ISMARA results: klf15+si:ch211-117k10.3

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for klf15+si:ch211-117k10.3

Z-value: 0.43

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Transcription factors associated with klf15+si:ch211-117k10.3

Gene Symbol	Gene ID	Gene Info
si_ch211-117k10.3 NCBI UniProt	ENSDARG00000090914	si_ch211-117k10.3
klf15 NCBI UniProt	ENSDARG00000091127	Kruppel-like factor 15

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
klf15	dr11_v1_chr23_-_35195908_35195908	-0.47	4.8e-02	Click!
si:ch211-117k10.3	dr11_v1_chr11_-_38513978_38513978	0.14	5.7e-01	Click!

Activity profile of klf15+si:ch211-117k10.3 motif

Sorted Z-values of klf15+si:ch211-117k10.3 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr24_-_38110779 Show fit	0.79	ENSDART00000147783	crp NCBI UniProt Show fit	c-reactive protein, pentraxin-related
chr25_+_150570 Show fit	0.63	ENSDART00000170892	adam10b NCBI UniProt Show fit	ADAM metallopeptidase domain 10b
chr3_-_16289826 Show fit	0.61	ENSDART00000131972	bckdhbl NCBI UniProt Show fit	branched chain keto acid dehydrogenase E1, beta polypeptide, like
chr20_-_14665002 Show fit	0.60	ENSDART00000152816	scrn2 NCBI UniProt Show fit	secernin 2
chr22_+_26853254 Show fit	0.60	ENSDART00000182487	tmem186 NCBI UniProt Show fit	transmembrane protein 186
chr20_-_48516765 Show fit	0.56	ENSDART00000150200	si:zfos-223e1.2 NCBI UniProt Show fit	si:zfos-223e1.2
chr2_-_44183613 Show fit	0.56	ENSDART00000079596	cadm3 NCBI UniProt Show fit	cell adhesion molecule 3
chr14_+_48960078 Show fit	0.47	ENSDART00000165514	mif NCBI UniProt Show fit	macrophage migration inhibitory factor
chr17_-_4395373 Show fit	0.46	ENSDART00000015923	klhl10a NCBI UniProt Show fit	kelch-like family member 10a
chr24_+_42131564 Show fit	0.46	ENSDART00000153854	wwp1 NCBI UniProt Show fit	WW domain containing E3 ubiquitin protein ligase 1

Showing 1 to 10 of 126 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of klf15+si:ch211-117k10.3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.6	GO:0006509	membrane protein ectodomain proteolysis(GO:0006509)
0.0	0.5	GO:0060117	auditory receptor cell development(GO:0060117)
0.1	0.4	GO:0043654	recognition of apoptotic cell(GO:0043654)
0.0	0.4	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.4	GO:0018149	peptide cross-linking(GO:0018149)
0.1	0.3	GO:0060898	spinal cord radial glial cell differentiation(GO:0021531) eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
0.1	0.3	GO:2001014	regulation of skeletal muscle cell differentiation(GO:2001014)
0.1	0.3	GO:0010226	response to lithium ion(GO:0010226)
0.0	0.3	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0	0.3	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)

Showing 1 to 10 of 19 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.2	GO:0044295	axonal growth cone(GO:0044295)
0.0	0.2	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.0	0.2	GO:0031209	SCAR complex(GO:0031209)

Showing 1 to 4 of 4 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.8	GO:0015485	cholesterol binding(GO:0015485)
0.2	0.6	GO:1902945	metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902945)
0.1	0.6	GO:0070004	cysteine-type exopeptidase activity(GO:0070004)
0.0	0.6	GO:0033691	sialic acid binding(GO:0033691)
0.1	0.4	GO:0030169	low-density lipoprotein particle binding(GO:0030169)
0.1	0.4	GO:0030060	L-malate dehydrogenase activity(GO:0030060)
0.0	0.4	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0	0.3	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0	0.3	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0	0.3	GO:0042813	Wnt-activated receptor activity(GO:0042813)

Showing 1 to 10 of 16 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
0.8	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.5	PID ERBB4 PATHWAY	ErbB4 signaling events
0.3	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Showing 1 to 3 of 3 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.0	0.4	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.0	0.4	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.2	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.0	0.2	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition

Showing 1 to 5 of 5 entries

Results for klf15+si:ch211-117k10.3

Z-value: 0.43

Motif logo

Transcription factors associated with klf15+si:ch211-117k10.3

Activity-expression correlation:

Activity profile of klf15+si:ch211-117k10.3 motif

Sorted Z-values of klf15+si:ch211-117k10.3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of klf15+si:ch211-117k10.3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: