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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for junba+junbb
Z-value: 1.86
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Transcription factors associated with junba+junbb
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| junba | dr11_v1_chr1_-_51734524_51734535 | -0.94 | 1.2e-08 | Click! |
| junbb | dr11_v1_chr3_-_7656059_7656059 | -0.88 | 1.9e-06 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_37478418 Show fit | 5.05 |
ENSDART00000146103
|
death-associated protein kinase 3 |
|
| chr10_-_34915886 Show fit | 4.72 |
ENSDART00000141201
ENSDART00000002166 |
cyclin A1 |
|
| chr13_+_42309688 Show fit | 4.67 |
ENSDART00000158367
|
insulin-degrading enzyme |
|
| chr7_+_46019780 Show fit | 4.54 |
ENSDART00000163991
|
cyclin E1 |
|
| chr25_-_23052707 Show fit | 4.48 |
ENSDART00000024633
|
dual specificity phosphatase 8a |
|
| chr17_+_25187226 Show fit | 4.46 |
ENSDART00000148431
|
CLN8, transmembrane ER and ERGIC protein |
|
| chr12_-_10512911 Show fit | 4.28 |
ENSDART00000124562
ENSDART00000106163 |
zgc:152977 |
|
| chr6_+_13232934 Show fit | 4.09 |
ENSDART00000089725
|
INO80 complex subunit Db |
|
| chr7_-_26532089 Show fit | 4.08 |
ENSDART00000121698
|
SUMO1/sentrin/SMT3 specific peptidase 3b |
|
| chr16_-_29387215 Show fit | 3.93 |
ENSDART00000148787
|
S100 calcium binding protein A1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of junba+junbb
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 12.9 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029) |
| 0.7 | 9.3 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.1 | 6.6 | GO:0006400 | tRNA modification(GO:0006400) |
| 0.1 | 6.4 | GO:0010942 | positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068) |
| 0.6 | 5.4 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of receptor activity(GO:2000273) |
| 0.1 | 5.4 | GO:0031101 | fin regeneration(GO:0031101) |
| 0.4 | 5.3 | GO:0048669 | collateral sprouting in absence of injury(GO:0048669) regulation of collateral sprouting in absence of injury(GO:0048696) |
| 0.9 | 5.2 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
| 1.0 | 5.1 | GO:1901841 | regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842) |
| 0.1 | 5.1 | GO:0055088 | lipid homeostasis(GO:0055088) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 28.3 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.1 | 8.9 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 6.9 | GO:0005740 | mitochondrial envelope(GO:0005740) |
| 0.0 | 6.0 | GO:0005764 | lysosome(GO:0005764) |
| 0.1 | 5.5 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 5.5 | GO:0005874 | microtubule(GO:0005874) |
| 1.6 | 4.7 | GO:0097124 | cyclin A2-CDK2 complex(GO:0097124) |
| 0.8 | 4.7 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 4.6 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970) |
| 0.0 | 4.6 | GO:0005923 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.6 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 10.7 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.7 | 9.3 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.0 | 9.0 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.4 | 6.5 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.4 | 5.4 | GO:0032041 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) |
| 0.2 | 5.4 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 5.4 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 5.2 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.2 | 5.1 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.4 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.6 | 9.8 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.2 | 5.6 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 4.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 4.2 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.3 | 3.8 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 3.8 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 3.7 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 3.5 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.1 | 2.8 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 10.8 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 1.0 | 9.8 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 1.2 | 5.8 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 5.4 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.3 | 4.7 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.3 | 4.3 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.2 | 4.1 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.1 | 4.0 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.1 | 4.0 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 3.7 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |