ENSDART00000152304
si:ch1073-357b18.4
si:ch1073-357b18.4
chr12_-_979789 0.01 ENSDART00000128188
daglb
diacylglycerol lipase, beta
chr7_-_61845282 0.01 ENSDART00000182586
HTRA3
HtrA serine peptidase 3
chr1_+_9004719 0.00 ENSDART00000006211
ENSDART00000137211
prkcba
protein kinase C, beta a

Network of associatons between targets according to the STRING database.

First level regulatory network of hic1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0010332 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.1 0.3 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.5 GO:0006670 sphingosine metabolic process(GO:0006670)
0.0 0.1 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.0 0.4 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 0.1 GO:0035372 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.0 0.8 GO:0051966 regulation of synaptic transmission, glutamatergic(GO:0051966)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.1 0.5 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.1 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.5 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis