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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for hnf4a+hnf4b

Z-value: 1.37

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Transcription factors associated with hnf4a+hnf4b

Gene Symbol Gene ID Gene Info
hnf4a
ENSDARG00000021494 hepatocyte nuclear factor 4, alpha
hnf4b
ENSDARG00000104742 hepatic nuclear factor 4, beta
hnf4a
ENSDARG00000112985 hepatocyte nuclear factor 4, alpha

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hnf4adr11_v1_chr23_+_25856541_25856641-0.798.2e-05Click!
CABZ01057488.1dr11_v1_chr7_+_69019851_690198510.672.3e-03Click!

Activity profile of hnf4a+hnf4b motif

Sorted Z-values of hnf4a+hnf4b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_2584423 5.54 ENSDART00000013506
zp3.2
zona pellucida glycoprotein 3, tandem duplicate 2
chr20_+_54304800 5.29 ENSDART00000121661
zp2.6
zona pellucida glycoprotein 2, tandem duplicate 6
chr19_-_27564458 4.46 ENSDART00000123155
si:dkeyp-46h3.6
si:dkeyp-46h3.6
chr9_+_8380728 4.45 ENSDART00000133501
si:ch1073-75o15.4
si:ch1073-75o15.4
chr20_-_43741159 4.34 ENSDART00000192621
si:dkeyp-50f7.2
si:dkeyp-50f7.2
chr16_-_17197546 4.33 ENSDART00000139939
ENSDART00000135146
ENSDART00000063800
ENSDART00000163606
gapdh
glyceraldehyde-3-phosphate dehydrogenase
chr1_+_24387659 4.18 ENSDART00000130356
qdprb2
quinoid dihydropteridine reductase b2
chr23_+_2740741 4.17 ENSDART00000134938
zgc:114123
zgc:114123
chr17_-_2590222 4.13 ENSDART00000185711
CR759892.1

chr17_-_2578026 4.06 ENSDART00000065821
zp3.2
zona pellucida glycoprotein 3, tandem duplicate 2
chr17_-_2595736 3.98 ENSDART00000128797
zp3.2
zona pellucida glycoprotein 3, tandem duplicate 2
chr19_-_27564980 3.96 ENSDART00000171967
si:dkeyp-46h3.8
si:dkeyp-46h3.8
chr16_-_17200120 3.94 ENSDART00000147739
gapdh
glyceraldehyde-3-phosphate dehydrogenase
chr17_-_2573021 3.83 ENSDART00000074181
zp3.2
zona pellucida glycoprotein 3, tandem duplicate 2
chr7_-_24520866 3.31 ENSDART00000077039
faah2b
fatty acid amide hydrolase 2b
chr16_-_25233515 3.09 ENSDART00000058943
zgc:110182
zgc:110182
chr22_-_24992532 2.94 ENSDART00000102751
si:dkey-179j5.5
si:dkey-179j5.5
chr19_-_18130567 2.70 ENSDART00000190659
ENSDART00000022803
snx10a
sorting nexin 10a
chr3_-_36440705 2.31 ENSDART00000162875
rogdi
rogdi homolog (Drosophila)
chr7_-_20611039 2.27 ENSDART00000170422
si:dkey-19b23.8
si:dkey-19b23.8
chr25_+_8925934 2.21 ENSDART00000073914
accs
1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)
chr18_-_46183462 2.18 ENSDART00000021192
kcnk6
potassium channel, subfamily K, member 6
chr3_+_27770110 2.09 ENSDART00000017962
eci1
enoyl-CoA delta isomerase 1
chr15_-_30857350 2.08 ENSDART00000138988
akap1b
A kinase (PRKA) anchor protein 1b
chr8_-_1264893 1.99 ENSDART00000190371
cdc14b
cell division cycle 14B
chr17_+_1360192 1.95 ENSDART00000184561
siva1
SIVA1, apoptosis-inducing factor
chr11_-_23687158 1.73 ENSDART00000189599
pik3c2b
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
chr5_+_9218318 1.70 ENSDART00000137774
si:ch211-12e13.1
si:ch211-12e13.1
chr7_+_24520518 1.66 ENSDART00000173604
btr09
bloodthirsty-related gene family, member 9
chr5_-_36597612 1.66 ENSDART00000031270
ENSDART00000122098
rhogc
ras homolog gene family, member Gc
chr14_+_24934736 1.59 ENSDART00000191821
ppargc1b
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr24_+_35911020 1.59 ENSDART00000088480
abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr16_+_22345513 1.58 ENSDART00000078000
zgc:123238
zgc:123238
chr15_+_29728377 1.57 ENSDART00000099958
zgc:153372
zgc:153372
chr23_-_31810222 1.56 ENSDART00000134319
ENSDART00000139076
hbs1l
HBS1-like translational GTPase
chr23_+_9522942 1.55 ENSDART00000137751
osbpl2b
oxysterol binding protein-like 2b
chr6_+_40952031 1.55 ENSDART00000189219
patz1
POZ (BTB) and AT hook containing zinc finger 1
chr24_+_35911300 1.54 ENSDART00000129679
abcd4
ATP-binding cassette, sub-family D (ALD), member 4
chr8_+_23827571 1.52 ENSDART00000040362
mapk14a
mitogen-activated protein kinase 14a
chr23_+_30730121 1.48 ENSDART00000134141
asxl1
additional sex combs like transcriptional regulator 1
chr18_+_27515640 1.47 ENSDART00000181593
tp53i11b
tumor protein p53 inducible protein 11b
chr20_+_36806398 1.40 ENSDART00000153317
abracl
ABRA C-terminal like
chr3_-_34561624 1.40 ENSDART00000129313
sept9a
septin 9a
chr3_+_31662126 1.39 ENSDART00000113441
mylk5
myosin, light chain kinase 5
chr23_+_9522781 1.39 ENSDART00000136486
osbpl2b
oxysterol binding protein-like 2b
chr22_-_31517300 1.38 ENSDART00000164799
slc6a6b
solute carrier family 6 (neurotransmitter transporter), member 6b
chr14_+_30413312 1.38 ENSDART00000186864
cnot7
CCR4-NOT transcription complex, subunit 7
chr14_+_989733 1.37 ENSDART00000161487
ENSDART00000127317
si:ch73-308l14.2
si:ch73-308l14.2
chr7_+_25126629 1.37 ENSDART00000077217
zgc:101765
zgc:101765
chr15_+_6459847 1.36 ENSDART00000157250
ENSDART00000065824
bace2
beta-site APP-cleaving enzyme 2
chr19_+_31532043 1.33 ENSDART00000136289
tmem64
transmembrane protein 64
chr16_+_10264601 1.28 ENSDART00000186167
mrs2
MRS2 magnesium transporter
chr15_+_40074923 1.26 ENSDART00000111018
ngef
neuronal guanine nucleotide exchange factor
chr3_-_15470944 1.26 ENSDART00000185302
spns1
spinster homolog 1 (Drosophila)
chr13_+_32807419 1.25 ENSDART00000085252
pqlc3
PQ loop repeat containing 3
chr25_+_15997957 1.24 ENSDART00000140047
ppfibp2b
PTPRF interacting protein, binding protein 2b (liprin beta 2)
chr22_+_21549419 1.22 ENSDART00000139411
plpp2b
phospholipid phosphatase 2b
chr13_+_5013572 1.20 ENSDART00000162425
psap
prosaposin
chr15_-_20412286 1.20 ENSDART00000008589
chp2
calcineurin-like EF-hand protein 2
chr17_-_49407091 1.20 ENSDART00000021950
mthfd1b
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b
chr11_-_18017287 1.19 ENSDART00000155443
qrich1
glutamine-rich 1
chr6_-_41138854 1.18 ENSDART00000128723
ENSDART00000151055
ENSDART00000132484
slc6a22.1
solute carrier family 6 member 22, tandem duplicate 1
chr18_-_12957451 1.18 ENSDART00000140403
srgap1a
SLIT-ROBO Rho GTPase activating protein 1a
chr15_+_34069746 1.18 ENSDART00000163513
arl4aa
ADP-ribosylation factor-like 4aa
chr23_-_43595956 1.16 ENSDART00000162186
itchb
itchy E3 ubiquitin protein ligase b
chr25_-_20049449 1.14 ENSDART00000104315
zgc:136858
zgc:136858
chr1_-_12064715 1.14 ENSDART00000143628
ENSDART00000103406
pla2g12a
phospholipase A2, group XIIA
chr4_-_19693978 1.13 ENSDART00000100974
ENSDART00000040405
snd1
staphylococcal nuclease and tudor domain containing 1
chr16_+_10264286 1.13 ENSDART00000091377
mrs2
MRS2 magnesium transporter
chr15_+_30310843 1.13 ENSDART00000112784
lyrm9
LYR motif containing 9
chr10_+_8875195 1.05 ENSDART00000141045
itga2.3
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), tandem duplicate 3
chr7_-_33868903 1.05 ENSDART00000173500
ENSDART00000178746
uacab
uveal autoantigen with coiled-coil domains and ankyrin repeats b
chr10_+_8197827 1.04 ENSDART00000026244
mtrex
Mtr4 exosome RNA helicase
chr5_+_32815745 1.01 ENSDART00000181535
crata
carnitine O-acetyltransferase a
chr22_-_7050 1.01 ENSDART00000127829
atad3
ATPase family, AAA domain containing 3
chr18_-_370286 1.01 ENSDART00000162633
si:ch211-79l17.1
si:ch211-79l17.1
chr13_+_8696825 1.01 ENSDART00000109059
ttc7a
tetratricopeptide repeat domain 7A
chr13_-_35808904 0.99 ENSDART00000171667
map3k4
mitogen-activated protein kinase kinase kinase 4
chr17_+_33418475 0.98 ENSDART00000169145
snap23.1
synaptosomal-associated protein 23.1
chr23_-_31810391 0.96 ENSDART00000189749
ENSDART00000180850
hbs1l
HBS1-like translational GTPase
chr18_-_43866526 0.95 ENSDART00000111309
treh
trehalase (brush-border membrane glycoprotein)
chr21_-_9446747 0.95 ENSDART00000158790
ptpn13
protein tyrosine phosphatase, non-receptor type 13
chr2_-_9989919 0.92 ENSDART00000180213
ENSDART00000184369
imp3
IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr5_-_55981288 0.90 ENSDART00000146616
si:dkey-189h5.6
si:dkey-189h5.6
chr17_+_15216022 0.88 ENSDART00000138831
gnpnat1
glucosamine-phosphate N-acetyltransferase 1
chr7_+_24115082 0.88 ENSDART00000182718
mrpl52
mitochondrial ribosomal protein L52
chr5_+_31959954 0.87 ENSDART00000142826
myo1hb
myosin IHb
chr14_+_24935131 0.84 ENSDART00000170871
ppargc1b
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr18_-_43866001 0.83 ENSDART00000150218
treh
trehalase (brush-border membrane glycoprotein)
chr21_-_11054876 0.81 ENSDART00000146576
nedd4l
neural precursor cell expressed, developmentally down-regulated 4-like
chr23_-_3759345 0.81 ENSDART00000132205
ENSDART00000137707
ENSDART00000189382
hmga1a
high mobility group AT-hook 1a
chr22_-_16317886 0.78 ENSDART00000163664
trmt13
tRNA methyltransferase 13 homolog (S. cerevisiae)
chr21_+_41743493 0.76 ENSDART00000192669
ppp2r2bb
protein phosphatase 2, regulatory subunit B, beta b
chr8_-_9570511 0.76 ENSDART00000044000
plxna3
plexin A3
chr25_+_418932 0.70 ENSDART00000059193
prtgb
protogenin homolog b (Gallus gallus)
chr8_+_47099033 0.69 ENSDART00000142979
arhgef16
Rho guanine nucleotide exchange factor (GEF) 16
chr25_-_8625601 0.67 ENSDART00000155280
GDPGP1
zgc:153343
chr7_-_51461649 0.66 ENSDART00000193947
ENSDART00000174328
arhgap36
Rho GTPase activating protein 36
chr21_-_27272657 0.65 ENSDART00000040754
ENSDART00000175009
mark2a
MAP/microtubule affinity-regulating kinase 2a
chr2_-_56649883 0.64 ENSDART00000191786
gpx4b
glutathione peroxidase 4b
chr9_+_41690153 0.64 ENSDART00000100226
ctdsp1
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
chr22_-_10774735 0.64 ENSDART00000081156
timm13
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr12_+_19138452 0.64 ENSDART00000141346
ENSDART00000066397
phf5a
PHD finger protein 5A
chr11_+_11152214 0.63 ENSDART00000148030
ly75
lymphocyte antigen 75
chr3_-_50139860 0.62 ENSDART00000101563
btr02
bloodthirsty-related gene family, member 2
chr4_+_11172964 0.62 ENSDART00000193598
ENSDART00000138661
tspan11
tetraspanin 11
chr8_+_54137350 0.60 ENSDART00000164153
brpf1
bromodomain and PHD finger containing, 1
chr5_-_41638039 0.60 ENSDART00000144525
epg5
ectopic P-granules autophagy protein 5 homolog (C. elegans)
chr22_+_30502555 0.60 ENSDART00000139128
ENSDART00000104747
zgc:171679
zgc:171679
chr7_+_65398161 0.59 ENSDART00000166109
ENSDART00000157399
usp47
ubiquitin specific peptidase 47
chr14_+_30413758 0.57 ENSDART00000092953
cnot7
CCR4-NOT transcription complex, subunit 7
chr2_+_6067371 0.56 ENSDART00000053868
ENSDART00000145244
aldh9a1b
aldehyde dehydrogenase 9 family, member A1b
chr9_+_8898024 0.55 ENSDART00000134954
ENSDART00000143671
ENSDART00000147098
ENSDART00000179969
ENSDART00000111214
ENSDART00000140232
ENSDART00000139687
ENSDART00000132443
ENSDART00000130208
naxd
NAD(P)HX dehydratase
chr21_-_13055195 0.55 ENSDART00000133517
myorg
myogenesis regulating glycosidase (putative)
chr16_+_7985886 0.55 ENSDART00000126041
ano10a
anoctamin 10a
chr8_-_20838342 0.54 ENSDART00000141345
si:ch211-133l5.7
si:ch211-133l5.7
chr9_+_21383620 0.54 ENSDART00000130023
ENSDART00000062656
ENSDART00000180081
cryl1
crystallin, lambda 1
chr10_+_10738880 0.54 ENSDART00000004181
slc27a4
solute carrier family 27 (fatty acid transporter), member 4
chr7_+_24114694 0.54 ENSDART00000127177
mrpl52
mitochondrial ribosomal protein L52
chr23_-_3759692 0.54 ENSDART00000028885
hmga1a
high mobility group AT-hook 1a
chr22_-_11648094 0.53 ENSDART00000191791
dpp4
dipeptidyl-peptidase 4
chr7_-_60351876 0.53 ENSDART00000098563
plcb3
phospholipase C, beta 3 (phosphatidylinositol-specific)
chr5_-_13076779 0.53 ENSDART00000192826
ypel1
yippee-like 1
chr20_+_27093042 0.52 ENSDART00000024595
ubr7
ubiquitin protein ligase E3 component n-recognin 7
chr8_+_6576940 0.52 ENSDART00000138135
vsig8b
V-set and immunoglobulin domain containing 8b
chr20_+_39250673 0.52 ENSDART00000153003
reps1
RALBP1 associated Eps domain containing 1
chr23_-_44786844 0.51 ENSDART00000148669
si:ch73-269m23.5
si:ch73-269m23.5
chr5_-_67267678 0.49 ENSDART00000156795
ENSDART00000125781
ENSDART00000125874
zcchc8
zinc finger, CCHC domain containing 8
chr10_-_11385155 0.48 ENSDART00000064214
plac8.1
placenta-specific 8, tandem duplicate 1
chr5_-_62317496 0.46 ENSDART00000180089
zgc:85789
zgc:85789
chr18_+_30157034 0.46 ENSDART00000177669
gse1
Gse1 coiled-coil protein
chr18_+_30157198 0.46 ENSDART00000172579
gse1
Gse1 coiled-coil protein
chr8_-_65189 0.45 ENSDART00000168412
hsd17b4
hydroxysteroid (17-beta) dehydrogenase 4
chr6_+_55819038 0.44 ENSDART00000108786
si:ch211-81n22.1
si:ch211-81n22.1
chr2_-_22660232 0.43 ENSDART00000174742
thap4
THAP domain containing 4
chr22_+_29994093 0.43 ENSDART00000104778
si:dkey-286j15.3
si:dkey-286j15.3
chr19_+_3215466 0.41 ENSDART00000181288
zgc:86598
zgc:86598
chr2_-_22659450 0.40 ENSDART00000115025
thap4
THAP domain containing 4
chr10_+_45128375 0.40 ENSDART00000164805
camk2b2
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2
chr4_+_6736746 0.38 ENSDART00000184175
tmem168a
transmembrane protein 168a
chr6_-_10912424 0.38 ENSDART00000036456
cycsb
cytochrome c, somatic b
chr1_-_46862190 0.37 ENSDART00000145167
agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr21_+_1119046 0.37 ENSDART00000184678
CABZ01088049.1

chr12_+_48681601 0.37 ENSDART00000187831
uros
uroporphyrinogen III synthase
chr10_-_6454386 0.36 ENSDART00000168549
ca9
carbonic anhydrase IX
chr23_-_21758253 0.35 ENSDART00000046613
vps13d
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr15_+_15403560 0.34 ENSDART00000049831
dhrs11b
dehydrogenase/reductase (SDR family) member 11b
chr7_-_5487593 0.33 ENSDART00000136594
arhgef11
Rho guanine nucleotide exchange factor (GEF) 11
chr17_+_23926796 0.32 ENSDART00000021177
pex13
peroxisomal biogenesis factor 13
chr5_-_67115872 0.32 ENSDART00000065262
rps6ka4
ribosomal protein S6 kinase, polypeptide 4
chr14_+_6182346 0.30 ENSDART00000075525
si:ch73-22a13.3
si:ch73-22a13.3
chr11_+_22134540 0.29 ENSDART00000190502
MDFI
si:dkey-91m3.1
chr6_+_18367388 0.29 ENSDART00000163394
dgke
diacylglycerol kinase, epsilon
chr8_+_8699085 0.28 ENSDART00000021209
uxt
ubiquitously-expressed, prefoldin-like chaperone
chr21_-_27273147 0.28 ENSDART00000143239
mark2a
MAP/microtubule affinity-regulating kinase 2a
chr14_+_6429399 0.28 ENSDART00000149783
ENSDART00000148461
abca1b
ATP-binding cassette, sub-family A (ABC1), member 1B
chr11_-_36957127 0.26 ENSDART00000168528
cacna1da
calcium channel, voltage-dependent, L type, alpha 1D subunit, a
chr16_+_23924040 0.25 ENSDART00000161124
si:dkey-7f3.14
si:dkey-7f3.14
chr6_+_36807861 0.25 ENSDART00000161708
si:ch73-29l19.1
si:ch73-29l19.1
chr6_-_46474483 0.25 ENSDART00000155761
rdh20
retinol dehydrogenase 20
chr21_-_18262287 0.24 ENSDART00000176716
vav2
vav 2 guanine nucleotide exchange factor
chr4_+_9360697 0.23 ENSDART00000128937
ENSDART00000156946
ipo8
importin 8
chr23_-_27479558 0.23 ENSDART00000013563
atf7a
activating transcription factor 7a
chr15_-_1885247 0.23 ENSDART00000149703
porb
P450 (cytochrome) oxidoreductase b
chr16_+_23947196 0.22 ENSDART00000103190
ENSDART00000132961
ENSDART00000147690
ENSDART00000142168
apoa4b.2
apolipoprotein A-IV b, tandem duplicate 2
chr20_-_25669813 0.22 ENSDART00000153118
si:dkeyp-117h8.2
si:dkeyp-117h8.2
chr18_+_31410652 0.21 ENSDART00000098504
def8
differentially expressed in FDCP 8 homolog (mouse)
chr6_-_43221581 0.21 ENSDART00000112239
si:dkey-178o16.4
si:dkey-178o16.4
chr3_-_58116314 0.21 ENSDART00000154901
si:ch211-256e16.6
si:ch211-256e16.6
chr11_-_30364847 0.20 ENSDART00000078387
pecr
peroxisomal trans-2-enoyl-CoA reductase
chr22_+_2417105 0.20 ENSDART00000106415
zgc:113220
zgc:113220
chr3_+_12744083 0.20 ENSDART00000158554
ENSDART00000169545
cyp2k21
cytochrome P450, family 2, subfamily k, polypeptide 21
chr9_-_1986014 0.20 ENSDART00000142842
hoxd12a
homeobox D12a
chr7_+_52135791 0.20 ENSDART00000098705
cyp2x12
cytochrome P450, family 2, subfamily X, polypeptide 12
chr2_-_24407933 0.19 ENSDART00000088584
si:dkey-208k22.6
si:dkey-208k22.6
chr4_+_33547662 0.18 ENSDART00000150439
si:dkey-84h14.2
si:dkey-84h14.2
chr6_-_35046735 0.18 ENSDART00000143649
uap1
UDP-N-acetylglucosamine pyrophosphorylase 1
chr12_-_44199316 0.18 ENSDART00000170378
si:ch73-329n5.1
si:ch73-329n5.1
chr8_+_1766206 0.18 ENSDART00000021820
serpind1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr11_+_30296332 0.18 ENSDART00000192843
ugt1b7
UDP glucuronosyltransferase 1 family, polypeptide B7
chr11_+_14281100 0.17 ENSDART00000193664
ENSDART00000161597
si:ch211-262i1.3
si:ch211-262i1.3
chr24_+_19593197 0.17 ENSDART00000151923
slco5a1a
solute carrier organic anion transporter family member 5A1a
chr18_-_34143189 0.16 ENSDART00000079341
plch1
phospholipase C, eta 1
chr7_+_31051603 0.16 ENSDART00000108721
tjp1a
tight junction protein 1a
chr13_+_12405051 0.16 ENSDART00000108543
atp10d
ATPase phospholipid transporting 10D
chr16_-_25607266 0.16 ENSDART00000192602
zgc:110410
zgc:110410
chr6_-_43047774 0.16 ENSDART00000161722
glyctk
glycerate kinase
chr12_+_26877381 0.16 ENSDART00000087329
znf438
zinc finger protein 438
chr24_-_36727922 0.15 ENSDART00000135142
si:ch73-334d15.1
si:ch73-334d15.1
chr25_-_27735290 0.14 ENSDART00000140663
zgc:153935
zgc:153935
chr18_+_36037223 0.14 ENSDART00000144410
tmem91
transmembrane protein 91
chr21_-_22910520 0.13 ENSDART00000065567
ENSDART00000191792
guca1d
guanylate cyclase activator 1d
chr23_-_27702561 0.13 ENSDART00000053876
dnajc22
DnaJ (Hsp40) homolog, subfamily C, member 22
chr15_-_26552652 0.13 ENSDART00000152336
serpinf2b
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b
chr25_-_12803723 0.13 ENSDART00000158787
ca5a
carbonic anhydrase Va
chr2_-_36914281 0.13 ENSDART00000008322
si:dkey-193b15.5
si:dkey-193b15.5
chr20_-_46128590 0.12 ENSDART00000123744
taar1b
trace amine associated receptor 1b
chr20_-_40754794 0.12 ENSDART00000187251
cx32.3
connexin 32.3
chr16_-_25606889 0.12 ENSDART00000077447
ENSDART00000131528
zgc:110410
zgc:110410
chr1_+_17900306 0.11 ENSDART00000089480
cyp4v8
cytochrome P450, family 4, subfamily V, polypeptide 8

Network of associatons between targets according to the STRING database.

First level regulatory network of hnf4a+hnf4b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 17.4 GO:2000344 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.6 1.8 GO:0005991 trehalose metabolic process(GO:0005991)
0.5 2.7 GO:0070986 left/right axis specification(GO:0070986)
0.5 1.6 GO:0018872 arsonoacetate metabolic process(GO:0018872)
0.5 3.7 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.5 4.2 GO:0033206 meiotic cytokinesis(GO:0033206) polar body extrusion after meiotic divisions(GO:0040038)
0.4 4.2 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.3 1.0 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.2 8.3 GO:0050821 protein stabilization(GO:0050821)
0.2 1.5 GO:0040016 embryonic cleavage(GO:0040016) positive regulation of myoblast fusion(GO:1901741)
0.2 1.0 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.2 2.0 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.2 1.9 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.1 2.4 GO:0015693 magnesium ion transport(GO:0015693)
0.1 2.1 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 0.6 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 0.8 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.1 1.4 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.1 1.3 GO:0090398 cellular senescence(GO:0090398)
0.1 0.8 GO:2000650 negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.1 2.7 GO:0016601 Rac protein signal transduction(GO:0016601)
0.1 1.7 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 1.1 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.1 0.6 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 1.2 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.1 2.5 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.1 0.8 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 1.8 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.2 GO:1903173 fatty alcohol metabolic process(GO:1903173)
0.1 0.6 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.1 0.3 GO:0016572 histone phosphorylation(GO:0016572)
0.1 0.4 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.0 0.6 GO:0031647 regulation of protein stability(GO:0031647)
0.0 0.6 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.0 2.4 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.0 1.4 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.1 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.0 1.3 GO:0072348 sulfur compound transport(GO:0072348)
0.0 1.0 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.0 1.2 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 0.3 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 1.0 GO:0016082 synaptic vesicle priming(GO:0016082)
0.0 0.5 GO:0090279 regulation of calcium ion import(GO:0090279)
0.0 1.9 GO:0097191 extrinsic apoptotic signaling pathway(GO:0097191)
0.0 0.3 GO:0033700 phospholipid efflux(GO:0033700)
0.0 0.3 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.0 0.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 2.1 GO:0031047 gene silencing by RNA(GO:0031047)
0.0 0.4 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.0 0.8 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.1 GO:0010459 cardiac conduction system development(GO:0003161) negative regulation of heart rate(GO:0010459)
0.0 0.2 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.0 1.2 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 1.2 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.0 1.0 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 1.2 GO:0030336 negative regulation of cell migration(GO:0030336)
0.0 0.1 GO:0032475 otolith formation(GO:0032475)
0.0 1.4 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 1.2 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 1.9 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.1 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.0 0.3 GO:0046834 lipid phosphorylation(GO:0046834)
0.0 0.5 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.6 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 0.4 GO:0035118 embryonic pectoral fin morphogenesis(GO:0035118)
0.0 0.0 GO:0021530 spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 0.1 GO:0036368 cone photoresponse recovery(GO:0036368)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.3 GO:0043291 RAVE complex(GO:0043291)
0.3 0.9 GO:0034457 Mpp10 complex(GO:0034457)
0.2 0.6 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.2 1.5 GO:0035517 PR-DUB complex(GO:0035517)
0.1 1.9 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 1.1 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.1 0.3 GO:1990429 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.1 0.5 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 3.1 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 0.3 GO:0061689 tricellular tight junction(GO:0061689)
0.0 15.1 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.4 GO:0031105 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.6 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 1.4 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.4 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.3 GO:0016272 prefoldin complex(GO:0016272)
0.0 1.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.6 GO:0005689 U2 snRNP(GO:0005686) U12-type spliceosomal complex(GO:0005689)
0.0 2.0 GO:0072686 mitotic spindle(GO:0072686)
0.0 1.2 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.1 GO:0005902 microvillus(GO:0005902)
0.0 4.5 GO:0005938 cell cortex(GO:0005938)
0.0 0.1 GO:0005915 cell-cell adherens junction(GO:0005913) zonula adherens(GO:0005915)
0.0 0.5 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 0.9 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 1.0 GO:0031201 SNARE complex(GO:0031201)
0.0 0.3 GO:0045178 basal plasma membrane(GO:0009925) basal part of cell(GO:0045178)
0.0 1.4 GO:0005802 trans-Golgi network(GO:0005802)
0.0 2.8 GO:0010008 endosome membrane(GO:0010008)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 8.3 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
1.6 17.4 GO:0035804 structural constituent of egg coat(GO:0035804)
1.0 4.2 GO:0070404 6,7-dihydropteridine reductase activity(GO:0004155) NADH binding(GO:0070404)
0.6 1.8 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.5 1.6 GO:0030791 arsenite methyltransferase activity(GO:0030791) methylarsonite methyltransferase activity(GO:0030792)
0.4 2.4 GO:0030331 estrogen receptor binding(GO:0030331)
0.3 2.5 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.3 1.5 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.3 0.5 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.3 1.0 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.2 3.7 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.2 0.6 GO:0043878 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity(GO:0043878)
0.2 0.5 GO:0052855 ATP-dependent NAD(P)H-hydrate dehydratase activity(GO:0047453) ADP-dependent NAD(P)H-hydrate dehydratase activity(GO:0052855)
0.2 1.2 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.1 0.7 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.1 1.9 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 2.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 1.4 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 0.8 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 1.7 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 1.2 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1 1.4 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 1.0 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 1.4 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 0.6 GO:0008420 CTD phosphatase activity(GO:0008420)
0.1 1.8 GO:0022840 leak channel activity(GO:0022840) potassium ion leak channel activity(GO:0022841) narrow pore channel activity(GO:0022842)
0.1 1.4 GO:0005343 organic acid:sodium symporter activity(GO:0005343)
0.1 16.4 GO:0030246 carbohydrate binding(GO:0030246)
0.1 0.2 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.1 0.3 GO:0090556 phospholipid-translocating ATPase activity(GO:0004012) phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.0 1.2 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.9 GO:0030515 snoRNA binding(GO:0030515)
0.0 1.2 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.6 GO:0010484 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.0 1.5 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.9 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.2 GO:0008887 glycerate kinase activity(GO:0008887)
0.0 1.9 GO:0032813 tumor necrosis factor receptor superfamily binding(GO:0032813)
0.0 0.2 GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity(GO:0003977)
0.0 3.0 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 2.2 GO:0030170 pyridoxal phosphate binding(GO:0030170)
0.0 0.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.1 GO:0102344 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.0 2.0 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.3 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.2 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.8 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.2 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.7 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 1.2 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.5 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.1 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 1.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.4 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 1.0 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.0 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.6 GO:0030898 actin-dependent ATPase activity(GO:0030898)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 8.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 1.0 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 1.5 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 1.7 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 2.0 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.5 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.6 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.7 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.5 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.8 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.1 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.3 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.3 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.4 7.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.3 1.8 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.3 1.1 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.1 2.1 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 1.9 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 0.8 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 0.4 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.1 0.5 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 1.7 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 0.9 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 2.3 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.5 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.5 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 1.2 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.4 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.4 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 1.6 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.3 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.6 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import