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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for isl1+isl1l

Z-value: 0.36

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Transcription factors associated with isl1+isl1l

Gene Symbol Gene ID Gene Info
isl1
ENSDARG00000004023 ISL LIM homeobox 1
isl1l
ENSDARG00000021055 islet1, like
isl1l
ENSDARG00000110204 islet1, like

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
isl1dr11_v1_chr5_-_40734045_40734045-0.933.0e-08Click!
isl1ldr11_v1_chr10_+_8680730_8680730-0.832.3e-05Click!

Activity profile of isl1+isl1l motif

Sorted Z-values of isl1+isl1l motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_29387215 1.45 ENSDART00000148787
s100a1
S100 calcium binding protein A1
chr9_-_35633827 1.04 ENSDART00000077745
zp2l1
zona pellucida glycoprotein 2, like 1
chr12_+_22672323 0.97 ENSDART00000123808
ENSDART00000159864
cdca9
cell division cycle associated 9
chr2_-_17114852 0.91 ENSDART00000006549
pif1
PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae)
chr20_-_38787341 0.87 ENSDART00000136771
dnajc5ga
DnaJ (Hsp40) homolog, subfamily C, member 5 gamma a
chr16_+_30117798 0.83 ENSDART00000135723
ENSDART00000000198
sema6e
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6E
chr20_-_45772306 0.81 ENSDART00000062092
trmt6
tRNA methyltransferase 6 homolog (S. cerevisiae)
chr13_+_46941930 0.80 ENSDART00000056962
fbxo5
F-box protein 5
chr25_+_36292057 0.75 ENSDART00000152329
bmb
brambleberry
chr20_-_38787047 0.74 ENSDART00000152913
ENSDART00000153430
dnajc5ga
DnaJ (Hsp40) homolog, subfamily C, member 5 gamma a
chr17_-_4252221 0.73 ENSDART00000152020
gdf3
growth differentiation factor 3
chr22_-_17653143 0.66 ENSDART00000089171
hmha1b
histocompatibility (minor) HA-1 b
chr1_-_9486214 0.66 ENSDART00000137821
micall2b
mical-like 2b
chr13_+_22712406 0.65 ENSDART00000132847
si:ch211-134m17.9
si:ch211-134m17.9
chr10_-_2943474 0.60 ENSDART00000188698
oclna
occludin a
chr8_-_51367298 0.59 ENSDART00000060628
chmp7
charged multivesicular body protein 7
chr4_+_26056548 0.59 ENSDART00000171204
SCYL2
si:ch211-244b2.1
chr23_+_19590598 0.59 ENSDART00000170149
slmapb
sarcolemma associated protein b
chr12_-_10505986 0.58 ENSDART00000152672
zgc:152977
zgc:152977
chr20_-_48407944 0.57 ENSDART00000085624
ipo13
importin 13
chr6_+_10338554 0.55 ENSDART00000186936
cobll1a
cordon-bleu WH2 repeat protein-like 1a
chr24_-_33308045 0.51 ENSDART00000149711
slc4a2b
solute carrier family 4 (anion exchanger), member 2b
chr8_-_25033681 0.51 ENSDART00000003493
nfyal
nuclear transcription factor Y, alpha, like
chr11_-_279328 0.50 ENSDART00000066179
npffl
neuropeptide FF-amide peptide precursor like
chr11_+_24316110 0.50 ENSDART00000186028
rem1
RAS (RAD and GEM)-like GTP-binding 1
chr21_-_35325466 0.50 ENSDART00000134780
ENSDART00000145930
ENSDART00000076715
ENSDART00000065341
ENSDART00000162189
ublcp1
ubiquitin-like domain containing CTD phosphatase 1
chr19_-_47570672 0.49 ENSDART00000112155
rrm2
ribonucleotide reductase M2 polypeptide
chr5_-_36597612 0.49 ENSDART00000031270
ENSDART00000122098
rhogc
ras homolog gene family, member Gc
chr3_+_24062748 0.49 ENSDART00000188574
cbx1a
chromobox homolog 1a (HP1 beta homolog Drosophila)
chr25_+_7492663 0.48 ENSDART00000166496
cat
catalase
chr22_-_3299100 0.47 ENSDART00000160305
si:zfos-943e10.1
si:zfos-943e10.1
chr21_-_21178410 0.46 ENSDART00000185277
ENSDART00000141341
ENSDART00000145872
ENSDART00000079678
ftsj1
FtsJ RNA methyltransferase homolog 1
chr14_-_41478265 0.45 ENSDART00000149886
ENSDART00000016002
tspan7
tetraspanin 7
chr25_+_7532627 0.45 ENSDART00000187660
ptdss2
phosphatidylserine synthase 2
chr10_+_26990095 0.43 ENSDART00000064111
faub
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed b
chr23_-_45398622 0.43 ENSDART00000053571
ENSDART00000149464
zgc:100911
zgc:100911
chr25_+_35889102 0.42 ENSDART00000023453
ENSDART00000125821
ENSDART00000135441
lsm14aa
LSM14A mRNA processing body assembly factor a
chr22_-_28644517 0.42 ENSDART00000189538
jagn1b
jagunal homolog 1b
chr23_+_20431388 0.42 ENSDART00000132920
ENSDART00000102963
ENSDART00000109899
ENSDART00000140219
slc35c2
solute carrier family 35 (GDP-fucose transporter), member C2
chr14_+_16287968 0.41 ENSDART00000106593
prpf19
pre-mRNA processing factor 19
chr23_+_20431140 0.40 ENSDART00000193950
slc35c2
solute carrier family 35 (GDP-fucose transporter), member C2
chr17_-_29271359 0.39 ENSDART00000104219
rcor1
REST corepressor 1
chr4_-_837768 0.39 ENSDART00000185280
ENSDART00000135618
sobpb
sine oculis binding protein homolog (Drosophila) b
chr18_+_3243292 0.39 ENSDART00000166580
pak1
p21 protein (Cdc42/Rac)-activated kinase 1
chr8_+_21254192 0.39 ENSDART00000167718
itpr3
inositol 1,4,5-trisphosphate receptor, type 3
chr14_-_30876299 0.39 ENSDART00000180305
ubl3b
ubiquitin-like 3b
chr4_-_12930086 0.39 ENSDART00000013604
lemd3
LEM domain containing 3
chr21_+_31253048 0.38 ENSDART00000178521
ENSDART00000132317
ENSDART00000040190
asl
argininosuccinate lyase
chr6_-_53326421 0.38 ENSDART00000191740
gnb1b
guanine nucleotide binding protein (G protein), beta polypeptide 1b
chr12_+_13205955 0.38 ENSDART00000092906
ppp1cab
protein phosphatase 1, catalytic subunit, alpha isozyme b
chr2_-_1622641 0.37 ENSDART00000082143
prkacbb
protein kinase, cAMP-dependent, catalytic, beta b
chr11_+_45110865 0.36 ENSDART00000158188
mgea5l
meningioma expressed antigen 5 (hyaluronidase) like
chr25_+_6122823 0.36 ENSDART00000191824
ENSDART00000067514
rbpms2a
RNA binding protein with multiple splicing 2a
chr22_+_438714 0.35 ENSDART00000136491
celsr2
cadherin, EGF LAG seven-pass G-type receptor 2
chr7_-_71585065 0.35 ENSDART00000128678
mettl4
methyltransferase like 4
chr18_-_12295092 0.35 ENSDART00000033248
fam107b
family with sequence similarity 107, member B
chr15_-_43625549 0.34 ENSDART00000168589
ctsc
cathepsin C
chr15_-_23529945 0.34 ENSDART00000152543
hmbsb
hydroxymethylbilane synthase, b
chr19_+_42432625 0.34 ENSDART00000076938
pogza
pogo transposable element derived with ZNF domain a
chr10_-_1961576 0.33 ENSDART00000042441
tdgf1
teratocarcinoma-derived growth factor 1
chr19_-_6193448 0.33 ENSDART00000151405
erf
Ets2 repressor factor
chr20_+_29209926 0.33 ENSDART00000152949
ENSDART00000153016
katnbl1
katanin p80 subunit B-like 1
chr12_+_14149686 0.33 ENSDART00000123741
kbtbd2
kelch repeat and BTB (POZ) domain containing 2
chr3_-_1283247 0.32 ENSDART00000149814
tcf20
transcription factor 20
chr6_-_39005133 0.32 ENSDART00000104116
ENSDART00000151750
vdrb
vitamin D receptor b
chr15_-_44052927 0.32 ENSDART00000166209
wu:fb44b02
wu:fb44b02
chr8_-_30338872 0.31 ENSDART00000137583
dock8
dedicator of cytokinesis 8
chr5_+_31168096 0.31 ENSDART00000086443
ENSDART00000192271
atp2a3
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
chr6_-_31682135 0.31 ENSDART00000153988
cachd1
cache domain containing 1
chr9_-_41507712 0.30 ENSDART00000135821
mfsd6b
major facilitator superfamily domain containing 6b
chr8_+_48942470 0.30 ENSDART00000005464
ENSDART00000132035
rer1
retention in endoplasmic reticulum sorting receptor 1
chr25_-_10769039 0.30 ENSDART00000186758
ENSDART00000121724
lrp5
low density lipoprotein receptor-related protein 5
chr4_-_13156971 0.29 ENSDART00000182164
grip1
glutamate receptor interacting protein 1
chr14_-_36437249 0.29 ENSDART00000016728
aga
aspartylglucosaminidase
chr23_-_32156278 0.28 ENSDART00000157479
nr4a1
nuclear receptor subfamily 4, group A, member 1
chr23_+_31596441 0.28 ENSDART00000053534
tbpl1
TBP-like 1
chr23_+_2703044 0.28 ENSDART00000182512
ENSDART00000105286
ncoa6
nuclear receptor coactivator 6
chr5_-_13076779 0.28 ENSDART00000192826
ypel1
yippee-like 1
chr20_+_18703951 0.28 ENSDART00000191070
eif5
eukaryotic translation initiation factor 5
chr4_+_9478500 0.27 ENSDART00000030738
lmf2b
lipase maturation factor 2b
chr16_-_55259199 0.27 ENSDART00000161130
iqgap3
IQ motif containing GTPase activating protein 3
chr11_+_30647545 0.27 ENSDART00000114792
gb:eh507706
expressed sequence EH507706
chr21_+_26522571 0.27 ENSDART00000134617
adssl
adenylosuccinate synthase, like
chr6_-_33707278 0.27 ENSDART00000188103
mast2
microtubule associated serine/threonine kinase 2
chr9_+_41459759 0.26 ENSDART00000132501
ENSDART00000100265
nemp2
nuclear envelope integral membrane protein 2
chr25_+_32390794 0.26 ENSDART00000012600
galk2
galactokinase 2
chr17_+_47090497 0.26 ENSDART00000169038
ENSDART00000159292
zgc:103755
zgc:103755
chr19_+_8612839 0.26 ENSDART00000144925
snx27a
sorting nexin family member 27a
chr17_-_13070602 0.26 ENSDART00000188311
ENSDART00000193428
CU469462.1

chr12_-_13205854 0.26 ENSDART00000077829
pelo
pelota mRNA surveillance and ribosome rescue factor
chr3_-_23513155 0.25 ENSDART00000170200
BX682558.1

chr5_+_66250856 0.25 ENSDART00000132789
secisbp2
SECIS binding protein 2
chr9_-_14137295 0.25 ENSDART00000127640
ENSDART00000189018
ENSDART00000188985
ttll4
tubulin tyrosine ligase-like family, member 4
chr17_+_33375469 0.24 ENSDART00000032827
zgc:162964
zgc:162964
chr7_-_30280934 0.24 ENSDART00000126741
serf2
small EDRK-rich factor 2
chr16_+_52999778 0.24 ENSDART00000011506
nkd2a
naked cuticle homolog 2a
chr3_-_18737126 0.24 ENSDART00000055767
e4f1
E4F transcription factor 1
chr5_-_19006290 0.24 ENSDART00000137022
golga3
golgin A3
chr11_-_31226578 0.23 ENSDART00000109698
nacc1b
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing b
chr3_+_13860815 0.23 ENSDART00000162451
ilf3b
interleukin enhancer binding factor 3b
chr8_+_52530889 0.23 ENSDART00000127729
ENSDART00000170360
ENSDART00000162687
stambpb
STAM binding protein b
chr10_-_17587832 0.23 ENSDART00000113101
smarcad1b
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 b
chr20_-_40360571 0.23 ENSDART00000144768
smpdl3a
sphingomyelin phosphodiesterase, acid-like 3A
chr23_-_36934944 0.23 ENSDART00000109976
ENSDART00000162179
acap3a
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3a
chr5_+_25762271 0.23 ENSDART00000181323
tmem2
transmembrane protein 2
chr8_-_53896982 0.22 ENSDART00000169206
MIB2
mindbomb E3 ubiquitin protein ligase 2
chr25_+_30131055 0.22 ENSDART00000152705
api5
apoptosis inhibitor 5
chr11_-_14813029 0.22 ENSDART00000004920
ENSDART00000122645
sgta
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr20_+_25712276 0.22 ENSDART00000121585
ENSDART00000185772
cep135
centrosomal protein 135
chr5_+_31791001 0.22 ENSDART00000043010
slc25a25b
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25b
chr5_-_33281046 0.22 ENSDART00000051344
ENSDART00000138116
surf6
surfeit 6
chr2_+_1881334 0.22 ENSDART00000161420
adgrl2b.1
adhesion G protein-coupled receptor L2b, tandem duplicate 1
chr16_+_9400661 0.22 ENSDART00000146174
ice1
KIAA0947-like (H. sapiens)
chr10_-_13343831 0.21 ENSDART00000135941
il11ra
interleukin 11 receptor, alpha
chr16_+_45337663 0.21 ENSDART00000147343
ENSDART00000185731
dnase2
deoxyribonuclease II, lysosomal
chr11_+_16216909 0.21 ENSDART00000081035
ENSDART00000147190
slc25a26
solute carrier family 25 (S-adenosylmethionine carrier), member 26
chr11_-_18017287 0.20 ENSDART00000155443
qrich1
glutamine-rich 1
chr1_+_30946231 0.20 ENSDART00000022841
metap1d
methionyl aminopeptidase type 1D (mitochondrial)
chr20_+_25711718 0.20 ENSDART00000033436
cep135
centrosomal protein 135
chr12_-_13205572 0.20 ENSDART00000152670
pelo
pelota mRNA surveillance and ribosome rescue factor
chr6_-_49898881 0.20 ENSDART00000150204
atp5f1e
ATP synthase F1 subunit epsilon
chr4_-_27897160 0.20 ENSDART00000066924
ENSDART00000066925
ENSDART00000193020
tbc1d22a
TBC1 domain family, member 22a
chr25_+_16098620 0.20 ENSDART00000142564
ENSDART00000165598
far1
fatty acyl CoA reductase 1
chr1_-_25144439 0.20 ENSDART00000132355
fbxw7
F-box and WD repeat domain containing 7
chr10_-_10018120 0.20 ENSDART00000132375
strbp
spermatid perinuclear RNA binding protein
chr8_-_22838364 0.20 ENSDART00000187954
ENSDART00000185368
ENSDART00000188210
magixa
MAGI family member, X-linked a
chr11_+_41459408 0.19 ENSDART00000182285
park7
parkinson protein 7
chr15_+_23657051 0.19 ENSDART00000078336
klc3
kinesin light chain 3
chr16_+_13883872 0.19 ENSDART00000101304
ENSDART00000136005
atg12
ATG12 autophagy related 12 homolog (S. cerevisiae)
chr10_+_7593185 0.19 ENSDART00000162617
ENSDART00000162590
ENSDART00000171744
ppp2cb
protein phosphatase 2, catalytic subunit, beta isozyme
chr15_+_11814969 0.19 ENSDART00000127248
FO704748.1

chr4_-_15103646 0.19 ENSDART00000138183
ENSDART00000181044
nrf1
nuclear respiratory factor 1
chr1_-_23596391 0.18 ENSDART00000155184
lcorl
ligand dependent nuclear receptor corepressor-like
chr7_+_36898850 0.18 ENSDART00000113342
tox3
TOX high mobility group box family member 3
chr6_-_19333947 0.17 ENSDART00000160887
gga3
ggolgi-associated, gamma adaptin ear containing, ARF binding protein 3
chr16_-_36979592 0.17 ENSDART00000168443
snrnp48
small nuclear ribonucleoprotein 48 (U11/U12)
chr19_-_7272921 0.17 ENSDART00000102075
ENSDART00000132887
ENSDART00000130234
ENSDART00000193535
ENSDART00000136528
rxrba
retinoid x receptor, beta a
chr14_+_23709134 0.17 ENSDART00000191162
ENSDART00000179754
ENSDART00000054266
gnpda1
glucosamine-6-phosphate deaminase 1
chr13_-_48388726 0.17 ENSDART00000169473
fbxo11a
F-box protein 11a
chr11_-_18107447 0.17 ENSDART00000187376
qrich1
glutamine-rich 1
chr10_+_35352435 0.17 ENSDART00000123936
si:dkey-259j3.5
si:dkey-259j3.5
chr22_-_16755885 0.17 ENSDART00000036467
patj
PATJ, crumbs cell polarity complex component
chr11_-_10850936 0.16 ENSDART00000091901
psmd14
proteasome 26S subunit, non-ATPase 14
chr6_+_36844127 0.16 ENSDART00000020505
chd1l
chromodomain helicase DNA binding protein 1-like
chr7_-_34192834 0.16 ENSDART00000125131
smad6a
SMAD family member 6a
chr2_+_45100963 0.15 ENSDART00000160122
CU929150.2

chr21_+_2506013 0.15 ENSDART00000162351
hmgcrb
3-hydroxy-3-methylglutaryl-CoA reductase b
chr25_+_459901 0.15 ENSDART00000154895
prtgb
protogenin homolog b (Gallus gallus)
chr22_+_26853254 0.15 ENSDART00000182487
tmem186
transmembrane protein 186
chr3_-_11008532 0.15 ENSDART00000165086
CR382337.3

chr18_+_35861930 0.15 ENSDART00000185223
ppp1r13l
protein phosphatase 1, regulatory subunit 13 like
chr7_-_54679595 0.15 ENSDART00000165320
ccnd1
cyclin D1
chr25_-_32381642 0.15 ENSDART00000133872
ENSDART00000006124
cops2
COP9 signalosome subunit 2
chr21_+_34981263 0.15 ENSDART00000132711
rbm11
RNA binding motif protein 11
chr2_-_31711547 0.14 ENSDART00000175525
ENSDART00000189763
ENSDART00000113498
lrrcc1
leucine rich repeat and coiled-coil centrosomal protein 1
chr9_+_37320222 0.14 ENSDART00000100622
slc15a2
solute carrier family 15 (oligopeptide transporter), member 2
chr8_+_20140321 0.14 ENSDART00000012120
acsbg2
acyl-CoA synthetase bubblegum family member 2
chr3_-_58650057 0.14 ENSDART00000057640
dhrs7ca
dehydrogenase/reductase (SDR family) member 7Ca
chr9_-_41025062 0.14 ENSDART00000002053
pms1
PMS1 homolog 1, mismatch repair system component
chr12_+_27034760 0.14 ENSDART00000181170
ENSDART00000153054
fbrs
fibrosin
chr15_+_1199407 0.13 ENSDART00000163827
mfsd1
major facilitator superfamily domain containing 1
chr7_+_67748939 0.13 ENSDART00000162978
dhx38
DEAH (Asp-Glu-Ala-His) box polypeptide 38
chr20_-_5400395 0.13 ENSDART00000168103
snw1
SNW domain containing 1
chr17_-_36529016 0.13 ENSDART00000025019
colec11
collectin sub-family member 11
chr13_-_15082024 0.13 ENSDART00000157482
sfxn5a
sideroflexin 5a
chr4_+_2230701 0.13 ENSDART00000080439
cmah
cytidine monophospho-N-acetylneuraminic acid hydroxylase
chr18_-_14743659 0.13 ENSDART00000125979
tshz3a
teashirt zinc finger homeobox 3a
chr13_+_31184796 0.12 ENSDART00000147085
ptpn20
protein tyrosine phosphatase, non-receptor type 20
chr7_+_67429185 0.12 ENSDART00000162553
ENSDART00000178646
kars
lysyl-tRNA synthetase
chr14_-_32631013 0.11 ENSDART00000176815
atp11c
ATPase phospholipid transporting 11C
chr23_-_28423048 0.11 ENSDART00000140448
c1ql4a
complement component 1, q subcomponent-like 4
chr23_-_351935 0.11 ENSDART00000140986
uhrf1bp1
UHRF1 binding protein 1
chr5_-_56948058 0.11 ENSDART00000083074
ENSDART00000191028
si:ch211-127d4.3
si:ch211-127d4.3
chr12_+_27034594 0.11 ENSDART00000111679
fbrs
fibrosin
chr13_-_9159852 0.11 ENSDART00000170185
ENSDART00000158697
ENSDART00000143393
ENSDART00000164973
ENSDART00000159910
HTRA2 (1 of many)
si:dkey-112g5.16
chr15_+_888704 0.11 ENSDART00000182796
si:dkey-7i4.9
si:dkey-7i4.9
chr3_-_25420931 0.11 ENSDART00000109601
ENSDART00000182184
bptf
bromodomain PHD finger transcription factor
chr16_-_35415004 0.11 ENSDART00000170401
ENSDART00000157832
ENSDART00000170048
taf12
TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr13_+_16522608 0.11 ENSDART00000182838
ENSDART00000143200
kcnma1a
potassium large conductance calcium-activated channel, subfamily M, alpha member 1a
chr17_-_2036850 0.10 ENSDART00000186048
ENSDART00000188838
ENSDART00000186423
spint1a
serine peptidase inhibitor, Kunitz type 1 a
chr3_-_25148047 0.10 ENSDART00000089325
mief1
mitochondrial elongation factor 1
chr15_-_24588649 0.10 ENSDART00000060469
gemin4
gem (nuclear organelle) associated protein 4
chr7_+_15677196 0.10 ENSDART00000192676
mef2ab
myocyte enhancer factor 2ab
chr9_+_8942258 0.10 ENSDART00000138836
ankrd10b
ankyrin repeat domain 10b
chr13_+_31177934 0.10 ENSDART00000144568
ptpn20
protein tyrosine phosphatase, non-receptor type 20
chr9_-_27720612 0.10 ENSDART00000000566
gtf2e1
general transcription factor IIE, polypeptide 1, alpha
chr8_+_23658626 0.10 ENSDART00000083605
tbc1d25
TBC1 domain family, member 25
chr10_+_35358675 0.10 ENSDART00000193263
si:dkey-259j3.5
si:dkey-259j3.5
chr11_-_35975026 0.10 ENSDART00000186219
itpr1b
inositol 1,4,5-trisphosphate receptor, type 1b
chr22_-_7563593 0.10 ENSDART00000106062
BX511034.1

chr21_-_30408775 0.09 ENSDART00000101037
nhp2
NHP2 ribonucleoprotein homolog (yeast)
chr22_-_31020690 0.09 ENSDART00000130604
ssuh2.4
ssu-2 homolog, tandem duplicate 4
chr15_-_20731297 0.09 ENSDART00000114464
tpst1
tyrosylprotein sulfotransferase 1
chr3_-_21062706 0.09 ENSDART00000155605
ENSDART00000153686
ENSDART00000157168
ENSDART00000156614
ENSDART00000155743
ENSDART00000156275
fam57ba
family with sequence similarity 57, member Ba
chr19_+_9786722 0.09 ENSDART00000138310
cacng6a
calcium channel, voltage-dependent, gamma subunit 6a
chr8_+_54055390 0.09 ENSDART00000102696
magi1a
membrane associated guanylate kinase, WW and PDZ domain containing 1a
chr22_+_31023205 0.08 ENSDART00000111561
zmp:0000000735
zmp:0000000735
chr12_+_10062953 0.08 ENSDART00000148689
slc4a1b
solute carrier family 4 (anion exchanger), member 1b (Diego blood group)
chr4_+_17539134 0.08 ENSDART00000013313
itfg2
integrin alpha FG-GAP repeat containing 2
chr17_+_44756247 0.08 ENSDART00000153773
cipca
CLOCK-interacting pacemaker a

Network of associatons between targets according to the STRING database.

First level regulatory network of isl1+isl1l

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:1904667 negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.2 0.8 GO:0000741 karyogamy(GO:0000741) pronuclear fusion(GO:0007344)
0.1 0.7 GO:1900145 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.1 0.4 GO:0038158 granulocyte colony-stimulating factor signaling pathway(GO:0038158)
0.1 0.5 GO:0032790 ribosome disassembly(GO:0032790)
0.1 0.3 GO:0090008 hypoblast development(GO:0090008)
0.1 0.4 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.1 0.3 GO:0035676 anterior lateral line neuromast hair cell development(GO:0035676)
0.1 0.5 GO:1901841 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 0.4 GO:0006526 arginine biosynthetic process(GO:0006526)
0.1 0.3 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.1 0.9 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.1 0.3 GO:0019884 antigen processing and presentation of exogenous peptide antigen(GO:0002478) antigen processing and presentation of exogenous antigen(GO:0019884) antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.1 0.2 GO:1903334 regulation of protein folding(GO:1903332) positive regulation of protein folding(GO:1903334) regulation of chaperone-mediated protein folding(GO:1903644) positive regulation of chaperone-mediated protein folding(GO:1903646)
0.1 0.4 GO:0051148 smooth muscle cell differentiation(GO:0051145) negative regulation of muscle cell differentiation(GO:0051148)
0.1 0.4 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.1 0.2 GO:0031645 negative regulation of myelination(GO:0031642) negative regulation of neurological system process(GO:0031645)
0.1 0.4 GO:0003232 bulbus arteriosus development(GO:0003232)
0.1 0.2 GO:2000378 negative regulation of reactive oxygen species metabolic process(GO:2000378)
0.1 0.2 GO:0070417 cellular response to cold(GO:0070417)
0.1 0.3 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
0.1 0.2 GO:0006043 glucosamine metabolic process(GO:0006041) glucosamine catabolic process(GO:0006043)
0.1 0.3 GO:0032615 interleukin-12 production(GO:0032615) regulation of interleukin-12 production(GO:0032655)
0.1 0.4 GO:0034063 stress granule assembly(GO:0034063)
0.1 0.2 GO:0070084 protein initiator methionine removal(GO:0070084)
0.0 1.6 GO:0006998 nuclear envelope organization(GO:0006998)
0.0 0.4 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.0 0.5 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.0 0.3 GO:0031112 positive regulation of microtubule polymerization or depolymerization(GO:0031112) positive regulation of microtubule polymerization(GO:0031116)
0.0 0.3 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.4 GO:1902624 positive regulation of neutrophil migration(GO:1902624)
0.0 0.3 GO:0006012 galactose metabolic process(GO:0006012)
0.0 0.1 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.7 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.0 0.1 GO:0090141 positive regulation of mitochondrial fission(GO:0090141)
0.0 0.4 GO:1900052 regulation of isoprenoid metabolic process(GO:0019747) regulation of vitamin metabolic process(GO:0030656) regulation of retinoic acid biosynthetic process(GO:1900052)
0.0 0.1 GO:0001120 DNA-templated transcriptional open complex formation(GO:0001112) transcriptional open complex formation at RNA polymerase II promoter(GO:0001113) protein-DNA complex remodeling(GO:0001120)
0.0 0.3 GO:0006517 protein deglycosylation(GO:0006517)
0.0 0.3 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0 0.1 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.0 0.1 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.0 0.2 GO:0006309 apoptotic DNA fragmentation(GO:0006309) cellular component disassembly involved in execution phase of apoptosis(GO:0006921) apoptotic nuclear changes(GO:0030262)
0.0 0.3 GO:0006167 AMP biosynthetic process(GO:0006167)
0.0 0.2 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.4 GO:0021754 facial nucleus development(GO:0021754)
0.0 0.5 GO:0046688 response to copper ion(GO:0046688)
0.0 0.1 GO:0042766 nucleosome mobilization(GO:0042766)
0.0 0.2 GO:0001955 blood vessel maturation(GO:0001955)
0.0 0.6 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.2 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.8 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.2 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.1 GO:1902514 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.0 0.1 GO:0042754 negative regulation of circadian rhythm(GO:0042754)
0.0 0.1 GO:0002753 cytoplasmic pattern recognition receptor signaling pathway(GO:0002753)
0.0 0.2 GO:0000729 DNA double-strand break processing(GO:0000729)
0.0 0.1 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.5 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.1 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0 0.4 GO:0010737 protein kinase A signaling(GO:0010737)
0.0 0.3 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 0.4 GO:0008345 larval locomotory behavior(GO:0008345) larval behavior(GO:0030537)
0.0 0.5 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.0 1.5 GO:0008016 regulation of heart contraction(GO:0008016)
0.0 0.2 GO:0060061 Spemann organizer formation(GO:0060061)
0.0 0.1 GO:0061549 sympathetic ganglion development(GO:0061549)
0.0 0.9 GO:1902668 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 0.2 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.1 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.1 GO:0015746 tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.0 0.6 GO:0036269 swimming behavior(GO:0036269)
0.0 0.0 GO:0035475 angioblast cell migration involved in selective angioblast sprouting(GO:0035475)
0.0 0.0 GO:0015670 carbon dioxide transport(GO:0015670)
0.0 0.0 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.0 0.1 GO:0072677 eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677) positive regulation of calcium ion import(GO:0090280)
0.0 0.1 GO:0006478 protein sulfation(GO:0006477) peptidyl-tyrosine sulfation(GO:0006478)
0.0 0.1 GO:0090104 pancreatic D cell differentiation(GO:0003311) pancreatic epsilon cell differentiation(GO:0090104)
0.0 0.5 GO:0043297 apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830)
0.0 0.6 GO:0051453 regulation of intracellular pH(GO:0051453)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0032133 chromosome passenger complex(GO:0032133)
0.1 0.7 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
0.1 0.2 GO:0072380 TRC complex(GO:0072380)
0.1 0.4 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.1 0.2 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0 1.0 GO:0044453 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.5 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.6 GO:0000815 ESCRT III complex(GO:0000815)
0.0 1.0 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.1 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.0 0.2 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.1 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.0 0.1 GO:0016589 NURF complex(GO:0016589)
0.0 0.5 GO:0030667 secretory granule membrane(GO:0030667)
0.0 0.1 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.0 0.9 GO:0005657 replication fork(GO:0005657)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.1 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.1 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.0 0.1 GO:0032300 mismatch repair complex(GO:0032300)
0.0 0.1 GO:0032797 SMN complex(GO:0032797)
0.0 0.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.2 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.0 1.0 GO:0005581 collagen trimer(GO:0005581)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.1 0.7 GO:0016429 tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
0.1 0.4 GO:0016842 amidine-lyase activity(GO:0016842)
0.1 0.4 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 0.5 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 0.3 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 0.3 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.1 0.2 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.1 0.3 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.1 0.5 GO:0004096 catalase activity(GO:0004096)
0.1 0.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.6 GO:0043495 protein anchor(GO:0043495)
0.0 0.1 GO:0042806 fucose binding(GO:0042806)
0.0 0.1 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.0 1.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.3 GO:0001217 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.0 0.5 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.2 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.1 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.2 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 0.5 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.6 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.3 GO:0070697 activin receptor binding(GO:0070697)
0.0 0.4 GO:0009008 DNA-methyltransferase activity(GO:0009008)
0.0 0.4 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.0 0.4 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.2 GO:0035925 AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.6 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.1 GO:0055105 ubiquitin-protein transferase inhibitor activity(GO:0055105)
0.0 0.1 GO:0015137 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0 0.2 GO:0016889 endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
0.0 0.1 GO:0042936 dipeptide transporter activity(GO:0042936) dipeptide transmembrane transporter activity(GO:0071916)
0.0 0.2 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.1 GO:0008489 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity(GO:0008489)
0.0 0.2 GO:0070740 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.0 0.2 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 0.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.5 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.1 GO:0019863 IgE binding(GO:0019863) immunoglobulin binding(GO:0019865)
0.0 0.1 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.0 0.1 GO:0016405 CoA-ligase activity(GO:0016405)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.3 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.1 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.3 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.3 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.3 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.5 PID FOXO PATHWAY FoxO family signaling
0.0 0.3 PID MYC PATHWAY C-MYC pathway
0.0 1.7 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.4 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.2 PID ARF 3PATHWAY Arf1 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.1 0.4 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 1.3 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.4 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.3 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.3 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.6 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.2 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.2 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.3 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.1 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.1 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.0 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions