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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for klf13+zgc:153115
Z-value: 1.33
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Transcription factors associated with klf13+zgc:153115
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| klf13 | dr11_v1_chr25_-_34512102_34512102 | -0.86 | 5.0e-06 | Click! |
| zgc:153115 | dr11_v1_chr2_-_7246338_7246338 | 0.63 | 4.7e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_-_17197546 Show fit | 7.52 |
ENSDART00000139939
ENSDART00000135146 ENSDART00000063800 ENSDART00000163606 |
glyceraldehyde-3-phosphate dehydrogenase |
|
| chr9_+_8380728 Show fit | 5.27 |
ENSDART00000133501
|
si:ch1073-75o15.4 |
|
| chr5_-_69482891 Show fit | 4.89 |
ENSDART00000109487
|
|
|
| chr10_-_34002185 Show fit | 4.69 |
ENSDART00000046599
|
zygote arrest 1-like |
|
| chr10_-_44017642 Show fit | 4.50 |
ENSDART00000135240
ENSDART00000014669 |
acyl-CoA dehydrogenase short chain |
|
| chr4_-_20177868 Show fit | 4.12 |
ENSDART00000003621
|
siaz-interacting nuclear protein |
|
| chr1_-_34450784 Show fit | 3.72 |
ENSDART00000140515
|
LIM domain 7b |
|
| chr23_-_31645760 Show fit | 3.70 |
ENSDART00000035031
|
serum/glucocorticoid regulated kinase 1 |
|
| chr7_+_1473929 Show fit | 3.62 |
ENSDART00000050687
|
lysophosphatidylcholine acyltransferase 4 |
|
| chr1_-_34450622 Show fit | 3.50 |
ENSDART00000083736
|
LIM domain 7b |
Network of associatons between targets according to the STRING database.
First level regulatory network of klf13+zgc:153115
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.5 | GO:0050821 | protein stabilization(GO:0050821) |
| 0.0 | 4.7 | GO:0006412 | translation(GO:0006412) |
| 1.1 | 4.5 | GO:0019626 | short-chain fatty acid catabolic process(GO:0019626) |
| 0.3 | 4.1 | GO:0001840 | neural plate development(GO:0001840) |
| 0.0 | 4.1 | GO:0001947 | heart looping(GO:0001947) |
| 0.0 | 3.7 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.2 | 3.6 | GO:0009086 | methionine biosynthetic process(GO:0009086) |
| 0.3 | 3.4 | GO:0032878 | regulation of establishment or maintenance of cell polarity(GO:0032878) |
| 1.1 | 3.2 | GO:0005997 | xylulose metabolic process(GO:0005997) |
| 0.8 | 3.1 | GO:0032801 | receptor catabolic process(GO:0032801) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.6 | GO:0005764 | lysosome(GO:0005764) |
| 0.1 | 3.4 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.2 | 2.9 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 2.7 | GO:0034703 | cation channel complex(GO:0034703) |
| 0.3 | 2.1 | GO:0043527 | tRNA methyltransferase complex(GO:0043527) |
| 0.0 | 2.1 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.2 | 2.0 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.0 | 2.0 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 2.0 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 1.8 | GO:0098636 | protein complex involved in cell adhesion(GO:0098636) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 7.5 | GO:0043891 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891) |
| 0.0 | 6.7 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.0 | 5.1 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.3 | 4.5 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.1 | 3.7 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.1 | 3.4 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.2 | 3.3 | GO:0045159 | myosin II binding(GO:0045159) |
| 0.1 | 3.2 | GO:0016646 | oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646) |
| 0.0 | 2.9 | GO:0015297 | antiporter activity(GO:0015297) |
| 0.1 | 2.7 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 5.3 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.0 | 1.5 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 1.2 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 1.0 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 0.9 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 0.7 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 0.5 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.5 | ST GA13 PATHWAY | G alpha 13 Pathway |
| 0.0 | 0.3 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 7.5 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 5.1 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.3 | 4.5 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.7 | 3.6 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.1 | 2.3 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.0 | 1.3 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 1.1 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.1 | 1.0 | REACTOME ALPHA LINOLENIC ACID ALA METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.0 | 0.9 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 0.8 | REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX | Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex |