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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for irx6a

Z-value: 0.51

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Transcription factors associated with irx6a

Gene Symbol Gene ID Gene Info
irx6a
ENSDARG00000034420 iroquois homeobox 6a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
irx6adr11_v1_chr7_-_35516251_355162510.446.9e-02Click!

Activity profile of irx6a motif

Sorted Z-values of irx6a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_+_2908764 1.69 ENSDART00000162362
wu:fj16a03
wu:fj16a03
chr20_-_7072487 1.55 ENSDART00000145954
si:ch211-121a2.2
si:ch211-121a2.2
chr20_+_23440632 1.50 ENSDART00000180685
ENSDART00000042820
si:dkey-90m5.4
si:dkey-90m5.4
chr1_-_59287410 1.21 ENSDART00000158011
ENSDART00000170580
col5a3b
collagen, type V, alpha 3b
chr10_+_45345574 1.14 ENSDART00000166085
ppiab
peptidylprolyl isomerase Ab (cyclophilin A)
chr16_+_25316973 1.10 ENSDART00000086409
dync1i1
dynein, cytoplasmic 1, intermediate chain 1
chr19_+_3653976 1.06 ENSDART00000125673
nedd9
neural precursor cell expressed, developmentally down-regulated 9
chr12_+_36891483 0.96 ENSDART00000048927
cox10
COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor
chr18_+_5549672 0.94 ENSDART00000184970
nnt2
nicotinamide nucleotide transhydrogenase 2
chr22_+_2937485 0.89 ENSDART00000082222
ENSDART00000135507
ENSDART00000143258
cep19
centrosomal protein 19
chr14_+_45471642 0.83 ENSDART00000126979
ENSDART00000172952
ENSDART00000173284
ubxn1
UBX domain protein 1
chr21_-_12036134 0.71 ENSDART00000031658
tpgs2
tubulin polyglutamylase complex subunit 2
chr9_+_23748342 0.62 ENSDART00000019053
faima
Fas apoptotic inhibitory molecule a
chr9_+_23748133 0.61 ENSDART00000180758
faima
Fas apoptotic inhibitory molecule a
chr8_-_6943155 0.55 ENSDART00000139545
ENSDART00000033294
wdr13
WD repeat domain 13
chr17_-_14705039 0.53 ENSDART00000154281
ENSDART00000123550
ptp4a2a
protein tyrosine phosphatase type IVA, member 2a
chr23_+_29885019 0.53 ENSDART00000167059
aurkaip1
aurora kinase A interacting protein 1
chr4_-_75175407 0.53 ENSDART00000180125
CABZ01043953.1

chr14_-_30747686 0.49 ENSDART00000008373
fosl1a
FOS-like antigen 1a
chr10_+_8629275 0.49 ENSDART00000129643
aplnrb
apelin receptor b
chr19_+_27342479 0.48 ENSDART00000184687
ddx39b
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr24_-_28229618 0.47 ENSDART00000145290
bcl2a
BCL2, apoptosis regulator a
chr5_-_48268049 0.47 ENSDART00000187454
mef2cb
myocyte enhancer factor 2cb
chr5_+_13427826 0.45 ENSDART00000083359
sec14l8
SEC14-like lipid binding 8
chr7_-_44672095 0.45 ENSDART00000073745
cmtm4
CKLF-like MARVEL transmembrane domain containing 4
chr17_+_8899016 0.43 ENSDART00000150214
psmc1a
proteasome 26S subunit, ATPase 1a
chr20_-_23440955 0.43 ENSDART00000153386
slc10a4
solute carrier family 10, member 4
chr3_-_18792492 0.39 ENSDART00000134208
ENSDART00000034373
hagh
hydroxyacylglutathione hydrolase
chr25_-_17494364 0.39 ENSDART00000154134
lrrc29
leucine rich repeat containing 29
chr8_+_28259347 0.35 ENSDART00000110857
fam212b
family with sequence similarity 212, member B
chr14_-_33177935 0.35 ENSDART00000180583
ENSDART00000078856
dlg3
discs, large homolog 3 (Drosophila)
chr15_+_33991928 0.34 ENSDART00000170177
vwde
von Willebrand factor D and EGF domains
chr14_-_8625845 0.33 ENSDART00000054760
zgc:162144
zgc:162144
chr16_-_44709832 0.29 ENSDART00000156784
si:ch211-151m7.6
si:ch211-151m7.6
chr25_+_7671640 0.27 ENSDART00000145367
kcnj11l
potassium inwardly-rectifying channel, subfamily J, member 11, like
chr18_+_19990412 0.24 ENSDART00000155054
ENSDART00000090310
pias1b
protein inhibitor of activated STAT, 1b
chr20_-_43723860 0.24 ENSDART00000122051
mixl1
Mix paired-like homeobox
chr18_+_8346920 0.22 ENSDART00000083421
cpt1b
carnitine palmitoyltransferase 1B (muscle)
chr20_+_35382482 0.21 ENSDART00000135284
vsnl1a
visinin-like 1a
chr8_+_29986265 0.21 ENSDART00000148258
ptch1
patched 1
chr13_+_23677949 0.21 ENSDART00000144215
pcnxl2
pecanex-like 2 (Drosophila)
chr19_-_26923273 0.21 ENSDART00000089609
skiv2l
SKI2 homolog, superkiller viralicidic activity 2-like
chr16_-_45398408 0.20 ENSDART00000004052
rgl2
ral guanine nucleotide dissociation stimulator-like 2
chr22_-_2937503 0.20 ENSDART00000092991
ENSDART00000131110
pigx
phosphatidylinositol glycan anchor biosynthesis, class X
chr5_-_24238733 0.19 ENSDART00000138170
plscr3a
phospholipid scramblase 3a
chr16_+_1803462 0.18 ENSDART00000183974
GRIK2
glutamate ionotropic receptor kainate type subunit 2
chr6_+_3827751 0.18 ENSDART00000003008
ENSDART00000122348
gad1b
glutamate decarboxylase 1b
chr15_-_3976035 0.16 ENSDART00000168061
si:ch73-309g22.1
si:ch73-309g22.1
chr3_-_12970418 0.16 ENSDART00000158747
pdgfab
platelet-derived growth factor alpha polypeptide b
chr22_+_2492397 0.14 ENSDART00000181596
CU570894.2

chr22_+_2431585 0.13 ENSDART00000167758
zgc:171435
zgc:171435
chr15_+_11381532 0.13 ENSDART00000124172
si:ch73-321d9.2
si:ch73-321d9.2
chr5_-_33460959 0.11 ENSDART00000085636
si:ch211-182d3.1
si:ch211-182d3.1
chr6_+_27304503 0.09 ENSDART00000154759
espnla
espin like a
chr5_-_69538058 0.07 ENSDART00000097251
zgc:153044
zgc:153044
chr7_-_31830936 0.07 ENSDART00000052514
ENSDART00000129720
cars
cysteinyl-tRNA synthetase
chr21_+_43882274 0.07 ENSDART00000075672
sra1
steroid receptor RNA activator 1
chr15_-_29573267 0.07 ENSDART00000099947
samsn1a
SAM domain, SH3 domain and nuclear localisation signals 1a
chr19_-_26923957 0.06 ENSDART00000182390
skiv2l
SKI2 homolog, superkiller viralicidic activity 2-like
chr2_+_54804385 0.06 ENSDART00000172309
twsg1a
twisted gastrulation BMP signaling modulator 1a
chr1_+_961607 0.06 ENSDART00000184660
n6amt1
N-6 adenine-specific DNA methyltransferase 1
chr13_+_43247936 0.05 ENSDART00000126850
ENSDART00000165331
smoc2
SPARC related modular calcium binding 2
chr20_-_13774826 0.05 ENSDART00000063831
opn8c
opsin 8, group member c
chr21_+_23108420 0.04 ENSDART00000192394
ENSDART00000088459
htr3b
5-hydroxytryptamine (serotonin) receptor 3B
chr4_+_62341346 0.04 ENSDART00000160601
znf1079
zinc finger protein 1079
chr23_+_45027263 0.04 ENSDART00000058364
hmgb2b
high mobility group box 2b
chr1_-_7951002 0.03 ENSDART00000138187
si:dkey-79f11.8
si:dkey-79f11.8
chr14_+_10567104 0.03 ENSDART00000160723
gpr174
G protein-coupled receptor 174
chr4_+_22613625 0.03 ENSDART00000131161
sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr6_-_131401 0.03 ENSDART00000151251
LRRC8E
si:zfos-323e3.4
chr14_-_10492072 0.02 ENSDART00000182525
lpar4
lysophosphatidic acid receptor 4
chr13_-_34683370 0.02 ENSDART00000113661
kif16bb
kinesin family member 16Bb
chr9_-_14108896 0.01 ENSDART00000135209
prkag3b
protein kinase, AMP-activated, gamma 3b non-catalytic subunit
chr15_-_14375452 0.01 ENSDART00000160675
ENSDART00000164028
ENSDART00000171642
dpf1
D4, zinc and double PHD fingers family 1

Network of associatons between targets according to the STRING database.

First level regulatory network of irx6a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0006740 NADPH regeneration(GO:0006740)
0.2 1.1 GO:0090527 actin filament reorganization(GO:0090527)
0.2 0.9 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.2 0.5 GO:1901232 regulation of convergent extension involved in axis elongation(GO:1901232) positive regulation of epiboly involved in gastrulation with mouth forming second(GO:1904088)
0.1 0.4 GO:0006089 lactate metabolic process(GO:0006089)
0.1 0.5 GO:1903589 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587) positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903589)
0.1 1.2 GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902041) negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.1 0.5 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.1 0.2 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0 0.8 GO:0031397 negative regulation of protein ubiquitination(GO:0031397)
0.0 0.7 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 1.1 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.4 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.3 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 0.2 GO:0048635 negative regulation of muscle organ development(GO:0048635)
0.0 0.2 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 0.5 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.5 GO:0006406 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 0.2 GO:0009437 carnitine metabolic process(GO:0009437)
0.0 1.1 GO:0010970 establishment of localization by movement along microtubule(GO:0010970)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 0.3 GO:0055087 Ski complex(GO:0055087)
0.0 0.4 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 1.3 GO:0005604 basement membrane(GO:0005604)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.2 0.9 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.1 0.5 GO:0060182 apelin receptor activity(GO:0060182)
0.1 1.1 GO:0045503 dynein light chain binding(GO:0045503)
0.1 0.4 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.1 1.1 GO:0016018 cyclosporin A binding(GO:0016018)
0.1 0.4 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 0.2 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 0.2 GO:0097108 hedgehog family protein binding(GO:0097108)
0.0 0.2 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 2.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.3 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.2 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.2 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.2 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.8 GO:0031593 polyubiquitin binding(GO:0031593)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID AURORA A PATHWAY Aurora A signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.1 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.2 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.2 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)