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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for hoxc8a

Z-value: 0.87

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Transcription factors associated with hoxc8a

Gene Symbol Gene ID Gene Info
ENSDARG00000070346 homeobox C8a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxc8adr11_v1_chr23_+_36101185_361011850.896.5e-07Click!

Activity profile of hoxc8a motif

Sorted Z-values of hoxc8a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr16_+_51180938 3.57 ENSDART00000169022
high mobility group nucleosomal binding domain 2
chr17_+_50248152 3.24 ENSDART00000153998
zinc finger, C2HC-type containing 1C
chr20_-_7072487 3.20 ENSDART00000145954
si:ch211-121a2.2
chr11_-_40728380 3.14 ENSDART00000023745
coiled-coil domain containing 114
chr5_-_29671586 2.87 ENSDART00000098336
sperm acrosome associated 9
chr5_+_29671681 2.41 ENSDART00000043096
adenylate kinase 8
chr2_+_16482338 2.30 ENSDART00000143912
F-box protein 36b
chr20_-_14925281 1.91 ENSDART00000152641
dynamin 3a
chr16_+_4497302 1.76 ENSDART00000081826
ENSDART00000148096
tetratricopeptide repeat domain 29
chr20_-_14924858 1.69 ENSDART00000047039
dynamin 3a
chr1_+_22691256 1.47 ENSDART00000017413
zinc finger, MYND-type containing 10
chr4_-_22472653 1.43 ENSDART00000066903
ENSDART00000130072
ENSDART00000123369
lysine (K)-specific methyltransferase 2E
chrM_+_9735 1.39 ENSDART00000093613
cytochrome c oxidase III, mitochondrial
chr10_+_6884627 1.34 ENSDART00000125262
ENSDART00000121729
ENSDART00000105384
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr7_-_40110140 1.34 ENSDART00000173469
si:ch73-174h16.5
chr5_+_19343880 1.31 ENSDART00000148130
acetyl-CoA carboxylase beta
chr21_+_30355767 1.26 ENSDART00000189948

chr18_+_3037998 1.23 ENSDART00000185844
ENSDART00000162657
ribosomal protein S3
chr8_-_13064330 1.19 ENSDART00000129168
si:dkey-208b23.5
chrM_+_9052 1.05 ENSDART00000093612
ATP synthase 6, mitochondrial
chr4_-_815871 1.05 ENSDART00000067455
dihydropyrimidinase-like 5b
chr24_-_38657683 1.00 ENSDART00000154843
si:ch1073-164k15.3
chr7_-_45999333 0.99 ENSDART00000158603
si:ch211-260e23.8
chr24_+_26997798 0.96 ENSDART00000089506
La ribonucleoprotein domain family, member 4B
chr13_+_13693722 0.93 ENSDART00000110509
si:ch211-194c3.5
chr8_-_12403077 0.92 ENSDART00000142150
PHD finger protein 19
chr10_+_42358426 0.88 ENSDART00000025691
drebrin-like a
chr7_-_48667056 0.87 ENSDART00000006378
cyclin-dependent kinase inhibitor 1Ca
chr3_+_30500968 0.87 ENSDART00000103447
si:dkey-13n23.3
chr7_-_24046999 0.87 ENSDART00000144616
ENSDART00000124653
ENSDART00000127813
dehydrogenase/reductase (SDR family) member 4
chr5_+_69981453 0.87 ENSDART00000143860
si:ch211-154e10.1
chr10_-_35108683 0.87 ENSDART00000049633
zgc:110006
chr20_+_40457599 0.81 ENSDART00000017553
serine incorporator 1
chr20_-_45812144 0.78 ENSDART00000147897
ENSDART00000147637
fermitin family member 1
chr25_-_3470910 0.71 ENSDART00000029067
ENSDART00000186737
HMG-box transcription factor 1
chr21_-_26490186 0.71 ENSDART00000009889
zgc:110540
chr15_+_15856178 0.67 ENSDART00000080338
dual specificity phosphatase 14
chr3_+_22442445 0.67 ENSDART00000190921
WNK lysine deficient protein kinase 4b
chr2_+_35993404 0.67 ENSDART00000170845
laminin, gamma 2
chr25_+_31868268 0.66 ENSDART00000022325
poly (ADP-ribose) polymerase family, member 16
chr7_-_67894046 0.66 ENSDART00000168964
si:ch73-315f9.2
chr23_+_40604951 0.60 ENSDART00000114959
cadherin 24, type 2a
chr10_-_5847655 0.58 ENSDART00000192773
ankyrin repeat domain 55
chr10_-_26744131 0.57 ENSDART00000020096
ENSDART00000162710
ENSDART00000179853
fibroblast growth factor 13b
chr21_-_32097908 0.54 ENSDART00000147387
si:ch211-160j14.3
chr2_+_20793982 0.53 ENSDART00000014785
proteoglycan 4a
chr8_+_18624658 0.53 ENSDART00000089141
fibronectin type III and SPRY domain containing 1
chr23_-_16485190 0.52 ENSDART00000155038
si:dkeyp-100a5.4
chr13_+_35339182 0.51 ENSDART00000019323
jagged 1b
chr2_-_30668580 0.49 ENSDART00000087270
catenin (cadherin-associated protein), delta 2b
chr20_+_11731039 0.49 ENSDART00000152215
ENSDART00000152585
si:ch211-155o21.3
chr14_-_30587814 0.49 ENSDART00000144912
ENSDART00000149714
transmembrane protein 265
chr16_+_13818743 0.47 ENSDART00000090191
folliculin
chr8_+_52637507 0.44 ENSDART00000163830
si:dkey-90l8.3
chr20_-_9095105 0.43 ENSDART00000140792
OMA1 zinc metallopeptidase
chr6_-_30210378 0.42 ENSDART00000157359
ENSDART00000113924
leucine rich repeat containing 7
chr2_-_17235891 0.42 ENSDART00000144251
artemin b
chr22_-_1079773 0.40 ENSDART00000136668
si:ch1073-15f12.3
chr10_+_11355841 0.38 ENSDART00000193067
ENSDART00000064215
COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)
chr18_+_17827149 0.36 ENSDART00000190237
ENSDART00000189345
si:ch211-216l23.1
chr16_-_28878080 0.36 ENSDART00000149501
si:dkey-239n17.4
chr23_+_36130883 0.35 ENSDART00000103132
homeobox C4a
chr11_-_1509773 0.34 ENSDART00000050762
phosphatase and actin regulator 3b
chr22_-_17474583 0.33 ENSDART00000148027
si:ch211-197g15.8
chr15_-_35252522 0.33 ENSDART00000144153
ENSDART00000059195
mitochondrial fission factor
chr2_+_4207209 0.30 ENSDART00000157903
ENSDART00000166476
GATA binding protein 6
chr15_-_15357178 0.30 ENSDART00000106120
3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2
chr5_+_66433287 0.30 ENSDART00000170757
kinetochore associated 1
chr13_+_31321297 0.28 ENSDART00000143308
anthrax toxin receptor 1d
chr2_+_31833997 0.28 ENSDART00000066788
ependymin related 1
chr11_-_21528056 0.27 ENSDART00000181626
SLIT-ROBO Rho GTPase activating protein 2
chr4_+_14727018 0.27 ENSDART00000124189
cytidine monophosphate N-acetylneuraminic acid synthetase a
chr11_+_33818179 0.25 ENSDART00000109418
speckle-type POZ protein-like b
chr9_-_21918963 0.24 ENSDART00000090782
LIM domain 7a
chr16_-_27749172 0.24 ENSDART00000145198
STEAP family member 4
chr4_+_14727212 0.24 ENSDART00000158094
cytidine monophosphate N-acetylneuraminic acid synthetase a
chr7_+_48667081 0.23 ENSDART00000083473
transient receptor potential cation channel, subfamily M, member 5
chr6_-_43283122 0.23 ENSDART00000186022
FERM domain containing 4Ba
chr13_+_36622100 0.23 ENSDART00000133198
si:ch211-67f24.7
chr1_-_40911332 0.23 ENSDART00000027463
H6 family homeobox 4
chr22_-_17474781 0.21 ENSDART00000186817
si:ch211-197g15.8
chr21_+_22738939 0.21 ENSDART00000151342
ENSDART00000079145
Rho GTPase activating protein 42a
chr10_+_2899108 0.19 ENSDART00000147031
endoplasmic reticulum aminopeptidase 1a
chr6_+_18321627 0.18 ENSDART00000183107
ENSDART00000189715
caspase recruitment domain family, member 14
chr21_+_29077509 0.18 ENSDART00000128561
endothelial cell surface expressed chemotaxis and apoptosis regulator
chr11_-_6188413 0.17 ENSDART00000109972
chemokine (C-C motif) ligand 44
chr5_-_42904329 0.17 ENSDART00000112807
chemokine (C-X-C motif) ligand 20
chr22_+_1170294 0.16 ENSDART00000159761
ENSDART00000169809
interferon regulatory factor 6
chr15_-_42736433 0.15 ENSDART00000154379
si:ch211-181d7.1
chr4_-_5333971 0.15 ENSDART00000067375
O-sialoglycoprotein endopeptidase
chr13_-_31812394 0.14 ENSDART00000124445
SERTA domain containing 4
chr11_+_30244356 0.14 ENSDART00000036050
ENSDART00000150080
retinoschisin 1a
chr17_-_43556208 0.14 ENSDART00000188424
5'-nucleotidase, cytosolic IAb
chr19_+_16064439 0.13 ENSDART00000151169
glucocorticoid modulatory element binding protein 1
chr21_-_35419486 0.13 ENSDART00000138529
si:dkeyp-23e4.3
chr18_+_27738349 0.11 ENSDART00000187816
tetraspanin 18b
chr10_-_21955231 0.11 ENSDART00000183695

chr1_-_58036509 0.11 ENSDART00000081122
si:ch211-114l13.7
chr5_+_63857055 0.10 ENSDART00000138950
regulator of G protein signaling 3b
chr11_-_11266882 0.09 ENSDART00000020256
lengsin, lens protein with glutamine synthetase domain
chr13_+_12299997 0.09 ENSDART00000108535
gamma-aminobutyric acid (GABA) A receptor, beta 1
chr15_-_14552101 0.08 ENSDART00000171169
numb homolog (Drosophila)-like
chr17_-_43556415 0.08 ENSDART00000190102
ENSDART00000193156
5'-nucleotidase, cytosolic IAb
chr20_-_9462433 0.07 ENSDART00000152674
ENSDART00000040557
zgc:101840
chr11_+_11267493 0.07 ENSDART00000148425
protein tyrosine phosphatase type IVA, member 1
chr8_-_31107537 0.07 ENSDART00000098925
vestigial like 4 like
chr8_+_22516728 0.07 ENSDART00000146013
si:ch211-261n11.3
chr17_+_26611929 0.07 ENSDART00000166450
ENSDART00000087023
tetratricopeptide repeat domain 7B
chr8_-_30204650 0.07 ENSDART00000133209
zgc:162939
chr12_-_4532066 0.06 ENSDART00000092687
transient receptor potential cation channel, subfamily M, member 4b, transient receptor potential cation channel, subfamily M, member 4b, tandem duplicate 2
chr15_+_31899312 0.06 ENSDART00000155315
furry homolog a (Drosophila)
chr6_+_40591149 0.06 ENSDART00000189060
ENSDART00000188298
fibroblast growth factor receptor substrate 3
chr14_-_46173265 0.05 ENSDART00000164321
zmp:0000000758
chr25_-_13490744 0.05 ENSDART00000056721
lactate dehydrogenase D
chr1_+_53842344 0.05 ENSDART00000114506
cytokine receptor family member B17
chr15_-_43284021 0.05 ENSDART00000041677
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr15_+_841383 0.04 ENSDART00000115077
zgc:174573
chr19_+_10592778 0.04 ENSDART00000135488
ENSDART00000151624
si:dkey-211g8.5
chr6_+_24398907 0.04 ENSDART00000167482
transforming growth factor, beta receptor III
chr2_+_3502430 0.04 ENSDART00000113395
zgc:92744
chr14_-_27121854 0.04 ENSDART00000173119
protocadherin 11
chr11_+_37250839 0.04 ENSDART00000170209
interleukin 17 receptor C
chr13_+_31070181 0.03 ENSDART00000110560
ENSDART00000146088
si:ch211-223a10.1
chr23_-_10831995 0.03 ENSDART00000142533
PDZ domain containing RING finger 3a
chr21_-_5856050 0.03 ENSDART00000115367

chr4_-_49582758 0.03 ENSDART00000180834
ENSDART00000187608
si:dkey-159n16.2
chr10_+_40568735 0.03 ENSDART00000136468
ENSDART00000182841
trace amine associated receptor 18i
chr16_-_21038015 0.02 ENSDART00000059239
sorting nexin 10b
chr11_-_7380674 0.01 ENSDART00000014979
ENSDART00000103418
vitellogenin 3, phosvitinless

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxc8a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0036159 inner dynein arm assembly(GO:0036159)
0.4 1.2 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.3 1.3 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
0.2 3.6 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.2 0.9 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.1 0.7 GO:0003096 renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294)
0.1 0.9 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.1 1.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.4 GO:0014707 branchiomeric skeletal muscle development(GO:0014707)
0.1 0.9 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.1 1.3 GO:0051445 regulation of meiotic cell cycle(GO:0051445)
0.1 0.5 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.1 0.3 GO:0001773 myeloid dendritic cell activation(GO:0001773) myeloid dendritic cell differentiation(GO:0043011)
0.1 0.2 GO:0015677 copper ion import(GO:0015677)
0.1 1.2 GO:2001235 positive regulation of apoptotic signaling pathway(GO:2001235)
0.1 1.0 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.1 0.3 GO:2001223 negative regulation of neuron migration(GO:2001223)
0.1 0.4 GO:1990845 adaptive thermogenesis(GO:1990845)
0.1 0.5 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 3.5 GO:0009142 nucleoside triphosphate biosynthetic process(GO:0009142)
0.0 0.8 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.0 0.4 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.0 0.6 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.5 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.3 GO:1901998 toxin transport(GO:1901998)
0.0 0.5 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.0 0.1 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.0 0.1 GO:0002369 T cell cytokine production(GO:0002369)
0.0 0.6 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.2 GO:0050909 sensory perception of taste(GO:0050909)
0.0 0.2 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747) regulation of vitamin metabolic process(GO:0030656) regulation of retinoic acid biosynthetic process(GO:1900052)
0.0 0.7 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 0.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.2 GO:0019885 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.2 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.0 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.2 GO:0035479 angioblast cell migration from lateral mesoderm to midline(GO:0035479)
0.0 0.2 GO:0031397 negative regulation of protein ubiquitination(GO:0031397)
0.0 0.7 GO:0043113 receptor clustering(GO:0043113)
0.0 0.1 GO:0006542 glutamine biosynthetic process(GO:0006542)
0.0 3.7 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 0.2 GO:0042119 granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.2 3.6 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.2 1.5 GO:0034451 centriolar satellite(GO:0034451)
0.1 0.7 GO:0097224 sperm connecting piece(GO:0097224)
0.1 0.3 GO:0044327 dendritic spine head(GO:0044327)
0.1 1.4 GO:0045277 respiratory chain complex IV(GO:0045277)
0.1 0.9 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.9 GO:0002102 podosome(GO:0002102)
0.1 1.0 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.1 0.7 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 1.3 GO:0043186 P granule(GO:0043186)
0.0 1.2 GO:0044447 axoneme part(GO:0044447)
0.0 0.4 GO:0008180 COP9 signalosome(GO:0008180)
0.0 1.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.1 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.5 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 3.5 GO:0000785 chromatin(GO:0000785)
0.0 0.6 GO:0030426 growth cone(GO:0030426)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.4 GO:0004127 cytidylate kinase activity(GO:0004127)
0.3 1.3 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.2 3.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 0.9 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.7 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.1 1.0 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 0.2 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.1 1.4 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.1 GO:0061711 N(6)-L-threonylcarbamoyladenine synthase(GO:0061711)
0.0 3.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.5 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 0.2 GO:0005153 interleukin-8 receptor binding(GO:0005153)
0.0 0.7 GO:0019869 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.0 0.9 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.5 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.7 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.5 GO:0005112 Notch binding(GO:0005112)
0.0 0.2 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.8 GO:0005178 integrin binding(GO:0005178)
0.0 0.1 GO:0004356 glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.0 0.3 GO:0031267 small GTPase binding(GO:0031267)
0.0 0.2 GO:0008253 5'-nucleotidase activity(GO:0008253)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.7 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.8 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.7 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization