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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for irf1b+irf2+irf2a

Z-value: 0.81

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Transcription factors associated with irf1b+irf2+irf2a

Gene Symbol Gene ID Gene Info
irf2a
ENSDARG00000007387 interferon regulatory factor 2a
irf2
ENSDARG00000040465 interferon regulatory factor 2
irf1b
ENSDARG00000043249 interferon regulatory factor 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
irf2adr11_v1_chr1_+_39865748_398657530.856.8e-06Click!
irf2dr11_v1_chr14_-_4121052_4121052-0.753.2e-04Click!
irf1bdr11_v1_chr21_+_45626136_45626136-0.475.0e-02Click!

Activity profile of irf1b+irf2+irf2a motif

Sorted Z-values of irf1b+irf2+irf2a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr23_+_43668756 1.97 ENSDART00000112598
otud4
OTU deubiquitinase 4
chr9_-_20853439 1.95 ENSDART00000028247
ENSDART00000133321
gdap2
ganglioside induced differentiation associated protein 2
chr15_+_25489406 1.94 ENSDART00000162482
zgc:152863
zgc:152863
chr14_+_36414856 1.72 ENSDART00000123343
ENSDART00000015761
neil3
nei-like DNA glycosylase 3
chr6_+_38896158 1.72 ENSDART00000029930
ENSDART00000131347
slc48a1b
solute carrier family 48 (heme transporter), member 1b
chr2_+_35603637 1.71 ENSDART00000147278
plk3
polo-like kinase 3 (Drosophila)
chr11_+_37638873 1.67 ENSDART00000186384
ENSDART00000184291
ENSDART00000131782
ENSDART00000140502
sh2d5
SH2 domain containing 5
chr2_-_42552666 1.61 ENSDART00000141399
dip2cb
disco-interacting protein 2 homolog Cb
chr16_+_23487051 1.58 ENSDART00000145496
icn2
ictacalcin 2
chr3_-_34586403 1.50 ENSDART00000151515
sept9a
septin 9a
chr5_+_44805269 1.46 ENSDART00000136965
ctsla
cathepsin La
chr14_-_41467497 1.46 ENSDART00000181220
mid1ip1l
MID1 interacting protein 1, like
chr11_+_1584747 1.45 ENSDART00000154583
si:dkey-40c23.2
si:dkey-40c23.2
chr5_+_44805028 1.44 ENSDART00000141198
ctsla
cathepsin La
chr19_-_47570672 1.39 ENSDART00000112155
rrm2
ribonucleotide reductase M2 polypeptide
chr23_-_36449111 1.38 ENSDART00000110478
zgc:174906
zgc:174906
chr5_+_44804791 1.34 ENSDART00000122288
ctsla
cathepsin La
chr3_+_51684963 1.33 ENSDART00000091180
ENSDART00000183711
ENSDART00000159493
baiap2a
BAI1-associated protein 2a
chr18_-_38270430 1.33 ENSDART00000139519
caprin1b
cell cycle associated protein 1b
chr22_-_8006342 1.33 ENSDART00000162028
sc:d217
sc:d217
chr3_-_36127234 1.31 ENSDART00000130917
coil
coilin p80
chr7_-_54430505 1.29 ENSDART00000167905
ano1
anoctamin 1, calcium activated chloride channel
chr8_-_51367298 1.27 ENSDART00000060628
chmp7
charged multivesicular body protein 7
chr20_-_23254876 1.26 ENSDART00000141510
ociad1
OCIA domain containing 1
chr2_-_32688905 1.24 ENSDART00000041146
nrbp2a
nuclear receptor binding protein 2a
chr7_+_40081630 1.22 ENSDART00000173559
zgc:112356
zgc:112356
chr22_-_37565348 1.21 ENSDART00000149482
ENSDART00000104478
fxr1
fragile X mental retardation, autosomal homolog 1
chr14_+_9485070 1.20 ENSDART00000161486
ENSDART00000137274
st3gal5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr13_+_7578111 1.20 ENSDART00000175431
gbf1
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr12_-_26537996 1.19 ENSDART00000087040
acsf2
acyl-CoA synthetase family member 2
chr24_-_34680956 1.18 ENSDART00000171009
ctnna1
catenin (cadherin-associated protein), alpha 1
chr7_+_39416336 1.15 ENSDART00000171783
CT030188.1

chr19_+_42336523 1.15 ENSDART00000151304
anp32e
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr4_+_20486041 1.14 ENSDART00000017572
ints13
integrator complex subunit 13
chr18_-_38270077 1.14 ENSDART00000185546
caprin1b
cell cycle associated protein 1b
chr19_-_35492693 1.13 ENSDART00000135838
ENSDART00000051745
ENSDART00000177052
ptp4a2b
protein tyrosine phosphatase type IVA, member 2b
chr14_-_33328031 1.12 ENSDART00000137997
sept6
septin 6
chr22_-_8174244 1.08 ENSDART00000156571
si:ch73-44m9.3
si:ch73-44m9.3
chr18_-_38270596 1.08 ENSDART00000098889
caprin1b
cell cycle associated protein 1b
chr7_+_55518519 1.06 ENSDART00000098476
ENSDART00000149915
cdt1
chromatin licensing and DNA replication factor 1
chr20_+_49787584 1.05 ENSDART00000193458
ENSDART00000181511
ENSDART00000185850
ENSDART00000185613
ENSDART00000191671
CABZ01078261.1

chr13_+_22675802 1.05 ENSDART00000145538
ENSDART00000143312
zgc:193505
zgc:193505
chr2_-_55797318 1.05 ENSDART00000158147
calr3b
calreticulin 3b
chr8_-_16725959 1.05 ENSDART00000183593
depdc1a
DEP domain containing 1a
chr19_-_31035155 1.04 ENSDART00000161882
bzw2
basic leucine zipper and W2 domains 2
chr9_-_14273652 1.04 ENSDART00000135458
abcb6b
ATP-binding cassette, sub-family B (MDR/TAP), member 6b
chr19_+_9111550 1.03 ENSDART00000088336
setdb1a
SET domain, bifurcated 1a
chr3_-_4501026 1.03 ENSDART00000163052
zgc:162198
zgc:162198
chr6_-_42949184 1.03 ENSDART00000147208
edem1
ER degradation enhancer, mannosidase alpha-like 1
chr16_+_14010242 0.99 ENSDART00000059928
fdps
farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase)
chr23_-_21763598 0.98 ENSDART00000145408
vps13d
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr17_+_50798484 0.97 ENSDART00000125787
stxbp6
syntaxin binding protein 6 (amisyn)
chr8_+_16726386 0.96 ENSDART00000144621
smim15
small integral membrane protein 15
chr4_-_1757460 0.95 ENSDART00000144074
tm7sf3
transmembrane 7 superfamily member 3
chr5_+_40835601 0.94 ENSDART00000147767
si:dkey-3h3.3
si:dkey-3h3.3
chr14_-_41478265 0.93 ENSDART00000149886
ENSDART00000016002
tspan7
tetraspanin 7
chr2_-_40889465 0.92 ENSDART00000192631
ENSDART00000180824
uggt1
UDP-glucose glycoprotein glucosyltransferase 1
chr21_-_26715270 0.92 ENSDART00000053794
banf1
barrier to autointegration factor 1
chr4_+_279669 0.91 ENSDART00000184884
CABZ01085275.1

chr23_-_21758253 0.91 ENSDART00000046613
vps13d
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr16_+_26439518 0.90 ENSDART00000041787
trim35-28
tripartite motif containing 35-28
chr3_+_36127287 0.90 ENSDART00000058605
ENSDART00000182500
scpep1
serine carboxypeptidase 1
chr16_+_30117798 0.89 ENSDART00000135723
ENSDART00000000198
sema6e
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6E
chr12_-_3053699 0.87 ENSDART00000139721
dcxr
dicarbonyl/L-xylulose reductase
chr20_+_715739 0.87 ENSDART00000136768
myo6a
myosin VIa
chr3_+_866044 0.87 ENSDART00000126857
FP102786.1

chr17_+_1632294 0.86 ENSDART00000191959
srp14
signal recognition particle 14
chr20_-_4793450 0.86 ENSDART00000053870
galca
galactosylceramidase a
chr3_-_21137362 0.86 ENSDART00000104051
cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr21_+_31253048 0.86 ENSDART00000178521
ENSDART00000132317
ENSDART00000040190
asl
argininosuccinate lyase
chr13_+_26703922 0.85 ENSDART00000020946
fancl
Fanconi anemia, complementation group L
chr23_+_2825940 0.85 ENSDART00000135781
plcg1
phospholipase C, gamma 1
chr24_-_31904924 0.84 ENSDART00000156060
ENSDART00000129741
ENSDART00000154276
si:ch73-78o10.1
si:ch73-78o10.1
chr6_+_41554794 0.84 ENSDART00000165424
srgap3
SLIT-ROBO Rho GTPase activating protein 3
chr25_-_12804450 0.83 ENSDART00000169717
ca5a
carbonic anhydrase Va
chr24_-_27256673 0.82 ENSDART00000181182
zmynd11
zinc finger, MYND-type containing 11
chr18_+_13248956 0.80 ENSDART00000080709
plcg2
phospholipase C, gamma 2
chr9_+_37754845 0.80 ENSDART00000100592
pdia5
protein disulfide isomerase family A, member 5
chr10_+_7718156 0.80 ENSDART00000189101
ggcx
gamma-glutamyl carboxylase
chr10_-_7821686 0.80 ENSDART00000121531
mat2aa
methionine adenosyltransferase II, alpha a
chr5_-_26247215 0.79 ENSDART00000136806
erap1b
endoplasmic reticulum aminopeptidase 1b
chr5_+_32815745 0.79 ENSDART00000181535
crata
carnitine O-acetyltransferase a
chr15_+_20352123 0.79 ENSDART00000011030
ENSDART00000163532
ENSDART00000169537
ENSDART00000161047
il15l
interleukin 15, like
chr6_+_29861288 0.79 ENSDART00000166782
dlg1
discs, large homolog 1 (Drosophila)
chr17_+_25871304 0.77 ENSDART00000185143
wapla
WAPL cohesin release factor a
chr17_-_7218481 0.77 ENSDART00000181967
SAMD5
sterile alpha motif domain containing 5
chr10_+_5954787 0.77 ENSDART00000161887
ENSDART00000160345
ENSDART00000190046
map3k1
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
chr21_+_19319804 0.75 ENSDART00000063621
abraxas2a
abraxas 2a, BRISC complex subunit
chr8_+_47897734 0.75 ENSDART00000140266
mfn2
mitofusin 2
chr15_-_2857961 0.75 ENSDART00000033263
ankrd49
ankyrin repeat domain 49
chr10_-_10016348 0.74 ENSDART00000129151
strbp
spermatid perinuclear RNA binding protein
chr6_+_13045885 0.74 ENSDART00000104757
casp8
caspase 8, apoptosis-related cysteine peptidase
chr14_-_45967712 0.73 ENSDART00000043751
ENSDART00000141357
macrod1
MACRO domain containing 1
chr7_+_66884291 0.73 ENSDART00000187499
sbf2
SET binding factor 2
chr14_-_1200854 0.72 ENSDART00000106672
arl9
ADP-ribosylation factor-like 9
chr6_-_52235118 0.72 ENSDART00000191243
tomm34
translocase of outer mitochondrial membrane 34
chr13_-_34858500 0.72 ENSDART00000184843
sptlc3
serine palmitoyltransferase, long chain base subunit 3
chr16_+_48631412 0.70 ENSDART00000154273
pbx2
pre-B-cell leukemia homeobox 2
chr7_-_30492018 0.69 ENSDART00000099639
ENSDART00000162705
ENSDART00000173663
adam10a
ADAM metallopeptidase domain 10a
chr21_-_13230925 0.69 ENSDART00000023834
setb
SET nuclear proto-oncogene b
chr21_-_33478164 0.69 ENSDART00000191542
si:ch73-42p12.2
si:ch73-42p12.2
chr11_-_2250767 0.69 ENSDART00000018131
hnrnpa1a
heterogeneous nuclear ribonucleoprotein A1a
chr15_-_14083028 0.69 ENSDART00000147796
ENSDART00000043492
ENSDART00000133080
trappc6bl
trafficking protein particle complex 6b-like
chr12_+_27285994 0.68 ENSDART00000087204
dusp3a
dual specificity phosphatase 3a
chr9_-_34260214 0.68 ENSDART00000012385
me3
malic enzyme 3, NADP(+)-dependent, mitochondrial
chr12_+_14149686 0.68 ENSDART00000123741
kbtbd2
kelch repeat and BTB (POZ) domain containing 2
chr11_-_30341431 0.67 ENSDART00000078378
cflara
CASP8 and FADD-like apoptosis regulator a
chr15_-_17169935 0.67 ENSDART00000110111
cul5a
cullin 5a
chr17_-_18797245 0.67 ENSDART00000045991
vrk1
vaccinia related kinase 1
chr25_-_2723682 0.67 ENSDART00000113382
adpgk
ADP-dependent glucokinase
chr13_-_36049008 0.66 ENSDART00000189978
lgmn
legumain
chr19_-_31035325 0.66 ENSDART00000147504
bzw2
basic leucine zipper and W2 domains 2
chr6_-_1566186 0.66 ENSDART00000156305
trim107
tripartite motif containing 107
chr4_-_26095755 0.65 ENSDART00000100611
ENSDART00000191266
si:ch211-244b2.3
si:ch211-244b2.3
chr25_-_12803723 0.65 ENSDART00000158787
ca5a
carbonic anhydrase Va
chr18_+_30998472 0.65 ENSDART00000154993
ENSDART00000099333
cd151l
CD151 antigen, like
chr22_-_11520405 0.65 ENSDART00000063157
slc26a11
solute carrier family 26 (anion exchanger), member 11
chr21_-_30181268 0.65 ENSDART00000167867
hnrnph1l
heterogeneous nuclear ribonucleoprotein H1, like
chr6_-_1566407 0.65 ENSDART00000112118
trim107
tripartite motif containing 107
chr13_+_11550454 0.65 ENSDART00000034935
ENSDART00000166908
desi2
desumoylating isopeptidase 2
chr25_-_19574146 0.65 ENSDART00000156811
si:ch211-59o9.10
si:ch211-59o9.10
chr8_-_13678415 0.65 ENSDART00000134153
ENSDART00000143331
si:dkey-258f14.3
si:dkey-258f14.3
chr21_+_25120546 0.64 ENSDART00000149507
ddx10
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
chr6_+_41555247 0.64 ENSDART00000084834
srgap3
SLIT-ROBO Rho GTPase activating protein 3
chr16_+_24978203 0.64 ENSDART00000156579
si:dkeyp-84f3.5
si:dkeyp-84f3.5
chr1_-_55750208 0.63 ENSDART00000142244
dnajb1b
DnaJ (Hsp40) homolog, subfamily B, member 1b
chr8_-_19051906 0.63 ENSDART00000089024
sema6bb
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Bb
chr8_-_14604606 0.63 ENSDART00000090254
ENSDART00000188953
cep350
centrosomal protein 350
chr5_+_52625975 0.63 ENSDART00000170341
ENSDART00000168317
apba1a
amyloid beta (A4) precursor protein-binding, family A, member 1a
chr5_+_19314574 0.62 ENSDART00000133247
rusc2
RUN and SH3 domain containing 2
chr18_-_6534516 0.62 ENSDART00000009217
ddx11
DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
chr13_+_7387822 0.62 ENSDART00000148240
exoc3l4
exocyst complex component 3-like 4
chr24_-_10828560 0.62 ENSDART00000132282
fam49bb
family with sequence similarity 49, member Bb
chr16_+_26439939 0.62 ENSDART00000143073
trim35-28
tripartite motif containing 35-28
chr22_+_31023205 0.61 ENSDART00000111561
zmp:0000000735
zmp:0000000735
chr1_-_51266394 0.61 ENSDART00000164016
kif16ba
kinesin family member 16Ba
chr14_-_14746767 0.61 ENSDART00000183755
ENSDART00000190938
ogt.1
O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1
chr13_-_33227411 0.61 ENSDART00000057386
golga5
golgin A5
chr11_-_11791718 0.61 ENSDART00000180476
cdc6
cell division cycle 6 homolog (S. cerevisiae)
chr7_+_66884570 0.60 ENSDART00000082664
sbf2
SET binding factor 2
chr13_-_6252498 0.60 ENSDART00000115157
tuba4l
tubulin, alpha 4 like
chr6_-_52234796 0.60 ENSDART00000001803
tomm34
translocase of outer mitochondrial membrane 34
chr21_-_40557281 0.60 ENSDART00000172327
taok1b
TAO kinase 1b
chr5_-_30382925 0.60 ENSDART00000125381
gig2o
grass carp reovirus (GCRV)-induced gene 2o
chr21_+_34992550 0.60 ENSDART00000109041
ENSDART00000135400
tmprss15
transmembrane protease, serine 15
chr11_+_31323746 0.59 ENSDART00000180220
ENSDART00000189937
sipa1l2
signal-induced proliferation-associated 1 like 2
chr10_-_25328814 0.59 ENSDART00000123820
tmem135
transmembrane protein 135
chr19_+_20201593 0.59 ENSDART00000163026
igf2bp3
insulin-like growth factor 2 mRNA binding protein 3
chr18_-_6534357 0.59 ENSDART00000192886
ddx11
DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
chr7_+_24023653 0.58 ENSDART00000141165
tinf2
TERF1 (TRF1)-interacting nuclear factor 2
chr4_-_9191220 0.58 ENSDART00000156919
hcfc2
host cell factor C2
chr2_-_42393590 0.58 ENSDART00000135529
slco5a1b
solute carrier organic anion transporter family member 5A1b
chr6_+_9793791 0.57 ENSDART00000149896
als2b
amyotrophic lateral sclerosis 2b (juvenile)
chr20_-_34663209 0.57 ENSDART00000132545
slc25a24
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr13_-_42066299 0.57 ENSDART00000111536
rmdn2
regulator of microtubule dynamics 2
chr21_-_13231101 0.56 ENSDART00000190943
setb
SET nuclear proto-oncogene b
chr21_-_21514176 0.56 ENSDART00000031205
nectin3b
nectin cell adhesion molecule 3b
chr2_+_9757453 0.56 ENSDART00000168972
pcyt1aa
phosphate cytidylyltransferase 1, choline, alpha a
chr3_+_27713610 0.55 ENSDART00000019004
arhgdig
Rho GDP dissociation inhibitor (GDI) gamma
chr4_+_26628822 0.55 ENSDART00000191030
ENSDART00000186113
ENSDART00000186764
ENSDART00000165158
iqsec3a
IQ motif and Sec7 domain 3a
chr19_+_15440841 0.55 ENSDART00000182329
lin28a
lin-28 homolog A (C. elegans)
chr6_-_1566581 0.54 ENSDART00000192993
trim107
tripartite motif containing 107
chr3_+_12593558 0.54 ENSDART00000186891
ENSDART00000159252
abca3b
ATP-binding cassette, sub-family A (ABC1), member 3b
chr13_-_25548733 0.53 ENSDART00000168099
ENSDART00000135788
ENSDART00000077655
mcmbp
minichromosome maintenance complex binding protein
chr6_+_9793495 0.53 ENSDART00000108524
als2b
amyotrophic lateral sclerosis 2b (juvenile)
chr8_+_36582915 0.53 ENSDART00000139482
pqbp1
polyglutamine binding protein 1
chr6_+_36839509 0.52 ENSDART00000190605
ENSDART00000104160
zgc:110788
zgc:110788
chr7_+_19483277 0.51 ENSDART00000173750
si:ch211-212k18.7
si:ch211-212k18.7
chr19_+_38167468 0.51 ENSDART00000160756
phf14
PHD finger protein 14
chr25_-_27722614 0.51 ENSDART00000190154
zgc:153935
zgc:153935
chr20_-_36408836 0.51 ENSDART00000076419
lbr
lamin B receptor
chr20_+_32481348 0.51 ENSDART00000185018
ostm1
osteopetrosis associated transmembrane protein 1
chr19_+_38168006 0.51 ENSDART00000087662
ENSDART00000177759
phf14
PHD finger protein 14
chr19_-_5865766 0.51 ENSDART00000191007
LO018585.1

chr5_+_17780475 0.50 ENSDART00000110783
ENSDART00000115227
chfr
checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
chr1_+_39865748 0.50 ENSDART00000131954
ENSDART00000130270
irf2a
interferon regulatory factor 2a
chr22_-_36926342 0.50 ENSDART00000151804
si:dkey-37m8.11
si:dkey-37m8.11
chr14_-_45967981 0.50 ENSDART00000188062
macrod1
MACRO domain containing 1
chr1_-_52201266 0.50 ENSDART00000143805
ENSDART00000023757
rab3da
RAB3D, member RAS oncogene family, a
chr4_-_12978925 0.49 ENSDART00000013839
tmbim4
transmembrane BAX inhibitor motif containing 4
chr21_-_43428040 0.49 ENSDART00000148325
stk26
serine/threonine protein kinase 26
chr9_-_39547907 0.49 ENSDART00000163635
erbb4b
erb-b2 receptor tyrosine kinase 4b
chr15_-_37867995 0.48 ENSDART00000192698
si:dkey-238d18.4
si:dkey-238d18.4
chr6_+_27452289 0.48 ENSDART00000186265
sned1
sushi, nidogen and EGF-like domains 1
chr23_-_4019928 0.48 ENSDART00000021062
slc9a8
solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
chr7_-_40578733 0.48 ENSDART00000173926
ENSDART00000010035
dnajb6b
DnaJ (Hsp40) homolog, subfamily B, member 6b
chr9_-_45601103 0.47 ENSDART00000180465
agr1
anterior gradient 1
chr12_+_17154655 0.46 ENSDART00000028003
ankrd22
ankyrin repeat domain 22
chr20_+_54295213 0.46 ENSDART00000074085
zp2.3
zona pellucida glycoprotein 2, tandem duplicate 3
chr17_-_35076730 0.46 ENSDART00000146590
mboat2a
membrane bound O-acyltransferase domain containing 2a
chr3_+_24094581 0.46 ENSDART00000138270
ENSDART00000131509
copz2
coatomer protein complex, subunit zeta 2
chr22_-_5553007 0.46 ENSDART00000165269
zgc:171601
zgc:171601
chr8_-_18880399 0.46 ENSDART00000169043
sh3gl1b
SH3-domain GRB2-like 1b
chr8_+_20415824 0.46 ENSDART00000009081
ENSDART00000145444
mob3a
MOB kinase activator 3A
chr18_-_44935174 0.45 ENSDART00000081025
pex16
peroxisomal biogenesis factor 16
chr15_+_8192715 0.45 ENSDART00000156442
ENSDART00000077660
mipep
mitochondrial intermediate peptidase
chr8_-_18879905 0.45 ENSDART00000100491
sh3gl1b
SH3-domain GRB2-like 1b
chr14_-_25095808 0.45 ENSDART00000184244
matr3l1.1
matrin 3-like 1.1
chr14_+_31618982 0.45 ENSDART00000026195
slc9a6a
solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6a
chr11_+_42600731 0.45 ENSDART00000182753
ENSDART00000192028
ENSDART00000085868
appl1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of irf1b+irf2+irf2a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.4 GO:0048308 organelle inheritance(GO:0048308) Golgi inheritance(GO:0048313)
0.5 2.0 GO:2000660 regulation of interleukin-1-mediated signaling pathway(GO:2000659) negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.4 1.2 GO:1901836 regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901836)
0.3 0.9 GO:0005997 xylulose metabolic process(GO:0005997)
0.3 0.8 GO:0035477 regulation of angioblast cell migration involved in selective angioblast sprouting(GO:0035477)
0.3 2.8 GO:1901678 heme transport(GO:0015886) iron coordination entity transport(GO:1901678)
0.3 1.9 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.3 1.3 GO:0030576 nuclear body organization(GO:0030575) Cajal body organization(GO:0030576)
0.3 0.8 GO:0060623 regulation of chromosome condensation(GO:0060623)
0.2 0.7 GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism(GO:0043903)
0.2 0.9 GO:0071788 endoplasmic reticulum tubular network maintenance(GO:0071788)
0.2 0.9 GO:0006526 arginine biosynthetic process(GO:0006526)
0.2 0.9 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.2 1.3 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.2 0.7 GO:0045668 negative regulation of osteoblast differentiation(GO:0045668)
0.2 1.0 GO:0045337 farnesyl diphosphate biosynthetic process(GO:0045337)
0.2 0.8 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.1 0.4 GO:0071514 genetic imprinting(GO:0071514)
0.1 0.8 GO:0017187 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.1 0.8 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.1 1.7 GO:0000076 DNA replication checkpoint(GO:0000076)
0.1 0.9 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.1 0.7 GO:0048662 regulation of smooth muscle cell proliferation(GO:0048660) negative regulation of smooth muscle cell proliferation(GO:0048662)
0.1 0.5 GO:1903573 negative regulation of response to endoplasmic reticulum stress(GO:1903573)
0.1 1.2 GO:0031937 methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.1 0.3 GO:0019062 virion attachment to host cell(GO:0019062) adhesion of symbiont to host(GO:0044406) adhesion of symbiont to host cell(GO:0044650)
0.1 0.9 GO:0035479 angioblast cell migration from lateral mesoderm to midline(GO:0035479)
0.1 0.4 GO:0060969 negative regulation of chromatin silencing(GO:0031936) negative regulation of gene silencing(GO:0060969)
0.1 0.9 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.1 0.9 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.1 1.3 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.1 0.4 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.1 1.0 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.1 0.3 GO:0014005 microglia development(GO:0014005)
0.1 0.7 GO:0046512 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.1 0.7 GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902041) negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.1 1.1 GO:0051642 centrosome localization(GO:0051642)
0.1 0.4 GO:0019563 glycerol catabolic process(GO:0019563)
0.1 0.9 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.1 0.2 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 0.5 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.1 0.8 GO:0036230 granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.1 0.3 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 0.3 GO:0036371 protein localization to T-tubule(GO:0036371)
0.1 1.2 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.1 0.2 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.1 0.9 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.4 GO:0051013 microtubule severing(GO:0051013)
0.0 0.2 GO:1903292 protein localization to Golgi membrane(GO:1903292)
0.0 0.8 GO:2000134 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 1.2 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.0 1.1 GO:0043486 histone exchange(GO:0043486)
0.0 0.3 GO:0086013 membrane repolarization during cardiac muscle cell action potential(GO:0086013)
0.0 0.4 GO:0007220 Notch receptor processing(GO:0007220)
0.0 0.4 GO:0031268 pseudopodium organization(GO:0031268) pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274)
0.0 1.9 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.2 GO:0070587 regulation of cell-cell adhesion involved in gastrulation(GO:0070587)
0.0 0.6 GO:1904356 regulation of telomere maintenance via telomere lengthening(GO:1904356)
0.0 0.3 GO:0044528 regulation of mitochondrial mRNA stability(GO:0044528)
0.0 1.0 GO:0071910 determination of liver left/right asymmetry(GO:0071910)
0.0 0.4 GO:0098719 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.2 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 1.7 GO:0006289 nucleotide-excision repair(GO:0006289)
0.0 0.3 GO:0035066 positive regulation of histone acetylation(GO:0035066)
0.0 0.2 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 1.2 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.0 0.3 GO:0070571 negative regulation of axon regeneration(GO:0048681) negative regulation of neuron projection regeneration(GO:0070571)
0.0 1.3 GO:0006626 protein targeting to mitochondrion(GO:0006626)
0.0 0.4 GO:0032933 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.9 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.6 GO:1903039 positive regulation of homotypic cell-cell adhesion(GO:0034112) positive regulation of T cell activation(GO:0050870) positive regulation of leukocyte cell-cell adhesion(GO:1903039)
0.0 0.6 GO:0034453 microtubule anchoring(GO:0034453)
0.0 1.5 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.7 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 3.0 GO:0017148 negative regulation of translation(GO:0017148)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.7 GO:0038061 NIK/NF-kappaB signaling(GO:0038061)
0.0 0.6 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.2 GO:0035188 hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0 0.2 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.5 GO:0006695 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.0 0.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797) regulation of stem cell proliferation(GO:0072091)
0.0 0.2 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.0 1.0 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 0.3 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 1.5 GO:0046890 regulation of lipid biosynthetic process(GO:0046890)
0.0 0.9 GO:0030261 chromosome condensation(GO:0030261)
0.0 0.6 GO:0007286 spermatid development(GO:0007286)
0.0 0.1 GO:0001919 regulation of receptor recycling(GO:0001919)
0.0 0.6 GO:0008272 sulfate transport(GO:0008272)
0.0 0.1 GO:0060339 negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.0 0.9 GO:0051453 regulation of intracellular pH(GO:0051453)
0.0 1.5 GO:0030336 negative regulation of cell migration(GO:0030336)
0.0 0.3 GO:0043551 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551) regulation of phospholipid metabolic process(GO:1903725)
0.0 2.2 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.6 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.2 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.0 0.1 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation(GO:1901533)
0.0 1.4 GO:0006334 nucleosome assembly(GO:0006334)
0.0 1.3 GO:0006090 pyruvate metabolic process(GO:0006090)
0.0 0.1 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.0 0.2 GO:0007020 microtubule nucleation(GO:0007020)
0.0 1.5 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 0.3 GO:0097320 membrane tubulation(GO:0097320)
0.0 0.8 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 0.2 GO:2000406 positive regulation of lymphocyte migration(GO:2000403) positive regulation of T cell migration(GO:2000406)
0.0 0.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.3 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.0 0.2 GO:0008105 asymmetric protein localization(GO:0008105) apical protein localization(GO:0045176)
0.0 0.2 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.1 GO:2000392 lamellipodium morphogenesis(GO:0072673) regulation of lamellipodium morphogenesis(GO:2000392)
0.0 1.7 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.5 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.8 GO:0050922 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of chemotaxis(GO:0050922) negative regulation of axon guidance(GO:1902668)
0.0 1.1 GO:0001894 tissue homeostasis(GO:0001894)
0.0 0.1 GO:0018197 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.5 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 0.2 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.0 0.6 GO:0030901 midbrain development(GO:0030901)
0.0 1.5 GO:0021782 glial cell development(GO:0021782)
0.0 0.5 GO:0007031 peroxisome organization(GO:0007031)
0.0 0.3 GO:0048546 digestive tract morphogenesis(GO:0048546)
0.0 0.1 GO:0007140 male meiosis(GO:0007140)
0.0 1.1 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 0.2 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.5 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.5 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0044326 dendritic spine neck(GO:0044326) dendritic filopodium(GO:1902737)
0.2 0.7 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.2 0.8 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.1 0.9 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 1.1 GO:0000812 Swr1 complex(GO:0000812)
0.1 1.3 GO:0000815 ESCRT III complex(GO:0000815)
0.1 0.9 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 0.5 GO:0005663 DNA replication factor C complex(GO:0005663)
0.1 1.3 GO:0015030 Cajal body(GO:0015030)
0.1 0.7 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1 2.6 GO:0005940 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.1 1.2 GO:0030057 desmosome(GO:0030057)
0.1 1.0 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 0.4 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.3 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.3 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.6 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.2 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0 1.2 GO:0000145 exocyst(GO:0000145)
0.0 0.8 GO:0032039 integrator complex(GO:0032039)
0.0 3.2 GO:0000922 spindle pole(GO:0000922)
0.0 0.9 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) nuclear chromosome, telomeric region(GO:0000784)
0.0 0.5 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.7 GO:0005801 cis-Golgi network(GO:0005801)
0.0 1.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.2 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 2.7 GO:0001726 ruffle(GO:0001726)
0.0 0.3 GO:0016586 RSC complex(GO:0016586)
0.0 0.6 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.5 GO:0042555 MCM complex(GO:0042555)
0.0 0.8 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.2 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024) nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.0 0.2 GO:0000938 GARP complex(GO:0000938)
0.0 0.1 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.5 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.1 GO:1902560 GMP reductase complex(GO:1902560)
0.0 5.2 GO:0005764 lysosome(GO:0005764)
0.0 0.3 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.0 0.3 GO:0030315 T-tubule(GO:0030315)
0.0 0.1 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 0.5 GO:0016605 PML body(GO:0016605)
0.0 1.3 GO:0005795 Golgi stack(GO:0005795)
0.0 0.6 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.3 GO:0070461 SAGA-type complex(GO:0070461)
0.0 0.5 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 1.6 GO:0043296 apical junction complex(GO:0043296)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
0.4 1.2 GO:0047760 medium-chain fatty acid-CoA ligase activity(GO:0031956) butyrate-CoA ligase activity(GO:0047760)
0.3 2.8 GO:0015232 heme transporter activity(GO:0015232)
0.3 1.0 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.3 1.1 GO:0070182 DNA polymerase binding(GO:0070182)
0.3 1.3 GO:0030620 U2 snRNA binding(GO:0030620)
0.2 0.7 GO:1902945 metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902945)
0.2 0.9 GO:0016842 amidine-lyase activity(GO:0016842)
0.2 0.8 GO:0008488 gamma-glutamyl carboxylase activity(GO:0008488)
0.2 0.8 GO:0004478 methionine adenosyltransferase activity(GO:0004478)
0.2 1.4 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.2 0.8 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.2 0.9 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.2 0.9 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.2 0.9 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.2 0.9 GO:0051748 UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
0.2 0.7 GO:0004473 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.1 0.6 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 1.4 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.1 2.0 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 1.7 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.1 1.0 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.1 0.6 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 0.9 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.1 1.0 GO:0015924 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.1 0.7 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1 0.6 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262) protein O-GlcNAc transferase activity(GO:0097363)
0.1 0.3 GO:0004061 arylformamidase activity(GO:0004061)
0.1 0.3 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 1.4 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.1 1.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.3 GO:0016436 rRNA (uridine) methyltransferase activity(GO:0016436)
0.1 0.3 GO:0004649 poly(ADP-ribose) glycohydrolase activity(GO:0004649)
0.1 1.0 GO:0043994 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.1 1.9 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 0.6 GO:0030332 cyclin binding(GO:0030332)
0.1 1.5 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 0.4 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0 0.5 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 1.6 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 0.2 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.2 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.2 GO:1900750 oligopeptide binding(GO:1900750)
0.0 0.4 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.4 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0 0.4 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.5 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.6 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 1.3 GO:0031072 heat shock protein binding(GO:0031072)
0.0 1.2 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.6 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0051500 D-aminoacyl-tRNA deacylase activity(GO:0051499) D-tyrosyl-tRNA(Tyr) deacylase activity(GO:0051500)
0.0 1.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 1.2 GO:0008013 beta-catenin binding(GO:0008013)
0.0 1.0 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 1.8 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.3 GO:0070628 proteasome binding(GO:0070628)
0.0 1.0 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.1 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.5 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 0.6 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.1 GO:0016657 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.0 0.5 GO:0005112 Notch binding(GO:0005112)
0.0 0.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.3 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 2.4 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.8 GO:0019902 phosphatase binding(GO:0019902)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.4 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.2 GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor(GO:0050664)
0.0 1.8 GO:0019208 phosphatase regulator activity(GO:0019208)
0.0 1.2 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.7 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.8 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.4 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 1.9 GO:0060090 binding, bridging(GO:0060090)
0.0 0.2 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.6 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.0 0.2 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.4 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 4.2 GO:0061630 ubiquitin protein ligase activity(GO:0061630)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 0.7 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1 2.0 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 1.2 PID ARF 3PATHWAY Arf1 pathway
0.0 0.8 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 1.1 PID BARD1 PATHWAY BARD1 signaling events
0.0 1.1 PID ATR PATHWAY ATR signaling pathway
0.0 0.8 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.2 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.3 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.5 PID P73PATHWAY p73 transcription factor network
0.0 0.9 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.6 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.7 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.6 PID E2F PATHWAY E2F transcription factor network
0.0 0.2 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.2 0.9 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.1 1.5 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 1.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 3.1 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 2.0 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 0.8 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 0.7 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.1 1.5 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 0.9 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 0.8 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 0.1 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 2.0 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.9 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 1.3 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.4 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 1.0 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.5 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 1.5 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.5 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.0 0.8 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.7 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.2 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.3 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.0 0.2 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.4 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.4 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.2 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.9 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.9 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.2 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.3 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.8 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways