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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for isl2a+isl2b

Z-value: 0.54

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Transcription factors associated with isl2a+isl2b

Gene Symbol Gene ID Gene Info
isl2a
ENSDARG00000003971 ISL LIM homeobox 2a
isl2b
ENSDARG00000053499 ISL LIM homeobox 2b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
isl2adr11_v1_chr25_-_32751982_327519820.928.9e-08Click!
isl2bdr11_v1_chr7_+_29992889_299928890.841.5e-05Click!

Activity profile of isl2a+isl2b motif

Sorted Z-values of isl2a+isl2b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_15433518 2.60 ENSDART00000026180
fabp7a
fatty acid binding protein 7, brain, a
chr17_+_15433671 2.33 ENSDART00000149568
fabp7a
fatty acid binding protein 7, brain, a
chr15_+_34988148 2.07 ENSDART00000076269
ccdc105
coiled-coil domain containing 105
chr10_-_17083180 1.63 ENSDART00000170083
fam166b
family with sequence similarity 166, member B
chr24_+_33622769 1.61 ENSDART00000079342
dnah5l
dynein, axonemal, heavy chain 5 like
chr5_-_41494831 1.51 ENSDART00000051081
eef2l2
eukaryotic translation elongation factor 2, like 2
chr5_+_69747417 1.37 ENSDART00000153717
si:ch211-275j6.5
si:ch211-275j6.5
chr3_-_19200571 1.36 ENSDART00000131503
ENSDART00000012335
rfx1a
regulatory factor X, 1a (influences HLA class II expression)
chr8_+_24747865 1.33 ENSDART00000078656
slc16a4
solute carrier family 16, member 4
chr3_-_39180048 1.25 ENSDART00000049720
cdk21
cyclin-dependent kinase 21
chr20_+_25586099 1.00 ENSDART00000063122
ENSDART00000134047
cyp2p10
cytochrome P450, family 2, subfamily P, polypeptide 10
chr17_-_12407106 1.00 ENSDART00000183540
ankef1b
ankyrin repeat and EF-hand domain containing 1b
chr23_-_36724575 0.97 ENSDART00000159560
agap2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr8_-_13046089 0.96 ENSDART00000137784
si:dkey-208b23.5
si:dkey-208b23.5
chr16_+_10972733 0.95 ENSDART00000049323
pou2f2a
POU class 2 homeobox 2a
chr3_+_14388010 0.86 ENSDART00000171726
ENSDART00000165452
tmem56b
transmembrane protein 56b
chr7_+_39166460 0.85 ENSDART00000052318
ENSDART00000146635
ENSDART00000173877
ENSDART00000173767
ENSDART00000173600
mdka
midkine a
chr21_+_11385031 0.84 ENSDART00000040598
cel.2
carboxyl ester lipase, tandem duplicate 2
chr24_-_26310854 0.80 ENSDART00000080113
apodb
apolipoprotein Db
chr18_-_48547564 0.77 ENSDART00000138607
kcnj1a.1
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1
chr24_+_12989727 0.74 ENSDART00000126842
ENSDART00000129309
flj11011l
hypothetical protein FLJ11011-like (H. sapiens)
chr2_-_293793 0.73 ENSDART00000082091
si:ch73-40a17.3
si:ch73-40a17.3
chr25_+_21833287 0.73 ENSDART00000187606
ckmt1
creatine kinase, mitochondrial 1
chr23_-_16485190 0.71 ENSDART00000155038
si:dkeyp-100a5.4
si:dkeyp-100a5.4
chr2_+_19522082 0.69 ENSDART00000146098
pimr49
Pim proto-oncogene, serine/threonine kinase, related 49
chr19_+_31904836 0.69 ENSDART00000162297
ENSDART00000088340
ENSDART00000151280
ENSDART00000151218
tpd52
tumor protein D52
chr6_-_8311044 0.68 ENSDART00000129674
slc44a2
solute carrier family 44 (choline transporter), member 2
chr6_-_49510553 0.67 ENSDART00000166238
rplp2
ribosomal protein, large P2
chr8_-_50147948 0.65 ENSDART00000149010
hp
haptoglobin
chr16_+_28728347 0.65 ENSDART00000149240
si:dkey-24i24.3
si:dkey-24i24.3
chr13_-_9450210 0.63 ENSDART00000133768
pimr152
Pim proto-oncogene, serine/threonine kinase, related 152
chr19_+_1688727 0.63 ENSDART00000115136
ENSDART00000166744
dennd3a
DENN/MADD domain containing 3a
chr4_-_9909371 0.61 ENSDART00000102656
si:dkey-22l11.6
si:dkey-22l11.6
chr14_-_24391424 0.60 ENSDART00000113376
ENSDART00000126894
fam13b
family with sequence similarity 13, member B
chr2_+_19633493 0.60 ENSDART00000147989
pimr54
Pim proto-oncogene, serine/threonine kinase, related 54
chr7_+_22657566 0.59 ENSDART00000141048
ponzr5
plac8 onzin related protein 5
chr20_-_23171430 0.58 ENSDART00000109234
spata18
spermatogenesis associated 18
chr13_+_9046473 0.58 ENSDART00000136557
pimr152
Pim proto-oncogene, serine/threonine kinase, related 152
chr20_+_11731039 0.58 ENSDART00000152215
ENSDART00000152585
si:ch211-155o21.3
si:ch211-155o21.3
chr6_+_9204099 0.57 ENSDART00000150167
ENSDART00000115394
tbx19
T-box 19
chr6_+_52350443 0.57 ENSDART00000151612
ENSDART00000151349
si:ch211-239j9.1
si:ch211-239j9.1
chr3_-_30061985 0.55 ENSDART00000189583
ppfia3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr2_+_19578446 0.55 ENSDART00000164758
pimr50
Pim proto-oncogene, serine/threonine kinase, related 50
chr7_+_26534131 0.54 ENSDART00000173980
si:dkey-62k3.5
si:dkey-62k3.5
chr2_-_293036 0.54 ENSDART00000171629
si:ch73-40a17.3
si:ch73-40a17.3
chr17_+_12285285 0.52 ENSDART00000154336
pimr174
Pim proto-oncogene, serine/threonine kinase, related 174
chr21_-_19314618 0.51 ENSDART00000188744
gpat3
glycerol-3-phosphate acyltransferase 3
chr13_-_9467944 0.50 ENSDART00000136582
pimr152
Pim proto-oncogene, serine/threonine kinase, related 152
chr1_-_669717 0.50 ENSDART00000160564
cyyr1
cysteine/tyrosine-rich 1
chr13_-_36391496 0.50 ENSDART00000100217
ENSDART00000140243
actn1
actinin, alpha 1
chr23_+_39695827 0.47 ENSDART00000113893
ENSDART00000186679
tmco4
transmembrane and coiled-coil domains 4
chr15_-_14884332 0.47 ENSDART00000165237
si:ch211-24o8.4
si:ch211-24o8.4
chr15_-_46779934 0.47 ENSDART00000085136
clcn2c
chloride channel 2c
chr3_-_13068189 0.46 ENSDART00000167180
prkar1b
protein kinase, cAMP-dependent, regulatory, type I, beta
chr1_-_52210950 0.46 ENSDART00000083946
pld6
phospholipase D family, member 6
chr20_+_40457599 0.46 ENSDART00000017553
serinc1
serine incorporator 1
chr7_-_48665305 0.46 ENSDART00000190507
cdkn1ca
cyclin-dependent kinase inhibitor 1Ca
chr8_-_52229462 0.46 ENSDART00000185949
ENSDART00000051825
tcf7l1b
transcription factor 7 like 1b
chr20_-_47188966 0.45 ENSDART00000152965
si:dkeyp-104f11.9
si:dkeyp-104f11.9
chr18_-_15932704 0.44 ENSDART00000127769
plekhg7
pleckstrin homology domain containing, family G (with RhoGef domain) member 7
chr1_-_42289704 0.43 ENSDART00000150124
si:ch211-71k14.1
si:ch211-71k14.1
chr16_-_21140097 0.43 ENSDART00000145837
ENSDART00000146500
si:dkey-271j15.3
si:dkey-271j15.3
chr22_-_5252005 0.41 ENSDART00000132942
ENSDART00000081801
ncln
nicalin
chr2_-_19520690 0.41 ENSDART00000133559
pimr52
Pim proto-oncogene, serine/threonine kinase, related 52
chr21_+_45841731 0.40 ENSDART00000038657
faxdc2
fatty acid hydroxylase domain containing 2
chr11_+_30057762 0.39 ENSDART00000164139
nhsb
Nance-Horan syndrome b (congenital cataracts and dental anomalies)
chr8_-_7475917 0.39 ENSDART00000082157
gata1b
GATA binding protein 1b
chr2_-_19520324 0.39 ENSDART00000079877
pimr52
Pim proto-oncogene, serine/threonine kinase, related 52
chr10_-_17222083 0.39 ENSDART00000134059
depdc5
DEP domain containing 5
chr21_-_20939488 0.39 ENSDART00000039043
rgs7bpb
regulator of G protein signaling 7 binding protein b
chr13_+_646700 0.38 ENSDART00000006892
tp53bp2a
tumor protein p53 binding protein, 2a
chr8_+_52637507 0.38 ENSDART00000163830
si:dkey-90l8.3
si:dkey-90l8.3
chr19_+_9186175 0.38 ENSDART00000039325
hcn3
hyperpolarization activated cyclic nucleotide-gated potassium channel 3
chr4_-_17669881 0.37 ENSDART00000066997
dram1
DNA-damage regulated autophagy modulator 1
chr24_-_12770357 0.37 ENSDART00000060826
ipo4
importin 4
chr17_-_14815557 0.36 ENSDART00000154473
nid2a
nidogen 2a (osteonidogen)
chr11_-_45138857 0.35 ENSDART00000166501
cant1b
calcium activated nucleotidase 1b
chr14_-_7137808 0.35 ENSDART00000054803
trpt1
tRNA phosphotransferase 1
chr11_-_1509773 0.35 ENSDART00000050762
phactr3b
phosphatase and actin regulator 3b
chr23_+_4253957 0.34 ENSDART00000008761
arl6ip5b
ADP-ribosylation factor-like 6 interacting protein 5b
chr1_-_50859053 0.34 ENSDART00000132779
ENSDART00000137648
si:dkeyp-123h10.2
si:dkeyp-123h10.2
chr24_+_13869092 0.32 ENSDART00000176492
eya1
EYA transcriptional coactivator and phosphatase 1
chr11_+_45436703 0.32 ENSDART00000168295
ENSDART00000173293
sos1
son of sevenless homolog 1 (Drosophila)
chr15_+_9327252 0.32 ENSDART00000144381
sgcg
sarcoglycan, gamma
chr23_-_18024543 0.29 ENSDART00000139695
pm20d1.1
peptidase M20 domain containing 1, tandem duplicate 1
chr25_+_7671640 0.29 ENSDART00000145367
kcnj11l
potassium inwardly-rectifying channel, subfamily J, member 11, like
chr22_-_36530902 0.28 ENSDART00000056188
polr2h
info polymerase (RNA) II (DNA directed) polypeptide H
chr25_+_13406069 0.28 ENSDART00000010495
znrf1
zinc and ring finger 1
chr7_+_59020972 0.28 ENSDART00000157873
hacd1
3-hydroxyacyl-CoA dehydratase 1
chr24_-_6078222 0.28 ENSDART00000146830
apbb1ip
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr12_+_24342303 0.28 ENSDART00000111239
nrxn1a
neurexin 1a
chr18_-_8398972 0.28 ENSDART00000136512
BEND7
si:ch211-220f12.4
chr6_+_54538948 0.28 ENSDART00000149270
tulp1b
tubby like protein 1b
chr22_+_18816662 0.26 ENSDART00000132476
cbarpb
calcium channel, voltage-dependent, beta subunit associated regulatory protein b
chr17_-_29224908 0.26 ENSDART00000156288
si:dkey-28g23.6
si:dkey-28g23.6
chr16_-_17072440 0.26 ENSDART00000002493
ENSDART00000178443
tnfrsf1a
tumor necrosis factor receptor superfamily, member 1a
chr12_-_4781801 0.25 ENSDART00000167490
ENSDART00000121718
mapta
microtubule-associated protein tau a
chr11_-_1400507 0.25 ENSDART00000173029
ENSDART00000172953
ENSDART00000111140
rpl29
ribosomal protein L29
chr14_-_413273 0.25 ENSDART00000163976
ENSDART00000179907
FAT4
FAT atypical cadherin 4
chr12_-_6880694 0.25 ENSDART00000171846
pcdh15b
protocadherin-related 15b
chr23_-_18913032 0.24 ENSDART00000136678
si:ch211-209j10.6
si:ch211-209j10.6
chr12_-_28363111 0.24 ENSDART00000016283
ENSDART00000164156
psmd11b
proteasome 26S subunit, non-ATPase 11b
chr3_+_38540411 0.24 ENSDART00000154943
si:dkey-7f16.3
si:dkey-7f16.3
chr22_+_19552987 0.24 ENSDART00000105315
hsd11b1la
hydroxysteroid (11-beta) dehydrogenase 1-like a
chr16_-_48400639 0.22 ENSDART00000159372
eif3ha
eukaryotic translation initiation factor 3, subunit H, a
chr1_+_55608520 0.22 ENSDART00000152307
adgre18
adhesion G protein-coupled receptor E18
chr2_-_22927958 0.21 ENSDART00000141621
myo7bb
myosin VIIBb
chr11_-_29737088 0.21 ENSDART00000159828
si:ch211-218g23.6
si:ch211-218g23.6
chr12_+_18899396 0.21 ENSDART00000105858
xrcc6
X-ray repair complementing defective repair in Chinese hamster cells 6
chr15_-_21702317 0.19 ENSDART00000155824
IL4I1
si:dkey-40g16.6
chr16_-_45094599 0.19 ENSDART00000155479
si:rp71-77l1.1
si:rp71-77l1.1
chr4_-_75158035 0.18 ENSDART00000174353
CABZ01066312.1

chr9_+_51147380 0.18 ENSDART00000003913
ifih1
interferon induced with helicase C domain 1
chr22_-_19552796 0.17 ENSDART00000148088
ENSDART00000105485
si:dkey-78l4.14
si:dkey-78l4.14
chr8_+_1651821 0.16 ENSDART00000060865
ENSDART00000186304
rasal1b
RAS protein activator like 1b (GAP1 like)
chr23_+_32406461 0.16 ENSDART00000179878
si:ch211-66i15.5
si:ch211-66i15.5
chr17_+_43595692 0.16 ENSDART00000156271
cfap99
cilia and flagella associated protein 99
chr16_+_23303859 0.15 ENSDART00000006093
slc50a1
solute carrier family 50 (sugar efflux transporter), member 1
chr12_+_18681477 0.15 ENSDART00000127981
ENSDART00000143979
rgs9b
regulator of G protein signaling 9b
chr3_+_32553714 0.15 ENSDART00000165638
pax10
paired box 10
chr25_+_35212919 0.15 ENSDART00000180127
ano5a
anoctamin 5a
chr2_+_10771787 0.14 ENSDART00000187782
gfi1aa
growth factor independent 1A transcription repressor a
chr10_-_43771447 0.14 ENSDART00000052307
arrdc3b
arrestin domain containing 3b
chr3_-_22216771 0.14 ENSDART00000130546
maptb
microtubule-associated protein tau b
chr1_-_10048514 0.14 ENSDART00000125358
ENSDART00000054835
rnf175
ring finger protein 175
chr14_-_4145594 0.14 ENSDART00000077348
casp3b
caspase 3, apoptosis-related cysteine peptidase b
chr13_-_12602920 0.14 ENSDART00000102311
lrit3b
leucine-rich repeat, immunoglobulin-like and transmembrane domains 3b
chr22_-_17482282 0.13 ENSDART00000105453
si:ch211-197g15.7
si:ch211-197g15.7
chr23_+_9353552 0.13 ENSDART00000163298
BX511246.1

chr1_-_55873178 0.12 ENSDART00000019936
prkacab
protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
chr8_-_53926228 0.12 ENSDART00000015554
ubiad1
UbiA prenyltransferase domain containing 1
chr6_+_39905021 0.12 ENSDART00000064904
endou
endonuclease, polyU-specific
chr5_-_19861766 0.12 ENSDART00000088904
gltpa
glycolipid transfer protein a
chr21_-_35419486 0.12 ENSDART00000138529
si:dkeyp-23e4.3
si:dkeyp-23e4.3
chr23_+_32426954 0.12 ENSDART00000192529
ENSDART00000172313
si:ch211-66i15.5
si:ch211-66i15.5
chr10_-_7756865 0.11 ENSDART00000114373
ENSDART00000125407
ENSDART00000016317
loxa
lysyl oxidase a
chr21_-_37194839 0.11 ENSDART00000175126
fgfr4
fibroblast growth factor receptor 4
chr3_-_36839115 0.10 ENSDART00000154553
ramp2
receptor (G protein-coupled) activity modifying protein 2
chr7_+_66822229 0.10 ENSDART00000112109
lyve1a
lymphatic vessel endothelial hyaluronic receptor 1a
chr1_+_51721851 0.10 ENSDART00000040397
prdx2
peroxiredoxin 2
chr19_+_24872159 0.10 ENSDART00000158490
si:ch211-195b13.1
si:ch211-195b13.1
chr15_-_14552101 0.10 ENSDART00000171169
numbl
numb homolog (Drosophila)-like
chr15_+_36115955 0.09 ENSDART00000032702
sst1.2
somatostatin 1, tandem duplicate 2
chr22_-_17844117 0.09 ENSDART00000159363
BX908731.1

chr20_-_5291012 0.09 ENSDART00000122892
cyp46a1.3
cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 3
chr6_+_9175886 0.08 ENSDART00000165333
si:ch211-207l14.1
si:ch211-207l14.1
chr11_-_20956309 0.08 ENSDART00000188659
CABZ01008739.1

chr3_-_19368435 0.08 ENSDART00000132987
s1pr5a
sphingosine-1-phosphate receptor 5a
chr4_-_77218637 0.08 ENSDART00000174325
psmb10
proteasome subunit beta 10
chr13_-_42560662 0.08 ENSDART00000124898
CR792417.1

chr19_+_16015881 0.07 ENSDART00000187135
ctps1a
CTP synthase 1a
chr13_+_7049823 0.07 ENSDART00000178997
ENSDART00000161443
rnaset2
ribonuclease T2
chr3_-_25119839 0.07 ENSDART00000154724
chadla
chondroadherin-like a
chr8_-_22273819 0.07 ENSDART00000121513
nphp4
nephronophthisis 4
chr11_+_29856032 0.07 ENSDART00000079150
grpr
gastrin-releasing peptide receptor
chr5_+_58550291 0.07 ENSDART00000184983
ENSDART00000044803
pou2f3
POU class 2 homeobox 3
chr18_-_3473081 0.07 ENSDART00000174975
myo7aa
myosin VIIAa
chr14_-_4682114 0.06 ENSDART00000014454
gabra4
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4
chr17_-_24353462 0.06 ENSDART00000191021
wdpcp
WD repeat containing planar cell polarity effector
chr21_-_35534401 0.06 ENSDART00000112308
si:dkeyp-23e4.3
si:dkeyp-23e4.3
chr16_+_28932038 0.06 ENSDART00000149480
npr1b
natriuretic peptide receptor 1b
chr7_+_20512419 0.06 ENSDART00000173907
si:dkey-19b23.14
si:dkey-19b23.14
chr2_-_59205393 0.05 ENSDART00000056417
ENSDART00000182452
ENSDART00000141876
ftr30
finTRIM family, member 30
chr5_+_56023186 0.05 ENSDART00000156230
fzd9a
frizzled class receptor 9a
chr19_-_5125663 0.04 ENSDART00000005547
ENSDART00000132642
gnb3b
guanine nucleotide binding protein (G protein), beta polypeptide 3b
chr12_+_16168342 0.04 ENSDART00000079326
ENSDART00000170024
lrp2b
low density lipoprotein receptor-related protein 2b
chr8_+_25913787 0.04 ENSDART00000190257
ENSDART00000062515
sema3h
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3H
chr19_+_45962016 0.04 ENSDART00000169710
utp23
UTP23, small subunit (SSU) processome component, homolog (yeast)
chr4_-_49582758 0.04 ENSDART00000180834
ENSDART00000187608
si:dkey-159n16.2
si:dkey-159n16.2
chr2_-_45027754 0.04 ENSDART00000168469
vwa5b2
von Willebrand factor A domain containing 5B2
chr22_-_17482810 0.03 ENSDART00000171293
si:ch211-197g15.7
si:ch211-197g15.7
chr18_+_30847237 0.03 ENSDART00000012374
foxf1
forkhead box F1
chr6_-_16717878 0.03 ENSDART00000153552
nomo
nodal modulator
chr6_-_54486410 0.03 ENSDART00000064679
CR847944.1

chr7_-_12821277 0.03 ENSDART00000091584
zgc:158785
zgc:158785
chr23_-_33350990 0.03 ENSDART00000144831
si:ch211-226m16.2
si:ch211-226m16.2
chr5_-_42083363 0.03 ENSDART00000162596
cxcl11.5
chemokine (C-X-C motif) ligand 11, duplicate 5
chr5_+_22791686 0.02 ENSDART00000014806
npas2
neuronal PAS domain protein 2
chr10_+_40568735 0.02 ENSDART00000136468
ENSDART00000182841
taar18i
trace amine associated receptor 18i
chr6_-_35046735 0.02 ENSDART00000143649
uap1
UDP-N-acetylglucosamine pyrophosphorylase 1
chr6_-_12588044 0.02 ENSDART00000047896
slc15a1b
solute carrier family 15 (oligopeptide transporter), member 1b
chr9_+_24008879 0.02 ENSDART00000190419
ENSDART00000191843
ENSDART00000148226
mlphb
melanophilin b
chr19_-_20403845 0.02 ENSDART00000151265
ENSDART00000147911
ENSDART00000151356
dazl
deleted in azoospermia-like
chr3_+_3681116 0.02 ENSDART00000109618
art4
ADP-ribosyltransferase 4 (Dombrock blood group)
chr20_-_46128590 0.02 ENSDART00000123744
taar1b
trace amine associated receptor 1b
chr1_+_55279124 0.02 ENSDART00000152660
si:ch211-286b5.6
si:ch211-286b5.6
chr22_-_23545307 0.02 ENSDART00000166915
crb1
crumbs family member 1, photoreceptor morphogenesis associated
chr12_-_34713690 0.01 ENSDART00000180807
bahcc1b
BAH domain and coiled-coil containing 1b
chr16_-_16761164 0.01 ENSDART00000135872
si:dkey-27n14.1
si:dkey-27n14.1
chr13_+_38430466 0.01 ENSDART00000132691
adgrb3
adhesion G protein-coupled receptor B3
chr20_+_66857 0.01 ENSDART00000114999
lrfn2b
leucine rich repeat and fibronectin type III domain containing 2b
chr10_-_40964739 0.01 ENSDART00000076359
npffr1l1
neuropeptide FF receptor 1 like 1
chr4_-_2219705 0.01 ENSDART00000131046
si:ch73-278m9.1
si:ch73-278m9.1
chr5_-_31901468 0.01 ENSDART00000147814
ENSDART00000141446
coro1cb
coronin, actin binding protein, 1Cb
chr22_-_23545828 0.00 ENSDART00000161253
crb1
crumbs family member 1, photoreceptor morphogenesis associated
chr14_-_30932373 0.00 ENSDART00000172988
si:zfos-80g12.1
si:zfos-80g12.1
chr22_-_12745589 0.00 ENSDART00000136841
plcd4a
phospholipase C, delta 4a
chr11_+_30663300 0.00 ENSDART00000161662
ttbk1a
tau tubulin kinase 1a

Network of associatons between targets according to the STRING database.

First level regulatory network of isl2a+isl2b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.2 0.7 GO:0015871 choline transport(GO:0015871)
0.1 1.6 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 0.4 GO:0098908 regulation of neuronal action potential(GO:0098908)
0.1 0.5 GO:0010456 cell proliferation in dorsal spinal cord(GO:0010456)
0.1 0.3 GO:0002432 granuloma formation(GO:0002432) chronic inflammatory response(GO:0002544) regulation of granuloma formation(GO:0002631) regulation of chronic inflammatory response(GO:0002676)
0.1 0.8 GO:0097104 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.1 0.4 GO:2000381 negative regulation of nodal signaling pathway(GO:1900108) negative regulation of mesoderm development(GO:2000381)
0.1 0.3 GO:2000275 regulation of oxidative phosphorylation uncoupler activity(GO:2000275)
0.1 0.5 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.1 1.4 GO:0006415 translational termination(GO:0006415)
0.1 0.5 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.7 GO:0046314 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.0 0.5 GO:0043046 DNA methylation involved in gamete generation(GO:0043046)
0.0 0.6 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 0.8 GO:1990399 sensory epithelium regeneration(GO:0070654) epithelium regeneration(GO:1990399)
0.0 0.2 GO:0010332 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.0 0.1 GO:0042373 vitamin K metabolic process(GO:0042373) cellular response to fluid shear stress(GO:0071498)
0.0 0.3 GO:1903306 negative regulation of calcium ion-dependent exocytosis(GO:0045955) negative regulation of regulated secretory pathway(GO:1903306)
0.0 0.3 GO:0016576 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.0 0.1 GO:1904251 regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.0 0.3 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.4 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.0 2.0 GO:0006414 translational elongation(GO:0006414)
0.0 0.7 GO:0030183 B cell differentiation(GO:0030183)
0.0 0.2 GO:0032608 interferon-beta production(GO:0032608) regulation of interferon-beta production(GO:0032648) positive regulation of interferon-beta production(GO:0032728)
0.0 0.5 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.5 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.8 GO:0007568 aging(GO:0007568)
0.0 0.5 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.0 0.2 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 1.0 GO:0042738 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0 1.1 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.2 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.5 GO:0055064 chloride ion homeostasis(GO:0055064)
0.0 0.1 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 4.9 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 1.1 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 0.6 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0 0.1 GO:0030216 keratinocyte differentiation(GO:0030216)
0.0 0.3 GO:0030497 fatty acid elongation(GO:0030497)
0.0 0.0 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.0 0.1 GO:0071450 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 GO:0036157 outer dynein arm(GO:0036157)
0.1 0.4 GO:1990130 Iml1 complex(GO:1990130)
0.1 0.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 1.0 GO:0044447 axoneme part(GO:0044447)
0.0 0.3 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 1.4 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.1 GO:0043202 vacuolar lumen(GO:0005775) lysosomal lumen(GO:0043202)
0.0 0.3 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 1.3 GO:0016592 mediator complex(GO:0016592)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.5 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.2 GO:0032420 stereocilium(GO:0032420)
0.0 0.0 GO:0097268 cytoophidium(GO:0097268)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.9 GO:0005504 fatty acid binding(GO:0005504)
0.3 0.8 GO:0004771 sterol esterase activity(GO:0004771)
0.2 0.7 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.1 1.4 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 1.3 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 1.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.1 0.3 GO:0102345 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.1 0.5 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 0.5 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.1 0.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.4 GO:0000254 C-4 methylsterol oxidase activity(GO:0000254)
0.1 0.7 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1 0.3 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.1 1.6 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 1.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.3 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.1 GO:0033897 ribonuclease T2 activity(GO:0033897)
0.0 0.4 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.0 0.4 GO:0002039 p53 binding(GO:0002039)
0.0 1.1 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.1 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 1.0 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.1 GO:0033781 cholesterol 24-hydroxylase activity(GO:0033781)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.4 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.0 0.2 GO:0070122 isopeptidase activity(GO:0070122)
0.0 0.1 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.0 GO:0003883 CTP synthase activity(GO:0003883)
0.0 0.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 0.5 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.5 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 0.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.6 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.2 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 0.6 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.5 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.3 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.2 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0 0.1 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation