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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for klf5l+klf6a+klf6b

Z-value: 0.28

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Transcription factors associated with klf5l+klf6a+klf6b

Gene Symbol Gene ID Gene Info
klf5l
ENSDARG00000018757 Kruppel-like factor 5 like
klf6a
ENSDARG00000029072 Kruppel-like factor 6a
klf6b
ENSDARG00000038561 Kruppel-like factor 6b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
klf5ldr11_v1_chr21_-_38153824_381538240.608.8e-03Click!
klf6bdr11_v1_chr2_+_48073972_48073972-0.126.3e-01Click!
klf6adr11_v1_chr24_-_4148914_4148915-0.077.9e-01Click!

Activity profile of klf5l+klf6a+klf6b motif

Sorted Z-values of klf5l+klf6a+klf6b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_-_127558 1.09 ENSDART00000149556
trpm7
transient receptor potential cation channel, subfamily M, member 7
chr17_-_2584423 0.95 ENSDART00000013506
zp3.2
zona pellucida glycoprotein 3, tandem duplicate 2
chr21_-_30293224 0.72 ENSDART00000101051
slbp2
stem-loop binding protein 2
chr15_-_45538773 0.54 ENSDART00000113494
MB21D2
Mab-21 domain containing 2
chr18_-_127873 0.49 ENSDART00000148490
trpm7
transient receptor potential cation channel, subfamily M, member 7
chr20_-_49889111 0.45 ENSDART00000058858
kif13bb
kinesin family member 13Bb
chr3_-_21118969 0.41 ENSDART00000129016
maza
MYC-associated zinc finger protein a (purine-binding transcription factor)
chr2_+_59015878 0.38 ENSDART00000148816
ENSDART00000122795
si:ch1073-391i24.1
si:ch1073-391i24.1
chr17_+_6793001 0.35 ENSDART00000030773
foxo3a
forkhead box O3A
chr16_-_7793457 0.35 ENSDART00000113483
trim71
tripartite motif containing 71, E3 ubiquitin protein ligase
chr6_-_7109063 0.33 ENSDART00000148548
nhej1
nonhomologous end-joining factor 1
chr20_+_26940178 0.33 ENSDART00000190888
cdca4
cell division cycle associated 4
chr13_-_12021566 0.32 ENSDART00000125430
pprc1
peroxisome proliferator-activated receptor gamma, coactivator-related 1
chr7_+_25126629 0.32 ENSDART00000077217
zgc:101765
zgc:101765
chr19_-_20106486 0.30 ENSDART00000043924
mpp6b
membrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6)
chr20_+_18703108 0.28 ENSDART00000181188
eif5
eukaryotic translation initiation factor 5
chr11_-_12158412 0.26 ENSDART00000147670
npepps
aminopeptidase puromycin sensitive
chr4_+_15006217 0.25 ENSDART00000090837
zc3hc1
zinc finger, C3HC-type containing 1
chr19_+_24324967 0.25 ENSDART00000090081
sema4ab
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Ab
chr11_-_11965033 0.24 ENSDART00000193683
abcc10
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr6_+_12503849 0.23 ENSDART00000149529
stk24b
serine/threonine kinase 24b (STE20 homolog, yeast)
chr24_+_24726956 0.23 ENSDART00000144574
ENSDART00000066628
mtfr1
mitochondrial fission regulator 1
chr4_+_3438510 0.23 ENSDART00000155320
atxn7l1
ataxin 7-like 1
chr5_-_23800376 0.22 ENSDART00000134184
gbgt1l4
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 4
chr13_-_23611960 0.19 ENSDART00000146216
prim2
DNA primase subunit 2
chr3_-_30909487 0.18 ENSDART00000025046
ppp1caa
protein phosphatase 1, catalytic subunit, alpha isozyme a
chr18_+_6641542 0.18 ENSDART00000160379
c2cd5
C2 calcium-dependent domain containing 5
chr20_+_700616 0.17 ENSDART00000168166
senp6a
SUMO1/sentrin specific peptidase 6a
chr3_+_17634952 0.17 ENSDART00000191833
rab5c
RAB5C, member RAS oncogene family
chr17_-_27273296 0.16 ENSDART00000077087
id3
inhibitor of DNA binding 3
chr19_+_7636941 0.16 ENSDART00000081611
ENSDART00000163805
ENSDART00000112404
cgnb
cingulin b
chr22_+_1786230 0.16 ENSDART00000169318
ENSDART00000164948
znf1154
zinc finger protein 1154
chr17_+_37253706 0.15 ENSDART00000076004
tmem62
transmembrane protein 62
chr20_-_7176809 0.15 ENSDART00000012247
ENSDART00000125019
dhcr24
24-dehydrocholesterol reductase
chr9_-_34842414 0.15 ENSDART00000126348
BX601644.1
Danio rerio cytokine receptor-like factor 2 (crlf2), mRNA.
chr10_-_38456382 0.14 ENSDART00000182129
gdpd5a
glycerophosphodiester phosphodiesterase domain containing 5a
chr7_-_45852270 0.13 ENSDART00000170224
shcbp1
SHC SH2-domain binding protein 1
chr2_+_38225427 0.12 ENSDART00000141614
si:ch211-14a17.11
si:ch211-14a17.11
chr20_+_4392687 0.11 ENSDART00000187271
im:7142702
im:7142702
chr13_+_23093743 0.11 ENSDART00000148034
pik3ap1
phosphoinositide-3-kinase adaptor protein 1
chr15_-_25613114 0.11 ENSDART00000182431
ENSDART00000187405
taok1a
TAO kinase 1a
chr7_-_32980017 0.11 ENSDART00000113744
pkp3b
plakophilin 3b
chr22_-_26558166 0.10 ENSDART00000111125
glis2a
GLIS family zinc finger 2a
chr2_+_24868010 0.08 ENSDART00000078838
rab3aa
RAB3A, member RAS oncogene family, a
chr24_+_36452927 0.07 ENSDART00000168181
zgc:114120
zgc:114120
chr3_-_33941319 0.07 ENSDART00000026090
ENSDART00000111878
gtf2f1
general transcription factor IIF, polypeptide 1
chr2_+_24867534 0.06 ENSDART00000158050
rab3aa
RAB3A, member RAS oncogene family, a
chr1_+_59538755 0.06 ENSDART00000166354
sp6
Sp6 transcription factor
chr21_-_24865454 0.05 ENSDART00000142907
igsf9bb
immunoglobulin superfamily, member 9Bb
chr21_-_24865217 0.05 ENSDART00000101136
igsf9bb
immunoglobulin superfamily, member 9Bb
chr4_+_14343706 0.05 ENSDART00000142845
prl2
prolactin 2
chr7_-_46019756 0.05 ENSDART00000162583
zgc:162297
zgc:162297
chr14_-_237130 0.04 ENSDART00000164988
bod1l1
biorientation of chromosomes in cell division 1-like 1
chr15_+_20543770 0.04 ENSDART00000092357
sgsm2
small G protein signaling modulator 2
chr6_-_10788065 0.04 ENSDART00000190968
wipf1b
WAS/WASL interacting protein family, member 1b
chr15_-_38202630 0.04 ENSDART00000183772
rhoga
ras homolog family member Ga
chr8_+_36621598 0.04 ENSDART00000180389
magixb
MAGI family member, X-linked b
chr14_+_46291022 0.03 ENSDART00000074099
cabp2b
calcium binding protein 2b
chr20_-_1268863 0.03 ENSDART00000109321
ENSDART00000027119
lats1
large tumor suppressor kinase 1
chr22_+_30496360 0.03 ENSDART00000189145
BX649490.4

chr25_+_2229301 0.02 ENSDART00000180198
pparab
peroxisome proliferator-activated receptor alpha b
chr4_+_53119675 0.02 ENSDART00000167470
si:dkey-8o9.2
si:dkey-8o9.2
chr9_+_13999620 0.02 ENSDART00000143229
cd28l
cd28-like molecule
chr16_-_563235 0.02 ENSDART00000016303
irx2a
iroquois homeobox 2a
chr5_-_37252111 0.02 ENSDART00000185110
lrch2
leucine-rich repeats and calponin homology (CH) domain containing 2
chr20_+_2039518 0.02 ENSDART00000043157
CABZ01088134.1

chr7_-_23768234 0.01 ENSDART00000173981
si:ch211-200p22.4
si:ch211-200p22.4
chr21_+_43253538 0.01 ENSDART00000179940
ENSDART00000164806
ENSDART00000147026
shroom1
shroom family member 1
chr13_+_23214100 0.01 ENSDART00000163393
sorbs1
sorbin and SH3 domain containing 1
chr21_+_30293564 0.00 ENSDART00000007412
zmat2
zinc finger, matrin-type 2
chr9_-_3496548 0.00 ENSDART00000102876
cybrd1
cytochrome b reductase 1
chr8_+_43056153 0.00 ENSDART00000186377
prnpa
prion protein a

Network of associatons between targets according to the STRING database.

First level regulatory network of klf5l+klf6a+klf6b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.1 0.7 GO:0040016 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) embryonic cleavage(GO:0040016)
0.1 0.4 GO:0010586 miRNA metabolic process(GO:0010586)
0.1 0.4 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.1 1.0 GO:0007339 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.0 0.1 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.0 0.2 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.2 GO:0090234 regulation of centromere complex assembly(GO:0090230) regulation of kinetochore assembly(GO:0090234)
0.0 0.2 GO:0010828 positive regulation of glucose transport(GO:0010828)
0.0 0.3 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.3 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.0 0.1 GO:0071684 hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0 0.2 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.3 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 0.2 GO:1990077 primosome complex(GO:1990077)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.1 1.0 GO:0035804 structural constituent of egg coat(GO:0035804)
0.1 0.3 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.4 GO:0035198 miRNA binding(GO:0035198)
0.0 0.7 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.2 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.1 GO:0001096 RNA polymerase II basal transcription factor binding(GO:0001091) TFIIF-class transcription factor binding(GO:0001096)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1