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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for hmx4

Z-value: 0.49

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Transcription factors associated with hmx4

Gene Symbol Gene ID Gene Info
hmx4
ENSDARG00000007941 H6 family homeobox 4
hmx4
ENSDARG00000115000 H6 family homeobox 4
hmx4
ENSDARG00000116208 H6 family homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hmx4dr11_v1_chr1_-_40911332_409113320.617.2e-03Click!

Activity profile of hmx4 motif

Sorted Z-values of hmx4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_233143 1.53 ENSDART00000175273
syngap1a
synaptic Ras GTPase activating protein 1a
chr3_+_31039923 1.43 ENSDART00000147706
cox6a2
cytochrome c oxidase subunit VIa polypeptide 2
chr22_+_7439476 1.18 ENSDART00000021594
ENSDART00000063389
zgc:92041
zgc:92041
chr3_-_22829710 1.12 ENSDART00000055659
cyb561
cytochrome b561
chr3_-_33422738 1.04 ENSDART00000075493
ccdc103
coiled-coil domain containing 103
chr22_+_7439186 0.95 ENSDART00000190667
zgc:92041
zgc:92041
chr23_+_39606108 0.83 ENSDART00000109464
g0s2
G0/G1 switch 2
chr14_-_36397768 0.80 ENSDART00000185199
ENSDART00000052562
spata4
spermatogenesis associated 4
chr17_-_5769196 0.80 ENSDART00000113885
si:dkey-100n19.2
si:dkey-100n19.2
chr1_+_49652967 0.79 ENSDART00000191296
tsga10
testis specific, 10
chr3_-_19200571 0.77 ENSDART00000131503
ENSDART00000012335
rfx1a
regulatory factor X, 1a (influences HLA class II expression)
chr7_-_1348640 0.76 ENSDART00000130012
ripk3
receptor-interacting serine-threonine kinase 3
chr25_-_6082509 0.74 ENSDART00000104755
cpeb1a
cytoplasmic polyadenylation element binding protein 1a
chr14_-_25042184 0.74 ENSDART00000131027
TMEM216
si:rp71-1d10.5
chr12_-_11649690 0.69 ENSDART00000149713
btbd16
BTB (POZ) domain containing 16
chr2_-_11662851 0.69 ENSDART00000145108
zgc:110130
zgc:110130
chr11_-_5865744 0.68 ENSDART00000104360
gamt
guanidinoacetate N-methyltransferase
chr7_-_18168493 0.66 ENSDART00000127428
peli3
pellino E3 ubiquitin protein ligase family member 3
chr6_+_59967994 0.65 ENSDART00000050457
zgc:65895
zgc:65895
chr2_+_49572059 0.64 ENSDART00000108861
sema4e
semaphorin 4e
chr23_-_28486893 0.63 ENSDART00000191348
tmem107l
transmembrane protein 107 like
chr19_+_23932259 0.63 ENSDART00000139040
si:dkey-222b8.1
si:dkey-222b8.1
chr15_-_47929455 0.63 ENSDART00000064462
psma6l
proteasome subunit alpha 6, like
chr6_+_59914126 0.63 ENSDART00000082325
ENSDART00000102127
aamp
angio-associated, migratory cell protein
chr6_-_7718200 0.62 ENSDART00000189664
ENSDART00000114282
rpsa
ribosomal protein SA
chr19_+_47394270 0.61 ENSDART00000171281
psmb2
proteasome subunit beta 2
chr15_-_39955785 0.60 ENSDART00000154556
msh5
mutS homolog 5
chr18_-_36066087 0.59 ENSDART00000059352
ENSDART00000145177
exosc5
exosome component 5
chr15_-_36533322 0.59 ENSDART00000156466
ENSDART00000121755
si:dkey-262k9.4
si:dkey-262k9.4
chr23_-_38054 0.58 ENSDART00000170393
CABZ01074076.1

chr4_-_9592402 0.58 ENSDART00000114060
cdnf
cerebral dopamine neurotrophic factor
chr12_-_37343858 0.58 ENSDART00000153281
tekt3
tektin 3
chr1_+_40237276 0.57 ENSDART00000037553
faah2a
fatty acid amide hydrolase 2a
chr17_-_6599484 0.57 ENSDART00000156927
ANKRD66
si:ch211-189e2.2
chr3_-_28750495 0.57 ENSDART00000054408
gsg1l
gsg1-like
chr10_+_7671260 0.55 ENSDART00000157608
fam136a
family with sequence similarity 136, member A
chr13_+_51869025 0.55 ENSDART00000187066
LT631684.1

chr3_-_41292275 0.52 ENSDART00000144088
sdk1a
sidekick cell adhesion molecule 1a
chr20_-_53435483 0.52 ENSDART00000135091
mettl24
methyltransferase like 24
chr20_-_22798794 0.51 ENSDART00000148084
fip1l1a
FIP1 like 1a (S. cerevisiae)
chr21_-_3422635 0.51 ENSDART00000150975
smad7
SMAD family member 7
chr25_+_35774544 0.51 ENSDART00000034737
ENSDART00000188162
cpne8
copine VIII
chr20_+_54356272 0.49 ENSDART00000145735
znf410
zinc finger protein 410
chr2_-_40191603 0.49 ENSDART00000180691
si:ch211-122l24.6
si:ch211-122l24.6
chr13_-_3370638 0.48 ENSDART00000029649
prkn
parkin RBR E3 ubiquitin protein ligase
chr17_-_53308832 0.48 ENSDART00000171946
ENSDART00000168269
si:ch1073-416d2.4
si:ch1073-416d2.4
chr18_+_5549672 0.47 ENSDART00000184970
nnt2
nicotinamide nucleotide transhydrogenase 2
chr1_+_8662530 0.47 ENSDART00000054989
fscn1b
fascin actin-bundling protein 1b
chr4_+_10017049 0.47 ENSDART00000144175
ccdc136b
coiled-coil domain containing 136b
chr7_-_10606 0.46 ENSDART00000192650
ENSDART00000186761
FO704772.2

chr10_+_14499201 0.46 ENSDART00000064901
katnal2
katanin p60 subunit A-like 2
chr19_+_58954 0.46 ENSDART00000162379
col14a1b
collagen, type XIV, alpha 1b
chr13_+_22659153 0.46 ENSDART00000143906
ENSDART00000140472
ENSDART00000078877
ENSDART00000182469
sncga
synuclein, gamma a
chr20_+_30797329 0.46 ENSDART00000145066
nhsl1b
NHS-like 1b
chr22_+_7497319 0.46 ENSDART00000034564
CELA1 (1 of many)
zgc:92511
chr21_-_5393125 0.46 ENSDART00000146061
psmd5
proteasome 26S subunit, non-ATPase 5
chr23_+_44307996 0.45 ENSDART00000042430
dlg4b
discs, large homolog 4b (Drosophila)
chr6_-_8736766 0.45 ENSDART00000143956
cavin2b
caveolae associated protein 2b
chr5_-_46273938 0.45 ENSDART00000080033
si:ch211-130m23.3
si:ch211-130m23.3
chr9_-_362971 0.45 ENSDART00000168944
si:dkey-11f4.7
si:dkey-11f4.7
chr16_+_4838808 0.45 ENSDART00000179363
ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr4_+_3287819 0.43 ENSDART00000168633
CABZ01085700.1

chr17_+_53156530 0.43 ENSDART00000126277
ENSDART00000156774
dph6
diphthamine biosynthesis 6
chr8_+_7144066 0.43 ENSDART00000146306
slc6a6a
solute carrier family 6 (neurotransmitter transporter), member 6a
chr3_+_62356578 0.42 ENSDART00000157030
iqck
IQ motif containing K
chr10_+_8968203 0.42 ENSDART00000110443
ENSDART00000080772
fstb
follistatin b
chr3_+_36424055 0.42 ENSDART00000170318
si:ch1073-443f11.2
si:ch1073-443f11.2
chr5_-_8171625 0.41 ENSDART00000167643
slc1a3a
solute carrier family 1 (glial high affinity glutamate transporter), member 3a
chr3_-_54992934 0.41 ENSDART00000053095
ENSDART00000145766
rhbdf1a
rhomboid 5 homolog 1a (Drosophila)
chr24_+_42148140 0.41 ENSDART00000010658
serpinb1l3
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 3
chr22_-_26945493 0.39 ENSDART00000077411
cxcl12b
chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)
chr15_-_31516558 0.39 ENSDART00000156427
ENSDART00000156072
ENSDART00000156047
hmgb1b
high mobility group box 1b
chr16_+_4839078 0.39 ENSDART00000150111
ibtk
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr17_+_51906053 0.38 ENSDART00000159072
ENSDART00000056869
flvcr2a
feline leukemia virus subgroup C cellular receptor family, member 2a
chr3_-_41292569 0.38 ENSDART00000111856
sdk1a
sidekick cell adhesion molecule 1a
chr6_+_48862 0.38 ENSDART00000082954
mbd5
methyl-CpG binding domain protein 5
chr11_+_30162407 0.38 ENSDART00000190333
ENSDART00000127502
cdkl5
cyclin-dependent kinase-like 5
chr6_+_25261297 0.38 ENSDART00000162824
ENSDART00000163490
ENSDART00000157790
ENSDART00000160978
ENSDART00000161545
ENSDART00000159978
kyat3
kynurenine aminotransferase 3
chr24_-_29030641 0.37 ENSDART00000156643
ENSDART00000150203
ENSDART00000144631
si:ch211-287n14.3
si:ch211-287n14.3
chr15_-_27710513 0.37 ENSDART00000005641
ENSDART00000134373
lhx1a
LIM homeobox 1a
chr11_+_30161699 0.36 ENSDART00000190504
cdkl5
cyclin-dependent kinase-like 5
chr1_+_12195700 0.36 ENSDART00000040307
tdrd7a
tudor domain containing 7 a
chr8_+_41037541 0.35 ENSDART00000129344
gpat2
glycerol-3-phosphate acyltransferase 2, mitochondrial
chr17_+_5768608 0.35 ENSDART00000157039
rp1l1a
retinitis pigmentosa 1-like 1a
chr25_-_225964 0.35 ENSDART00000193424
CABZ01113818.1

chr8_-_43997538 0.35 ENSDART00000186449
rimbp2
RIMS binding protein 2
chr2_+_14992879 0.35 ENSDART00000137546
pimr55
Pim proto-oncogene, serine/threonine kinase, related 55
chr7_+_71683853 0.35 ENSDART00000163002
emilin2b
elastin microfibril interfacer 2b
chr2_+_19633493 0.34 ENSDART00000147989
pimr54
Pim proto-oncogene, serine/threonine kinase, related 54
chr11_+_40831620 0.34 ENSDART00000160023
errfi1a
ERBB receptor feedback inhibitor 1a
chr10_-_42923385 0.34 ENSDART00000076731
ACOT12
acyl-CoA thioesterase 12
chr6_-_37469775 0.34 ENSDART00000156546
plcxd1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr14_-_28052474 0.33 ENSDART00000172948
ENSDART00000135337
TSC22D3 (1 of many)
zgc:64189
si:ch211-220e11.3
zgc:64189
chr25_-_18330503 0.33 ENSDART00000104496
dusp6
dual specificity phosphatase 6
chr15_+_19544052 0.32 ENSDART00000062560
zgc:77784
zgc:77784
chr2_+_19522082 0.32 ENSDART00000146098
pimr49
Pim proto-oncogene, serine/threonine kinase, related 49
chr17_+_1323699 0.32 ENSDART00000172540
adssl1
adenylosuccinate synthase like 1
chr7_+_19552381 0.31 ENSDART00000169060
si:ch211-212k18.5
si:ch211-212k18.5
chr1_+_59154521 0.31 ENSDART00000130089
ENSDART00000152456
soul5l
heme-binding protein soul5, like
chr25_-_32751982 0.31 ENSDART00000012862
isl2a
ISL LIM homeobox 2a
chr22_-_10826 0.31 ENSDART00000125700
mrpl20
mitochondrial ribosomal protein L20
chr2_-_19576640 0.31 ENSDART00000141021
pimr51
Pim proto-oncogene, serine/threonine kinase, related 51
chr5_-_12093618 0.31 ENSDART00000161542
lrrc74b
leucine rich repeat containing 74B
chr24_-_42148339 0.31 ENSDART00000112680
rmdn1
regulator of microtubule dynamics 1
chr2_+_19578446 0.29 ENSDART00000164758
pimr50
Pim proto-oncogene, serine/threonine kinase, related 50
chr22_-_12160283 0.29 ENSDART00000146785
ENSDART00000128176
tmem163b
transmembrane protein 163b
chr17_+_23937262 0.29 ENSDART00000113276
si:ch211-189k9.2
si:ch211-189k9.2
chr21_-_37650271 0.29 ENSDART00000172087
ENSDART00000171297
ENSDART00000166750
ndfip1l
Nedd4 family interacting protein 1, like
chr20_-_9095105 0.28 ENSDART00000140792
oma1
OMA1 zinc metallopeptidase
chr25_+_17313568 0.28 ENSDART00000125459
cnot1
CCR4-NOT transcription complex, subunit 1
chr3_-_22191132 0.28 ENSDART00000154226
ENSDART00000155528
ENSDART00000155190
maptb
microtubule-associated protein tau b
chr1_-_10841348 0.27 ENSDART00000148305
dmd
dystrophin
chr1_-_12027 0.27 ENSDART00000164359
rpl24
ribosomal protein L24
chr6_-_13376060 0.27 ENSDART00000104732
ENSDART00000125271
arl6ip6
ADP-ribosylation factor-like 6 interacting protein 6
chr19_+_5674907 0.27 ENSDART00000042189
pdk2b
pyruvate dehydrogenase kinase, isozyme 2b
chr3_+_59935606 0.27 ENSDART00000154157
arhgdia
Rho GDP dissociation inhibitor (GDI) alpha
chr22_+_7742211 0.27 ENSDART00000140896
CELA1 (1 of many)
zgc:92511
chr7_-_37858569 0.27 ENSDART00000129156
ENSDART00000173552
ENSDART00000178306
adcy7
adenylate cyclase 7
chr4_-_8093753 0.26 ENSDART00000133434
wnk1b
WNK lysine deficient protein kinase 1b
chr23_+_4324625 0.26 ENSDART00000146302
ENSDART00000136792
ENSDART00000135027
ENSDART00000179819
sgk2a
serum/glucocorticoid regulated kinase 2a
chr22_+_39074688 0.26 ENSDART00000153547
ip6k1
inositol hexakisphosphate kinase 1
chr2_-_31376606 0.26 ENSDART00000098988
ENSDART00000125746
clul1
clusterin-like 1 (retinal)
chr4_-_4507761 0.25 ENSDART00000130588
tbc1d30
TBC1 domain family, member 30
chr14_+_1240235 0.25 ENSDART00000127477
adad1
adenosine deaminase domain containing 1 (testis-specific)
chr23_-_15090782 0.25 ENSDART00000133624
si:ch211-218g4.2
si:ch211-218g4.2
chr7_+_29153018 0.25 ENSDART00000138065
tmppe
transmembrane protein with metallophosphoesterase domain
chr14_+_1240604 0.25 ENSDART00000188258
adad1
adenosine deaminase domain containing 1 (testis-specific)
chr9_-_34300707 0.25 ENSDART00000049805
ildr2
immunoglobulin-like domain containing receptor 2
chr22_+_3303671 0.24 ENSDART00000075049
gipc3
GIPC PDZ domain containing family, member 3
chr6_-_8277221 0.24 ENSDART00000053869
slc44a2
solute carrier family 44 (choline transporter), member 2
chr10_-_29892486 0.24 ENSDART00000099983
bsx
brain-specific homeobox
chr24_+_42149296 0.24 ENSDART00000154231
serpinb1l3
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 3
chr24_+_42149453 0.23 ENSDART00000128766
serpinb1l3
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 3
chr13_+_22295905 0.23 ENSDART00000180133
ENSDART00000181125
usp54a
ubiquitin specific peptidase 54a
chr5_+_31860043 0.23 ENSDART00000036235
ENSDART00000140541
iscub
iron-sulfur cluster assembly enzyme b
chr19_+_5604241 0.23 ENSDART00000011025
wipf2b
WAS/WASL interacting protein family, member 2b
chr8_+_26034623 0.23 ENSDART00000004521
ENSDART00000142555
arih2
ariadne homolog 2 (Drosophila)
chr22_+_2417105 0.23 ENSDART00000106415
zgc:113220
zgc:113220
chr8_-_52859301 0.23 ENSDART00000162004
nr5a1a
nuclear receptor subfamily 5, group A, member 1a
chr14_+_39156 0.23 ENSDART00000082184
tmem107
transmembrane protein 107
chr25_-_169291 0.23 ENSDART00000128344
lipcb
lipase, hepatic b
chr6_-_40744720 0.23 ENSDART00000154916
ENSDART00000186922
p4htm
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr19_-_33274978 0.22 ENSDART00000020301
ENSDART00000114714
fam92a1
family with sequence similarity 92, member A1
chr12_-_10038870 0.22 ENSDART00000152250
ngfrb
nerve growth factor receptor b
chr2_+_28453338 0.22 ENSDART00000020456
mmp15b
matrix metallopeptidase 15b
chr16_+_12022543 0.22 ENSDART00000012673
gnb3a
guanine nucleotide binding protein (G protein), beta polypeptide 3a
chr15_+_21276735 0.22 ENSDART00000111213
ubash3bb
ubiquitin associated and SH3 domain containing Bb
chr8_+_19668654 0.21 ENSDART00000091436
foxe3
forkhead box E3
chr9_+_40874194 0.21 ENSDART00000141548
hibch
3-hydroxyisobutyryl-CoA hydrolase
chr20_+_26556174 0.21 ENSDART00000138492
irf4b
interferon regulatory factor 4b
chr4_+_2269815 0.21 ENSDART00000075788
si:ch73-89b15.3
si:ch73-89b15.3
chr19_-_43542568 0.21 ENSDART00000051720
BX649384.1

chr4_+_77993103 0.21 ENSDART00000174392
terfa
telomeric repeat binding factor a
chr20_+_38032143 0.21 ENSDART00000032161
galnt14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr10_-_43029001 0.21 ENSDART00000171494
ssbp2
single-stranded DNA binding protein 2
chr3_-_30061985 0.20 ENSDART00000189583
ppfia3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr22_-_13042992 0.20 ENSDART00000028787
ahr1b
aryl hydrocarbon receptor 1b
chr8_+_53051701 0.20 ENSDART00000131514
nadka
NAD kinase a
chr21_+_9628854 0.20 ENSDART00000161753
ENSDART00000160711
mapk10
mitogen-activated protein kinase 10
chr8_-_21184759 0.20 ENSDART00000139257
gls2a
glutaminase 2a (liver, mitochondrial)
chr14_+_8275115 0.20 ENSDART00000129055
nrg2b
neuregulin 2b
chr12_+_26621906 0.19 ENSDART00000158440
ENSDART00000046959
arhgap12b
Rho GTPase activating protein 12b
chr16_-_7443388 0.19 ENSDART00000017445
prdm1a
PR domain containing 1a, with ZNF domain
chr9_-_47472998 0.19 ENSDART00000134480
tns1b
tensin 1b
chr1_+_23784905 0.19 ENSDART00000171951
ENSDART00000188521
ENSDART00000183029
ENSDART00000187183
slit2
slit homolog 2 (Drosophila)
chr1_-_17735861 0.19 ENSDART00000018238
pdlim3a
PDZ and LIM domain 3a
chr16_-_32233463 0.19 ENSDART00000102016
calhm6
calcium homeostasis modulator family member 6
chr7_+_54605640 0.19 ENSDART00000168474
fgf3
fibroblast growth factor 3
chr8_+_48491387 0.19 ENSDART00000086053
PRDM16
si:ch211-263k4.2
chr16_+_28881235 0.19 ENSDART00000146525
chtopb
chromatin target of PRMT1b
chr11_+_39135050 0.19 ENSDART00000180571
ENSDART00000189685
cdc42
cell division cycle 42
chr11_-_22303678 0.19 ENSDART00000159527
ENSDART00000159681
tfeb
transcription factor EB
chr11_+_24889170 0.18 ENSDART00000113310
lmod1b
leiomodin 1b (smooth muscle)
chr14_-_31060082 0.18 ENSDART00000111601
ENSDART00000161113
mbnl3
muscleblind-like splicing regulator 3
chr23_+_13721826 0.18 ENSDART00000142494
zbtb46
zinc finger and BTB domain containing 46
chr17_-_25395395 0.18 ENSDART00000170233
fam167b
family with sequence similarity 167, member B
chr20_-_26531850 0.18 ENSDART00000183317
ENSDART00000131994
mthfd1l
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
chr7_-_29223614 0.18 ENSDART00000173598
herc1
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
chr3_+_37824268 0.18 ENSDART00000137038
asic2
acid-sensing (proton-gated) ion channel 2
chr6_+_18298444 0.18 ENSDART00000166018
card14
caspase recruitment domain family, member 14
chr11_+_12879635 0.18 ENSDART00000182515
ENSDART00000081296
si:dkey-11m19.5
si:dkey-11m19.5
chr3_+_54581987 0.18 ENSDART00000018071
eif3g
eukaryotic translation initiation factor 3, subunit G
chr20_+_42668875 0.17 ENSDART00000048890
slc22a2
solute carrier family 22 (organic cation transporter), member 2
chr16_+_5774977 0.17 ENSDART00000134202
ccka
cholecystokinin a
chr10_+_44824072 0.17 ENSDART00000162669
slc4a5
solute carrier family 4 (sodium bicarbonate cotransporter), member 5
chr14_-_17586798 0.17 ENSDART00000065002
selenot2
selenoprotein T, 2
chr23_+_19564392 0.17 ENSDART00000144746
atp6ap1lb
ATPase H+ transporting accessory protein 1 like b
chr16_-_20707742 0.16 ENSDART00000103630
creb5b
cAMP responsive element binding protein 5b
chr8_+_52619365 0.16 ENSDART00000162953
cyr61l2
cysteine-rich, angiogenic inducer, 61 like 2
chr14_-_34044369 0.16 ENSDART00000149396
ENSDART00000123607
ENSDART00000190746
cyfip2
cytoplasmic FMR1 interacting protein 2
chr4_+_2267641 0.16 ENSDART00000165503
si:ch73-89b15.3
si:ch73-89b15.3
chr12_-_10220036 0.16 ENSDART00000134619
mpp2b
membrane protein, palmitoylated 2b (MAGUK p55 subfamily member 2)
chr5_-_24333684 0.16 ENSDART00000051553
znf703
zinc finger protein 703
chr23_+_32039386 0.16 ENSDART00000133801
mylk2
myosin light chain kinase 2
chr4_-_178510 0.16 ENSDART00000169805
eps8
epidermal growth factor receptor pathway substrate 8
chr4_-_77216726 0.16 ENSDART00000099943
psmb10
proteasome subunit beta 10
chr3_+_59784632 0.16 ENSDART00000084729
pecam1
platelet/endothelial cell adhesion molecule 1
chr7_-_33921366 0.15 ENSDART00000052397
pias1a
protein inhibitor of activated STAT, 1a
chr25_+_14507567 0.15 ENSDART00000015681
dbx1b
developing brain homeobox 1b
chr4_+_77981553 0.15 ENSDART00000174108
ENSDART00000122459
terfa
telomeric repeat binding factor a

Network of associatons between targets according to the STRING database.

First level regulatory network of hmx4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0036159 inner dynein arm assembly(GO:0036159)
0.2 0.7 GO:0006600 creatine metabolic process(GO:0006600) creatine biosynthetic process(GO:0006601)
0.2 0.5 GO:0097113 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.1 0.7 GO:0008592 regulation of Toll signaling pathway(GO:0008592)
0.1 0.6 GO:0010693 regulation of alkaline phosphatase activity(GO:0010692) negative regulation of alkaline phosphatase activity(GO:0010693)
0.1 0.4 GO:0097377 regulation of morphogenesis of a branching structure(GO:0060688) positive regulation of mesonephros development(GO:0061213) regulation of mesonephros development(GO:0061217) regulation of kidney development(GO:0090183) positive regulation of kidney development(GO:0090184) regulation of branching involved in ureteric bud morphogenesis(GO:0090189) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190) interneuron axon guidance(GO:0097376) spinal cord interneuron axon guidance(GO:0097377) dorsal spinal cord interneuron axon guidance(GO:0097378)
0.1 0.5 GO:0006740 NADPH regeneration(GO:0006740)
0.1 1.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.6 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.1 0.4 GO:0021730 trigeminal sensory nucleus development(GO:0021730)
0.1 0.4 GO:0097037 heme export(GO:0097037)
0.1 0.4 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.1 0.3 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.1 0.4 GO:0032207 regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208)
0.1 0.9 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.1 0.4 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1 0.2 GO:1902746 negative regulation of epithelial cell differentiation(GO:0030857) regulation of lens fiber cell differentiation(GO:1902746)
0.1 0.2 GO:0007414 axonal defasciculation(GO:0007414)
0.1 0.2 GO:0021985 neurohypophysis development(GO:0021985)
0.1 0.2 GO:0015871 choline transport(GO:0015871)
0.1 0.1 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.1 0.2 GO:0015695 organic cation transport(GO:0015695)
0.1 0.5 GO:0098787 mRNA cleavage involved in mRNA processing(GO:0098787) pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.1 0.6 GO:0000710 meiotic mismatch repair(GO:0000710)
0.1 0.4 GO:1990511 piRNA biosynthetic process(GO:1990511)
0.0 0.4 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 0.3 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.0 0.5 GO:1900407 regulation of cellular response to oxidative stress(GO:1900407)
0.0 0.3 GO:0060420 regulation of heart growth(GO:0060420)
0.0 0.6 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.0 1.4 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.1 GO:0015942 formate metabolic process(GO:0015942) histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.0 0.5 GO:0006382 adenosine to inosine editing(GO:0006382)
0.0 0.4 GO:0051224 negative regulation of protein transport(GO:0051224) negative regulation of establishment of protein localization(GO:1904950)
0.0 0.1 GO:0036076 ligamentous ossification(GO:0036076)
0.0 0.4 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.0 0.3 GO:1990845 adaptive thermogenesis(GO:1990845)
0.0 0.2 GO:0006574 valine catabolic process(GO:0006574)
0.0 0.2 GO:0021982 pineal gland development(GO:0021982)
0.0 0.7 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.4 GO:0030719 P granule organization(GO:0030719)
0.0 0.3 GO:0048845 venous blood vessel morphogenesis(GO:0048845)
0.0 0.5 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.2 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.1 GO:0043476 pigment accumulation(GO:0043476)
0.0 0.6 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.2 GO:0006543 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.0 0.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.5 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.2 GO:0001709 cell fate determination(GO:0001709)
0.0 0.1 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.0 0.1 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228) protein localization to nuclear envelope(GO:0090435)
0.0 0.2 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.0 0.6 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.1 GO:1903060 N-terminal protein palmitoylation(GO:0006500) negative regulation of lipoprotein metabolic process(GO:0050748) regulation of N-terminal protein palmitoylation(GO:0060254) negative regulation of N-terminal protein palmitoylation(GO:0060262) negative regulation of protein lipidation(GO:1903060)
0.0 0.3 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.3 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 0.1 GO:0072047 proximal/distal pattern formation involved in nephron development(GO:0072047) proximal/distal pattern formation involved in pronephric nephron development(GO:0072196)
0.0 0.2 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.0 1.1 GO:0022900 electron transport chain(GO:0022900)
0.0 0.1 GO:0090133 mesendoderm migration(GO:0090133) cell migration involved in mesendoderm migration(GO:0090134)
0.0 0.1 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.0 0.1 GO:2000650 negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.0 0.2 GO:0030325 adrenal gland development(GO:0030325)
0.0 0.1 GO:0019857 5-methylcytosine catabolic process(GO:0006211) 5-methylcytosine metabolic process(GO:0019857)
0.0 0.3 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.1 GO:0006168 adenine salvage(GO:0006168)
0.0 0.3 GO:0010765 positive regulation of sodium ion transport(GO:0010765) positive regulation of sodium ion transmembrane transport(GO:1902307) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.0 0.1 GO:0051703 regulation of proton transport(GO:0010155) social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.0 0.2 GO:0006228 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.0 0.3 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.0 GO:0021961 posterior commissure morphogenesis(GO:0021961)
0.0 0.1 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.0 0.2 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.2 GO:0048922 posterior lateral line neuromast deposition(GO:0048922)
0.0 0.3 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.4 GO:0072348 sulfur compound transport(GO:0072348)
0.0 0.2 GO:0019471 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.0 0.7 GO:0010842 retina layer formation(GO:0010842)
0.0 0.2 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.3 GO:0006829 zinc II ion transport(GO:0006829)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 0.4 GO:0010369 chromocenter(GO:0010369)
0.1 1.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 1.0 GO:0036157 outer dynein arm(GO:0036157)
0.1 0.6 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 0.6 GO:0000176 nuclear exosome (RNase complex)(GO:0000176) cytoplasmic exosome (RNase complex)(GO:0000177)
0.1 0.9 GO:0036038 MKS complex(GO:0036038)
0.0 0.8 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.5 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.1 GO:0031251 PAN complex(GO:0031251)
0.0 0.1 GO:0043220 compact myelin(GO:0043218) Schmidt-Lanterman incisure(GO:0043220)
0.0 0.2 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.0 0.5 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.2 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.4 GO:0070187 telosome(GO:0070187)
0.0 0.1 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.6 GO:0036126 sperm flagellum(GO:0036126)
0.0 0.2 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.5 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.2 GO:0005930 axoneme(GO:0005930)
0.0 0.1 GO:0044611 nuclear pore inner ring(GO:0044611)
0.0 0.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.7 GO:0044306 axon terminus(GO:0043679) neuron projection terminus(GO:0044306)
0.0 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.2 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.2 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.1 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.4 GO:0043186 P granule(GO:0043186)
0.0 1.2 GO:0030658 transport vesicle membrane(GO:0030658)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.2 0.5 GO:1903136 cuprous ion binding(GO:1903136)
0.1 0.5 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.1 0.2 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 0.3 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 0.4 GO:0004104 cholinesterase activity(GO:0004104)
0.1 0.2 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.1 0.3 GO:0050699 WW domain binding(GO:0050699)
0.1 1.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.4 GO:0015232 heme transporter activity(GO:0015232)
0.0 0.3 GO:0042974 estrogen receptor binding(GO:0030331) retinoic acid receptor binding(GO:0042974)
0.0 0.5 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.3 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.0 0.4 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.4 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.5 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.8 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.1 GO:0031704 apelin receptor binding(GO:0031704)
0.0 0.3 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.6 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.2 GO:0005035 death receptor activity(GO:0005035)
0.0 0.2 GO:0048763 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.0 0.1 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.0 0.3 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.3 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.6 GO:0043236 laminin binding(GO:0043236)
0.0 0.5 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.5 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.5 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.1 GO:0016841 folic acid binding(GO:0005542) ammonia-lyase activity(GO:0016841)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.3 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.4 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.2 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.1 GO:0003999 adenine phosphoribosyltransferase activity(GO:0003999)
0.0 0.5 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.4 GO:0048185 activin binding(GO:0048185)
0.0 0.2 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.4 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.2 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0 0.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.1 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
0.0 0.2 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.1 GO:0019202 amino acid kinase activity(GO:0019202)
0.0 0.1 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.1 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.0 0.3 GO:0019869 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.0 0.3 GO:0000828 inositol hexakisphosphate kinase activity(GO:0000828)
0.0 0.2 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.0 0.2 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.2 GO:0015101 organic cation transmembrane transporter activity(GO:0015101)
0.0 0.4 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.4 GO:0005343 organic acid:sodium symporter activity(GO:0005343)
0.0 0.3 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.2 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.3 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.1 GO:0004962 endothelin receptor activity(GO:0004962)
0.0 0.1 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 0.2 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 0.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID ALK1 PATHWAY ALK1 signaling events
0.0 0.2 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.3 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.3 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 1.1 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.4 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.2 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 0.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 0.7 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 0.6 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.5 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 1.2 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.1 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.3 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.2 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.3 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.2 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.2 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.2 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.4 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.8 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.1 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.6 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.1 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.2 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters