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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for hoxc6a+hoxc6b

Z-value: 0.82

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Transcription factors associated with hoxc6a+hoxc6b

Gene Symbol Gene ID Gene Info
hoxc6a
ENSDARG00000070343 homeobox C6a
hoxc6b
ENSDARG00000101954 homeobox C6b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxc6bdr11_v1_chr11_+_2198831_2198831-0.903.2e-07Click!
hoxc6adr11_v1_chr23_+_36115541_36115541-0.841.3e-05Click!

Activity profile of hoxc6a+hoxc6b motif

Sorted Z-values of hoxc6a+hoxc6b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_+_54299419 2.59 ENSDART00000056089
ENSDART00000193107
si:zfos-1505d6.3
si:zfos-1505d6.3
chr16_+_29509133 2.50 ENSDART00000112116
ctss2.1
cathepsin S, ortholog2, tandem duplicate 1
chr20_+_54309148 2.48 ENSDART00000099360
zp2.1
zona pellucida glycoprotein 2, tandem duplicate 1
chr20_+_54304800 2.39 ENSDART00000121661
zp2.6
zona pellucida glycoprotein 2, tandem duplicate 6
chr9_+_54039006 2.35 ENSDART00000112441
tlr7
toll-like receptor 7
chr25_+_22320738 2.29 ENSDART00000073566
cyp11a1
cytochrome P450, family 11, subfamily A, polypeptide 1
chr10_-_34916208 2.01 ENSDART00000187371
ccna1
cyclin A1
chr24_+_15020402 1.87 ENSDART00000148102
dok6
docking protein 6
chr3_+_7808459 1.66 ENSDART00000162374
hook2
hook microtubule-tethering protein 2
chr5_-_37103487 1.58 ENSDART00000149211
il13ra2
interleukin 13 receptor, alpha 2
chr4_-_5108844 1.58 ENSDART00000132666
ENSDART00000136096
tmem209
transmembrane protein 209
chr2_+_15048410 1.46 ENSDART00000058484
cnn3b
calponin 3, acidic b
chr2_-_31833347 1.45 ENSDART00000109460
nol7
nucleolar protein 7
chr2_-_15324837 1.41 ENSDART00000015655
tecrl2b
trans-2,3-enoyl-CoA reductase-like 2b
chr2_+_56657804 1.39 ENSDART00000113964
POLR2E (1 of many)
RNA polymerase II subunit E
chr1_-_51038885 1.34 ENSDART00000035150
spast
spastin
chr11_-_10456387 1.24 ENSDART00000011087
ENSDART00000081827
ect2
epithelial cell transforming 2
chr21_+_43172506 1.22 ENSDART00000121725
zcchc10
zinc finger, CCHC domain containing 10
chr10_+_11261576 1.19 ENSDART00000155333
hsdl2
hydroxysteroid dehydrogenase like 2
chr11_-_10456553 1.18 ENSDART00000169509
ENSDART00000185574
ENSDART00000188276
ect2
epithelial cell transforming 2
chr24_-_38110779 1.13 ENSDART00000147783
crp
c-reactive protein, pentraxin-related
chr2_-_17392799 1.11 ENSDART00000136470
ENSDART00000141188
st3gal3b
ST3 beta-galactoside alpha-2,3-sialyltransferase 3b
chr17_+_30369396 1.06 ENSDART00000076611
greb1
growth regulation by estrogen in breast cancer 1
chr5_+_41477526 1.06 ENSDART00000153567
pias2
protein inhibitor of activated STAT, 2
chr5_+_41477954 1.05 ENSDART00000185871
pias2
protein inhibitor of activated STAT, 2
chr8_-_39884359 1.02 ENSDART00000131372
mlec
malectin
chr12_+_23912074 1.01 ENSDART00000152864
svila
supervillin a
chr6_+_12527725 0.97 ENSDART00000149328
stk24b
serine/threonine kinase 24b (STE20 homolog, yeast)
chr23_-_20051369 0.90 ENSDART00000049836
bgnb
biglycan b
chr14_+_21722235 0.90 ENSDART00000183667
stx3a
syntaxin 3A
chr11_-_44979281 0.90 ENSDART00000190972
ldb1b
LIM-domain binding 1b
chr8_+_29635968 0.88 ENSDART00000139029
ENSDART00000091409
smarcad1a
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 a
chr8_+_26874924 0.87 ENSDART00000141794
rimkla
ribosomal modification protein rimK-like family member A
chr6_+_7533601 0.85 ENSDART00000057823
pa2g4a
proliferation-associated 2G4, a
chr1_+_47499888 0.85 ENSDART00000027624
stn1
STN1, CST complex subunit
chr21_-_44081540 0.84 ENSDART00000130833
FO704810.1

chr20_+_22799641 0.84 ENSDART00000131132
scfd2
sec1 family domain containing 2
chr16_-_7793457 0.82 ENSDART00000113483
trim71
tripartite motif containing 71, E3 ubiquitin protein ligase
chr5_+_29851433 0.82 ENSDART00000143434
ubash3ba
ubiquitin associated and SH3 domain containing Ba
chr2_-_17393216 0.80 ENSDART00000123137
st3gal3b
ST3 beta-galactoside alpha-2,3-sialyltransferase 3b
chr13_+_33268657 0.80 ENSDART00000002095
tmem39b
transmembrane protein 39B
chr22_+_2751887 0.80 ENSDART00000133652
si:dkey-20i20.11
si:dkey-20i20.11
chr3_+_40164129 0.78 ENSDART00000102526
gfer
growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae)
chr7_-_5375214 0.78 ENSDART00000033316
vangl2
VANGL planar cell polarity protein 2
chr15_+_34592215 0.77 ENSDART00000099776
tspan13a
tetraspanin 13a
chr18_+_35128685 0.77 ENSDART00000151579
si:ch211-195m9.3
si:ch211-195m9.3
chr4_+_12966640 0.76 ENSDART00000113357
vhll
von Hippel-Lindau tumor suppressor like
chr19_+_43885770 0.74 ENSDART00000135599
lypla2
lysophospholipase II
chr7_-_8712148 0.73 ENSDART00000065488
tex261
testis expressed 261
chr9_+_24065855 0.72 ENSDART00000161468
ENSDART00000171577
ENSDART00000172743
ENSDART00000159324
ENSDART00000079689
ENSDART00000023196
ENSDART00000101577
lrrfip1a
leucine rich repeat (in FLII) interacting protein 1a
chr15_-_26931541 0.71 ENSDART00000027563
ccdc9
coiled-coil domain containing 9
chr4_+_2482046 0.71 ENSDART00000103371
zdhhc17
zinc finger, DHHC-type containing 17
chr14_-_16082806 0.71 ENSDART00000165656
mxd3
MAX dimerization protein 3
chr16_-_42965192 0.69 ENSDART00000113714
mtx1a
metaxin 1a
chr10_+_43039947 0.68 ENSDART00000193434
atg10
ATG10 autophagy related 10 homolog (S. cerevisiae)
chr13_-_52089003 0.68 ENSDART00000187600
tmem254
transmembrane protein 254
chr1_+_513986 0.67 ENSDART00000109083
ENSDART00000081945
txnl4b
thioredoxin-like 4B
chr8_+_31717175 0.66 ENSDART00000013434
oxct1a
3-oxoacid CoA transferase 1a
chr16_+_54209504 0.66 ENSDART00000020033
xrcc1
X-ray repair complementing defective repair in Chinese hamster cells 1
chr24_+_21514283 0.65 ENSDART00000007066
cdk8
cyclin-dependent kinase 8
chr3_+_23029484 0.64 ENSDART00000187900
nags
N-acetylglutamate synthase
chr22_-_16154771 0.63 ENSDART00000009464
slc30a7
solute carrier family 30 (zinc transporter), member 7
chr1_+_27977297 0.62 ENSDART00000180692
ENSDART00000166819
sugt1
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
chr2_-_10877765 0.61 ENSDART00000100607
cdc7
cell division cycle 7 homolog (S. cerevisiae)
chr23_+_1029450 0.61 ENSDART00000189196
si:zfos-905g2.1
si:zfos-905g2.1
chr8_+_31716872 0.59 ENSDART00000161121
oxct1a
3-oxoacid CoA transferase 1a
chr7_-_49594995 0.59 ENSDART00000174161
ENSDART00000109147
brsk2b
BR serine/threonine kinase 2b
chr25_-_21031007 0.57 ENSDART00000138985
gnaia
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a
chr15_+_29140126 0.57 ENSDART00000060034
zgc:113149
zgc:113149
chr10_-_13343831 0.56 ENSDART00000135941
il11ra
interleukin 11 receptor, alpha
chr1_-_513762 0.56 ENSDART00000148162
ENSDART00000144606
trmt10c
tRNA methyltransferase 10C, mitochondrial RNase P subunit
chr16_-_44945224 0.56 ENSDART00000156921
ncam3
neural cell adhesion molecule 3
chr22_-_21676364 0.55 ENSDART00000183668
tle2b
transducin like enhancer of split 2b
chr11_+_17984354 0.52 ENSDART00000179986
rpusd4
RNA pseudouridylate synthase domain containing 4
chr12_-_11560794 0.52 ENSDART00000149098
ENSDART00000169975
plekha1b
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1b
chr7_+_7696665 0.52 ENSDART00000091099
ino80b
INO80 complex subunit B
chr11_+_17984167 0.52 ENSDART00000020283
ENSDART00000188329
rpusd4
RNA pseudouridylate synthase domain containing 4
chr25_-_27621268 0.51 ENSDART00000146205
ENSDART00000073511
hyal6
hyaluronoglucosaminidase 6
chr3_+_29179329 0.51 ENSDART00000085216
ENSDART00000190136
cacna1i
calcium channel, voltage-dependent, T type, alpha 1I subunit
chr14_-_48765262 0.51 ENSDART00000166463
cnot6b
CCR4-NOT transcription complex, subunit 6b
chr18_+_924949 0.50 ENSDART00000170888
ENSDART00000193163
pkma
pyruvate kinase M1/2a
chr24_+_19415124 0.50 ENSDART00000186931
sulf1
sulfatase 1
chr23_+_4709607 0.49 ENSDART00000166503
ENSDART00000158752
ENSDART00000163860
ENSDART00000172739
raf1a
raf1a
Raf-1 proto-oncogene, serine/threonine kinase a
Raf-1 proto-oncogene, serine/threonine kinase a
chr4_-_5019113 0.49 ENSDART00000189321
ENSDART00000081990
strip2
striatin interacting protein 2
chr3_+_52545014 0.49 ENSDART00000018908
slc27a1a
solute carrier family 27 (fatty acid transporter), member 1a
chr16_-_27677930 0.48 ENSDART00000145991
tbrg4
transforming growth factor beta regulator 4
chr25_-_25058508 0.48 ENSDART00000087570
ENSDART00000178891
FQ311928.1

chr6_+_4229360 0.47 ENSDART00000191347
ENSDART00000130642
FO082877.1

chr7_+_66884291 0.47 ENSDART00000187499
sbf2
SET binding factor 2
chr3_-_20040636 0.47 ENSDART00000104118
atxn7l3
ataxin 7-like 3
chr7_-_50410524 0.45 ENSDART00000083346
hypk
huntingtin interacting protein K
chr24_+_16985181 0.44 ENSDART00000135580
eif2s3
eukaryotic translation initiation factor 2, subunit 3 gamma
chr7_+_24573721 0.44 ENSDART00000173938
ENSDART00000173681
si:dkeyp-75h12.7
si:dkeyp-75h12.7
chr7_-_34448076 0.43 ENSDART00000170935
nr1h3
nuclear receptor subfamily 1, group H, member 3
chr8_-_36287046 0.41 ENSDART00000162877
si:busm1-194e12.11
si:busm1-194e12.11
chr3_+_28939759 0.40 ENSDART00000141904
lgals1l1
lectin, galactoside-binding, soluble, 1 (galectin 1)-like 1
chr5_+_61459422 0.40 ENSDART00000050902
polr2j
polymerase (RNA) II (DNA directed) polypeptide J
chr3_+_26342768 0.40 ENSDART00000163832
si:ch211-156b7.4
si:ch211-156b7.4
chr7_-_46777876 0.39 ENSDART00000193954
tshz3b
teashirt zinc finger homeobox 3b
chr23_-_18707418 0.39 ENSDART00000144668
ENSDART00000141205
ENSDART00000016765
zgc:103759
zgc:103759
chr19_+_46158078 0.38 ENSDART00000183933
ENSDART00000164055
cap2
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr13_+_35528607 0.38 ENSDART00000075414
ENSDART00000112947
wdr27
WD repeat domain 27
chr12_+_1139690 0.37 ENSDART00000160442
CABZ01072885.1

chr15_-_17618800 0.36 ENSDART00000157185
adamts15b
ADAM metallopeptidase with thrombospondin type 1 motif, 15b
chr2_+_37140448 0.35 ENSDART00000045016
ENSDART00000142940
pex19
peroxisomal biogenesis factor 19
chr7_+_4474880 0.34 ENSDART00000143528
si:dkey-83f18.14
si:dkey-83f18.14
chr20_-_34750363 0.33 ENSDART00000152845
znf395b
zinc finger protein 395b
chr21_-_1640547 0.33 ENSDART00000151041
zgc:152948
zgc:152948
chr4_-_11064073 0.32 ENSDART00000150760
si:dkey-21h14.8
si:dkey-21h14.8
chr5_+_32076109 0.32 ENSDART00000051357
ENSDART00000144510
zmat5
zinc finger, matrin-type 5
chr10_+_29850330 0.32 ENSDART00000168898
hspa8
heat shock protein 8
chr17_-_16422654 0.31 ENSDART00000150149
tdp1
tyrosyl-DNA phosphodiesterase 1
chr2_+_10878406 0.31 ENSDART00000091497
tceanc2
transcription elongation factor A (SII) N-terminal and central domain containing 2
chr7_-_67248829 0.31 ENSDART00000192442
znf143a
zinc finger protein 143a
chr1_+_32051581 0.30 ENSDART00000146602
sts
steroid sulfatase (microsomal), isozyme S
chr15_-_43284021 0.30 ENSDART00000041677
serpine2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr2_+_11923615 0.29 ENSDART00000126118
trove2
TROVE domain family, member 2
chr21_-_26028205 0.28 ENSDART00000034875
sdf2
stromal cell-derived factor 2
chr13_+_15656042 0.28 ENSDART00000134240
mark3a
MAP/microtubule affinity-regulating kinase 3a
chr7_+_66884570 0.28 ENSDART00000082664
sbf2
SET binding factor 2
chr17_-_25831569 0.27 ENSDART00000148743
hhat
hedgehog acyltransferase
chr18_+_13275735 0.27 ENSDART00000148127
plcg2
phospholipase C, gamma 2
chr9_+_2574122 0.27 ENSDART00000166326
ENSDART00000191822
CIR1
si:ch73-167c12.2
chr11_-_36156935 0.27 ENSDART00000124935
ENSDART00000138609
brk1
gpx1a
BRICK1, SCAR/WAVE actin-nucleating complex subunit
glutathione peroxidase 1a
chr8_+_50953776 0.26 ENSDART00000013870
zgc:56596
zgc:56596
chr3_-_31254379 0.26 ENSDART00000189376
apnl
actinoporin-like protein
chr4_+_5796761 0.26 ENSDART00000164854
si:ch73-352p4.8
si:ch73-352p4.8
chr10_+_34047352 0.25 ENSDART00000169333
HTRA2 (1 of many)
si:dkey-10b15.8
chr8_-_45867358 0.25 ENSDART00000132810
adam9
ADAM metallopeptidase domain 9
chr24_+_9693951 0.24 ENSDART00000082411
topbp1
DNA topoisomerase II binding protein 1
chr4_+_76926059 0.24 ENSDART00000136192
si:dkey-240n22.6
si:dkey-240n22.6
chr9_-_42418470 0.24 ENSDART00000144353
calcrla
calcitonin receptor-like a
chr7_-_66868543 0.24 ENSDART00000149680
ampd3a
adenosine monophosphate deaminase 3a
chr22_-_24791505 0.24 ENSDART00000136837
vtg4
vitellogenin 4
chr5_+_33498253 0.22 ENSDART00000140993
ms4a17c.2
membrane-spanning 4-domains, subfamily A, member 17c.2
chr20_-_34750045 0.22 ENSDART00000186130
znf395b
zinc finger protein 395b
chr17_+_20589553 0.22 ENSDART00000154447
si:ch73-288o11.4
si:ch73-288o11.4
chr5_-_13251907 0.22 ENSDART00000176774
ENSDART00000030553
top3b
DNA topoisomerase III beta
chr14_+_36521005 0.22 ENSDART00000192286
TENM3
si:dkey-237h12.3
chr13_+_9468535 0.21 ENSDART00000135088
ENSDART00000164270
ENSDART00000099619
ENSDART00000164656
HTRA2 (1 of many)
si:dkey-265c15.6
chr8_+_36560019 0.20 ENSDART00000136418
ENSDART00000061378
ENSDART00000185237
sf3a1
splicing factor 3a, subunit 1
chr24_-_6898302 0.20 ENSDART00000158646
dpp6a
dipeptidyl-peptidase 6a
chr1_+_6862917 0.19 ENSDART00000182953
erbb4a
erb-b2 receptor tyrosine kinase 4a
chr19_-_5769728 0.19 ENSDART00000133106
si:ch211-264f5.6
si:ch211-264f5.6
chr2_-_37140423 0.19 ENSDART00000144220
tspan37
tetraspanin 37
chr15_+_857148 0.19 ENSDART00000156949
si:dkey-7i4.13
si:dkey-7i4.13
chr2_+_2169337 0.19 ENSDART00000179939
higd1a
HIG1 hypoxia inducible domain family, member 1A
chr8_-_53044300 0.19 ENSDART00000191653
nr6a1a
nuclear receptor subfamily 6, group A, member 1a
chr12_+_48480632 0.19 ENSDART00000158157
arhgap44
Rho GTPase activating protein 44
chr4_+_59845617 0.18 ENSDART00000167626
ENSDART00000123157
si:dkey-196n19.2
si:dkey-196n19.2
chr5_+_55225497 0.18 ENSDART00000144087
tmc2a
transmembrane channel-like 2a
chr9_+_310331 0.18 ENSDART00000172446
ENSDART00000187731
ENSDART00000193970
stac3
SH3 and cysteine rich domain 3
chr19_-_5769553 0.18 ENSDART00000175003
si:ch211-264f5.6
si:ch211-264f5.6
chr6_-_52788213 0.17 ENSDART00000179880
rbpjl
recombination signal binding protein for immunoglobulin kappa J region-like
chr15_-_17619306 0.17 ENSDART00000184011
adamts15b
ADAM metallopeptidase with thrombospondin type 1 motif, 15b
chr21_-_36571804 0.16 ENSDART00000138129
wwc1
WW and C2 domain containing 1
chr23_+_45339684 0.16 ENSDART00000149410
ENSDART00000102441
psip1b
PC4 and SFRS1 interacting protein 1b
chr17_+_16564921 0.15 ENSDART00000151904
foxn3
forkhead box N3
chr22_-_20166660 0.15 ENSDART00000085913
ENSDART00000188241
btbd2a
BTB (POZ) domain containing 2a
chr12_-_4532066 0.14 ENSDART00000092687
trpm4b.2
transient receptor potential cation channel, subfamily M, member 4b, transient receptor potential cation channel, subfamily M, member 4b, tandem duplicate 2
chr10_-_7386475 0.14 ENSDART00000167963
nrg1
neuregulin 1
chr2_+_20605925 0.14 ENSDART00000191510
olfml2bb
olfactomedin-like 2Bb
chr22_-_9183944 0.13 ENSDART00000188599
si:ch211-213a13.5
si:ch211-213a13.5
chr4_+_33012407 0.13 ENSDART00000151873
si:dkey-26h11.2
si:dkey-26h11.2
chr6_-_11768198 0.13 ENSDART00000183463
march7
membrane-associated ring finger (C3HC4) 7
chr10_+_31248036 0.13 ENSDART00000193574
robo4
roundabout, axon guidance receptor, homolog 4 (Drosophila)
chr17_+_51682429 0.13 ENSDART00000004379
nol10
nucleolar protein 10
chr4_-_46915962 0.13 ENSDART00000169555
si:ch211-134c10.1
si:ch211-134c10.1
chr13_+_38430466 0.12 ENSDART00000132691
adgrb3
adhesion G protein-coupled receptor B3
chr5_+_71802014 0.12 ENSDART00000124939
ENSDART00000097164
LHX3
LIM homeobox 3
chr22_+_1568306 0.12 ENSDART00000163223
si:ch211-255f4.9
si:ch211-255f4.9
chr21_-_38853737 0.12 ENSDART00000184100
tlr22
toll-like receptor 22
chr24_+_34113424 0.12 ENSDART00000105572
gbx1
gastrulation brain homeobox 1
chr4_-_67980261 0.12 ENSDART00000182305
si:ch211-223k15.1
si:ch211-223k15.1
chr13_+_7292061 0.12 ENSDART00000179504
CABZ01072077.1
Danio rerio neuroblast differentiation-associated protein AHNAK-like (LOC795051), mRNA.
chr3_-_50443607 0.11 ENSDART00000074036
rcvrna
recoverin a
chr25_-_27722614 0.11 ENSDART00000190154
zgc:153935
zgc:153935
chr3_+_23092762 0.11 ENSDART00000142884
ENSDART00000024136
gngt2a
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2a
chr24_-_33873451 0.11 ENSDART00000159840
asic1c
acid-sensing (proton-gated) ion channel 1c
chr17_-_2386569 0.10 ENSDART00000121614
PLCB2
phospholipase C beta 2
chr7_+_4694924 0.09 ENSDART00000144873
si:ch211-225k7.3
si:ch211-225k7.3
chr16_-_41515662 0.09 ENSDART00000166201
ENSDART00000127243
siglec15l
sialic acid binding Ig-like lectin 15, like
chr14_-_17306261 0.09 ENSDART00000191747
jakmip1
janus kinase and microtubule interacting protein 1
chr24_-_6897884 0.09 ENSDART00000080766
dpp6a
dipeptidyl-peptidase 6a
chr1_+_19303241 0.09 ENSDART00000129970
si:dkeyp-118a3.2
si:dkeyp-118a3.2
chr9_+_11281969 0.08 ENSDART00000110691
wnt6b
wingless-type MMTV integration site family, member 6b
chr17_+_26611929 0.08 ENSDART00000166450
ENSDART00000087023
ttc7b
tetratricopeptide repeat domain 7B
chr9_+_41080029 0.08 ENSDART00000141179
ENSDART00000019289
zgc:136439
zgc:136439
chr4_+_19700308 0.07 ENSDART00000027919
pax4
paired box 4
chr20_+_25225112 0.06 ENSDART00000153088
ENSDART00000127291
ENSDART00000130494
moxd1
monooxygenase, DBH-like 1
chr24_+_21540842 0.06 ENSDART00000091529
wasf3b
WAS protein family, member 3b
chr9_-_32177117 0.06 ENSDART00000078568
sf3b1
splicing factor 3b, subunit 1
chr2_+_3201345 0.06 ENSDART00000130349
wnt9a
wingless-type MMTV integration site family, member 9A
chr7_-_11596450 0.06 ENSDART00000173863
stard5
StAR-related lipid transfer (START) domain containing 5
chr21_+_11685009 0.06 ENSDART00000014668
pcsk1
proprotein convertase subtilisin/kexin type 1
chr7_-_71829649 0.06 ENSDART00000160449
cacnb2a
calcium channel, voltage-dependent, beta 2a
chr8_+_17775247 0.05 ENSDART00000112356
si:ch211-150o23.3
si:ch211-150o23.3
chr9_+_54290896 0.05 ENSDART00000149175
pou4f3
POU class 4 homeobox 3
chr22_-_27296889 0.05 ENSDART00000155724
si:dkey-208m12.3
si:dkey-208m12.3
chr20_-_38617766 0.05 ENSDART00000050474
slc30a2
solute carrier family 30 (zinc transporter), member 2

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxc6a+hoxc6b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.5 3.6 GO:0031112 positive regulation of microtubule polymerization or depolymerization(GO:0031112)
0.3 1.3 GO:0046952 ketone body catabolic process(GO:0046952)
0.2 2.4 GO:0000915 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.2 1.0 GO:0000012 single strand break repair(GO:0000012)
0.2 0.9 GO:0098967 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.2 1.0 GO:0000455 enzyme-directed rRNA pseudouridine synthesis(GO:0000455)
0.2 0.8 GO:0010586 miRNA metabolic process(GO:0010586)
0.2 0.6 GO:0006526 arginine biosynthetic process(GO:0006526)
0.2 0.8 GO:0008591 regulation of Wnt signaling pathway, calcium modulating pathway(GO:0008591)
0.1 0.4 GO:1904729 regulation of intestinal absorption(GO:1904478) regulation of intestinal lipid absorption(GO:1904729)
0.1 0.7 GO:0048011 neurotrophin TRK receptor signaling pathway(GO:0048011)
0.1 0.6 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.1 0.4 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.1 0.5 GO:0031650 heat generation(GO:0031649) regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652) regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072)
0.1 0.4 GO:0045046 peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.1 0.9 GO:0000729 DNA double-strand break processing(GO:0000729)
0.1 2.1 GO:0016925 protein sumoylation(GO:0016925)
0.1 0.5 GO:2000290 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.1 0.2 GO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902165)
0.1 0.5 GO:0044528 regulation of mitochondrial mRNA stability(GO:0044528)
0.1 0.3 GO:1902946 positive regulation of receptor-mediated endocytosis(GO:0048260) protein localization to early endosome(GO:1902946)
0.0 0.1 GO:0002369 T cell cytokine production(GO:0002369)
0.0 0.1 GO:0036135 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) Schwann cell migration(GO:0036135) cardiac neuron differentiation(GO:0060945) cardiac neuron development(GO:0060959)
0.0 0.3 GO:0010269 response to selenium ion(GO:0010269)
0.0 0.1 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.0 0.3 GO:0044364 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883)
0.0 0.5 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.0 1.1 GO:0021983 pituitary gland development(GO:0021983)
0.0 2.0 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.5 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 0.6 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 0.2 GO:1901387 positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.0 0.8 GO:0016233 telomere capping(GO:0016233)
0.0 0.5 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.3 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.5 GO:0055117 regulation of cardiac muscle contraction(GO:0055117)
0.0 1.0 GO:0051014 actin filament severing(GO:0051014)
0.0 0.4 GO:0016074 snoRNA metabolic process(GO:0016074)
0.0 0.2 GO:0097250 mitochondrial respiratory chain supercomplex assembly(GO:0097250)
0.0 1.1 GO:0050821 protein stabilization(GO:0050821)
0.0 1.0 GO:0042761 very long-chain fatty acid biosynthetic process(GO:0042761)
0.0 1.7 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 0.1 GO:0016322 neuron remodeling(GO:0016322)
0.0 0.2 GO:0032475 otolith formation(GO:0032475)
0.0 0.7 GO:0006829 zinc II ion transport(GO:0006829)
0.0 0.1 GO:0006589 octopamine biosynthetic process(GO:0006589) dopamine catabolic process(GO:0042420) norepinephrine biosynthetic process(GO:0042421) octopamine metabolic process(GO:0046333)
0.0 0.2 GO:0060005 reflex(GO:0060004) vestibular reflex(GO:0060005)
0.0 0.3 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.0 0.1 GO:0060827 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827)
0.0 0.8 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.1 GO:0045124 regulation of bone resorption(GO:0045124)
0.0 0.2 GO:0032264 IMP salvage(GO:0032264)
0.0 0.1 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.5 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.4 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 0.2 GO:0006265 DNA topological change(GO:0006265)
0.0 0.2 GO:0048844 artery morphogenesis(GO:0048844)
0.0 0.1 GO:0036368 cone photoresponse recovery(GO:0036368)
0.0 0.1 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.3 0.8 GO:1990879 CST complex(GO:1990879)
0.1 0.8 GO:0030891 VCB complex(GO:0030891)
0.1 0.4 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 0.3 GO:0044218 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.1 0.7 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.1 0.6 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.7 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.3 GO:0071818 BAT3 complex(GO:0071818)
0.0 0.9 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.5 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.9 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.5 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.3 GO:0031209 SCAR complex(GO:0031209)
0.0 0.1 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.2 GO:0005686 U2 snRNP(GO:0005686)
0.0 1.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.8 GO:0030496 midbody(GO:0030496)
0.0 1.5 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.7 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.7 GO:0016592 mediator complex(GO:0016592)
0.0 0.2 GO:0030315 T-tubule(GO:0030315)
0.0 0.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.7 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.9 GO:0030141 secretory granule(GO:0030141)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0016713 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.3 1.3 GO:0048487 beta-tubulin binding(GO:0048487)
0.3 0.9 GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590) citrate-L-glutamate ligase activity(GO:0072591)
0.3 1.9 GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
0.3 0.8 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.3 1.3 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.2 0.7 GO:0019777 Atg12 transferase activity(GO:0019777)
0.2 0.6 GO:0034618 arginine binding(GO:0034618)
0.2 2.1 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 0.6 GO:0052905 tRNA (guanine(9)-N(1))-methyltransferase activity(GO:0052905)
0.1 0.4 GO:1990174 phosphodiesterase decapping endonuclease activity(GO:1990174)
0.1 0.9 GO:0030274 LIM domain binding(GO:0030274)
0.1 0.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 0.6 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.3 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.1 0.5 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 0.8 GO:0035198 miRNA binding(GO:0035198)
0.1 0.2 GO:0001605 adrenomedullin receptor activity(GO:0001605) calcitonin gene-related peptide receptor activity(GO:0001635)
0.1 0.8 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.1 0.5 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 1.0 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.7 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.6 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 1.7 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.4 GO:0016936 galactoside binding(GO:0016936)
0.0 0.9 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.5 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.8 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.7 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.5 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.2 GO:0045735 nutrient reservoir activity(GO:0045735)
0.0 2.3 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.4 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 2.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.5 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.1 GO:0004500 dopamine beta-monooxygenase activity(GO:0004500)
0.0 2.6 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 0.3 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.1 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 0.3 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 1.4 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.0 1.0 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.5 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.9 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.7 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.2 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 2.5 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.3 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.4 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 0.5 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.1 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 0.4 GO:0000049 tRNA binding(GO:0000049)
0.0 0.7 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.1 GO:0032052 bile acid binding(GO:0032052)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.2 2.1 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 2.0 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 2.4 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 1.1 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 1.4 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.4 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.7 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 1.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.4 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.1 PID ERBB NETWORK PATHWAY ErbB receptor signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.3 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.2 2.3 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 2.0 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 1.1 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 1.0 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.0 0.7 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.7 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.0 2.0 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.3 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.7 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.3 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.1 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.8 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.6 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 0.5 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.3 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.0 0.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.4 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor