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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for irf5

Z-value: 1.27

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Transcription factors associated with irf5

Gene Symbol Gene ID Gene Info
irf5
ENSDARG00000045681 interferon regulatory factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
irf5dr11_v1_chr4_-_13613148_136131480.672.6e-03Click!

Activity profile of irf5 motif

Sorted Z-values of irf5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_69187585 3.53 ENSDART00000160499
ENSDART00000166258
marveld3
MARVEL domain containing 3
chr18_+_44532668 2.73 ENSDART00000140672
st14a
suppression of tumorigenicity 14 (colon carcinoma) a
chr18_+_44532370 2.58 ENSDART00000086952
st14a
suppression of tumorigenicity 14 (colon carcinoma) a
chr18_+_44532199 2.53 ENSDART00000135386
st14a
suppression of tumorigenicity 14 (colon carcinoma) a
chr10_-_22150419 2.42 ENSDART00000006173
cldn7b
claudin 7b
chr23_+_2666944 2.36 ENSDART00000192861
CABZ01057928.1

chr17_-_2039511 2.33 ENSDART00000160223
spint1a
serine peptidase inhibitor, Kunitz type 1 a
chr15_-_33964897 2.29 ENSDART00000172075
ENSDART00000158126
ENSDART00000160456
lsr
lipolysis stimulated lipoprotein receptor
chr10_-_15879569 2.22 ENSDART00000136789
tjp2a
tight junction protein 2a (zona occludens 2)
chr15_+_44201056 2.21 ENSDART00000162433
ENSDART00000148336
CU655961.4

chr18_+_44532883 2.13 ENSDART00000121994
st14a
suppression of tumorigenicity 14 (colon carcinoma) a
chr2_-_21438492 2.09 ENSDART00000046098
plcd1b
phospholipase C, delta 1b
chr24_-_34680956 2.01 ENSDART00000171009
ctnna1
catenin (cadherin-associated protein), alpha 1
chr14_+_32918484 2.01 ENSDART00000105721
lnx2b
ligand of numb-protein X 2b
chr7_+_46020508 1.97 ENSDART00000170294
ccne1
cyclin E1
chr9_+_23003208 1.94 ENSDART00000021060
eaf2
ELL associated factor 2
chr17_+_22381215 1.93 ENSDART00000162670
ENSDART00000128875
slc8a1b
solute carrier family 8 (sodium/calcium exchanger), member 1b
chr13_-_23051766 1.92 ENSDART00000111774
supv3l1
SUV3-like helicase
chr20_+_6535438 1.92 ENSDART00000145763
si:ch211-191a24.4
si:ch211-191a24.4
chr20_+_6535176 1.90 ENSDART00000054652
si:ch211-191a24.4
si:ch211-191a24.4
chr23_-_10745288 1.87 ENSDART00000140745
ENSDART00000013768
eif4e3
eukaryotic translation initiation factor 4E family member 3
chr7_+_19483277 1.87 ENSDART00000173750
si:ch211-212k18.7
si:ch211-212k18.7
chr5_+_44805028 1.85 ENSDART00000141198
ctsla
cathepsin La
chr5_+_44805269 1.83 ENSDART00000136965
ctsla
cathepsin La
chr10_+_4046448 1.83 ENSDART00000123086
ENSDART00000052268
pitpnb
phosphatidylinositol transfer protein, beta
chr5_-_67241633 1.82 ENSDART00000114783
clip1a
CAP-GLY domain containing linker protein 1a
chr5_+_44804791 1.82 ENSDART00000122288
ctsla
cathepsin La
chr25_+_28862660 1.81 ENSDART00000154681
si:ch211-106e7.2
si:ch211-106e7.2
chr19_-_15420678 1.76 ENSDART00000151454
ENSDART00000027697
serinc2
serine incorporator 2
chr9_+_41459759 1.76 ENSDART00000132501
ENSDART00000100265
nemp2
nuclear envelope integral membrane protein 2
chr21_-_25295087 1.74 ENSDART00000087910
ENSDART00000147860
st14b
suppression of tumorigenicity 14 (colon carcinoma) b
chr3_-_4501026 1.71 ENSDART00000163052
zgc:162198
zgc:162198
chr14_-_33278084 1.69 ENSDART00000132850
stard14
START domain containing 14
chr14_-_33277743 1.67 ENSDART00000048130
stard14
START domain containing 14
chr18_+_27337994 1.66 ENSDART00000136172
si:dkey-29p10.4
si:dkey-29p10.4
chr6_+_44163727 1.66 ENSDART00000064878
gxylt2
glucoside xylosyltransferase 2
chr14_+_15768942 1.63 ENSDART00000158998
ergic1
endoplasmic reticulum-golgi intermediate compartment 1
chr18_+_45666489 1.62 ENSDART00000180147
ENSDART00000151351
prrg4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr9_+_32178374 1.60 ENSDART00000078576
coq10b
coenzyme Q10B
chr19_+_4968947 1.57 ENSDART00000003634
ENSDART00000134808
stard3
StAR-related lipid transfer (START) domain containing 3
chr5_+_39099172 1.56 ENSDART00000006079
bmp2k
BMP2 inducible kinase
chr9_-_30264415 1.54 ENSDART00000060150
mid1ip1a
MID1 interacting protein 1a
chr6_+_58280936 1.54 ENSDART00000155244
ralgapb
Ral GTPase activating protein, beta subunit (non-catalytic)
chr5_-_13766651 1.52 ENSDART00000134064
mxd1
MAX dimerization protein 1
chr5_-_69716501 1.49 ENSDART00000158956
mob1a
MOB kinase activator 1A
chr19_+_9113932 1.47 ENSDART00000060442
setdb1a
SET domain, bifurcated 1a
chr5_+_39099380 1.43 ENSDART00000166657
bmp2k
BMP2 inducible kinase
chr25_-_12809361 1.43 ENSDART00000162750
ca5a
carbonic anhydrase Va
chr2_+_38025260 1.43 ENSDART00000075905
hnrnpc
heterogeneous nuclear ribonucleoprotein C
chr3_-_36127234 1.42 ENSDART00000130917
coil
coilin p80
chr10_+_7719796 1.41 ENSDART00000191795
ggcx
gamma-glutamyl carboxylase
chr7_-_9717020 1.39 ENSDART00000029668
lrrk1
leucine-rich repeat kinase 1
chr20_+_27087539 1.37 ENSDART00000062094
tmem251
transmembrane protein 251
chr2_-_55797318 1.37 ENSDART00000158147
calr3b
calreticulin 3b
chr23_+_31942040 1.34 ENSDART00000088607
nemp1
nuclear envelope integral membrane protein 1
chr6_-_33916756 1.32 ENSDART00000137447
ENSDART00000138488
nasp
nuclear autoantigenic sperm protein (histone-binding)
chr12_-_3077395 1.32 ENSDART00000002867
ENSDART00000126315
rfng
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr4_-_20108833 1.31 ENSDART00000100867
fam3c
family with sequence similarity 3, member C
chr5_-_13086616 1.31 ENSDART00000051664
ypel1
yippee-like 1
chr22_-_4439311 1.31 ENSDART00000169317
uhrf1
ubiquitin-like with PHD and ring finger domains 1
chr14_-_41467497 1.29 ENSDART00000181220
mid1ip1l
MID1 interacting protein 1, like
chr5_-_29531948 1.29 ENSDART00000098360
arrdc1a
arrestin domain containing 1a
chr22_+_336256 1.27 ENSDART00000019155
btg2
B-cell translocation gene 2
chr3_-_40976288 1.25 ENSDART00000193553
cyp3c1
cytochrome P450, family 3, subfamily c, polypeptide 1
chr20_+_26939742 1.24 ENSDART00000138369
ENSDART00000062061
ENSDART00000152992
cdca4
cell division cycle associated 4
chr11_+_10909183 1.23 ENSDART00000064860
rbms1a
RNA binding motif, single stranded interacting protein 1a
chr5_+_58455488 1.22 ENSDART00000038602
ENSDART00000127958
slc37a2
solute carrier family 37 (glucose-6-phosphate transporter), member 2
chr8_-_19266325 1.20 ENSDART00000036148
ENSDART00000137994
zgc:77486
zgc:77486
chr1_-_55750208 1.20 ENSDART00000142244
dnajb1b
DnaJ (Hsp40) homolog, subfamily B, member 1b
chr7_+_19482877 1.17 ENSDART00000077868
si:ch211-212k18.7
si:ch211-212k18.7
chr22_-_17688868 1.17 ENSDART00000012336
ENSDART00000147070
tjp3
tight junction protein 3
chr6_-_1566186 1.17 ENSDART00000156305
trim107
tripartite motif containing 107
chr15_-_1835189 1.15 ENSDART00000154369
taf15
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr6_-_1566581 1.15 ENSDART00000192993
trim107
tripartite motif containing 107
chr6_-_1566407 1.14 ENSDART00000112118
trim107
tripartite motif containing 107
chr15_+_44184367 1.14 ENSDART00000162918
ENSDART00000110060
zgc:165514
zgc:165514
chr9_-_28274932 1.14 ENSDART00000137582
ENSDART00000146932
creb1b
cAMP responsive element binding protein 1b
chr7_+_38808027 1.13 ENSDART00000052323
harbi1
harbinger transposase derived 1
chr21_-_22122312 1.12 ENSDART00000101726
slc35f2
solute carrier family 35, member F2
chr3_-_40976463 1.09 ENSDART00000128450
ENSDART00000018676
cyp3c1
cytochrome P450, family 3, subfamily c, polypeptide 1
chr5_-_12587053 1.08 ENSDART00000162780
vsig10
V-set and immunoglobulin domain containing 10
chr15_+_1534644 1.07 ENSDART00000130413
smc4
structural maintenance of chromosomes 4
chr21_-_30273418 1.07 ENSDART00000187069
ENSDART00000181492
zgc:175066
zgc:175066
chr23_+_31000243 1.07 ENSDART00000085263
selenoi
selenoprotein I
chr25_+_15997957 1.05 ENSDART00000140047
ppfibp2b
PTPRF interacting protein, binding protein 2b (liprin beta 2)
chr2_-_37353098 1.01 ENSDART00000056522
skila
SKI-like proto-oncogene a
chr16_-_41667101 1.01 ENSDART00000084528
atp2c1
ATPase secretory pathway Ca2+ transporting 1
chr25_+_16646113 1.00 ENSDART00000110426
cecr2
cat eye syndrome chromosome region, candidate 2
chr19_+_26922780 0.99 ENSDART00000187396
ENSDART00000188978
nelfe
negative elongation factor complex member E
chr22_-_8006342 0.99 ENSDART00000162028
sc:d217
sc:d217
chr16_+_19637384 0.98 ENSDART00000184773
ENSDART00000191895
ENSDART00000182020
ENSDART00000135359
macc1
metastasis associated in colon cancer 1
chr7_-_20865005 0.98 ENSDART00000190752
fis1
fission, mitochondrial 1
chr21_+_19319804 0.97 ENSDART00000063621
abraxas2a
abraxas 2a, BRISC complex subunit
chr18_+_37015185 0.97 ENSDART00000191305
sipa1l3
signal-induced proliferation-associated 1 like 3
chr5_+_57442271 0.94 ENSDART00000097395
prpf4
PRP4 pre-mRNA processing factor 4 homolog (yeast)
chr13_+_25364324 0.93 ENSDART00000187471
chuk
conserved helix-loop-helix ubiquitous kinase
chr6_-_23002373 0.92 ENSDART00000037709
ENSDART00000170369
nol11
nucleolar protein 11
chr8_+_47897734 0.91 ENSDART00000140266
mfn2
mitofusin 2
chr9_-_23765480 0.90 ENSDART00000027212
si:ch211-219a4.6
si:ch211-219a4.6
chr17_-_22552678 0.88 ENSDART00000079401
si:ch211-125o16.4
si:ch211-125o16.4
chr7_+_54222156 0.88 ENSDART00000165201
ENSDART00000158518
pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr9_-_28275600 0.87 ENSDART00000170094
creb1b
cAMP responsive element binding protein 1b
chr7_+_56472585 0.87 ENSDART00000135259
ENSDART00000073596
ist1
increased sodium tolerance 1 homolog (yeast)
chr5_+_20030414 0.85 ENSDART00000181430
ENSDART00000047841
ENSDART00000182813
sgsm1a
small G protein signaling modulator 1a
chr11_+_2855430 0.85 ENSDART00000172837
kif21b
kinesin family member 21B
chr3_-_55650771 0.84 ENSDART00000162413
axin2
axin 2 (conductin, axil)
chr6_-_24203980 0.83 ENSDART00000170915
si:ch73-389b16.2
si:ch73-389b16.2
chr7_+_32693890 0.79 ENSDART00000121972
slc39a13
solute carrier family 39 (zinc transporter), member 13
chr20_+_20751425 0.78 ENSDART00000177048
ppp1r13bb
protein phosphatase 1, regulatory subunit 13Bb
chr18_+_16133595 0.77 ENSDART00000080423
ctsd
cathepsin D
chr4_+_15011341 0.76 ENSDART00000124452
ube2h
ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)
chr17_-_24879003 0.74 ENSDART00000123147
zbtb8a
zinc finger and BTB domain containing 8A
chr19_+_42227400 0.72 ENSDART00000131574
ENSDART00000135436
jtb
jumping translocation breakpoint
chr21_+_39100289 0.71 ENSDART00000075958
slc13a2
solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
chr13_-_33700461 0.71 ENSDART00000160520
mad2l1bp
MAD2L1 binding protein
chr13_+_22863516 0.70 ENSDART00000113082
ENSDART00000189200
hnrnph3
heterogeneous nuclear ribonucleoprotein H3 (2H9)
chr15_-_33818872 0.70 ENSDART00000158325
n4bp2l2
NEDD4 binding protein 2-like 2
chr12_-_41759686 0.70 ENSDART00000172175
ENSDART00000165152
ppp2r2d
protein phosphatase 2, regulatory subunit B, delta
chr19_-_10214264 0.69 ENSDART00000053300
ENSDART00000148225
znf865
zinc finger protein 865
chr23_-_35396845 0.68 ENSDART00000142038
ENSDART00000049373
ENSDART00000181978
ENSDART00000171357
cmtr1
cap methyltransferase 1
chr5_-_37959874 0.68 ENSDART00000031719
mpzl2b
myelin protein zero-like 2b
chr14_-_49992709 0.67 ENSDART00000159988
fam193b
family with sequence similarity 193, member B
chr20_+_45620076 0.66 ENSDART00000113806
hnrnpa0l
heterogeneous nuclear ribonucleoprotein A0, like
chr13_-_25484659 0.66 ENSDART00000135321
ENSDART00000022799
tial1
TIA1 cytotoxic granule-associated RNA binding protein-like 1
chr8_+_23802384 0.64 ENSDART00000137820
si:ch211-163l21.8
si:ch211-163l21.8
chr16_+_33144306 0.64 ENSDART00000101953
rhbdl2
rhomboid, veinlet-like 2 (Drosophila)
chr3_+_36127287 0.64 ENSDART00000058605
ENSDART00000182500
scpep1
serine carboxypeptidase 1
chr3_-_55650417 0.64 ENSDART00000171441
axin2
axin 2 (conductin, axil)
chr2_+_34967022 0.64 ENSDART00000134926
astn1
astrotactin 1
chr25_+_20272145 0.64 ENSDART00000109605
si:dkey-219c3.2
si:dkey-219c3.2
chr11_-_6206520 0.63 ENSDART00000150199
ENSDART00000148246
ENSDART00000019440
pole4
polymerase (DNA-directed), epsilon 4, accessory subunit
chr2_-_37140423 0.61 ENSDART00000144220
tspan37
tetraspanin 37
chr25_+_8447565 0.60 ENSDART00000142090
fanci
Fanconi anemia, complementation group I
chr8_+_17168114 0.60 ENSDART00000183901
cenph
centromere protein H
chr6_-_53334259 0.59 ENSDART00000172465
gnb1b
guanine nucleotide binding protein (G protein), beta polypeptide 1b
chr16_+_48616220 0.58 ENSDART00000004751
ENSDART00000130045
pbx2
pre-B-cell leukemia homeobox 2
chr25_+_27410352 0.58 ENSDART00000154362
pot1
protection of telomeres 1 homolog
chr24_+_8904741 0.57 ENSDART00000140924
gnal
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr14_-_31814149 0.56 ENSDART00000173393
arhgef6
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr16_+_26601364 0.55 ENSDART00000087537
epb41l4b
erythrocyte membrane protein band 4.1 like 4B
chr22_-_11648094 0.55 ENSDART00000191791
dpp4
dipeptidyl-peptidase 4
chr2_+_34967210 0.55 ENSDART00000141796
astn1
astrotactin 1
chr19_-_29303788 0.54 ENSDART00000112167
srfbp1
serum response factor binding protein 1
chr8_+_41647539 0.54 ENSDART00000136492
ENSDART00000138799
ENSDART00000134404
si:ch211-158d24.4
si:ch211-158d24.4
chr6_-_45869127 0.53 ENSDART00000062459
ENSDART00000180563
rbm19
RNA binding motif protein 19
chr24_-_3407507 0.53 ENSDART00000132648
nck1b
NCK adaptor protein 1b
chr23_-_4019928 0.52 ENSDART00000021062
slc9a8
solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
chr15_+_31911989 0.51 ENSDART00000111472
brca2
breast cancer 2, early onset
chr12_+_27243059 0.51 ENSDART00000066269
arl4d
ADP-ribosylation factor-like 4D
chr5_+_57726425 0.51 ENSDART00000134684
fdxacb1
ferredoxin-fold anticodon binding domain containing 1
chr14_+_16345003 0.50 ENSDART00000003040
ENSDART00000165193
itln3
intelectin 3
chr3_-_29941357 0.50 ENSDART00000147732
ENSDART00000137973
ENSDART00000103523
grna
granulin a
chr2_-_6115688 0.49 ENSDART00000081663
prdx1
peroxiredoxin 1
chr24_-_10828560 0.49 ENSDART00000132282
fam49bb
family with sequence similarity 49, member Bb
chr10_-_2971407 0.49 ENSDART00000132526
marveld2a
MARVEL domain containing 2a
chr23_-_4019699 0.46 ENSDART00000159780
slc9a8
solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
chr22_+_18319230 0.46 ENSDART00000184747
ENSDART00000184649
gatad2ab
GATA zinc finger domain containing 2Ab
chr21_+_17301790 0.46 ENSDART00000145057
tsc1b
TSC complex subunit 1b
chr23_-_12906228 0.46 ENSDART00000138807
ndnl2
necdin-like 2
chr6_-_10728057 0.45 ENSDART00000002247
sp3b
Sp3b transcription factor
chr16_-_26525901 0.44 ENSDART00000110260
l3mbtl1b
l(3)mbt-like 1b (Drosophila)
chr2_+_58377395 0.44 ENSDART00000193511
vapal
VAMP (vesicle-associated membrane protein)-associated protein A, like
chr5_+_66326004 0.44 ENSDART00000144351
malt1
MALT paracaspase 1
chr22_-_14255659 0.43 ENSDART00000167088
si:ch211-246m6.5
si:ch211-246m6.5
chr20_+_1316803 0.41 ENSDART00000152586
ENSDART00000152165
nup43
nucleoporin 43
chr5_+_50913357 0.41 ENSDART00000092938
col4a3bpa
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein a
chr22_+_18319666 0.39 ENSDART00000033103
gatad2ab
GATA zinc finger domain containing 2Ab
chr10_+_35358675 0.38 ENSDART00000193263
si:dkey-259j3.5
si:dkey-259j3.5
chr5_-_30382925 0.38 ENSDART00000125381
gig2o
grass carp reovirus (GCRV)-induced gene 2o
chr17_+_34805897 0.37 ENSDART00000137090
ENSDART00000077626
id2a
inhibitor of DNA binding 2a
chr5_+_69716458 0.37 ENSDART00000159594
mthfd2
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
chr20_+_1316495 0.36 ENSDART00000064439
nup43
nucleoporin 43
chr18_+_17624295 0.36 ENSDART00000151865
ENSDART00000190408
ENSDART00000189204
ENSDART00000188894
ENSDART00000033762
ENSDART00000193471
nlrc5
NLR family, CARD domain containing 5
chr16_+_10841163 0.36 ENSDART00000065467
dedd1
death effector domain-containing 1
chr25_-_27665978 0.35 ENSDART00000123590
si:ch211-91p5.3
si:ch211-91p5.3
chr9_+_23808546 0.34 ENSDART00000041992
dhrs12
dehydrogenase/reductase (SDR family) member 12
chr21_+_33187992 0.34 ENSDART00000162745
ENSDART00000188388
BX072577.1

chr18_+_10884996 0.34 ENSDART00000147613
mical3a
microtubule associated monooxygenase, calponin and LIM domain containing 3a
chr3_+_15773991 0.33 ENSDART00000089923
znf652
zinc finger protein 652
chr20_+_36806398 0.33 ENSDART00000153317
abracl
ABRA C-terminal like
chr6_+_49771626 0.33 ENSDART00000134207
ctsz
cathepsin Z
chr9_+_41156818 0.33 ENSDART00000105764
ENSDART00000147052
stat4
signal transducer and activator of transcription 4
chr23_-_45501177 0.32 ENSDART00000150103
col24a1
collagen type XXIV alpha 1
chr15_-_2640966 0.32 ENSDART00000063320
cldne
claudin e
chr5_+_36895860 0.31 ENSDART00000134493
srsf7a
serine/arginine-rich splicing factor 7a
chr24_+_37688729 0.30 ENSDART00000137017
h3f3d
H3 histone, family 3D
chr18_+_42970208 0.28 ENSDART00000084454
nectin1b
nectin cell adhesion molecule 1b
chr22_-_16419126 0.27 ENSDART00000193348
cts12
cathepsin 12
chr11_+_39969048 0.27 ENSDART00000193693
per3
period circadian clock 3
chr6_+_49771372 0.26 ENSDART00000063251
ctsz
cathepsin Z
chr1_-_1885516 0.26 ENSDART00000122187
ENSDART00000131675
si:ch211-132g1.3
si:ch211-132g1.3
chr16_+_35595312 0.26 ENSDART00000170438
si:ch211-1i11.3
si:ch211-1i11.3
chr10_-_5821584 0.25 ENSDART00000166388
il6st
interleukin 6 signal transducer
chr9_-_55772937 0.23 ENSDART00000159192
akap17a
A kinase (PRKA) anchor protein 17A
chr4_-_6373735 0.23 ENSDART00000140100
MDFIC
si:ch73-156e19.1
chr4_-_77557279 0.22 ENSDART00000180113
AL935186.10

chr13_-_37631092 0.22 ENSDART00000108855
si:dkey-188i13.7
si:dkey-188i13.7
chr9_+_18215940 0.21 ENSDART00000055872
dnajc15
DnaJ (Hsp40) homolog, subfamily C, member 15
chr9_-_39968820 0.21 ENSDART00000100311
IKZF2
si:zfos-1425h8.1
chr22_+_15979430 0.21 ENSDART00000189703
ENSDART00000192674
rc3h1a
ring finger and CCCH-type domains 1a

Network of associatons between targets according to the STRING database.

First level regulatory network of irf5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0010633 negative regulation of epithelial cell migration(GO:0010633)
0.4 1.2 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.4 2.4 GO:0060876 semicircular canal formation(GO:0060876)
0.3 1.3 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.3 0.9 GO:1901836 regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901836)
0.3 1.8 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.3 1.4 GO:0030575 nuclear body organization(GO:0030575) Cajal body organization(GO:0030576)
0.3 1.9 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.2 1.7 GO:0016266 O-glycan processing(GO:0016266)
0.2 1.4 GO:0017187 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.2 1.3 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.2 1.0 GO:0055071 manganese ion homeostasis(GO:0055071)
0.2 0.9 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.2 3.0 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.2 1.0 GO:0016559 peroxisome fission(GO:0016559)
0.1 3.4 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 1.3 GO:0044030 regulation of DNA methylation(GO:0044030)
0.1 0.9 GO:0048662 regulation of smooth muscle cell proliferation(GO:0048660) negative regulation of smooth muscle cell proliferation(GO:0048662)
0.1 1.2 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.1 0.6 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.1 0.6 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.1 1.5 GO:0031937 methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.1 1.0 GO:1902038 positive regulation of hematopoietic stem cell differentiation(GO:1902038)
0.1 1.3 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.1 1.0 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 0.6 GO:2000279 negative regulation of DNA biosynthetic process(GO:2000279)
0.1 1.9 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 0.3 GO:0044406 virion attachment to host cell(GO:0019062) adhesion of symbiont to host(GO:0044406) adhesion of symbiont to host cell(GO:0044650)
0.1 0.4 GO:0046532 regulation of photoreceptor cell differentiation(GO:0046532)
0.1 1.1 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1 1.9 GO:0014812 muscle cell migration(GO:0014812)
0.1 1.2 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.1 1.1 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.1 1.6 GO:1901661 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.1 0.9 GO:0014028 notochord formation(GO:0014028)
0.1 1.2 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.1 12.1 GO:0008544 epidermis development(GO:0008544)
0.1 0.6 GO:0044090 positive regulation of vacuole organization(GO:0044090)
0.1 0.7 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 1.3 GO:0021654 rhombomere boundary formation(GO:0021654)
0.1 0.1 GO:0007618 mating(GO:0007618)
0.1 2.8 GO:0046890 regulation of lipid biosynthetic process(GO:0046890)
0.1 0.5 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.1 1.8 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.1 0.4 GO:0060339 negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.1 0.6 GO:1902624 positive regulation of neutrophil migration(GO:1902624)
0.1 2.0 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.1 0.3 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.0 0.5 GO:0071451 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.0 0.8 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.9 GO:0007032 endosome organization(GO:0007032)
0.0 0.7 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 1.6 GO:0030301 cholesterol transport(GO:0030301)
0.0 0.2 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.0 2.0 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.5 GO:0007530 sex determination(GO:0007530)
0.0 0.9 GO:0048920 posterior lateral line neuromast primordium migration(GO:0048920)
0.0 0.6 GO:0051382 kinetochore assembly(GO:0051382)
0.0 1.2 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 1.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.2 GO:0048680 positive regulation of axon regeneration(GO:0048680) positive regulation of neuron projection regeneration(GO:0070572)
0.0 0.5 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077)
0.0 1.4 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 1.8 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.4 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.0 2.1 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.0 0.2 GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.0 0.2 GO:0006567 threonine metabolic process(GO:0006566) threonine catabolic process(GO:0006567)
0.0 0.4 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.0 GO:0007343 egg activation(GO:0007343)
0.0 0.0 GO:0009838 abscission(GO:0009838) mitotic cytokinesis checkpoint(GO:0044878)
0.0 0.4 GO:0048546 digestive tract morphogenesis(GO:0048546)
0.0 2.4 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.5 GO:0050870 positive regulation of homotypic cell-cell adhesion(GO:0034112) positive regulation of T cell activation(GO:0050870) positive regulation of leukocyte cell-cell adhesion(GO:1903039)
0.0 0.3 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 1.0 GO:0051453 regulation of intracellular pH(GO:0051453)
0.0 0.6 GO:0060059 embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0 0.3 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 1.0 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.0 1.0 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.7 GO:0000281 mitotic cytokinesis(GO:0000281)
0.0 0.4 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.0 1.0 GO:0001894 tissue homeostasis(GO:0001894)
0.0 0.6 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 3.7 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.0 1.6 GO:0006413 translational initiation(GO:0006413)
0.0 0.1 GO:0015959 diadenosine polyphosphate metabolic process(GO:0015959) diadenosine polyphosphate catabolic process(GO:0015961)
0.0 0.4 GO:0070972 protein localization to endoplasmic reticulum(GO:0070972)
0.0 2.2 GO:0031016 pancreas development(GO:0031016)
0.0 0.5 GO:0030490 maturation of SSU-rRNA(GO:0030490)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
0.3 1.9 GO:0005845 mRNA cap binding complex(GO:0005845)
0.2 1.9 GO:0032783 ELL-EAF complex(GO:0032783)
0.2 1.9 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2 1.6 GO:0044232 organelle membrane contact site(GO:0044232)
0.2 0.9 GO:0043034 costamere(GO:0043034)
0.2 2.1 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.2 0.6 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.2 0.9 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 0.5 GO:0061689 tricellular tight junction(GO:0061689)
0.1 1.0 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 1.0 GO:0032021 NELF complex(GO:0032021)
0.1 0.3 GO:0005592 collagen type XI trimer(GO:0005592)
0.1 2.0 GO:0030057 desmosome(GO:0030057)
0.1 0.5 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.1 0.5 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 1.0 GO:0031010 ISWI-type complex(GO:0031010)
0.1 1.3 GO:0000792 heterochromatin(GO:0000792)
0.1 9.7 GO:0070160 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.1 1.4 GO:0015030 Cajal body(GO:0015030)
0.1 3.1 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 0.8 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 1.8 GO:0035371 microtubule plus-end(GO:0035371)
0.1 1.6 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 0.9 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306)
0.1 0.2 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.9 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.9 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.0 2.8 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.6 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 1.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 6.2 GO:0005764 lysosome(GO:0005764)
0.0 1.2 GO:0005811 lipid particle(GO:0005811)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.1 GO:0070545 PeBoW complex(GO:0070545)
0.0 1.9 GO:0042383 sarcolemma(GO:0042383)
0.0 0.5 GO:0030686 90S preribosome(GO:0030686)
0.0 1.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.1 GO:0061702 inflammasome complex(GO:0061702)
0.0 0.7 GO:0030496 midbody(GO:0030496)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 1.0 GO:0048786 presynaptic active zone(GO:0048786)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0061513 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.4 1.4 GO:0008488 gamma-glutamyl carboxylase activity(GO:0008488)
0.3 1.3 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.3 1.9 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.3 1.4 GO:0030620 U2 snRNA binding(GO:0030620)
0.3 1.8 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.3 1.3 GO:1990756 protein binding, bridging involved in substrate recognition for ubiquitination(GO:1990756)
0.2 3.0 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.2 1.7 GO:0035252 UDP-xylosyltransferase activity(GO:0035252)
0.2 0.9 GO:0008384 IkappaB kinase activity(GO:0008384)
0.2 1.1 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
0.2 1.6 GO:0048039 ubiquinone binding(GO:0048039)
0.2 0.5 GO:0016436 rRNA (uridine) methyltransferase activity(GO:0016436)
0.2 1.0 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.2 1.5 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.1 0.6 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 1.9 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.1 0.6 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.1 0.9 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 0.6 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 1.9 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 2.0 GO:0035497 cAMP response element binding(GO:0035497)
0.1 0.4 GO:0033149 FFAT motif binding(GO:0033149)
0.1 0.7 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.1 1.0 GO:0015386 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.1 1.2 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 1.2 GO:0030544 Hsp70 protein binding(GO:0030544)
0.1 0.5 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 0.6 GO:0043515 kinetochore binding(GO:0043515)
0.1 2.1 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.1 1.8 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 1.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 12.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.8 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.2 GO:0016453 C-acetyltransferase activity(GO:0016453)
0.0 2.0 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.8 GO:0002039 p53 binding(GO:0002039)
0.0 0.4 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.0 6.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.6 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.0 2.3 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 1.3 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.1 GO:0034416 bisphosphoglycerate phosphatase activity(GO:0034416)
0.0 0.2 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.3 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.6 GO:0016251 obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.0 0.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 2.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 1.6 GO:0015485 cholesterol binding(GO:0015485)
0.0 1.5 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.5 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.6 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 1.4 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 3.7 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 1.4 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.2 GO:0001671 ATPase activator activity(GO:0001671)
0.0 1.0 GO:0051082 unfolded protein binding(GO:0051082)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 2.0 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 1.5 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.1 0.9 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.1 3.5 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.6 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.1 PID AURORA B PATHWAY Aurora B signaling
0.0 0.8 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 0.3 PID IL23 PATHWAY IL23-mediated signaling events
0.0 1.1 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.6 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.4 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.5 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.0 0.3 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 1.2 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.5 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.2 PID IL6 7 PATHWAY IL6-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 0.6 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 1.4 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 0.9 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 2.0 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.7 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1 2.0 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 1.3 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 0.5 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.7 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.6 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.6 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.8 REACTOME PI METABOLISM Genes involved in PI Metabolism
0.0 0.6 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.5 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.2 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 1.7 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.4 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 1.0 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.6 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 2.4 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.1 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.1 REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex