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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for hmx2_hmx3a

Z-value: 1.00

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Transcription factors associated with hmx2_hmx3a

Gene Symbol Gene ID Gene Info
hmx2
ENSDARG00000070954 H6 family homeobox 2
hmx2
ENSDARG00000115364 H6 family homeobox 2
hmx3a
ENSDARG00000070955 H6 family homeobox 3a
hmx3a
ENSDARG00000115051 H6 family homeobox 3a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hmx3adr11_v1_chr17_-_21793113_21793113-0.233.6e-01Click!
hmx2dr11_v1_chr17_-_21784152_217841520.136.0e-01Click!

Activity profile of hmx2_hmx3a motif

Sorted Z-values of hmx2_hmx3a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_50701748 2.35 ENSDART00000191938
ENSDART00000183220
ENSDART00000049464
fermt2
fermitin family member 2
chr16_+_54209504 1.86 ENSDART00000020033
xrcc1
X-ray repair complementing defective repair in Chinese hamster cells 1
chr24_-_3477103 1.83 ENSDART00000143723
idi1
isopentenyl-diphosphate delta isomerase 1
chr5_-_65662996 1.49 ENSDART00000147707
camsap1b
calmodulin regulated spectrin-associated protein 1b
chr19_+_41479990 1.45 ENSDART00000087187
ago2
argonaute RISC catalytic component 2
chr18_-_15532016 1.35 ENSDART00000165279
ppfibp1b
PTPRF interacting protein, binding protein 1b (liprin beta 1)
chr4_+_9911043 1.27 ENSDART00000159762
ENSDART00000091599
sbf1
SET binding factor 1
chr4_-_1720648 1.16 ENSDART00000103484
gas2l3
growth arrest-specific 2 like 3
chr1_-_27014872 1.15 ENSDART00000147414
ENSDART00000134032
ENSDART00000192087
ENSDART00000189111
ENSDART00000187348
ENSDART00000187248
cntln
centlein, centrosomal protein
chr22_+_8979955 1.14 ENSDART00000144005
si:ch211-213a13.1
si:ch211-213a13.1
chr4_+_9911534 1.10 ENSDART00000109452
sbf1
SET binding factor 1
chr13_-_4018888 1.10 ENSDART00000058238
tjap1
tight junction associated protein 1 (peripheral)
chr5_-_19444930 1.09 ENSDART00000136259
ENSDART00000188499
kctd10
potassium channel tetramerization domain containing 10
chr3_+_32410746 1.09 ENSDART00000025496
rras
RAS related
chr22_-_20812822 1.03 ENSDART00000193778
dot1l
DOT1-like histone H3K79 methyltransferase
chr12_-_25887864 1.02 ENSDART00000152983
si:dkey-193p11.2
si:dkey-193p11.2
chr4_-_4592287 0.92 ENSDART00000155287
rassf3
Ras association (RalGDS/AF-6) domain family member 3
chr15_+_21262917 0.92 ENSDART00000101000
gkup
glucuronokinase with putative uridyl pyrophosphorylase
chr1_-_23596391 0.90 ENSDART00000155184
lcorl
ligand dependent nuclear receptor corepressor-like
chr18_+_18439332 0.88 ENSDART00000043843
siah1
siah E3 ubiquitin protein ligase 1
chr20_+_6535176 0.87 ENSDART00000054652
si:ch211-191a24.4
si:ch211-191a24.4
chr18_-_3527686 0.84 ENSDART00000169049
capn5a
calpain 5a
chr8_-_53044300 0.84 ENSDART00000191653
nr6a1a
nuclear receptor subfamily 6, group A, member 1a
chr8_-_22538588 0.82 ENSDART00000144041
csde1
cold shock domain containing E1, RNA-binding
chr11_-_34577034 0.81 ENSDART00000133302
ENSDART00000184367
pfkfb4a
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4a
chr12_+_33320504 0.80 ENSDART00000021491
csnk1db
casein kinase 1, delta b
chr2_+_15128418 0.79 ENSDART00000141921
arhgap29b
Rho GTPase activating protein 29b
chr10_+_44956660 0.78 ENSDART00000169225
ENSDART00000189298
il1b
interleukin 1, beta
chr9_+_38457806 0.77 ENSDART00000142512
mcm3ap
minichromosome maintenance complex component 3 associated protein
chr19_-_7043355 0.76 ENSDART00000104845
tapbp.1
TAP binding protein (tapasin), tandem duplicate 1
chr15_-_41689981 0.76 ENSDART00000059327
spsb4b
splA/ryanodine receptor domain and SOCS box containing 4b
chr7_+_9981757 0.76 ENSDART00000113429
ENSDART00000173233
adamts17
ADAM metallopeptidase with thrombospondin type 1 motif, 17
chr12_+_1609563 0.74 ENSDART00000163559
SLC39A11
solute carrier family 39 member 11
chr25_-_36263115 0.74 ENSDART00000143046
ENSDART00000139002
dus2
dihydrouridine synthase 2
chr22_+_30137374 0.73 ENSDART00000187808
add3a
adducin 3 (gamma) a
chr13_+_15816573 0.73 ENSDART00000137061
klc1a
kinesin light chain 1a
chr1_+_51386649 0.73 ENSDART00000152289
atg4da
autophagy related 4D, cysteine peptidase a
chr20_-_34670236 0.72 ENSDART00000033325
slc25a24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr1_+_45958904 0.68 ENSDART00000108528
arhgef7b
Rho guanine nucleotide exchange factor (GEF) 7b
chr23_-_14990865 0.67 ENSDART00000147799
ndrg3b
ndrg family member 3b
chr9_-_14273652 0.66 ENSDART00000135458
abcb6b
ATP-binding cassette, sub-family B (MDR/TAP), member 6b
chr3_+_26244353 0.66 ENSDART00000103733
atad5a
ATPase family, AAA domain containing 5a
chr17_+_45737992 0.66 ENSDART00000135073
ENSDART00000143525
ENSDART00000158165
ENSDART00000184167
ENSDART00000109525
aspg
asparaginase homolog (S. cerevisiae)
chr15_-_28569786 0.65 ENSDART00000127845
ssh2a
slingshot protein phosphatase 2a
chr16_+_31511739 0.64 ENSDART00000049420
ndrg1b
N-myc downstream regulated 1b
chr2_+_15128027 0.64 ENSDART00000016071
arhgap29b
Rho GTPase activating protein 29b
chr21_-_14692119 0.64 ENSDART00000123047
ehmt1b
euchromatic histone-lysine N-methyltransferase 1b
chr8_+_50946379 0.62 ENSDART00000139649
b2ml
beta-2-microglobulin, like
chr18_+_45573251 0.62 ENSDART00000191309
kifc3
kinesin family member C3
chr14_-_14746051 0.61 ENSDART00000163199
ENSDART00000170623
ENSDART00000158629
ENSDART00000171581
ogt.1
O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1
chr1_+_15258641 0.60 ENSDART00000033018
pi4k2b
phosphatidylinositol 4-kinase type 2 beta
chr18_+_46151505 0.59 ENSDART00000015034
ENSDART00000141287
blvrb
biliverdin reductase B
chr16_-_9830451 0.59 ENSDART00000148528
grhl2a
grainyhead-like transcription factor 2a
chr15_-_33172246 0.59 ENSDART00000158666
nbeab
neurobeachin b
chr11_+_41858807 0.59 ENSDART00000161605
iffo2b
intermediate filament family orphan 2b
chr2_-_40890264 0.58 ENSDART00000123886
uggt1
UDP-glucose glycoprotein glucosyltransferase 1
chr17_+_20237948 0.58 ENSDART00000031547
smndc1
survival motor neuron domain containing 1
chr2_-_57918314 0.58 ENSDART00000138265
si:dkeyp-68b7.7
si:dkeyp-68b7.7
chr1_+_54124209 0.58 ENSDART00000187730
LO017722.1

chr3_+_45365098 0.58 ENSDART00000052746
ENSDART00000156555
ube2ia
ubiquitin-conjugating enzyme E2Ia
chr3_-_58165254 0.57 ENSDART00000093031
snu13a
SNU13 homolog, small nuclear ribonucleoprotein a (U4/U6.U5)
chr23_+_32029304 0.57 ENSDART00000185217
tpx2
TPX2, microtubule-associated, homolog (Xenopus laevis)
chr13_+_15656042 0.57 ENSDART00000134240
mark3a
MAP/microtubule affinity-regulating kinase 3a
chr22_+_14117078 0.56 ENSDART00000013575
bzw1a
basic leucine zipper and W2 domains 1a
chr11_+_13423776 0.56 ENSDART00000102553
homer3b
homer scaffolding protein 3b
chr1_-_53407448 0.56 ENSDART00000160033
ENSDART00000172322
elmod2
ELMO/CED-12 domain containing 2
chr17_+_20237727 0.55 ENSDART00000180115
smndc1
survival motor neuron domain containing 1
chr23_+_32028574 0.55 ENSDART00000145501
ENSDART00000143121
ENSDART00000111877
tpx2
TPX2, microtubule-associated, homolog (Xenopus laevis)
chr8_-_19051906 0.54 ENSDART00000089024
sema6bb
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Bb
chr16_-_31790285 0.54 ENSDART00000184655
chd4b
chromodomain helicase DNA binding protein 4b
chr20_+_4221978 0.53 ENSDART00000171898
ipcef1
interaction protein for cytohesin exchange factors 1
chr4_-_3023182 0.53 ENSDART00000127894
plekha5
pleckstrin homology domain containing, family A member 5
chr5_+_30392148 0.53 ENSDART00000086765
stk36
serine/threonine kinase 36 (fused homolog, Drosophila)
chr4_-_20081621 0.52 ENSDART00000024647
dennd6b
DENN/MADD domain containing 6B
chr22_+_2751887 0.52 ENSDART00000133652
si:dkey-20i20.11
si:dkey-20i20.11
chr18_-_3527988 0.52 ENSDART00000157669
capn5a
calpain 5a
chr20_-_40367493 0.52 ENSDART00000075096
smpdl3a
sphingomyelin phosphodiesterase, acid-like 3A
chr23_-_36303216 0.52 ENSDART00000188720
cbx5
chromobox homolog 5 (HP1 alpha homolog, Drosophila)
chr8_-_39884359 0.51 ENSDART00000131372
mlec
malectin
chr2_-_40890004 0.51 ENSDART00000191746
uggt1
UDP-glucose glycoprotein glucosyltransferase 1
chr22_-_25043103 0.51 ENSDART00000015512
polr3f
polymerase (RNA) III (DNA directed) polypeptide F
chr3_-_26806032 0.51 ENSDART00000143710
pigq
phosphatidylinositol glycan anchor biosynthesis, class Q
chr19_-_868187 0.51 ENSDART00000186626
eomesa
eomesodermin homolog a
chr15_-_20839763 0.51 ENSDART00000141746
ENSDART00000182369
aldh3a2a
aldehyde dehydrogenase 3 family, member A2a
chr3_+_45364849 0.50 ENSDART00000153974
ube2ia
ubiquitin-conjugating enzyme E2Ia
chr2_+_9821757 0.50 ENSDART00000018408
ENSDART00000141227
ENSDART00000144681
ENSDART00000148227
anxa13l
annexin A13, like
chr9_+_23009608 0.50 ENSDART00000079879
si:dkey-91i10.3
si:dkey-91i10.3
chr24_+_744713 0.49 ENSDART00000067764
stk17a
serine/threonine kinase 17a
chr3_-_40232615 0.49 ENSDART00000155969
flii
flightless I actin binding protein
chr6_+_58289335 0.49 ENSDART00000177399
ralgapb
Ral GTPase activating protein, beta subunit (non-catalytic)
chr19_-_46037835 0.49 ENSDART00000163815
nup153
nucleoporin 153
chr16_+_40043673 0.48 ENSDART00000102552
ENSDART00000125484
trmt11
tRNA methyltransferase 11 homolog (S. cerevisiae)
chr15_+_2856696 0.47 ENSDART00000163434
mre11a
MRE11 homolog A, double strand break repair nuclease
chr24_-_40901410 0.47 ENSDART00000170688
wdr48a
WD repeat domain 48a
chr4_-_12930086 0.46 ENSDART00000013604
lemd3
LEM domain containing 3
chr11_-_4023940 0.45 ENSDART00000058728
ENSDART00000171245
nek4
NIMA-related kinase 4
chr7_-_48391571 0.45 ENSDART00000180034
sin3ab
SIN3 transcription regulator family member Ab
chr21_-_22117085 0.44 ENSDART00000146673
slc35f2
solute carrier family 35, member F2
chr7_+_35193832 0.44 ENSDART00000189002
zdhhc1
zinc finger, DHHC-type containing 1
chr6_+_4229360 0.44 ENSDART00000191347
ENSDART00000130642
FO082877.1

chr16_-_13680692 0.44 ENSDART00000047452
ube2s
ubiquitin-conjugating enzyme E2S
chr7_-_26270014 0.44 ENSDART00000079347
serpine1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr21_+_18907102 0.44 ENSDART00000160185
ENSDART00000190175
ENSDART00000017937
ENSDART00000191546
ENSDART00000130519
ENSDART00000137143
smpd4
sphingomyelin phosphodiesterase 4
chr24_-_26981848 0.43 ENSDART00000183198
stag1b
stromal antigen 1b
chr4_-_7875808 0.43 ENSDART00000162276
nudt5
nudix (nucleoside diphosphate linked moiety X)-type motif 5
chr24_-_16905018 0.43 ENSDART00000066759
mtrr
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
chr24_+_12983434 0.42 ENSDART00000145214
ENSDART00000146911
ENSDART00000066700
eloca
elongin C paralog a
chr17_+_21887823 0.42 ENSDART00000131929
ENSDART00000165192
plekha1a
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1a
chr13_-_4367083 0.42 ENSDART00000124716
si:dkeyp-121d4.3
si:dkeyp-121d4.3
chr10_+_2600830 0.42 ENSDART00000101012
CU856539.2

chr2_+_34112100 0.42 ENSDART00000056666
ENSDART00000146624
klhl20
kelch-like family member 20
chr6_-_4228640 0.41 ENSDART00000162497
ENSDART00000179923
trak2
trafficking protein, kinesin binding 2
chr14_+_35237613 0.41 ENSDART00000163465
ebf3a
early B cell factor 3a
chr10_-_26202766 0.41 ENSDART00000136393
fhdc3
FH2 domain containing 3
chr3_+_28502419 0.41 ENSDART00000151081
sept12
septin 12
chr16_-_7793457 0.41 ENSDART00000113483
trim71
tripartite motif containing 71, E3 ubiquitin protein ligase
chr9_-_7287375 0.41 ENSDART00000128352
mitd1
MIT, microtubule interacting and transport, domain containing 1
chr25_-_3590923 0.41 ENSDART00000164149
si:ch211-272n13.3
si:ch211-272n13.3
chr25_-_25058508 0.41 ENSDART00000087570
ENSDART00000178891
FQ311928.1

chr22_+_20172018 0.40 ENSDART00000188104
hmg20b
high mobility group 20B
chr10_+_35352435 0.40 ENSDART00000123936
si:dkey-259j3.5
si:dkey-259j3.5
chr1_+_53321878 0.40 ENSDART00000143909
tbc1d9
TBC1 domain family, member 9 (with GRAM domain)
chr19_-_5865766 0.40 ENSDART00000191007
LO018585.1

chr2_-_19321927 0.40 ENSDART00000182808
zfyve9a
zinc finger, FYVE domain containing 9a
chr5_-_28016805 0.40 ENSDART00000078642
vps37b
vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr21_-_36453594 0.40 ENSDART00000193176
cnot8
CCR4-NOT transcription complex, subunit 8
chr15_-_2856362 0.39 ENSDART00000168300
ankrd49
ankyrin repeat domain 49
chr23_+_38957738 0.39 ENSDART00000193480
ATP9A
ATPase phospholipid transporting 9A (putative)
chr13_+_1131748 0.39 ENSDART00000054318
wdr92
WD repeat domain 92
chr23_-_33350990 0.39 ENSDART00000144831
si:ch211-226m16.2
si:ch211-226m16.2
chr16_+_28994709 0.39 ENSDART00000088023
gon4l
gon-4-like (C. elegans)
chr8_+_7097929 0.39 ENSDART00000188955
ENSDART00000184772
ENSDART00000109581
abtb1
ankyrin repeat and BTB (POZ) domain containing 1
chr4_-_837768 0.39 ENSDART00000185280
ENSDART00000135618
sobpb
sine oculis binding protein homolog (Drosophila) b
chr6_+_2174082 0.38 ENSDART00000073936
acvr1bb
activin A receptor type 1Bb
chr20_-_9194257 0.38 ENSDART00000133012
ylpm1
YLP motif containing 1
chr14_-_6285555 0.38 ENSDART00000182280
ENSDART00000147184
elp1
elongator complex protein 1
chr23_+_21261313 0.38 ENSDART00000104268
ENSDART00000159046
emc1
ER membrane protein complex subunit 1
chr19_-_19379084 0.38 ENSDART00000165206
smarcc1b
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1b
chr25_-_13789955 0.37 ENSDART00000167742
ENSDART00000165116
ENSDART00000171461
ckap5
cytoskeleton associated protein 5
chr19_-_11336782 0.37 ENSDART00000131014
sept7a
septin 7a
chr7_+_9326234 0.37 ENSDART00000104536
chsy1
chondroitin sulfate synthase 1
chr2_-_58581663 0.37 ENSDART00000004431
epb41l3b
erythrocyte membrane protein band 4.1-like 3b
chr5_-_11809710 0.36 ENSDART00000186998
ENSDART00000181363
ENSDART00000180681
nf2a
neurofibromin 2a (merlin)
chr9_-_7287128 0.36 ENSDART00000176281
ENSDART00000065803
mitd1
MIT, microtubule interacting and transport, domain containing 1
chr8_+_28358161 0.36 ENSDART00000062682
adipor1b
adiponectin receptor 1b
chr5_+_37032038 0.36 ENSDART00000045036
nfkbib
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr1_+_12295142 0.36 ENSDART00000158595
gne
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
chr10_-_9269733 0.36 ENSDART00000064974
anxa3b
annexin A3b
chr8_-_51365566 0.36 ENSDART00000182396
chmp7
charged multivesicular body protein 7
chr8_+_2656681 0.36 ENSDART00000185067
ENSDART00000165943
fam102aa
family with sequence similarity 102, member Aa
chr18_+_35128685 0.36 ENSDART00000151579
si:ch211-195m9.3
si:ch211-195m9.3
chr23_+_16807209 0.36 ENSDART00000141966
zgc:114081
zgc:114081
chr1_-_493218 0.35 ENSDART00000031635
ercc5
excision repair cross-complementation group 5
chr4_+_25607101 0.35 ENSDART00000133929
acot14
acyl-CoA thioesterase 14
chr11_+_31323746 0.35 ENSDART00000180220
ENSDART00000189937
sipa1l2
signal-induced proliferation-associated 1 like 2
chr8_+_2543525 0.35 ENSDART00000129569
ENSDART00000128227
gle1
GLE1 RNA export mediator homolog (yeast)
chr6_+_4299164 0.35 ENSDART00000159759
nbeal1
neurobeachin-like 1
chr23_+_2666944 0.34 ENSDART00000192861
CABZ01057928.1

chr23_+_28374458 0.34 ENSDART00000140058
ENSDART00000144240
zgc:153867
zgc:153867
chr3_-_15210491 0.34 ENSDART00000037906
hirip3
HIRA interacting protein 3
chr5_+_18014931 0.34 ENSDART00000142562
ascc2
activating signal cointegrator 1 complex subunit 2
chr14_+_12170460 0.34 ENSDART00000146521
rhogd
ras homolog gene family, member Gd
chr5_+_57337630 0.34 ENSDART00000012586
slc31a1
solute carrier family 31 (copper transporter), member 1
chr8_-_53044089 0.34 ENSDART00000135982
nr6a1a
nuclear receptor subfamily 6, group A, member 1a
chr9_+_22780901 0.34 ENSDART00000110992
ENSDART00000143972
rif1
replication timing regulatory factor 1
chr18_+_15841449 0.34 ENSDART00000141800
ENSDART00000091349
eea1
early endosome antigen 1
chr12_-_979789 0.34 ENSDART00000128188
daglb
diacylglycerol lipase, beta
chr13_+_7049823 0.33 ENSDART00000178997
ENSDART00000161443
rnaset2
ribonuclease T2
chr14_-_14687004 0.33 ENSDART00000169970
gcna
germ cell nuclear acidic peptidase
chr2_-_38225388 0.33 ENSDART00000146485
ENSDART00000128043
acin1a
apoptotic chromatin condensation inducer 1a
chr21_-_35325466 0.33 ENSDART00000134780
ENSDART00000145930
ENSDART00000076715
ENSDART00000065341
ENSDART00000162189
ublcp1
ubiquitin-like domain containing CTD phosphatase 1
chr16_+_40340222 0.33 ENSDART00000190631
mettl6
methyltransferase like 6
chr5_+_38913621 0.33 ENSDART00000137112
fras1
Fraser extracellular matrix complex subunit 1
chr25_+_18436301 0.32 ENSDART00000056180
cep41
centrosomal protein 41
chr22_+_724639 0.32 ENSDART00000105323
zgc:162255
zgc:162255
chr6_+_3716666 0.32 ENSDART00000041627
ssb
Sjogren syndrome antigen B (autoantigen La)
chr5_+_31036911 0.32 ENSDART00000141463
ENSDART00000162121
zzef1
zinc finger, ZZ-type with EF hand domain 1
chr19_-_17303500 0.32 ENSDART00000162355
sf3a3
splicing factor 3a, subunit 3
chr14_-_25099988 0.32 ENSDART00000144168
matr3l1.1
matrin 3-like 1.1
chr10_-_13343831 0.32 ENSDART00000135941
il11ra
interleukin 11 receptor, alpha
chr2_+_44348473 0.32 ENSDART00000155166
ENSDART00000098146
zgc:152670
zgc:152670
chr13_-_38730267 0.32 ENSDART00000157524
lmbrd1
LMBR1 domain containing 1
chr7_+_31120766 0.32 ENSDART00000173703
tjp1a
tight junction protein 1a
chr24_+_39227519 0.32 ENSDART00000184611
ENSDART00000193494
ENSDART00000190728
ENSDART00000168705
MPRIP
si:ch73-103b11.2
chr12_+_34953038 0.32 ENSDART00000187022
ENSDART00000123988
ENSDART00000027034
qki2
QKI, KH domain containing, RNA binding 2
chr12_+_13319132 0.32 ENSDART00000049167
psme2
proteasome activator subunit 2
chr11_+_24786378 0.31 ENSDART00000015374
cyb5r1
cytochrome b5 reductase 1
chr6_+_58280936 0.31 ENSDART00000155244
ralgapb
Ral GTPase activating protein, beta subunit (non-catalytic)
chr8_-_4972916 0.31 ENSDART00000101576
tmem230b
transmembrane protein 230b
chr5_-_48664522 0.31 ENSDART00000083229
mblac2
metallo-beta-lactamase domain containing 2
chr22_+_789795 0.31 ENSDART00000185230
ENSDART00000192538
ENSDART00000171045
ENSDART00000180188
cry1bb
cryptochrome circadian clock 1bb
chr18_-_7677208 0.31 ENSDART00000092456
shank3a
SH3 and multiple ankyrin repeat domains 3a
chr6_+_59642695 0.31 ENSDART00000166373
ENSDART00000161030
R3HDM2
R3H domain containing 2
chr2_-_44777592 0.31 ENSDART00000113351
ENSDART00000169310
ncapd2
non-SMC condensin I complex, subunit D2
chr3_+_39579393 0.30 ENSDART00000055170
cln3
ceroid-lipofuscinosis, neuronal 3
chr11_+_31324335 0.30 ENSDART00000088093
sipa1l2
signal-induced proliferation-associated 1 like 2
chr13_+_36923052 0.30 ENSDART00000026313
tmx1
thioredoxin-related transmembrane protein 1
chr8_+_21254192 0.30 ENSDART00000167718
itpr3
inositol 1,4,5-trisphosphate receptor, type 3
chr7_+_36467315 0.30 ENSDART00000138893
aktip
akt interacting protein
chr4_-_5019113 0.30 ENSDART00000189321
ENSDART00000081990
strip2
striatin interacting protein 2

Network of associatons between targets according to the STRING database.

First level regulatory network of hmx2_hmx3a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
0.4 1.8 GO:0000012 single strand break repair(GO:0000012)
0.3 1.4 GO:0035279 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.3 1.1 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.3 1.1 GO:0036306 embryonic heart tube elongation(GO:0036306)
0.3 1.0 GO:2000677 histone H3-K79 methylation(GO:0034729) regulation of transcription regulatory region DNA binding(GO:2000677)
0.2 0.7 GO:0071896 protein localization to adherens junction(GO:0071896)
0.2 0.8 GO:2000660 regulation of interleukin-1-mediated signaling pathway(GO:2000659) negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.2 1.1 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.2 1.5 GO:0031113 regulation of microtubule polymerization(GO:0031113)
0.2 0.5 GO:0055109 invagination involved in gastrulation with mouth forming second(GO:0055109) morphogenesis of an epithelial fold(GO:0060571)
0.2 1.2 GO:0021534 cell proliferation in hindbrain(GO:0021534)
0.2 0.5 GO:0090085 regulation of protein deubiquitination(GO:0090085) positive regulation of protein deubiquitination(GO:1903003)
0.2 0.5 GO:0006043 glucosamine metabolic process(GO:0006041) glucosamine catabolic process(GO:0006043)
0.1 0.4 GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis.(GO:0002926)
0.1 0.4 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.1 1.1 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 0.4 GO:0010755 regulation of plasminogen activation(GO:0010755)
0.1 0.4 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 0.6 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.1 0.1 GO:0031112 positive regulation of microtubule polymerization or depolymerization(GO:0031112)
0.1 0.2 GO:0036037 CD8-positive, alpha-beta T cell activation(GO:0036037)
0.1 0.4 GO:0010586 miRNA metabolic process(GO:0010586)
0.1 0.6 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 1.1 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.1 1.3 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.1 1.1 GO:0045199 maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.1 0.3 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.1 0.4 GO:0072574 hepatocyte proliferation(GO:0072574) epithelial cell proliferation involved in liver morphogenesis(GO:0072575)
0.1 0.4 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.1 0.2 GO:0006145 purine nucleobase catabolic process(GO:0006145)
0.1 0.8 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1 0.3 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.1 0.2 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1 2.0 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
0.1 0.7 GO:0015886 heme transport(GO:0015886) iron coordination entity transport(GO:1901678)
0.1 0.7 GO:0021702 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.1 0.2 GO:0019852 L-ascorbic acid transport(GO:0015882) L-ascorbic acid metabolic process(GO:0019852)
0.1 0.2 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.1 0.6 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.1 0.4 GO:0060876 semicircular canal formation(GO:0060876)
0.1 0.5 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.1 0.3 GO:0048209 regulation of vesicle targeting, to, from or within Golgi(GO:0048209)
0.1 0.7 GO:0050667 homocysteine metabolic process(GO:0050667)
0.1 0.2 GO:0098921 endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921)
0.1 0.3 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.1 0.2 GO:0070221 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
0.0 0.8 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.3 GO:0014009 glial cell proliferation(GO:0014009)
0.0 0.2 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.0 0.9 GO:0007032 endosome organization(GO:0007032)
0.0 0.2 GO:0035678 neuromast hair cell morphogenesis(GO:0035678)
0.0 0.2 GO:0032964 collagen biosynthetic process(GO:0032964)
0.0 0.5 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.2 GO:0072116 kidney rudiment formation(GO:0072003) pronephros formation(GO:0072116)
0.0 0.3 GO:2000463 postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.0 0.3 GO:0015809 arginine transport(GO:0015809)
0.0 0.3 GO:1905168 positive regulation of double-strand break repair via homologous recombination(GO:1905168)
0.0 0.3 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
0.0 0.6 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.3 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.0 0.1 GO:0015822 mitochondrial ornithine transport(GO:0000066) ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352) mitochondrial L-ornithine transmembrane transport(GO:1990575)
0.0 0.2 GO:0006004 fucose metabolic process(GO:0006004)
0.0 0.2 GO:0014045 establishment of endothelial blood-brain barrier(GO:0014045)
0.0 0.2 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.0 0.4 GO:0006032 chitin catabolic process(GO:0006032)
0.0 0.2 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.1 GO:0030220 platelet formation(GO:0030220) platelet morphogenesis(GO:0036344)
0.0 1.1 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 0.2 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.5 GO:0061300 cerebellum vasculature development(GO:0061300)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.3 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.1 GO:0055071 manganese ion homeostasis(GO:0055071)
0.0 0.2 GO:0003315 heart rudiment formation(GO:0003315)
0.0 0.1 GO:0014014 negative regulation of gliogenesis(GO:0014014)
0.0 0.1 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.0 0.3 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0 3.7 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 1.2 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.1 GO:0015744 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
0.0 0.2 GO:1905097 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.0 0.2 GO:0050848 regulation of calcium-mediated signaling(GO:0050848)
0.0 0.2 GO:0021877 forebrain neuron fate commitment(GO:0021877)
0.0 0.2 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.5 GO:0006405 RNA export from nucleus(GO:0006405)
0.0 0.1 GO:0071072 heat generation(GO:0031649) regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652) regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072)
0.0 0.2 GO:2001240 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.0 0.1 GO:1904729 regulation of intestinal absorption(GO:1904478) regulation of intestinal lipid absorption(GO:1904729)
0.0 0.1 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.1 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.1 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.1 GO:0051570 regulation of histone H3-K9 methylation(GO:0051570)
0.0 0.2 GO:0006108 malate metabolic process(GO:0006108)
0.0 1.7 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.3 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.0 0.8 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.2 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948) reelin-mediated signaling pathway(GO:0038026)
0.0 0.4 GO:0006047 UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.0 0.4 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 0.3 GO:0055117 regulation of cardiac muscle contraction(GO:0055117)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.2 GO:0051443 positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.0 0.2 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491)
0.0 0.6 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.6 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 0.2 GO:0021535 cell migration in hindbrain(GO:0021535)
0.0 3.2 GO:0043087 regulation of GTPase activity(GO:0043087)
0.0 0.2 GO:0006798 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.0 0.5 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 0.1 GO:0048194 Golgi vesicle budding(GO:0048194)
0.0 0.6 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.3 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.3 GO:0019471 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.0 0.9 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.3 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.0 0.3 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.4 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.2 GO:0034394 protein localization to cell surface(GO:0034394)
0.0 0.1 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 0.1 GO:0035776 pronephric proximal tubule development(GO:0035776)
0.0 0.6 GO:0032272 negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.0 0.5 GO:0071711 basement membrane organization(GO:0071711)
0.0 0.1 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.3 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0 0.9 GO:0030917 midbrain-hindbrain boundary development(GO:0030917)
0.0 0.1 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.0 0.1 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.0 GO:0034421 post-translational protein acetylation(GO:0034421)
0.0 0.2 GO:0051897 positive regulation of protein kinase B signaling(GO:0051897)
0.0 0.2 GO:0007634 optokinetic behavior(GO:0007634)
0.0 0.5 GO:0042752 regulation of circadian rhythm(GO:0042752)
0.0 0.1 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752)
0.0 0.1 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.2 GO:0032204 regulation of telomere maintenance(GO:0032204)
0.0 0.1 GO:0060561 apoptotic process involved in morphogenesis(GO:0060561) apoptotic process involved in patterning of blood vessels(GO:1902262)
0.0 0.6 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 0.2 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 0.8 GO:0051402 neuron apoptotic process(GO:0051402)
0.0 0.5 GO:0035082 axoneme assembly(GO:0035082)
0.0 0.1 GO:0046146 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.0 0.1 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.3 GO:0031258 lamellipodium membrane(GO:0031258)
0.3 1.0 GO:0005880 nuclear microtubule(GO:0005880)
0.2 1.4 GO:0005845 mRNA cap binding complex(GO:0005845)
0.2 0.8 GO:0070390 transcription export complex 2(GO:0070390)
0.1 1.5 GO:0036449 microtubule minus-end(GO:0036449)
0.1 0.3 GO:0043202 vacuolar lumen(GO:0005775) lysosomal lumen(GO:0043202)
0.1 0.6 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 0.6 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 0.5 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.5 GO:0030870 Mre11 complex(GO:0030870)
0.1 0.3 GO:0008537 proteasome activator complex(GO:0008537)
0.1 1.1 GO:0015030 Cajal body(GO:0015030)
0.1 0.2 GO:0070209 ASTRA complex(GO:0070209)
0.1 0.3 GO:0070695 FHF complex(GO:0070695)
0.0 0.3 GO:0000938 GARP complex(GO:0000938)
0.0 0.3 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.1 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.0 0.5 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.4 GO:0070449 elongin complex(GO:0070449)
0.0 1.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.6 GO:0071564 npBAF complex(GO:0071564)
0.0 0.7 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.4 GO:0000153 cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0 0.2 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.4 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.4 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.3 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.2 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.4 GO:0000109 nucleotide-excision repair complex(GO:0000109)
0.0 0.7 GO:0044453 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.3 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.0 0.4 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 1.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.6 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.2 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.0 0.4 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.6 GO:0030667 secretory granule membrane(GO:0030667)
0.0 0.3 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 1.1 GO:0031941 filamentous actin(GO:0031941)
0.0 0.1 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.0 0.8 GO:0032156 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.2 GO:0035032 extrinsic component of vacuolar membrane(GO:0000306) phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0 0.8 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.1 GO:0043220 compact myelin(GO:0043218) Schmidt-Lanterman incisure(GO:0043220)
0.0 1.4 GO:0005814 centriole(GO:0005814)
0.0 0.4 GO:0008278 cohesin complex(GO:0008278)
0.0 1.5 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.2 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.4 GO:1990752 microtubule end(GO:1990752)
0.0 1.9 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.1 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.8 GO:0005643 nuclear pore(GO:0005643)
0.0 0.3 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 1.1 GO:0005871 kinesin complex(GO:0005871)
0.0 0.1 GO:0000974 Prp19 complex(GO:0000974)
0.0 0.2 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.1 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.0 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.1 GO:0098833 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.0 1.5 GO:0014069 postsynaptic density(GO:0014069)
0.0 1.1 GO:0005882 intermediate filament(GO:0005882)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.4 GO:0070883 pre-miRNA binding(GO:0070883)
0.3 1.1 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.3 1.9 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.3 1.0 GO:0031151 histone methyltransferase activity (H3-K79 specific)(GO:0031151)
0.2 1.1 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.2 0.7 GO:0030586 [methionine synthase] reductase activity(GO:0030586)
0.2 0.5 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.2 0.5 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.2 0.9 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.1 0.5 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.1 0.4 GO:0009384 UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761) N-acylmannosamine kinase activity(GO:0009384)
0.1 0.6 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.1 0.3 GO:0033897 ribonuclease T2 activity(GO:0033897)
0.1 0.6 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262) protein O-GlcNAc transferase activity(GO:0097363)
0.1 0.8 GO:0048019 receptor antagonist activity(GO:0048019)
0.1 0.7 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 0.6 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 0.7 GO:0015232 heme transporter activity(GO:0015232)
0.1 0.7 GO:0004067 asparaginase activity(GO:0004067)
0.1 1.1 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 0.5 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 0.2 GO:0004560 alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928)
0.1 1.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.5 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 1.5 GO:0051011 microtubule minus-end binding(GO:0051011)
0.1 0.3 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.1 0.2 GO:0015526 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.1 0.4 GO:0016361 activin receptor activity, type I(GO:0016361)
0.1 0.2 GO:1901612 cardiolipin binding(GO:1901612)
0.1 0.2 GO:0004471 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.1 0.2 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.1 0.8 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.1 0.3 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 1.9 GO:0003684 damaged DNA binding(GO:0003684)
0.1 0.2 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.1 0.2 GO:0070224 sulfide:quinone oxidoreductase activity(GO:0070224)
0.0 0.6 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.1 GO:0047690 aspartyltransferase activity(GO:0047690)
0.0 0.5 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 0.3 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 1.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.3 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.8 GO:0002039 p53 binding(GO:0002039)
0.0 0.3 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.0 0.4 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238)
0.0 0.2 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.2 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.3 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.2 GO:0043560 insulin-activated receptor activity(GO:0005009) insulin receptor substrate binding(GO:0043560)
0.0 0.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.0 2.2 GO:0005178 integrin binding(GO:0005178)
0.0 0.2 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.0 1.4 GO:0019003 GDP binding(GO:0019003)
0.0 0.4 GO:0004568 chitinase activity(GO:0004568)
0.0 0.5 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.2 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.1 GO:0015140 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140)
0.0 0.4 GO:0004859 phospholipase inhibitor activity(GO:0004859) lipase inhibitor activity(GO:0055102)
0.0 0.1 GO:0034416 bisphosphoglycerate phosphatase activity(GO:0034416)
0.0 0.9 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.2 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.2 GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
0.0 0.3 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0 0.6 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 1.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.1 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 0.1 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.1 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.6 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 0.5 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.2 GO:0015157 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 0.2 GO:0008494 translation activator activity(GO:0008494)
0.0 0.1 GO:0004361 glutaryl-CoA dehydrogenase activity(GO:0004361)
0.0 0.3 GO:0070740 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.0 1.0 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 2.5 GO:0019208 phosphatase regulator activity(GO:0019208)
0.0 0.2 GO:0043495 protein anchor(GO:0043495)
0.0 0.1 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.0 0.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.1 GO:0016212 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0 0.4 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.2 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.0 0.1 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 0.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0035252 UDP-xylosyltransferase activity(GO:0035252)
0.0 0.3 GO:0030552 cAMP binding(GO:0030552)
0.0 0.8 GO:0030295 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.0 0.4 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.2 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.0 0.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.1 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.2 GO:0045503 dynein light chain binding(GO:0045503)
0.0 0.0 GO:0004394 heparan sulfate 2-O-sulfotransferase activity(GO:0004394)
0.0 0.1 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 5.0 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.1 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.1 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 1.0 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.6 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.2 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.0 GO:0030366 molybdopterin synthase activity(GO:0030366)
0.0 0.1 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.1 GO:0004362 glutathione-disulfide reductase activity(GO:0004362)
0.0 0.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.2 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.0 0.1 GO:0030172 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.0 0.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.2 GO:0000993 RNA polymerase II core binding(GO:0000993)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.5 PID AURORA A PATHWAY Aurora A signaling
0.0 1.9 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 1.1 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.5 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.6 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.5 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.9 PID AURORA B PATHWAY Aurora B signaling
0.0 0.3 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.4 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.7 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.5 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.1 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.5 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.2 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.4 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.4 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 0.3 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.2 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.3 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.9 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.1 1.1 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 1.8 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 0.6 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 1.0 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 1.0 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.0 0.6 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.2 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.1 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.3 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.8 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.2 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.5 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.3 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.4 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.6 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.8 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.4 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.4 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.4 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.0 0.4 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.2 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.2 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.9 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.3 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.3 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.5 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 0.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.0 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.4 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.5 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.1 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism