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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for jun

Z-value: 0.40

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Transcription factors associated with jun

Gene Symbol Gene ID Gene Info
jun
ENSDARG00000043531 Jun proto-oncogene, AP-1 transcription factor subunit

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
jundr11_v1_chr20_+_15552657_155526570.865.2e-06Click!

Activity profile of jun motif

Sorted Z-values of jun motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_24488403 1.34 ENSDART00000052421
txnipa
thioredoxin interacting protein a
chr11_-_24681292 1.32 ENSDART00000089601
olfml3b
olfactomedin-like 3b
chr20_+_26880668 1.25 ENSDART00000077769
serpinb1
serpin peptidase inhibitor, clade B (ovalbumin), member 1
chr3_-_61593274 1.23 ENSDART00000154132
ENSDART00000055071
nptx2a
neuronal pentraxin 2a
chr24_+_31361407 1.12 ENSDART00000162668
cremb
cAMP responsive element modulator b
chr25_-_1126311 1.04 ENSDART00000161863
spg11
spastic paraplegia 11
chr7_-_52963493 1.02 ENSDART00000052029
cart3
cocaine- and amphetamine-regulated transcript 3
chr21_+_22845317 1.02 ENSDART00000065555
birc2
baculoviral IAP repeat containing 2
chr6_-_40842768 0.99 ENSDART00000076160
mustn1a
musculoskeletal, embryonic nuclear protein 1a
chr22_-_10110959 0.87 ENSDART00000031005
ENSDART00000147580
gls2b
glutaminase 2b (liver, mitochondrial)
chr10_+_31222433 0.83 ENSDART00000185080
tmem218
transmembrane protein 218
chr10_+_31222656 0.83 ENSDART00000140988
ENSDART00000143387
tmem218
transmembrane protein 218
chr13_+_6086730 0.82 ENSDART00000049328
fam120b
family with sequence similarity 120B
chr22_+_16497670 0.80 ENSDART00000014330
ier5
immediate early response 5
chr8_+_17933475 0.79 ENSDART00000100651
erich3
glutamate-rich 3
chr1_+_44340124 0.77 ENSDART00000160696
CT033803.2

chr15_-_46779934 0.76 ENSDART00000085136
clcn2c
chloride channel 2c
chr3_+_39922602 0.74 ENSDART00000193937
cacna1ha
calcium channel, voltage-dependent, T type, alpha 1H subunit a
chr16_+_42829735 0.73 ENSDART00000014956
polr3glb
polymerase (RNA) III (DNA directed) polypeptide G like b
chr9_-_710896 0.71 ENSDART00000180478
ndufb3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3
chr1_-_59252973 0.71 ENSDART00000167061
si:ch1073-286c18.5
si:ch1073-286c18.5
chr1_+_44360973 0.69 ENSDART00000167568
si:ch211-165a10.5
si:ch211-165a10.5
chr6_+_48348415 0.68 ENSDART00000064826
mov10a
Mov10 RISC complex RNA helicase a
chr4_-_6809323 0.68 ENSDART00000099467
ifrd1
interferon-related developmental regulator 1
chr2_+_17524278 0.67 ENSDART00000165633
pimr196
Pim proto-oncogene, serine/threonine kinase, related 196
chr7_+_20587506 0.66 ENSDART00000172416
ENSDART00000170633
si:dkey-19b23.7
si:dkey-19b23.7
chr1_-_40123943 0.64 ENSDART00000146917
si:ch211-113e8.10
si:ch211-113e8.10
chr5_-_57480660 0.60 ENSDART00000147875
ENSDART00000142776
si:ch211-202f5.2
si:ch211-202f5.2
chr13_-_24328794 0.58 ENSDART00000145351
si:ch211-202m22.1
si:ch211-202m22.1
chr5_-_69523816 0.56 ENSDART00000112692
si:ch211-157p22.10
si:ch211-157p22.10
chr1_+_44260085 0.56 ENSDART00000171416
si:dkey-59p5.1
si:dkey-59p5.1
chr16_+_41517188 0.55 ENSDART00000049976
si:dkey-11p23.7
si:dkey-11p23.7
chr18_+_20838786 0.54 ENSDART00000138692
ttc23
tetratricopeptide repeat domain 23
chr1_+_44249616 0.53 ENSDART00000164173
si:ch211-165a10.10
si:ch211-165a10.10
chr12_+_1455147 0.53 ENSDART00000018752
cops3
COP9 signalosome subunit 3
chr24_+_24923166 0.53 ENSDART00000065288
pcyt1ba
phosphate cytidylyltransferase 1, choline, beta a
chr25_-_7753207 0.51 ENSDART00000126499
phf21ab
PHD finger protein 21Ab
chr12_+_20506197 0.51 ENSDART00000153010
si:zfos-754c12.2
si:zfos-754c12.2
chr5_+_37087583 0.49 ENSDART00000049900
tagln2
transgelin 2
chr21_-_30545121 0.49 ENSDART00000019199
rab39ba
RAB39B, member RAS oncogene family a
chr10_-_27566481 0.49 ENSDART00000078920
auts2a
autism susceptibility candidate 2a
chr16_-_45225520 0.48 ENSDART00000158855
fxyd1
FXYD domain containing ion transport regulator 1 (phospholemman)
chr6_+_33885828 0.46 ENSDART00000179994
gpbp1l1
GC-rich promoter binding protein 1-like 1
chr12_+_7497882 0.46 ENSDART00000134608
phyhiplb
phytanoyl-CoA 2-hydroxylase interacting protein-like b
chr1_+_2190714 0.45 ENSDART00000132126
mbnl2
muscleblind-like splicing regulator 2
chr8_+_50534948 0.45 ENSDART00000174435
PEBP4
phosphatidylethanolamine binding protein 4
chr16_+_10972733 0.44 ENSDART00000049323
pou2f2a
POU class 2 homeobox 2a
chr24_-_33693070 0.44 ENSDART00000137483
si:dkeyp-87a6.2
si:dkeyp-87a6.2
chr16_-_21785261 0.44 ENSDART00000078858
si:ch73-86n18.1
si:ch73-86n18.1
chr23_+_24600494 0.44 ENSDART00000184854
nckap5l
NCK-associated protein 5-like
chr7_+_5566582 0.43 ENSDART00000145458
si:ch211-165f21.4
si:ch211-165f21.4
chr3_+_7617353 0.42 ENSDART00000165551
zgc:109949
zgc:109949
chr11_+_2416064 0.42 ENSDART00000067117
ube2v1
ubiquitin-conjugating enzyme E2 variant 1
chr14_+_33882973 0.41 ENSDART00000019396
clic2
chloride intracellular channel 2
chr11_+_13630107 0.40 ENSDART00000172220
si:ch211-1a19.3
si:ch211-1a19.3
chr10_+_31344227 0.40 ENSDART00000184470
AL845320.2

chr1_+_6640437 0.40 ENSDART00000147638
si:ch211-93g23.2
si:ch211-93g23.2
chr4_-_16412084 0.40 ENSDART00000188460
dcn
decorin
chr4_+_1600034 0.40 ENSDART00000146779
slc38a2
solute carrier family 38, member 2
chr7_+_14005111 0.39 ENSDART00000187365
furina
furin (paired basic amino acid cleaving enzyme) a
chr14_+_1240235 0.39 ENSDART00000127477
adad1
adenosine deaminase domain containing 1 (testis-specific)
chr4_+_357810 0.39 ENSDART00000163436
ENSDART00000103645
tmem181
transmembrane protein 181
chr13_-_37649595 0.39 ENSDART00000115354
si:dkey-188i13.10
si:dkey-188i13.10
chr17_+_10817675 0.39 ENSDART00000156090
pimr177
Pim proto-oncogene, serine/threonine kinase, related 177
chr3_+_56905103 0.39 ENSDART00000124728
ENSDART00000154408
otop2
otopetrin 2
chr2_-_293793 0.39 ENSDART00000082091
si:ch73-40a17.3
si:ch73-40a17.3
chr8_-_23573084 0.38 ENSDART00000139084
wasb
Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b
chr7_-_35432901 0.38 ENSDART00000026712
mmp2
matrix metallopeptidase 2
chr1_+_44350628 0.38 ENSDART00000171939
CT033803.1

chr14_+_1240604 0.37 ENSDART00000188258
adad1
adenosine deaminase domain containing 1 (testis-specific)
chr23_-_4915118 0.37 ENSDART00000060714
atp6ap1a
ATPase H+ transporting accessory protein 1a
chr22_+_24220937 0.37 ENSDART00000165380
uchl5
ubiquitin carboxyl-terminal hydrolase L5
chr5_+_15819651 0.37 ENSDART00000081230
ENSDART00000186969
ENSDART00000134206
hspb8
heat shock protein b8
chr4_-_57572054 0.37 ENSDART00000158610
pimr168
Pim proto-oncogene, serine/threonine kinase, related 168
chr9_-_2572790 0.37 ENSDART00000135076
ENSDART00000016710
scrn3
secernin 3
chr17_+_7524389 0.37 ENSDART00000067579
klhl10b.2
kelch-like family member 10b, tandem duplicate 2
chr7_+_22688781 0.37 ENSDART00000173509
ugt5g1
UDP glucuronosyltransferase 5 family, polypeptide G1
chr13_+_10621257 0.36 ENSDART00000008603
prepl
prolyl endopeptidase-like
chr20_-_25626198 0.36 ENSDART00000126716
paics
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr13_+_9213805 0.36 ENSDART00000131455
pimr158
Pim proto-oncogene, serine/threonine kinase, related 158
chr16_+_42830152 0.36 ENSDART00000159730
polr3glb
polymerase (RNA) III (DNA directed) polypeptide G like b
chr14_-_26436760 0.35 ENSDART00000088677
si:dkeyp-110e4.6
si:dkeyp-110e4.6
chr16_-_13818061 0.35 ENSDART00000132982
ENSDART00000144856
leng9
leukocyte receptor cluster (LRC) member 9
chr3_+_24986145 0.35 ENSDART00000055428
cbx7a
chromobox homolog 7a
chr4_-_9637398 0.35 ENSDART00000150253
dclre1c
DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)
chr20_-_40487208 0.35 ENSDART00000075070
ENSDART00000142029
hsf2
heat shock transcription factor 2
chr23_+_16814968 0.35 ENSDART00000161299
zgc:100832
zgc:100832
chr19_-_41404870 0.35 ENSDART00000167772
sem1
SEM1, 26S proteasome complex subunit
chr24_+_38522254 0.35 ENSDART00000156189
si:ch1073-66l23.1
si:ch1073-66l23.1
chr2_+_48288461 0.33 ENSDART00000141495
hes6
hes family bHLH transcription factor 6
chr17_-_6536305 0.33 ENSDART00000154855
cenpo
centromere protein O
chr22_+_36547670 0.33 ENSDART00000125991
ENSDART00000186372
armc9
armadillo repeat containing 9
chr10_+_26747755 0.32 ENSDART00000100329
f9b
coagulation factor IXb
chr5_-_19052184 0.32 ENSDART00000133330
fam214b
family with sequence similarity 214, member B
chr23_+_28128453 0.32 ENSDART00000182618
c1galt1a
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1a
chr8_+_50531709 0.32 ENSDART00000193352
PEBP4
phosphatidylethanolamine binding protein 4
chr16_+_49005321 0.32 ENSDART00000160919
CABZ01068499.1

chr14_+_49382180 0.32 ENSDART00000158329
tnip1
TNFAIP3 interacting protein 1
chr14_-_26436951 0.32 ENSDART00000140173
si:dkeyp-110e4.6
si:dkeyp-110e4.6
chr15_-_28223757 0.32 ENSDART00000110969
ENSDART00000138401
scarf1
scavenger receptor class F, member 1
chr19_+_23932259 0.31 ENSDART00000139040
si:dkey-222b8.1
si:dkey-222b8.1
chr8_+_20037368 0.30 ENSDART00000029175
ENSDART00000170792
fcho1
FCH domain only 1
chr17_+_12255642 0.30 ENSDART00000155175
pimr175
Pim proto-oncogene, serine/threonine kinase, related 175
chr17_+_51682429 0.30 ENSDART00000004379
nol10
nucleolar protein 10
chr23_-_37113396 0.30 ENSDART00000102886
ENSDART00000134461
zgc:193690
zgc:193690
chr8_+_40210398 0.30 ENSDART00000167612
rnf34a
ring finger protein 34a
chr14_+_46216703 0.29 ENSDART00000136045
ENSDART00000142317
mgst2
microsomal glutathione S-transferase 2
chr25_-_35045250 0.29 ENSDART00000156508
ENSDART00000126590
zgc:114046
zgc:114046
chr11_-_22371105 0.29 ENSDART00000146873
tmem183a
transmembrane protein 183A
chr1_+_52518176 0.29 ENSDART00000003278
tacr3l
tachykinin receptor 3-like
chr15_-_35134918 0.29 ENSDART00000157196
si:ch211-272b8.7
si:ch211-272b8.7
chr16_+_54674556 0.29 ENSDART00000167040
pop1
POP1 homolog, ribonuclease P/MRP subunit
chr6_+_52350443 0.29 ENSDART00000151612
ENSDART00000151349
si:ch211-239j9.1
si:ch211-239j9.1
chr23_+_35714574 0.28 ENSDART00000164616
tuba1c
tubulin, alpha 1c
chr8_-_18667693 0.28 ENSDART00000100516
stap2b
signal transducing adaptor family member 2b
chr11_-_25324534 0.28 ENSDART00000158598
si:ch211-232b12.5
si:ch211-232b12.5
chr3_-_26017592 0.27 ENSDART00000030890
hmox1a
heme oxygenase 1a
chr15_+_9327252 0.27 ENSDART00000144381
sgcg
sarcoglycan, gamma
chr16_-_48673938 0.27 ENSDART00000156969
notchl
notch homolog, like
chr5_-_34616599 0.27 ENSDART00000050271
ENSDART00000097975
hexb
hexosaminidase B (beta polypeptide)
chr9_+_26199674 0.27 ENSDART00000139510
si:dkey-111i23.1
si:dkey-111i23.1
chr1_+_44239558 0.27 ENSDART00000100335
si:dkey-59p5.2
si:dkey-59p5.2
chr5_+_23599259 0.27 ENSDART00000138902
kat5b
K(lysine) acetyltransferase 5b
chr20_+_51478939 0.27 ENSDART00000149758
tlr5a
toll-like receptor 5a
chr5_-_26879302 0.27 ENSDART00000098571
ENSDART00000139086
zgc:64051
zgc:64051
chr21_+_8341774 0.27 ENSDART00000129749
ENSDART00000055325
ENSDART00000133804
psmb7
proteasome subunit beta 7
chr5_-_21888368 0.27 ENSDART00000020725
smarca1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr19_-_7495006 0.27 ENSDART00000148836
rfx5
regulatory factor X, 5
chr21_-_21020708 0.26 ENSDART00000064032
eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
chr1_+_41849152 0.26 ENSDART00000053685
smox
spermine oxidase
chr4_-_20208166 0.26 ENSDART00000066891
gsap
gamma-secretase activating protein
chr20_+_25625872 0.26 ENSDART00000078385
ppat
phosphoribosyl pyrophosphate amidotransferase
chr5_-_55623443 0.26 ENSDART00000005671
ENSDART00000176341
hnrpkl
heterogeneous nuclear ribonucleoprotein K, like
chr15_+_714203 0.26 ENSDART00000153847
si:dkey-7i4.24
si:dkey-7i4.24
chr7_+_33172066 0.26 ENSDART00000174013
si:ch211-194p6.12
si:ch211-194p6.12
chr1_-_25679339 0.26 ENSDART00000161703
ENSDART00000054230
fgg
fibrinogen gamma chain
chr2_+_47581997 0.26 ENSDART00000112579
scg2b
secretogranin II (chromogranin C), b
chr9_-_2573121 0.26 ENSDART00000181340
scrn3
secernin 3
chr10_-_34741738 0.26 ENSDART00000163072
dclk1a
doublecortin-like kinase 1a
chr14_+_6287871 0.25 ENSDART00000105344
tbc1d2
TBC1 domain family, member 2
chr19_+_22216778 0.25 ENSDART00000052521
nfatc1
nuclear factor of activated T cells 1
chr10_+_28428222 0.25 ENSDART00000135003
si:ch211-222e20.4
si:ch211-222e20.4
chr3_-_58189429 0.25 ENSDART00000156092
si:ch211-256e16.11
si:ch211-256e16.11
chr21_+_33459524 0.25 ENSDART00000053205
cd74b
CD74 molecule, major histocompatibility complex, class II invariant chain b
chr5_-_22501663 0.25 ENSDART00000133174
si:dkey-27p18.5
si:dkey-27p18.5
chr4_-_17822447 0.25 ENSDART00000185502
dnajb9b
DnaJ (Hsp40) homolog, subfamily B, member 9b
chr4_+_77971104 0.24 ENSDART00000188609
zgc:113921
zgc:113921
chr8_+_3530761 0.24 ENSDART00000081272
gcn1
GCN1 eIF2 alpha kinase activator homolog
chr21_+_17880511 0.24 ENSDART00000080481
rxraa
retinoid X receptor, alpha a
chr10_+_38610741 0.24 ENSDART00000126444
mmp13a
matrix metallopeptidase 13a
chr10_+_187760 0.24 ENSDART00000161007
ENSDART00000160651
ets2
v-ets avian erythroblastosis virus E26 oncogene homolog 2
chr25_+_10485103 0.24 ENSDART00000104576
psmd13
proteasome 26S subunit, non-ATPase 13
chr17_-_43399896 0.23 ENSDART00000156033
ENSDART00000156418
itpk1b
inositol-tetrakisphosphate 1-kinase b
chr8_-_25338709 0.23 ENSDART00000131616
atp5pb
ATP synthase peripheral stalk-membrane subunit b
chr13_+_50368668 0.23 ENSDART00000127610
dnajc12
DnaJ (Hsp40) homolog, subfamily C, member 12
chr24_-_25186895 0.23 ENSDART00000081029
plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr3_-_26017831 0.23 ENSDART00000179982
hmox1a
heme oxygenase 1a
chr13_-_17723417 0.23 ENSDART00000183834
vdac2
voltage-dependent anion channel 2
chr4_-_69189894 0.22 ENSDART00000169596
si:ch211-209j12.1
si:ch211-209j12.1
chr8_+_41038141 0.22 ENSDART00000075620
gpat2
glycerol-3-phosphate acyltransferase 2, mitochondrial
chr19_+_10396042 0.22 ENSDART00000028048
ENSDART00000151735
necap1
NECAP endocytosis associated 1
chr7_-_28696556 0.22 ENSDART00000148822
adgrg1
adhesion G protein-coupled receptor G1
chr3_+_27027781 0.22 ENSDART00000065495
emp2
epithelial membrane protein 2
chr13_+_9237493 0.22 ENSDART00000140240
pimr159
Pim proto-oncogene, serine/threonine kinase, related 159
chr7_-_22941472 0.22 ENSDART00000190334
tnfsf10l
TNF superfamily member 10, like
chr9_-_2594410 0.22 ENSDART00000188306
ENSDART00000164276
sp9
sp9 transcription factor
chr23_-_37113215 0.22 ENSDART00000146835
zgc:193690
zgc:193690
chr3_+_26064091 0.21 ENSDART00000143697
si:dkeyp-69e1.8
si:dkeyp-69e1.8
chr10_+_40583930 0.21 ENSDART00000134523
taar18j
trace amine associated receptor 18j
chr15_-_30832171 0.21 ENSDART00000152414
ENSDART00000152790
msi2b
musashi RNA-binding protein 2b
chr6_-_60079551 0.21 ENSDART00000154753
pmepa1
prostate transmembrane protein, androgen induced 1
chr2_-_49997055 0.21 ENSDART00000140294
si:ch211-106n13.3
si:ch211-106n13.3
chr3_+_32118670 0.21 ENSDART00000055287
ENSDART00000111688
zgc:109934
zgc:109934
chr3_-_39648021 0.20 ENSDART00000055171
grapa
GRB2-related adaptor protein a
chr11_-_10770053 0.20 ENSDART00000179213
slc4a10a
solute carrier family 4, sodium bicarbonate transporter, member 10a
chr5_+_37785152 0.20 ENSDART00000053511
ENSDART00000189812
myo1ca
myosin Ic, paralog a
chr20_-_26531850 0.20 ENSDART00000183317
ENSDART00000131994
mthfd1l
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
chr2_-_898899 0.20 ENSDART00000058289
dusp22b
dual specificity phosphatase 22b
chr4_+_16715267 0.20 ENSDART00000143849
pkp2
plakophilin 2
chr18_+_3052408 0.20 ENSDART00000181563
kctd14
potassium channel tetramerization domain containing 14
chr17_-_7861219 0.20 ENSDART00000148604
syne1b
spectrin repeat containing, nuclear envelope 1b
chr20_+_51479263 0.19 ENSDART00000148798
tlr5a
toll-like receptor 5a
chr5_+_15350954 0.19 ENSDART00000140990
ENSDART00000137287
ENSDART00000061653
pebp1
phosphatidylethanolamine binding protein 1
chr6_-_49063085 0.19 ENSDART00000156124
si:ch211-105j21.9
si:ch211-105j21.9
chr23_+_42336084 0.19 ENSDART00000158959
ENSDART00000161812
cyp2aa7
cyp2aa8
cytochrome P450, family 2, subfamily AA, polypeptide 7
cytochrome P450, family 2, subfamily AA, polypeptide 8
chr2_+_30379650 0.19 ENSDART00000129542
crispld1b
cysteine-rich secretory protein LCCL domain containing 1b
chr23_+_4324625 0.19 ENSDART00000146302
ENSDART00000136792
ENSDART00000135027
ENSDART00000179819
sgk2a
serum/glucocorticoid regulated kinase 2a
chr25_+_2282265 0.19 ENSDART00000076417
cdkn1bb
cyclin-dependent kinase inhibitor 1Bb
chr12_+_29173523 0.19 ENSDART00000153212
adgra1a
adhesion G protein-coupled receptor A1a
chr2_-_3038904 0.19 ENSDART00000186795
guk1a
guanylate kinase 1a
chr5_+_45677781 0.19 ENSDART00000163120
ENSDART00000126537
gc
group-specific component (vitamin D binding protein)
chr2_-_37837472 0.18 ENSDART00000165347
mettl17
methyltransferase like 17
chr7_+_34492744 0.18 ENSDART00000109635
ENSDART00000173844
calml4a
calmodulin-like 4a
chr20_+_7084154 0.18 ENSDART00000136448
ftr85
finTRIM family, member 85
chr8_-_31606514 0.18 ENSDART00000018886
ghra
growth hormone receptor a
chr16_+_50006872 0.17 ENSDART00000157100
ube2e2
ubiquitin-conjugating enzyme E2E 2
chr20_-_26532167 0.17 ENSDART00000061914
mthfd1l
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
chr4_+_47656992 0.17 ENSDART00000161148
znf1040
zinc finger protein 1040
chr19_-_27564458 0.16 ENSDART00000123155
si:dkeyp-46h3.6
si:dkeyp-46h3.6
chr24_-_2736809 0.16 ENSDART00000171805
fars2
phenylalanyl-tRNA synthetase 2, mitochondrial

Network of associatons between targets according to the STRING database.

First level regulatory network of jun

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0060547 negative regulation of necroptotic process(GO:0060546) negative regulation of necrotic cell death(GO:0060547)
0.2 1.0 GO:0035988 chondrocyte proliferation(GO:0035988)
0.2 0.5 GO:0043576 respiratory gaseous exchange(GO:0007585) regulation of respiratory gaseous exchange(GO:0043576)
0.1 1.0 GO:0008343 adult feeding behavior(GO:0008343)
0.1 0.5 GO:0034146 toll-like receptor 5 signaling pathway(GO:0034146)
0.1 0.5 GO:0045124 regulation of bone resorption(GO:0045124)
0.1 0.9 GO:0006543 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.1 0.2 GO:1902230 macrophage cytokine production(GO:0010934) regulation of macrophage cytokine production(GO:0010935) positive regulation of macrophage cytokine production(GO:0060907) negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.1 0.3 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.1 0.2 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.1 0.2 GO:0003093 renal system process involved in regulation of blood volume(GO:0001977) renal system process involved in regulation of systemic arterial blood pressure(GO:0003071) regulation of glomerular filtration(GO:0003093)
0.1 0.8 GO:0006382 adenosine to inosine editing(GO:0006382)
0.1 0.6 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 0.3 GO:0006691 leukotriene metabolic process(GO:0006691) leukotriene biosynthetic process(GO:0019370)
0.1 0.2 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 1.0 GO:0001966 thigmotaxis(GO:0001966)
0.0 0.8 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 0.2 GO:0030326 embryonic limb morphogenesis(GO:0030326)
0.0 0.3 GO:1900118 negative regulation of execution phase of apoptosis(GO:1900118) regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001270) negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0 0.2 GO:0010991 SMAD protein complex assembly(GO:0007183) regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.2 GO:0090387 phagosome maturation involved in apoptotic cell clearance(GO:0090386) phagolysosome assembly involved in apoptotic cell clearance(GO:0090387)
0.0 0.4 GO:0006868 glutamine transport(GO:0006868)
0.0 0.3 GO:1902093 positive regulation of sperm motility(GO:1902093)
0.0 0.1 GO:0070314 G1 to G0 transition(GO:0070314)
0.0 0.8 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.2 GO:0070445 regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.0 0.5 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.4 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848) telomere maintenance in response to DNA damage(GO:0043247)
0.0 1.1 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 0.5 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.3 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 0.2 GO:1990511 piRNA biosynthetic process(GO:1990511)
0.0 0.1 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.3 GO:0042987 beta-amyloid formation(GO:0034205) amyloid precursor protein catabolic process(GO:0042987)
0.0 0.1 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.0 0.2 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.0 0.4 GO:0060971 embryonic heart tube left/right pattern formation(GO:0060971)
0.0 0.2 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.7 GO:0048246 macrophage chemotaxis(GO:0048246)
0.0 0.3 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.4 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 0.1 GO:0060959 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) Schwann cell migration(GO:0036135) cardiac neuron differentiation(GO:0060945) cardiac neuron development(GO:0060959)
0.0 0.1 GO:0097101 blood vessel endothelial cell fate specification(GO:0097101)
0.0 0.4 GO:0060324 face development(GO:0060324)
0.0 0.3 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 0.2 GO:0044854 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.0 0.4 GO:0035701 hematopoietic stem cell migration(GO:0035701)
0.0 0.2 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.0 0.1 GO:0033119 negative regulation of RNA splicing(GO:0033119) negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.0 0.3 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.5 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.3 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.0 0.1 GO:1902269 polyamine transport(GO:0015846) polyamine transmembrane transport(GO:1902047) regulation of polyamine transmembrane transport(GO:1902267) positive regulation of polyamine transmembrane transport(GO:1902269)
0.0 0.4 GO:0006301 postreplication repair(GO:0006301)
0.0 0.4 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.4 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.5 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 0.1 GO:0015824 proline transport(GO:0015824)
0.0 0.1 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
0.0 0.1 GO:0034695 response to prostaglandin E(GO:0034695) cellular response to prostaglandin E stimulus(GO:0071380)
0.0 0.3 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 5.8 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 1.1 GO:0051966 regulation of synaptic transmission, glutamatergic(GO:0051966)
0.0 0.1 GO:0003222 ventricular trabecula myocardium morphogenesis(GO:0003222)
0.0 0.1 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.2 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) response to growth hormone(GO:0060416) cellular response to growth hormone stimulus(GO:0071378)
0.0 0.4 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.0 GO:0002676 granuloma formation(GO:0002432) chronic inflammatory response(GO:0002544) regulation of granuloma formation(GO:0002631) regulation of chronic inflammatory response(GO:0002676)
0.0 0.2 GO:0030719 P granule organization(GO:0030719)
0.0 0.2 GO:0021772 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.0 0.0 GO:0099540 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551) cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.0 0.1 GO:0045852 pH elevation(GO:0045852) intracellular pH elevation(GO:0051454)
0.0 0.1 GO:1902882 regulation of response to oxidative stress(GO:1902882)
0.0 0.5 GO:1903670 regulation of sprouting angiogenesis(GO:1903670)
0.0 1.0 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.1 GO:0032228 regulation of synaptic transmission, GABAergic(GO:0032228)
0.0 0.3 GO:0055064 chloride ion homeostasis(GO:0055064)
0.0 0.3 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.3 GO:0021999 neural plate anterior/posterior regionalization(GO:0021999)
0.0 0.0 GO:0006524 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
0.0 0.1 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.1 GO:0030325 adrenal gland development(GO:0030325)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005577 fibrinogen complex(GO:0005577)
0.1 1.1 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 0.3 GO:0031511 Mis6-Sim4 complex(GO:0031511)
0.1 0.3 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.1 0.3 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.1 0.4 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.1 0.4 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
0.1 0.6 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 0.2 GO:0033391 chromatoid body(GO:0033391)
0.1 0.2 GO:0060171 stereocilium membrane(GO:0060171)
0.0 1.1 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.5 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.3 GO:0016589 NURF complex(GO:0016589)
0.0 0.2 GO:0070195 growth hormone receptor complex(GO:0070195)
0.0 0.4 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 0.3 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.3 GO:0097225 sperm midpiece(GO:0097225)
0.0 0.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.4 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.7 GO:0043186 P granule(GO:0043186)
0.0 0.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.7 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.3 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.2 GO:0014704 intercalated disc(GO:0014704)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.3 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.4 GO:0017053 transcriptional repressor complex(GO:0017053)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0032574 5'-3' RNA helicase activity(GO:0032574)
0.1 0.6 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.1 0.5 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.1 0.7 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 0.9 GO:0004359 glutaminase activity(GO:0004359)
0.1 0.4 GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639)
0.1 0.5 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.1 0.3 GO:0048531 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263) beta-1,3-galactosyltransferase activity(GO:0048531)
0.1 1.0 GO:0043028 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.1 0.2 GO:0047325 inositol tetrakisphosphate 1-kinase activity(GO:0047325) inositol-1,3,4-trisphosphate 6-kinase activity(GO:0052725) inositol-1,3,4-trisphosphate 5-kinase activity(GO:0052726)
0.1 0.3 GO:0019948 SUMO activating enzyme activity(GO:0019948)
0.1 0.3 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.1 0.8 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1 0.3 GO:0015288 porin activity(GO:0015288)
0.1 0.2 GO:0005499 vitamin D binding(GO:0005499)
0.1 0.4 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.1 0.3 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.1 0.3 GO:0046592 polyamine oxidase activity(GO:0046592)
0.0 0.2 GO:0004903 growth hormone receptor activity(GO:0004903)
0.0 0.4 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 0.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.8 GO:0008308 voltage-gated chloride channel activity(GO:0005247) voltage-gated anion channel activity(GO:0008308)
0.0 0.2 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.2 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.3 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.3 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.2 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.3 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.2 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.1 GO:0008887 glycerate kinase activity(GO:0008887)
0.0 0.4 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.0 0.3 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 0.3 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 1.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.2 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.2 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.3 GO:0070628 proteasome binding(GO:0070628)
0.0 0.1 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.0 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.1 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.0 0.1 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 0.1 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.1 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0 0.0 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 0.3 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.0 GO:0060175 brain-derived neurotrophic factor binding(GO:0048403) brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.0 1.0 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 0.1 GO:0035252 UDP-xylosyltransferase activity(GO:0035252)
0.0 0.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.4 GO:0005518 collagen binding(GO:0005518)
0.0 0.3 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 1.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.4 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.0 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
0.0 0.1 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.1 GO:0043121 neurotrophin binding(GO:0043121)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.8 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.0 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.3 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.4 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.4 PID IL1 PATHWAY IL1-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 0.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 0.7 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.6 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 1.0 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.6 REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS Genes involved in TGF-beta receptor signaling activates SMADs
0.0 0.3 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.3 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.3 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.1 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.3 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.1 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.2 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA