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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for irf4a+irf4b

Z-value: 1.05

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Transcription factors associated with irf4a+irf4b

Gene Symbol Gene ID Gene Info
irf4a
ENSDARG00000006560 interferon regulatory factor 4a
irf4b
ENSDARG00000055374 interferon regulatory factor 4b
irf4b
ENSDARG00000115381 interferon regulatory factor 4b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
irf4adr11_v1_chr2_-_879800_8798000.895.4e-07Click!
irf4bdr11_v1_chr20_+_26556174_265561740.718.9e-04Click!

Activity profile of irf4a+irf4b motif

Sorted Z-values of irf4a+irf4b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_27242498 2.74 ENSDART00000152609
ENSDART00000152170
si:dkey-11c5.11
si:dkey-11c5.11
chr14_-_30960470 2.72 ENSDART00000129989
si:ch211-191o15.6
si:ch211-191o15.6
chr19_-_7110617 2.45 ENSDART00000104838
psmb8a
proteasome subunit beta 8A
chr14_+_33329761 2.22 ENSDART00000161138
sowahd
sosondowah ankyrin repeat domain family d
chr4_-_12795030 2.06 ENSDART00000150427
b2m
beta-2-microglobulin
chr5_+_65157576 1.80 ENSDART00000159599
cfap157
cilia and flagella associated protein 157
chr4_-_8611841 1.80 ENSDART00000067322
fbxl14b
F-box and leucine-rich repeat protein 14b
chr6_+_15762647 1.79 ENSDART00000127133
ENSDART00000128939
iqca1
IQ motif containing with AAA domain 1
chr4_-_12795436 1.71 ENSDART00000131026
ENSDART00000075127
b2m
beta-2-microglobulin
chr14_+_33329420 1.67 ENSDART00000171090
ENSDART00000164062
sowahd
sosondowah ankyrin repeat domain family d
chr19_-_6303099 1.67 ENSDART00000133371
pou2f2a
POU class 2 homeobox 2a
chr10_+_5060191 1.61 ENSDART00000145908
ENSDART00000122397
carm1l
coactivator-associated arginine methyltransferase 1, like
chr25_+_16646113 1.60 ENSDART00000110426
cecr2
cat eye syndrome chromosome region, candidate 2
chr13_+_17694845 1.44 ENSDART00000079778
ifit8
interferon-induced protein with tetratricopeptide repeats 8
chr20_-_3911546 1.41 ENSDART00000169787
cnksr3
cnksr family member 3
chr16_+_29492937 1.40 ENSDART00000011497
ctsk
cathepsin K
chr1_-_7570181 1.40 ENSDART00000103588
mxa
myxovirus (influenza) resistance A
chr25_+_36045072 1.25 ENSDART00000126326
rpgrip1l
RPGRIP1-like
chr8_-_27687095 1.21 ENSDART00000086946
mov10b.1
Moloney leukemia virus 10b, tandem duplicate 1
chr18_+_17624295 1.20 ENSDART00000151865
ENSDART00000190408
ENSDART00000189204
ENSDART00000188894
ENSDART00000033762
ENSDART00000193471
nlrc5
NLR family, CARD domain containing 5
chr15_-_17071328 1.17 ENSDART00000122617
si:ch211-24o10.6
si:ch211-24o10.6
chr4_-_815871 1.16 ENSDART00000067455
dpysl5b
dihydropyrimidinase-like 5b
chr4_-_17669881 1.15 ENSDART00000066997
dram1
DNA-damage regulated autophagy modulator 1
chr9_-_32837860 1.11 ENSDART00000142227
mxe
myxovirus (influenza virus) resistance E
chr9_-_30576522 1.10 ENSDART00000101085
morc3a
MORC family CW-type zinc finger 3a
chr10_-_5821584 1.09 ENSDART00000166388
il6st
interleukin 6 signal transducer
chr4_-_26107841 1.05 ENSDART00000172012
si:ch211-244b2.4
si:ch211-244b2.4
chr6_+_11249706 1.02 ENSDART00000186547
ENSDART00000193287
atg9a
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr11_-_42472941 0.95 ENSDART00000166624
arf4b
ADP-ribosylation factor 4b
chr1_-_7582859 0.94 ENSDART00000110696
mxb
myxovirus (influenza) resistance B
chr5_+_13385837 0.94 ENSDART00000191190
ccl19a.1
chemokine (C-C motif) ligand 19a, tandem duplicate 1
chr17_+_43895158 0.93 ENSDART00000111123
msh4
mutS homolog 4
chr2_-_24554416 0.92 ENSDART00000052061
cnn2
calponin 2
chr6_+_11250033 0.87 ENSDART00000065411
ENSDART00000132677
atg9a
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr15_+_2421432 0.86 ENSDART00000193772
hephl1a
hephaestin-like 1a
chr6_-_18400548 0.85 ENSDART00000179797
ENSDART00000164891
trim25
tripartite motif containing 25
chr17_+_35362851 0.84 ENSDART00000137659
cmpk2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr13_-_50200348 0.82 ENSDART00000038391
pkz
protein kinase containing Z-DNA binding domains
chr2_-_26620803 0.76 ENSDART00000003946
ENSDART00000126826
tmem59
transmembrane protein 59
chr1_-_35924495 0.76 ENSDART00000184424
smad1
SMAD family member 1
chr25_-_774350 0.74 ENSDART00000166321
ENSDART00000160386
IRAK4
interleukin 1 receptor associated kinase 4
chr19_+_10832092 0.72 ENSDART00000191851
tomm40l
translocase of outer mitochondrial membrane 40 homolog, like
chr18_-_23875370 0.67 ENSDART00000130163
nr2f2
nuclear receptor subfamily 2, group F, member 2
chr8_-_18229169 0.66 ENSDART00000131764
ENSDART00000143036
ENSDART00000145986
si:ch211-241d21.5
si:ch211-241d21.5
chr13_-_45475289 0.66 ENSDART00000043345
rsrp1
arginine/serine-rich protein 1
chr13_-_50200042 0.65 ENSDART00000074230
pkz
protein kinase containing Z-DNA binding domains
chr7_-_19614916 0.64 ENSDART00000169029
zgc:194655
zgc:194655
chr5_+_69716458 0.63 ENSDART00000159594
mthfd2
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
chr14_-_25309058 0.62 ENSDART00000159569
htr4
5-hydroxytryptamine receptor 4
chr21_-_22543611 0.61 ENSDART00000177084
myo5b
myosin VB
chr2_+_37975026 0.61 ENSDART00000034802
si:rp71-1g18.13
si:rp71-1g18.13
chr6_+_39493864 0.61 ENSDART00000086263
mettl7a
methyltransferase like 7A
chr9_+_51147764 0.61 ENSDART00000188480
ifih1
interferon induced with helicase C domain 1
chr2_+_2818645 0.60 ENSDART00000163587
rock1
Rho-associated, coiled-coil containing protein kinase 1
chr7_+_19615056 0.60 ENSDART00000124752
ENSDART00000190297
si:ch211-212k18.15
si:ch211-212k18.15
chr20_+_38525567 0.56 ENSDART00000147787
znf512
zinc finger protein 512
chr21_+_45626136 0.54 ENSDART00000158742
irf1b
interferon regulatory factor 1b
chr11_-_6206520 0.53 ENSDART00000150199
ENSDART00000148246
ENSDART00000019440
pole4
polymerase (DNA-directed), epsilon 4, accessory subunit
chr4_-_6373735 0.52 ENSDART00000140100
MDFIC
si:ch73-156e19.1
chr15_-_41734639 0.51 ENSDART00000154230
ENSDART00000167443
ftr90
finTRIM family, member 90
chr8_+_50983551 0.49 ENSDART00000142061
si:dkey-32e23.4
si:dkey-32e23.4
chr22_-_17474583 0.49 ENSDART00000148027
si:ch211-197g15.8
si:ch211-197g15.8
chr22_+_19365220 0.47 ENSDART00000132781
ENSDART00000135672
ENSDART00000153630
si:dkey-21e2.12
si:dkey-21e2.12
chr15_-_21702317 0.45 ENSDART00000155824
IL4I1
si:dkey-40g16.6
chr24_-_3407507 0.45 ENSDART00000132648
nck1b
NCK adaptor protein 1b
chr15_-_40175894 0.43 ENSDART00000156632
si:ch211-281l24.3
si:ch211-281l24.3
chr12_-_35936329 0.43 ENSDART00000166634
rnf213b
ring finger protein 213b
chr5_+_59397739 0.41 ENSDART00000148659
clip2
CAP-GLY domain containing linker protein 2
chr15_-_42760110 0.41 ENSDART00000152490
si:ch211-181d7.3
si:ch211-181d7.3
chr15_+_2421729 0.38 ENSDART00000082294
ENSDART00000156428
hephl1a
hephaestin-like 1a
chr9_+_51147380 0.38 ENSDART00000003913
ifih1
interferon induced with helicase C domain 1
chr17_-_23603263 0.38 ENSDART00000079559
ifit16
interferon-induced protein with tetratricopeptide repeats 16
chr6_-_1566581 0.36 ENSDART00000192993
trim107
tripartite motif containing 107
chr14_-_25309360 0.34 ENSDART00000088940
htr4
5-hydroxytryptamine receptor 4
chr1_+_31674297 0.32 ENSDART00000044214
wbp1lb
WW domain binding protein 1-like b
chr15_-_41749364 0.32 ENSDART00000155464
ftr73
finTRIM family, member 73
chr22_-_17474781 0.32 ENSDART00000186817
si:ch211-197g15.8
si:ch211-197g15.8
chr7_-_8881514 0.31 ENSDART00000081620
vax2
ventral anterior homeobox 2
chr3_-_29941357 0.30 ENSDART00000147732
ENSDART00000137973
ENSDART00000103523
grna
granulin a
chr4_+_11464255 0.29 ENSDART00000008584
gdi2
GDP dissociation inhibitor 2
chr1_-_1885516 0.29 ENSDART00000122187
ENSDART00000131675
si:ch211-132g1.3
si:ch211-132g1.3
chr24_-_11467549 0.27 ENSDART00000082264
pxdc1b
PX domain containing 1b
chr8_-_51340931 0.27 ENSDART00000178209
kansl3
KAT8 regulatory NSL complex subunit 3
chr4_-_18434924 0.25 ENSDART00000190271
socs2
suppressor of cytokine signaling 2
chr20_-_35012093 0.25 ENSDART00000062761
cnstb
consortin, connexin sorting protein b
chr18_-_16179129 0.25 ENSDART00000125353
slc6a15
solute carrier family 6 (neutral amino acid transporter), member 15
chr20_-_51547464 0.22 ENSDART00000099486
disp1
dispatched homolog 1 (Drosophila)
chr20_-_25436389 0.22 ENSDART00000153266
itsn2a
intersectin 2a
chr22_-_10604526 0.22 ENSDART00000091777
bap1
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
chr21_-_38031038 0.22 ENSDART00000179483
ENSDART00000076238
rbm41
RNA binding motif protein 41
chr20_+_2227860 0.22 ENSDART00000152321
tmem200a
transmembrane protein 200A
chr21_+_28728030 0.22 ENSDART00000097307
puraa
purine-rich element binding protein Aa
chr25_-_483808 0.21 ENSDART00000104720
si:ch1073-385f13.3
si:ch1073-385f13.3
chr23_-_30045661 0.19 ENSDART00000122239
ENSDART00000103480
ccdc187
coiled-coil domain containing 187
chr5_+_35502290 0.18 ENSDART00000191222
CR762390.1

chr10_+_8101729 0.17 ENSDART00000138875
ENSDART00000123447
ENSDART00000185333
pstpip2
proline-serine-threonine phosphatase interacting protein 2
chr8_-_51340773 0.17 ENSDART00000060633
kansl3
KAT8 regulatory NSL complex subunit 3
chr6_+_11250316 0.16 ENSDART00000137122
atg9a
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr6_+_34512313 0.15 ENSDART00000102554
lrp8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr13_+_22476742 0.15 ENSDART00000078759
ENSDART00000130101
ENSDART00000137220
ENSDART00000133065
ENSDART00000147348
ldb3a
LIM domain binding 3a
chr4_+_68562464 0.14 ENSDART00000192954
BX548011.4

chr16_+_48753664 0.14 ENSDART00000155148
si:ch73-31d8.2
si:ch73-31d8.2
chr19_-_791016 0.12 ENSDART00000037515
msto1
misato 1, mitochondrial distribution and morphology regulator
chr8_+_45361775 0.11 ENSDART00000015193
chmp4bb
charged multivesicular body protein 4Bb
chr14_+_25817246 0.11 ENSDART00000136733
glra1
glycine receptor, alpha 1
chr21_+_25793970 0.09 ENSDART00000101217
CLDN4 (1 of many)
zgc:136892
chr3_-_4501026 0.08 ENSDART00000163052
zgc:162198
zgc:162198
chr5_-_45894802 0.08 ENSDART00000097648
crfb6
cytokine receptor family member b6
chr18_-_23874929 0.08 ENSDART00000134910
nr2f2
nuclear receptor subfamily 2, group F, member 2
chr18_-_23875219 0.07 ENSDART00000059976
nr2f2
nuclear receptor subfamily 2, group F, member 2
chr8_+_47897734 0.07 ENSDART00000140266
mfn2
mitofusin 2
chr18_-_24988645 0.07 ENSDART00000136434
ENSDART00000085735
chd2
chromodomain helicase DNA binding protein 2
chr17_+_40879331 0.06 ENSDART00000046003
slc4a1ap
solute carrier family 4 (anion exchanger), member 1, adaptor protein
chr14_-_33585809 0.04 ENSDART00000023540
sash3
SAM and SH3 domain containing 3
chr9_+_42269059 0.03 ENSDART00000113435
si:dkey-10c21.1
si:dkey-10c21.1
chr23_-_29553691 0.02 ENSDART00000053804
ube4b
ubiquitination factor E4B, UFD2 homolog (S. cerevisiae)
chr22_-_10605045 0.02 ENSDART00000184812
bap1
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
chr6_+_41186320 0.01 ENSDART00000025241
opn1mw2
opsin 1 (cone pigments), medium-wave-sensitive, 2
chr12_-_23658888 0.01 ENSDART00000088319
map3k8
mitogen-activated protein kinase kinase kinase 8
chr17_-_23727978 0.01 ENSDART00000079600
minpp1a
multiple inositol-polyphosphate phosphatase 1a

Network of associatons between targets according to the STRING database.

First level regulatory network of irf4a+irf4b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.0 GO:0045824 negative regulation of innate immune response(GO:0045824)
0.3 0.9 GO:0039529 RIG-I signaling pathway(GO:0039529) regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway(GO:0039531) regulation of RIG-I signaling pathway(GO:0039535)
0.3 0.8 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.3 0.8 GO:0060845 lymphatic endothelial cell fate commitment(GO:0060838) venous endothelial cell differentiation(GO:0060843) venous endothelial cell fate commitment(GO:0060845)
0.3 1.8 GO:0007288 sperm axoneme assembly(GO:0007288)
0.2 1.2 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.2 2.0 GO:0044805 late nucleophagy(GO:0044805)
0.2 0.6 GO:1903392 epicardial cell to mesenchymal cell transition(GO:0003347) negative regulation of adherens junction organization(GO:1903392)
0.2 3.4 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.2 1.0 GO:0032728 interferon-beta production(GO:0032608) regulation of interferon-beta production(GO:0032648) positive regulation of interferon-beta production(GO:0032728)
0.2 1.1 GO:0070572 positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.2 0.6 GO:0003245 growth involved in heart morphogenesis(GO:0003241) cardiac chamber ballooning(GO:0003242) cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.1 0.4 GO:0070589 cell wall biogenesis(GO:0042546) cell wall macromolecule biosynthetic process(GO:0044038) cellular component macromolecule biosynthetic process(GO:0070589)
0.1 1.2 GO:0046548 retinal rod cell development(GO:0046548)
0.1 0.5 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.1 0.4 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 0.9 GO:0000710 meiotic mismatch repair(GO:0000710)
0.1 0.2 GO:0090004 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.1 1.2 GO:0018216 peptidyl-arginine methylation(GO:0018216)
0.1 1.0 GO:0032098 regulation of appetite(GO:0032098)
0.1 1.2 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.1 2.0 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 0.2 GO:0015820 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.1 0.5 GO:0050688 regulation of defense response to virus(GO:0050688)
0.1 0.2 GO:0035521 monoubiquitinated protein deubiquitination(GO:0035520) monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.1 1.2 GO:0006825 copper ion transport(GO:0006825)
0.1 2.9 GO:0051607 defense response to virus(GO:0051607)
0.0 0.2 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.4 GO:0043981 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.0 0.9 GO:0043535 regulation of blood vessel endothelial cell migration(GO:0043535)
0.0 0.6 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 0.7 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.3 GO:0090259 regulation of retinal ganglion cell axon guidance(GO:0090259)
0.0 0.3 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.0 0.1 GO:0009838 abscission(GO:0009838) mitotic cytokinesis checkpoint(GO:0044878)
0.0 0.1 GO:0071361 cellular response to ethanol(GO:0071361)
0.0 1.6 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.0 0.8 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 1.8 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.9 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.2 GO:0042694 muscle cell fate specification(GO:0042694)
0.0 1.4 GO:0009612 response to mechanical stimulus(GO:0009612)
0.0 1.1 GO:0010506 regulation of autophagy(GO:0010506)
0.0 0.6 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.8 GO:0042612 MHC class I protein complex(GO:0042612)
0.2 3.4 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.2 0.5 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 1.6 GO:0031010 ISWI-type complex(GO:0031010)
0.1 1.2 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 2.0 GO:0005839 proteasome core complex(GO:0005839)
0.1 0.7 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 1.6 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.9 GO:0000795 synaptonemal complex(GO:0000795)
0.0 1.2 GO:0043186 P granule(GO:0043186)
0.0 0.2 GO:0035517 PR-DUB complex(GO:0035517)
0.0 0.4 GO:0044545 NSL complex(GO:0044545)
0.0 1.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.8 GO:0036064 ciliary basal body(GO:0036064)
0.0 0.6 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.3 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.4 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0032574 5'-3' RNA helicase activity(GO:0032574)
0.4 1.5 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.3 0.8 GO:0009041 uridylate kinase activity(GO:0009041)
0.2 1.6 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.1 2.1 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.8 GO:0001972 retinoic acid binding(GO:0001972)
0.1 0.3 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.1 1.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.1 1.2 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 0.6 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.1 0.6 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.1 0.2 GO:0071253 connexin binding(GO:0071253)
0.1 0.2 GO:0030626 U12 snRNA binding(GO:0030626)
0.1 0.9 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.2 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.0 0.7 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.0 1.0 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 0.6 GO:0031386 protein tag(GO:0031386)
0.0 0.2 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.2 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.9 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.3 GO:0070411 I-SMAD binding(GO:0070411)
0.0 1.0 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 5.8 GO:0008017 microtubule binding(GO:0008017)
0.0 0.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.1 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.5 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 0.6 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 1.1 PID IL27 PATHWAY IL27-mediated signaling events
0.1 0.8 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.8 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.3 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.8 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.2 1.0 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.1 1.8 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 0.7 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.1 1.4 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 1.1 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 0.8 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 1.2 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.6 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.2 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.8 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.6 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 0.2 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling