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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for irf10+irf8+irf9

Z-value: 0.82

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Transcription factors associated with irf10+irf8+irf9

Gene Symbol Gene ID Gene Info
irf9
ENSDARG00000016457 interferon regulatory factor 9
irf10
ENSDARG00000027658 interferon regulatory factor 10
irf8
ENSDARG00000056407 interferon regulatory factor 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
irf9dr11_v1_chr12_+_13282797_132828070.951.1e-09Click!
irf10dr11_v1_chr23_+_642001_6420520.911.5e-07Click!
irf8dr11_v1_chr18_+_30567945_305679450.626.3e-03Click!

Activity profile of irf10+irf8+irf9 motif

Sorted Z-values of irf10+irf8+irf9 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_59029485 2.59 ENSDART00000050140
CABZ01088367.1

chr2_+_52122663 2.52 ENSDART00000111266
theg
theg spermatid protein
chr4_-_13567387 2.26 ENSDART00000132971
ENSDART00000102010
mdm1
Mdm1 nuclear protein homolog (mouse)
chr10_-_34889053 2.25 ENSDART00000136966
ccdc169
coiled-coil domain containing 169
chr13_-_37608441 2.24 ENSDART00000140230
zgc:123068
zgc:123068
chr24_+_37902687 2.17 ENSDART00000042273
ccdc78
coiled-coil domain containing 78
chr19_-_7115229 2.02 ENSDART00000001930
psmb13a
proteasome subunit beta 13a
chr8_-_50525360 1.91 ENSDART00000175648
CABZ01060030.1

chr10_+_5060191 1.85 ENSDART00000145908
ENSDART00000122397
carm1l
coactivator-associated arginine methyltransferase 1, like
chr12_-_30583668 1.84 ENSDART00000153406
casp7
caspase 7, apoptosis-related cysteine peptidase
chr20_-_16223245 1.66 ENSDART00000014721
echdc2
enoyl CoA hydratase domain containing 2
chr3_+_29941777 1.58 ENSDART00000113889
ifi35
interferon-induced protein 35
chr2_-_24554416 1.57 ENSDART00000052061
cnn2
calponin 2
chr15_-_17071328 1.56 ENSDART00000122617
si:ch211-24o10.6
si:ch211-24o10.6
chr20_+_54356540 1.52 ENSDART00000143591
znf410
zinc finger protein 410
chr6_+_29217392 1.52 ENSDART00000006386
atp1b1a
ATPase Na+/K+ transporting subunit beta 1a
chr19_+_7115223 1.47 ENSDART00000001359
psmb12
proteasome subunit beta 12
chr4_-_12795030 1.47 ENSDART00000150427
b2m
beta-2-microglobulin
chr20_+_54356272 1.45 ENSDART00000145735
znf410
zinc finger protein 410
chr10_-_9410068 1.42 ENSDART00000041382
morn5
MORN repeat containing 5
chr9_-_30576522 1.38 ENSDART00000101085
morc3a
MORC family CW-type zinc finger 3a
chr19_-_7110617 1.25 ENSDART00000104838
psmb8a
proteasome subunit beta 8A
chr15_-_31067589 1.21 ENSDART00000060157
lgals9l3
lectin, galactoside-binding, soluble, 9 (galectin 9)-like 3
chr18_+_26422124 1.20 ENSDART00000060245
ctsh
cathepsin H
chr1_-_47161996 1.18 ENSDART00000053153
mhc1zba
major histocompatibility complex class I ZBA
chr16_+_29492937 1.17 ENSDART00000011497
ctsk
cathepsin K
chr18_+_34667486 1.08 ENSDART00000163583
CR626874.1

chr10_-_4375190 1.07 ENSDART00000016102
CABZ01073795.1

chr10_+_26645953 1.04 ENSDART00000131482
adgrg4b
adhesion G protein-coupled receptor G4b
chr4_-_779796 1.03 ENSDART00000128743
tmem214
transmembrane protein 214
chr13_-_37642890 1.02 ENSDART00000146483
ENSDART00000136071
ENSDART00000111786
si:dkey-188i13.9
si:dkey-188i13.9
chr13_+_27232848 0.98 ENSDART00000138043
rin2
Ras and Rab interactor 2
chr25_-_27665978 0.97 ENSDART00000123590
si:ch211-91p5.3
si:ch211-91p5.3
chr4_-_26108053 0.93 ENSDART00000066951
si:ch211-244b2.4
si:ch211-244b2.4
chr15_+_2421432 0.93 ENSDART00000193772
hephl1a
hephaestin-like 1a
chr1_+_2129164 0.91 ENSDART00000074923
ENSDART00000124534
mbnl2
muscleblind-like splicing regulator 2
chr24_+_12945803 0.89 ENSDART00000005105
psme1
proteasome activator subunit 1
chr15_+_13984879 0.89 ENSDART00000159438
zgc:162730
zgc:162730
chr16_+_29514473 0.88 ENSDART00000034102
ctss2.2
cathepsin S, ortholog 2, tandem duplicate 2
chr22_-_10580194 0.86 ENSDART00000105848
SHISA4 (1 of many)
si:dkey-42i9.7
chr19_-_325584 0.85 ENSDART00000134266
gpd1c
glycerol-3-phosphate dehydrogenase 1c
chr3_-_23596532 0.85 ENSDART00000124921
ube2z
ubiquitin-conjugating enzyme E2Z
chr15_-_21702317 0.84 ENSDART00000155824
IL4I1
si:dkey-40g16.6
chr15_-_29162193 0.84 ENSDART00000138449
ENSDART00000099885
xaf1
XIAP associated factor 1
chr21_+_8341774 0.83 ENSDART00000129749
ENSDART00000055325
ENSDART00000133804
psmb7
proteasome subunit beta 7
chr15_-_47929455 0.81 ENSDART00000064462
psma6l
proteasome subunit alpha 6, like
chr22_+_12798569 0.81 ENSDART00000005720
stat1a
signal transducer and activator of transcription 1a
chr3_-_12026741 0.81 ENSDART00000132238
cfap70
cilia and flagella associated protein 70
chr10_+_26646104 0.80 ENSDART00000187685
adgrg4b
adhesion G protein-coupled receptor G4b
chr22_+_38301365 0.79 ENSDART00000137339
traf5
Tnf receptor-associated factor 5
chr13_+_28495419 0.79 ENSDART00000025583
fgf8a
fibroblast growth factor 8a
chr23_+_642001 0.78 ENSDART00000030643
ENSDART00000124850
irf10
interferon regulatory factor 10
chr4_-_26107841 0.78 ENSDART00000172012
si:ch211-244b2.4
si:ch211-244b2.4
chr25_+_14092871 0.76 ENSDART00000067239
guca1g
guanylate cyclase activator 1g
chr17_+_35362851 0.75 ENSDART00000137659
cmpk2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr25_+_4979446 0.74 ENSDART00000154131
ENSDART00000155537
si:ch73-265h17.1
si:ch73-265h17.1
chr18_-_12270845 0.73 ENSDART00000143923
ENSDART00000125555
ENSDART00000062360
ENSDART00000062216
nup205
nucleoporin 205
chr19_+_7124337 0.72 ENSDART00000031380
tap2a
transporter associated with antigen processing, subunit type a
chr20_+_38525567 0.72 ENSDART00000147787
znf512
zinc finger protein 512
chr5_+_13373593 0.72 ENSDART00000051668
ENSDART00000183883
ccl19a.2
chemokine (C-C motif) ligand 19a, tandem duplicate 2
chr4_-_17669881 0.71 ENSDART00000066997
dram1
DNA-damage regulated autophagy modulator 1
chr13_-_45155792 0.70 ENSDART00000163556
runx3
runt-related transcription factor 3
chr7_+_25053331 0.70 ENSDART00000173998
si:dkey-23i12.7
si:dkey-23i12.7
chr5_-_24869213 0.68 ENSDART00000112287
ENSDART00000144635
gas2l1
growth arrest-specific 2 like 1
chr23_-_31974060 0.67 ENSDART00000168087
BX927210.1

chr22_-_17499513 0.65 ENSDART00000105460
si:ch211-197g15.6
si:ch211-197g15.6
chr25_+_35942867 0.63 ENSDART00000066985
hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
chr8_+_20679759 0.63 ENSDART00000088668
nfic
nuclear factor I/C
chr25_-_35524166 0.63 ENSDART00000156782
slc5a12
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr11_-_23458792 0.60 ENSDART00000032844
plekha6
pleckstrin homology domain containing, family A member 6
chr18_+_16246806 0.60 ENSDART00000142584
alx1
ALX homeobox 1
chr22_+_1683185 0.60 ENSDART00000158109
si:dkey-1b17.6
si:dkey-1b17.6
chr23_+_642395 0.58 ENSDART00000186995
irf10
interferon regulatory factor 10
chr15_+_17321218 0.58 ENSDART00000143796
cltcb
clathrin, heavy chain b (Hc)
chr18_+_10884996 0.57 ENSDART00000147613
mical3a
microtubule associated monooxygenase, calponin and LIM domain containing 3a
chr8_+_1187928 0.56 ENSDART00000127252
slc35d2
solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2
chr15_+_24588963 0.55 ENSDART00000155075
zgc:198241
zgc:198241
chr19_-_18855513 0.54 ENSDART00000162708
ppt2
palmitoyl-protein thioesterase 2
chr1_+_2128970 0.54 ENSDART00000180074
ENSDART00000022019
ENSDART00000098059
mbnl2
muscleblind-like splicing regulator 2
chr12_-_4598237 0.54 ENSDART00000152489
irf3
interferon regulatory factor 3
chr11_-_19775182 0.53 ENSDART00000037894
namptb
nicotinamide phosphoribosyltransferase b
chr9_+_51147764 0.51 ENSDART00000188480
ifih1
interferon induced with helicase C domain 1
chr22_-_36750589 0.51 ENSDART00000010824
acy1
aminoacylase 1
chr23_-_4409668 0.51 ENSDART00000081823
si:ch73-142c19.1
si:ch73-142c19.1
chr12_+_27114199 0.51 ENSDART00000150017
ttll6
tubulin tyrosine ligase-like family, member 6
chr7_-_66877058 0.50 ENSDART00000155954
adma
adrenomedullin a
chr12_+_38556462 0.50 ENSDART00000021069
ENSDART00000145377
rpl38
ribosomal protein L38
chr12_-_290413 0.49 ENSDART00000152496
adprm
ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
chr10_+_2899108 0.49 ENSDART00000147031
erap1a
endoplasmic reticulum aminopeptidase 1a
chr15_-_43873005 0.49 ENSDART00000190326
NOX4
NADPH oxidase 4
chr5_+_8919698 0.48 ENSDART00000046440
agpat9l
1-acylglycerol-3-phosphate O-acyltransferase 9, like
chr3_+_1942219 0.48 ENSDART00000114520
zgc:165583
zgc:165583
chr19_+_22085925 0.48 ENSDART00000185636
atp9b
ATPase phospholipid transporting 9B
chr22_-_17474583 0.48 ENSDART00000148027
si:ch211-197g15.8
si:ch211-197g15.8
chr13_-_50200042 0.47 ENSDART00000074230
pkz
protein kinase containing Z-DNA binding domains
chr8_-_27656765 0.47 ENSDART00000078491
mov10b.2
Moloney leukemia virus 10b, tandem duplicate 2
chr2_-_43135700 0.47 ENSDART00000098284
ftr14
finTRIM family, member 14
chr25_-_6223567 0.47 ENSDART00000067512
psma4
proteasome subunit alpha 4
chr24_-_28419444 0.47 ENSDART00000105749
nrros
negative regulator of reactive oxygen species
chr21_+_27340682 0.47 ENSDART00000011305
dpp3
dipeptidyl-peptidase 3
chr13_-_50200348 0.46 ENSDART00000038391
pkz
protein kinase containing Z-DNA binding domains
chr25_-_6420800 0.46 ENSDART00000153768
ptpn9a
protein tyrosine phosphatase, non-receptor type 9, a
chr17_+_23942268 0.45 ENSDART00000154153
si:ch211-189k9.2
si:ch211-189k9.2
chr16_-_9802449 0.45 ENSDART00000081208
tapbpl
TAP binding protein (tapasin)-like
chr15_+_2421729 0.45 ENSDART00000082294
ENSDART00000156428
hephl1a
hephaestin-like 1a
chr6_+_52947186 0.45 ENSDART00000155831
uba7
ubiquitin-like modifier activating enzyme 7
chr5_+_68267908 0.45 ENSDART00000130835
tnfsf13
TNF superfamily member 13
chr15_-_42760110 0.45 ENSDART00000152490
si:ch211-181d7.3
si:ch211-181d7.3
chr12_-_35936329 0.44 ENSDART00000166634
rnf213b
ring finger protein 213b
chr3_-_23596809 0.44 ENSDART00000156897
ube2z
ubiquitin-conjugating enzyme E2Z
chr16_-_9802998 0.44 ENSDART00000154217
tapbpl
TAP binding protein (tapasin)-like
chr7_-_19614916 0.44 ENSDART00000169029
zgc:194655
zgc:194655
chr16_-_43344859 0.44 ENSDART00000058680
psma2
proteasome subunit alpha 2
chr13_-_37631092 0.44 ENSDART00000108855
si:dkey-188i13.7
si:dkey-188i13.7
chr15_+_9861973 0.43 ENSDART00000170945
si:dkey-13m3.2
si:dkey-13m3.2
chr12_-_290782 0.41 ENSDART00000152527
ENSDART00000105694
adprm
ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
chr2_+_45479841 0.40 ENSDART00000151856
si:ch211-66k16.28
si:ch211-66k16.28
chr7_+_19615056 0.40 ENSDART00000124752
ENSDART00000190297
si:ch211-212k18.15
si:ch211-212k18.15
chr13_+_27232694 0.40 ENSDART00000131128
rin2
Ras and Rab interactor 2
chr21_+_33503835 0.39 ENSDART00000125658
clint1b
clathrin interactor 1b
chr13_-_7474324 0.39 ENSDART00000162550
si:dkey-196h17.9
si:dkey-196h17.9
chr19_-_18855717 0.38 ENSDART00000158192
ppt2
palmitoyl-protein thioesterase 2
chr4_+_5842433 0.38 ENSDART00000124085
ENSDART00000179848
usp18
ubiquitin specific peptidase 18
chr4_+_34417403 0.37 ENSDART00000186032
ENSDART00000167909
si:ch211-246b8.2
si:ch211-246b8.2
chr22_-_5958066 0.37 ENSDART00000145821
si:rp71-36a1.3
si:rp71-36a1.3
chr1_-_50710468 0.37 ENSDART00000080389
fam13a
family with sequence similarity 13, member A
chr3_-_61203203 0.37 ENSDART00000171787
pvalb1
parvalbumin 1
chr7_+_15618127 0.37 ENSDART00000080160
lrrc28
leucine rich repeat containing 28
chr23_-_37835794 0.37 ENSDART00000137358
cd40
CD40 molecule, TNF receptor superfamily member 5
chr7_-_37563883 0.37 ENSDART00000148805
nod2
nucleotide-binding oligomerization domain containing 2
chr5_-_52784152 0.37 ENSDART00000169307
fam189a2
family with sequence similarity 189, member A2
chr14_+_6159356 0.37 ENSDART00000157730
bscl2l
Bernardinelli-Seip congenital lipodystrophy 2, like
chr25_-_34979548 0.36 ENSDART00000153904
si:dkey-108k21.7
si:dkey-108k21.7
chr16_-_31686602 0.36 ENSDART00000170357
c1s
complement component 1, s subcomponent
chr22_+_9060699 0.36 ENSDART00000133993
BX248395.1

chr3_-_45361573 0.35 ENSDART00000154796
il21r.1
interleukin 21 receptor, tandem duplicate 1
chr10_+_3875716 0.35 ENSDART00000189268
ENSDART00000180624
TTC28
tetratricopeptide repeat domain 28
chr17_+_24006792 0.35 ENSDART00000122415
si:ch211-63b16.4
si:ch211-63b16.4
chr25_-_25550938 0.35 ENSDART00000150412
ENSDART00000103622
irf7
interferon regulatory factor 7
chr6_+_52947699 0.35 ENSDART00000180913
uba7
ubiquitin-like modifier activating enzyme 7
chr7_-_5191797 0.35 ENSDART00000172955
si:ch73-223f5.1
si:ch73-223f5.1
chr23_-_37575030 0.35 ENSDART00000031875
tor1l3
torsin family 1 like 3
chr9_+_51147380 0.34 ENSDART00000003913
ifih1
interferon induced with helicase C domain 1
chr18_+_33580391 0.33 ENSDART00000189300
si:dkey-47k20.4
si:dkey-47k20.4
chr24_+_10310577 0.32 ENSDART00000141718
otulina
OTU deubiquitinase with linear linkage specificity a
chr22_-_17474781 0.32 ENSDART00000186817
si:ch211-197g15.8
si:ch211-197g15.8
chr9_-_40935934 0.32 ENSDART00000155604
C2orf88
Small membrane A-kinase anchor protein
chr2_+_30144979 0.31 ENSDART00000129365
ENSDART00000130344
kcnb2
potassium voltage-gated channel, Shab-related subfamily, member 2
chr5_-_37820878 0.31 ENSDART00000165513
AL935065.1
Danio rerio uncharacterized LOC567472 (LOC567472), mRNA.
chr10_+_40623414 0.30 ENSDART00000187616
zgc:172131
zgc:172131
chr22_-_17459587 0.29 ENSDART00000142267
si:ch211-197g15.10
si:ch211-197g15.10
chr22_+_8772363 0.29 ENSDART00000161461
si:dkey-182g1.10
si:dkey-182g1.10
chr12_-_19151708 0.29 ENSDART00000057124
tefa
thyrotrophic embryonic factor a
chr4_+_3358383 0.29 ENSDART00000075320
nampta
nicotinamide phosphoribosyltransferase a
chr15_-_31043183 0.29 ENSDART00000100145
lgals9l1
lectin, galactoside-binding, soluble, 9 (galectin 9)-like 1
chr5_-_67661102 0.29 ENSDART00000013605
zbtb20
zinc finger and BTB domain containing 20
chr6_+_32834007 0.29 ENSDART00000157353
cyldl
cylindromatosis (turban tumor syndrome), like
chr11_-_36350421 0.28 ENSDART00000141477
psma5
proteasome subunit alpha 5
chr1_-_54938137 0.28 ENSDART00000147212
crtac1a
cartilage acidic protein 1a
chr1_-_1885516 0.28 ENSDART00000122187
ENSDART00000131675
si:ch211-132g1.3
si:ch211-132g1.3
chr3_-_52661242 0.28 ENSDART00000138018
zgc:113210
zgc:113210
chr7_-_804515 0.28 ENSDART00000159359
rela
v-rel avian reticuloendotheliosis viral oncogene homolog A
chr20_-_20402500 0.28 ENSDART00000190747
ENSDART00000185065
prkchb
protein kinase C, eta, b
chr25_-_35960229 0.28 ENSDART00000073434
snx20
sorting nexin 20
chr4_+_40953320 0.28 ENSDART00000151912
znf1136
zinc finger protein 1136
chr2_-_47870649 0.27 ENSDART00000142854
ftr05
finTRIM family, member 5
chr5_+_38662125 0.27 ENSDART00000136949
si:dkey-58f10.13
si:dkey-58f10.13
chr10_+_17776981 0.27 ENSDART00000141693
ccl19b
chemokine (C-C motif) ligand 19b
chr18_+_19990412 0.26 ENSDART00000155054
ENSDART00000090310
pias1b
protein inhibitor of activated STAT, 1b
chr6_+_58569808 0.26 ENSDART00000154393
helz2
helicase with zinc finger 2, transcriptional coactivator
chr8_-_25422186 0.26 ENSDART00000113492
ENSDART00000131736
kcnq2a
potassium voltage-gated channel, KQT-like subfamily, member 2a
chr2_+_41926707 0.26 ENSDART00000023208
zgc:110183
zgc:110183
chr22_+_1560991 0.26 ENSDART00000190639
AL954741.4

chr15_-_36369743 0.25 ENSDART00000155942
si:dkey-23k10.3
si:dkey-23k10.3
chr18_+_29402623 0.25 ENSDART00000014703
mafa
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog a (paralog a)
chr16_-_5115993 0.25 ENSDART00000138654
ttk
ttk protein kinase
chr3_-_4455951 0.25 ENSDART00000193908
ENSDART00000074077
trim35-3
tripartite motif containing 35-3
chr16_+_13855039 0.25 ENSDART00000113764
ENSDART00000143983
zgc:174888
zgc:174888
chr1_-_52443379 0.24 ENSDART00000144676
si:ch211-217k17.11
si:ch211-217k17.11
chr16_+_36906693 0.24 ENSDART00000160645
si:ch73-215d9.1
si:ch73-215d9.1
chr4_+_18707174 0.24 ENSDART00000142343
wnt7ba
wingless-type MMTV integration site family, member 7Ba
chr3_-_1938588 0.23 ENSDART00000013001
ENSDART00000186405
zgc:152753
zgc:152753
chr16_+_25806400 0.23 ENSDART00000154652
irgq1
immunity-related GTPase family, q1
chr16_+_48678655 0.23 ENSDART00000150156
tap1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr6_+_32834760 0.22 ENSDART00000121562
cyldl
cylindromatosis (turban tumor syndrome), like
chr5_+_45895613 0.22 ENSDART00000083937
polk
polymerase (DNA directed) kappa
chr1_-_30510839 0.21 ENSDART00000168189
ENSDART00000174868
igf2bp2b
insulin-like growth factor 2 mRNA binding protein 2b
chr1_-_49530615 0.21 ENSDART00000113315
si:ch211-281g13.5
si:ch211-281g13.5
chr15_-_34845414 0.20 ENSDART00000009892
gabbr1a
gamma-aminobutyric acid (GABA) B receptor, 1a
chr1_-_25177086 0.20 ENSDART00000144711
ENSDART00000177225
tmem154
transmembrane protein 154
chr15_+_32268790 0.20 ENSDART00000154457
fhdc4
FH2 domain containing 4
chr10_+_26689262 0.20 ENSDART00000123195
ENSDART00000132946
tmtops3b
teleost multiple tissue opsin 3b
chr16_+_43344475 0.19 ENSDART00000085282
mrpl32
mitochondrial ribosomal protein L32
chr2_-_38141997 0.19 ENSDART00000143469
trim110
tripartite motif containing 110
chr6_-_32834385 0.19 ENSDART00000129803
zc3h3
zinc finger CCCH-type containing 3
chr22_-_4778018 0.18 ENSDART00000143968
si:ch73-256j6.5
si:ch73-256j6.5
chr6_+_38427357 0.18 ENSDART00000148678
gabrb3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr12_-_17028255 0.18 ENSDART00000152678
ifit10
interferon-induced protein with tetratricopeptide repeats 10
chr4_+_43522680 0.17 ENSDART00000182252
si:dkeyp-53e4.4
si:dkeyp-53e4.4
chr11_+_25481046 0.17 ENSDART00000065940
opn1lw2
opsin 1 (cone pigments), long-wave-sensitive, 2

Network of associatons between targets according to the STRING database.

First level regulatory network of irf10+irf8+irf9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 0.4 GO:0035666 TRIF-dependent toll-like receptor signaling pathway(GO:0035666)
0.3 2.3 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.3 1.5 GO:0032689 negative regulation of interferon-gamma production(GO:0032689) CD4-positive, alpha-beta T cell proliferation(GO:0035739) regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000561) negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.2 0.7 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.2 7.6 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.2 1.5 GO:0098773 skin epidermis development(GO:0098773)
0.2 0.9 GO:0006116 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
0.2 0.5 GO:0036363 transforming growth factor beta activation(GO:0036363)
0.1 0.9 GO:0032608 interferon-beta production(GO:0032608) regulation of interferon-beta production(GO:0032648) positive regulation of interferon-beta production(GO:0032728)
0.1 0.8 GO:0021572 rhombomere 5 development(GO:0021571) rhombomere 6 development(GO:0021572) tongue development(GO:0043586) tongue morphogenesis(GO:0043587) taste bud development(GO:0061193) taste bud morphogenesis(GO:0061194) taste bud formation(GO:0061195)
0.1 0.6 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.1 0.4 GO:2000737 negative regulation of hematopoietic progenitor cell differentiation(GO:1901533) negative regulation of stem cell differentiation(GO:2000737)
0.1 0.8 GO:0034340 response to type I interferon(GO:0034340) type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.1 1.5 GO:0045824 negative regulation of innate immune response(GO:0045824)
0.1 0.5 GO:0071763 nuclear membrane organization(GO:0071763)
0.1 0.5 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
0.1 0.5 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.1 0.4 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 0.3 GO:0044771 meiotic cell cycle phase transition(GO:0044771) metaphase/anaphase transition of meiotic cell cycle(GO:0044785) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902102) negative regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902103) regulation of meiotic chromosome separation(GO:1905132) negative regulation of meiotic chromosome separation(GO:1905133)
0.1 1.3 GO:0018216 peptidyl-arginine methylation(GO:0018216)
0.1 1.4 GO:0006825 copper ion transport(GO:0006825)
0.1 0.6 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.1 0.7 GO:0006999 nuclear pore organization(GO:0006999)
0.1 1.6 GO:0043535 regulation of blood vessel endothelial cell migration(GO:0043535)
0.1 0.2 GO:0042590 antigen processing and presentation of exogenous peptide antigen(GO:0002478) antigen processing and presentation of exogenous antigen(GO:0019884) antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.1 0.3 GO:1990108 protein linear deubiquitination(GO:1990108)
0.1 0.5 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.4 GO:0034389 lipid particle organization(GO:0034389)
0.0 1.7 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 0.7 GO:0046686 response to cadmium ion(GO:0046686)
0.0 0.7 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.4 GO:0051601 exocyst localization(GO:0051601)
0.0 0.1 GO:0060584 regulation of systemic arterial blood pressure by endothelin(GO:0003100) vein smooth muscle contraction(GO:0014826) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0 0.7 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.3 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 1.0 GO:0097194 execution phase of apoptosis(GO:0097194)
0.0 0.1 GO:0055057 neuroblast division(GO:0055057)
0.0 0.5 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 2.2 GO:0014904 myotube cell development(GO:0014904) skeletal muscle fiber development(GO:0048741)
0.0 0.1 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 1.0 GO:0034341 response to interferon-gamma(GO:0034341) cellular response to interferon-gamma(GO:0071346)
0.0 0.8 GO:0002062 chondrocyte differentiation(GO:0002062)
0.0 0.2 GO:0019885 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.5 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.0 0.1 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 0.5 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.4 GO:0031638 zymogen activation(GO:0031638)
0.0 0.1 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.0 0.8 GO:0010952 positive regulation of endopeptidase activity(GO:0010950) positive regulation of peptidase activity(GO:0010952)
0.0 0.5 GO:0045332 phospholipid translocation(GO:0045332)
0.0 1.2 GO:0060348 bone development(GO:0060348)
0.0 0.3 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.0 0.1 GO:0048769 sarcomerogenesis(GO:0048769)
0.0 0.5 GO:0048747 muscle fiber development(GO:0048747)
0.0 0.6 GO:0051607 defense response to virus(GO:0051607)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 7.6 GO:0005839 proteasome core complex(GO:0005839)
0.2 1.5 GO:0042612 MHC class I protein complex(GO:0042612)
0.2 0.9 GO:0008537 proteasome activator complex(GO:0008537)
0.2 0.7 GO:0044611 nuclear pore inner ring(GO:0044611)
0.2 1.5 GO:0090533 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.1 0.9 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.6 GO:0071439 clathrin complex(GO:0071439)
0.1 0.4 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 0.3 GO:0043194 axon initial segment(GO:0043194)
0.0 0.3 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.2 GO:0097648 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.0 1.8 GO:0005814 centriole(GO:0005814)
0.0 0.1 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.5 GO:0030125 clathrin vesicle coat(GO:0030125)
0.0 0.5 GO:0043186 P granule(GO:0043186)
0.0 0.4 GO:0000145 exocyst(GO:0000145)
0.0 0.1 GO:0005790 smooth endoplasmic reticulum(GO:0005790)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.1 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.3 1.9 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.2 0.7 GO:0009041 uridylate kinase activity(GO:0009041)
0.2 0.9 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.2 0.9 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.2 1.7 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.2 0.5 GO:0032574 5'-3' RNA helicase activity(GO:0032574)
0.2 0.6 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.2 0.6 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.1 1.5 GO:0016936 galactoside binding(GO:0016936)
0.1 0.9 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 0.6 GO:0005461 UDP-glucuronic acid transmembrane transporter activity(GO:0005461) UDP-N-acetylgalactosamine transmembrane transporter activity(GO:0005463)
0.1 1.8 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 0.8 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 0.8 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 0.8 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.1 1.4 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 1.5 GO:0001671 ATPase activator activity(GO:0001671)
0.1 0.4 GO:0015440 peptide antigen-transporting ATPase activity(GO:0015433) peptide-transporting ATPase activity(GO:0015440) TAP binding(GO:0046977)
0.1 0.9 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.1 0.5 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.5 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.6 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 0.1 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.4 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.5 GO:0070739 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.0 1.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.3 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.1 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.0 0.4 GO:0031386 protein tag(GO:0031386)
0.0 0.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 0.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 1.0 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.5 GO:0019894 kinesin binding(GO:0019894)
0.0 0.1 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.3 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.1 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.0 0.9 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.3 GO:0004698 protein kinase C activity(GO:0004697) calcium-dependent protein kinase C activity(GO:0004698)
0.0 0.6 GO:0071949 FAD binding(GO:0071949)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 0.1 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.5 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.6 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 1.4 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.2 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.6 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.1 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.5 PID PTP1B PATHWAY Signaling events mediated by PTP1B

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.2 1.8 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 1.7 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 1.2 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 2.5 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 3.0 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 0.9 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.3 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.4 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.2 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.0 0.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.6 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.3 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.4 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.7 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 0.1 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.4 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 0.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells