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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for lhx3+lhx4

Z-value: 1.58

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Transcription factors associated with lhx3+lhx4

Gene Symbol Gene ID Gene Info
lhx3
ENSDARG00000003803 LIM homeobox 3
lhx4
ENSDARG00000039458 LIM homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX3dr11_v1_chr5_+_71802014_718020140.873.2e-06Click!
lhx4dr11_v1_chr8_-_14484599_144845990.873.2e-06Click!

Activity profile of lhx3+lhx4 motif

Sorted Z-values of lhx3+lhx4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_17083180 6.77 ENSDART00000170083
fam166b
family with sequence similarity 166, member B
chr8_+_43340995 6.17 ENSDART00000038566
rflna
refilin A
chr2_+_49799470 5.64 ENSDART00000146325
si:ch211-190k17.19
si:ch211-190k17.19
chr9_-_48407408 5.50 ENSDART00000058248
zgc:172182
zgc:172182
chr24_+_35787629 4.67 ENSDART00000136721
si:dkeyp-7a3.1
si:dkeyp-7a3.1
chr18_+_25752592 4.58 ENSDART00000111767
si:ch211-39k3.2
si:ch211-39k3.2
chr7_-_28148310 4.47 ENSDART00000044208
lmo1
LIM domain only 1
chr5_+_69747417 4.42 ENSDART00000153717
si:ch211-275j6.5
si:ch211-275j6.5
chr8_-_13046089 4.41 ENSDART00000137784
si:dkey-208b23.5
si:dkey-208b23.5
chr5_+_6954162 4.34 ENSDART00000086666
stpg2
sperm-tail PG-rich repeat containing 2
chr15_+_21672281 4.31 ENSDART00000153923
si:dkey-40g16.5
si:dkey-40g16.5
chr3_+_39853788 4.08 ENSDART00000154869
cacna1ha
calcium channel, voltage-dependent, T type, alpha 1H subunit a
chr10_+_26972755 3.98 ENSDART00000042162
tm7sf2
transmembrane 7 superfamily member 2
chr14_-_858985 3.97 ENSDART00000148687
ENSDART00000149375
slc34a1a
solute carrier family 34 (type II sodium/phosphate cotransporter), member 1a
chr11_+_25257022 3.86 ENSDART00000156052
tp53inp2
tumor protein p53 inducible nuclear protein 2
chr1_-_34750169 3.77 ENSDART00000149380
si:dkey-151m22.8
si:dkey-151m22.8
chr15_-_20939579 3.60 ENSDART00000152371
usp2a
ubiquitin specific peptidase 2a
chr6_+_49551614 3.60 ENSDART00000022581
rab22a
RAB22A, member RAS oncogene family
chr3_+_26145013 3.60 ENSDART00000162546
ENSDART00000129561
atp2a1
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
chr20_+_25586099 3.60 ENSDART00000063122
ENSDART00000134047
cyp2p10
cytochrome P450, family 2, subfamily P, polypeptide 10
chr17_+_15433518 3.57 ENSDART00000026180
fabp7a
fatty acid binding protein 7, brain, a
chr15_-_18162647 3.45 ENSDART00000012064
pih1d2
PIH1 domain containing 2
chr21_+_45502773 3.32 ENSDART00000160059
ENSDART00000165704
si:dkey-223p19.2
si:dkey-223p19.2
chr15_-_34567370 3.29 ENSDART00000099793
sostdc1a
sclerostin domain containing 1a
chr23_-_39666519 3.26 ENSDART00000110868
ENSDART00000190961
vwa1
von Willebrand factor A domain containing 1
chr5_-_54672763 3.24 ENSDART00000159009
spag8
sperm associated antigen 8
chr17_+_15433671 3.23 ENSDART00000149568
fabp7a
fatty acid binding protein 7, brain, a
chr11_-_2838699 3.18 ENSDART00000066189
lhfpl5a
LHFPL tetraspan subfamily member 5a
chr5_-_41494831 3.18 ENSDART00000051081
eef2l2
eukaryotic translation elongation factor 2, like 2
chr14_+_46313396 3.15 ENSDART00000047525
cryba1l1
crystallin, beta A1, like 1
chr2_-_1548330 3.13 ENSDART00000082155
ENSDART00000108481
ENSDART00000111272
dab1b
Dab, reelin signal transducer, homolog 1b (Drosophila)
chr5_+_42386705 3.06 ENSDART00000143034
pimr58
Pim proto-oncogene, serine/threonine kinase, related 58
chr5_+_42407962 3.06 ENSDART00000188489
BX548073.11

chr18_-_17485419 3.05 ENSDART00000018764
foxl1
forkhead box L1
chr5_+_42400777 3.01 ENSDART00000183114
BX548073.8

chr22_-_24285432 3.00 ENSDART00000164083
si:ch211-117l17.4
si:ch211-117l17.4
chr5_+_42379517 2.94 ENSDART00000103325
pimr59
Pim proto-oncogene, serine/threonine kinase, related 59
chr4_+_9669717 2.94 ENSDART00000004604
si:dkey-153k10.9
si:dkey-153k10.9
chr24_-_38657683 2.88 ENSDART00000154843
si:ch1073-164k15.3
si:ch1073-164k15.3
chr5_+_42393896 2.88 ENSDART00000189550
BX548073.13

chr17_-_39772999 2.87 ENSDART00000155727
pimr60
Pim proto-oncogene, serine/threonine kinase, related 60
chr17_-_24603925 2.83 ENSDART00000142589
si:dkey-148f10.4
si:dkey-148f10.4
chr20_+_11731039 2.82 ENSDART00000152215
ENSDART00000152585
si:ch211-155o21.3
si:ch211-155o21.3
chr12_-_35830625 2.80 ENSDART00000180028
CU459056.1

chr9_+_34641237 2.79 ENSDART00000133996
shox
short stature homeobox
chr10_+_22381802 2.76 ENSDART00000112484
nlgn2b
neuroligin 2b
chr11_-_25733910 2.73 ENSDART00000171935
brpf3a
bromodomain and PHD finger containing, 3a
chr2_-_43942595 2.70 ENSDART00000147925
si:ch211-195h23.4
si:ch211-195h23.4
chr23_-_16485190 2.67 ENSDART00000155038
si:dkeyp-100a5.4
si:dkeyp-100a5.4
chr15_+_36309070 2.65 ENSDART00000157034
gmnc
geminin coiled-coil domain containing
chr7_-_58729894 2.53 ENSDART00000149347
chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr2_+_14992879 2.48 ENSDART00000137546
pimr55
Pim proto-oncogene, serine/threonine kinase, related 55
chr21_-_5799122 2.46 ENSDART00000129351
ENSDART00000151202
ccni
cyclin I
chr5_+_2815021 2.41 ENSDART00000020472
hpda
4-hydroxyphenylpyruvate dioxygenase a
chr6_+_52350443 2.37 ENSDART00000151612
ENSDART00000151349
si:ch211-239j9.1
si:ch211-239j9.1
chr19_+_43297546 2.35 ENSDART00000168002
laptm5
lysosomal protein transmembrane 5
chr7_+_26629084 2.31 ENSDART00000101044
ENSDART00000173765
hsbp1a
heat shock factor binding protein 1a
chr20_+_4060839 2.27 ENSDART00000178565
TRIM67
tripartite motif containing 67
chr4_-_9909371 2.24 ENSDART00000102656
si:dkey-22l11.6
si:dkey-22l11.6
chr14_-_1355544 2.23 ENSDART00000060417
cetn4
centrin 4
chr2_+_19522082 2.22 ENSDART00000146098
pimr49
Pim proto-oncogene, serine/threonine kinase, related 49
chr13_-_37649595 2.21 ENSDART00000115354
si:dkey-188i13.10
si:dkey-188i13.10
chr20_+_19512727 2.20 ENSDART00000063696
atraid
all-trans retinoic acid-induced differentiation factor
chr20_-_53981626 2.16 ENSDART00000023550
hsp90aa1.2
heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2
chr19_+_31873308 2.14 ENSDART00000146560
ENSDART00000133045
si:dkeyp-34f6.4
si:dkeyp-34f6.4
chr3_-_39180048 2.14 ENSDART00000049720
cdk21
cyclin-dependent kinase 21
chr24_+_40860320 2.13 ENSDART00000161351
gorasp1b
golgi reassembly stacking protein 1b
chr5_-_34185115 2.10 ENSDART00000192771
fibcd1
fibrinogen C domain containing 1
chr8_-_24697586 2.08 ENSDART00000188639
BX324132.4

chr14_+_6615564 2.00 ENSDART00000139292
si:dkeyp-44a8.2
si:dkeyp-44a8.2
chr15_-_46779934 1.97 ENSDART00000085136
clcn2c
chloride channel 2c
chr16_-_28856112 1.97 ENSDART00000078543
syt11b
synaptotagmin XIb
chr17_-_29119362 1.95 ENSDART00000104204
foxg1a
forkhead box G1a
chr23_-_37113396 1.94 ENSDART00000102886
ENSDART00000134461
zgc:193690
zgc:193690
chr25_-_16146851 1.93 ENSDART00000104043
dkk3b
dickkopf WNT signaling pathway inhibitor 3b
chr2_-_30668580 1.93 ENSDART00000087270
ctnnd2b
catenin (cadherin-associated protein), delta 2b
chr19_-_4010263 1.91 ENSDART00000159605
ENSDART00000165541
map7d1b
MAP7 domain containing 1b
chr18_+_20838786 1.90 ENSDART00000138692
ttc23
tetratricopeptide repeat domain 23
chr1_+_12195700 1.86 ENSDART00000040307
tdrd7a
tudor domain containing 7 a
chr1_-_669717 1.86 ENSDART00000160564
cyyr1
cysteine/tyrosine-rich 1
chr24_-_26310854 1.84 ENSDART00000080113
apodb
apolipoprotein Db
chr2_+_19578446 1.78 ENSDART00000164758
pimr50
Pim proto-oncogene, serine/threonine kinase, related 50
chr2_+_19578079 1.77 ENSDART00000144413
pimr50
Pim proto-oncogene, serine/threonine kinase, related 50
chr6_+_25257728 1.77 ENSDART00000162581
kyat3
kynurenine aminotransferase 3
chr1_-_19502322 1.74 ENSDART00000181888
ENSDART00000044030
kitb
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b
chr16_+_28728347 1.73 ENSDART00000149240
si:dkey-24i24.3
si:dkey-24i24.3
chr1_+_49668423 1.72 ENSDART00000150880
tsga10
testis specific, 10
chr21_-_275377 1.70 ENSDART00000157509
rln1
relaxin 1
chr10_+_26747755 1.69 ENSDART00000100329
f9b
coagulation factor IXb
chr6_-_8311044 1.69 ENSDART00000129674
slc44a2
solute carrier family 44 (choline transporter), member 2
chr15_-_23376541 1.67 ENSDART00000078570
c1qtnf5
C1q and TNF related 5
chr24_+_26997798 1.67 ENSDART00000089506
larp4b
La ribonucleoprotein domain family, member 4B
chr17_+_12285285 1.64 ENSDART00000154336
pimr174
Pim proto-oncogene, serine/threonine kinase, related 174
chr16_-_41004731 1.64 ENSDART00000102591
KCNV1
si:dkey-201i6.2
chr4_-_52165969 1.63 ENSDART00000171130
si:dkeyp-44b5.4
si:dkeyp-44b5.4
chr5_-_67911111 1.63 ENSDART00000051833
gsx1
GS homeobox 1
chr20_-_52338782 1.61 ENSDART00000109735
ENSDART00000132941
si:ch1073-287p18.1
si:ch1073-287p18.1
chr23_-_37113215 1.60 ENSDART00000146835
zgc:193690
zgc:193690
chr4_+_57881965 1.58 ENSDART00000162234
si:dkeyp-44b5.4
si:dkeyp-44b5.4
chr5_+_40299568 1.58 ENSDART00000142157
arl15a
ADP-ribosylation factor-like 15a
chr16_-_27566552 1.58 ENSDART00000142102
zgc:153215
zgc:153215
chr5_-_30715225 1.57 ENSDART00000016758
ftr82
finTRIM family, member 82
chr13_-_36535128 1.56 ENSDART00000043312
srsf5a
serine/arginine-rich splicing factor 5a
chr15_+_9861973 1.56 ENSDART00000170945
si:dkey-13m3.2
si:dkey-13m3.2
chr10_-_5844915 1.55 ENSDART00000185929
ankrd55
ankyrin repeat domain 55
chr8_-_12403077 1.54 ENSDART00000142150
phf19
PHD finger protein 19
chr21_+_45841731 1.53 ENSDART00000038657
faxdc2
fatty acid hydroxylase domain containing 2
chr18_+_27821856 1.52 ENSDART00000131712
si:ch211-222m18.4
si:ch211-222m18.4
chr14_-_2933185 1.51 ENSDART00000161677
ENSDART00000162446
ENSDART00000109378
si:dkey-201i24.6
si:dkey-201i24.6
chr6_+_13117598 1.50 ENSDART00000104744
casp8l1
caspase 8, apoptosis-related cysteine peptidase, like 1
chr10_-_5847655 1.50 ENSDART00000192773
ankrd55
ankyrin repeat domain 55
chr14_-_413273 1.49 ENSDART00000163976
ENSDART00000179907
FAT4
FAT atypical cadherin 4
chr11_+_40812590 1.47 ENSDART00000186690
errfi1a
ERBB receptor feedback inhibitor 1a
chr19_-_10043142 1.45 ENSDART00000193016
grin2da
glutamate receptor, ionotropic, N-methyl D-aspartate 2D, a
chr6_-_20952187 1.44 ENSDART00000074327
igfbp2a
insulin-like growth factor binding protein 2a
chr18_-_48547564 1.42 ENSDART00000138607
kcnj1a.1
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1
chr7_+_20475788 1.42 ENSDART00000171155
si:dkey-19b23.13
si:dkey-19b23.13
chr24_+_39108243 1.41 ENSDART00000156353
mss51
MSS51 mitochondrial translational activator
chr13_+_9046473 1.39 ENSDART00000136557
pimr152
Pim proto-oncogene, serine/threonine kinase, related 152
chr1_-_42289704 1.37 ENSDART00000150124
si:ch211-71k14.1
si:ch211-71k14.1
chr4_-_948776 1.36 ENSDART00000023483
sim1b
single-minded family bHLH transcription factor 1b
chr16_-_21140097 1.36 ENSDART00000145837
ENSDART00000146500
si:dkey-271j15.3
si:dkey-271j15.3
chr23_+_4253957 1.35 ENSDART00000008761
arl6ip5b
ADP-ribosylation factor-like 6 interacting protein 5b
chr22_-_26865181 1.35 ENSDART00000138311
hmox2a
heme oxygenase 2a
chr20_+_7584211 1.35 ENSDART00000132481
ENSDART00000127975
ENSDART00000144551
bloc1s2
biogenesis of lysosomal organelles complex-1, subunit 2
chr16_+_46111849 1.35 ENSDART00000172232
sv2a
synaptic vesicle glycoprotein 2A
chr7_+_38811800 1.35 ENSDART00000052322
zgc:110699
zgc:110699
chr1_-_5455498 1.35 ENSDART00000040368
ENSDART00000114035
mnx2b
motor neuron and pancreas homeobox 2b
chr25_-_4146947 1.34 ENSDART00000129268
fads2
fatty acid desaturase 2
chr2_+_33368414 1.33 ENSDART00000077462
slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr15_+_9327252 1.32 ENSDART00000144381
sgcg
sarcoglycan, gamma
chr22_+_38173960 1.31 ENSDART00000010537
cp
ceruloplasmin
chr6_-_59942335 1.31 ENSDART00000168416
fbxl3b
F-box and leucine-rich repeat protein 3b
chr7_+_19552381 1.29 ENSDART00000169060
si:ch211-212k18.5
si:ch211-212k18.5
chr14_-_7137808 1.28 ENSDART00000054803
trpt1
tRNA phosphotransferase 1
chr25_+_34915576 1.26 ENSDART00000073441
sntb2
syntrophin, beta 2
chr6_+_9427641 1.26 ENSDART00000022620
kalrnb
kalirin RhoGEF kinase b
chr4_+_45148652 1.25 ENSDART00000150798
si:dkey-51d8.9
si:dkey-51d8.9
chr20_-_9095105 1.24 ENSDART00000140792
oma1
OMA1 zinc metallopeptidase
chr11_-_1509773 1.24 ENSDART00000050762
phactr3b
phosphatase and actin regulator 3b
chr10_-_31015535 1.22 ENSDART00000146116
panx3
pannexin 3
chr19_+_1688727 1.19 ENSDART00000115136
ENSDART00000166744
dennd3a
DENN/MADD domain containing 3a
chr9_+_10692905 1.18 ENSDART00000061499
cxcr4b
chemokine (C-X-C motif), receptor 4b
chr15_-_31514818 1.18 ENSDART00000153978
hmgb1b
high mobility group box 1b
chr17_+_11675362 1.18 ENSDART00000157911
kif26ba
kinesin family member 26Ba
chr11_-_6048490 1.17 ENSDART00000066164
plvapb
plasmalemma vesicle associated protein b
chr20_+_40457599 1.17 ENSDART00000017553
serinc1
serine incorporator 1
chr2_+_42072231 1.17 ENSDART00000084517
vcpip1
valosin containing protein (p97)/p47 complex interacting protein 1
chr3_-_30061985 1.16 ENSDART00000189583
ppfia3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr14_+_44794936 1.16 ENSDART00000128881
zgc:195212
zgc:195212
chr22_-_26865361 1.14 ENSDART00000182504
hmox2a
heme oxygenase 2a
chr21_-_14811058 1.11 ENSDART00000143100
phpt1
phosphohistidine phosphatase 1
chr25_+_34915762 1.08 ENSDART00000191776
sntb2
syntrophin, beta 2
chr25_+_13406069 1.07 ENSDART00000010495
znrf1
zinc and ring finger 1
chr12_-_28363111 1.06 ENSDART00000016283
ENSDART00000164156
psmd11b
proteasome 26S subunit, non-ATPase 11b
chr24_-_40860603 1.05 ENSDART00000188032
CU633479.7

chr22_-_36530902 1.05 ENSDART00000056188
polr2h
info polymerase (RNA) II (DNA directed) polypeptide H
chr12_-_6880694 1.05 ENSDART00000171846
pcdh15b
protocadherin-related 15b
chr24_+_13316737 1.05 ENSDART00000191658
SBSPON
somatomedin B and thrombospondin type 1 domain containing
chr2_-_9059955 1.05 ENSDART00000022768
ak5
adenylate kinase 5
chr9_+_28598577 1.05 ENSDART00000142623
ENSDART00000135947
si:ch73-7i4.1
si:ch73-7i4.1
chr15_-_21014270 1.04 ENSDART00000154019
si:ch211-212c13.10
si:ch211-212c13.10
chr21_-_20939488 1.03 ENSDART00000039043
rgs7bpb
regulator of G protein signaling 7 binding protein b
chr8_+_52637507 1.03 ENSDART00000163830
si:dkey-90l8.3
si:dkey-90l8.3
chr24_-_6078222 1.03 ENSDART00000146830
apbb1ip
amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
chr16_-_28878080 1.03 ENSDART00000149501
si:dkey-239n17.4
si:dkey-239n17.4
chr7_+_29954709 1.02 ENSDART00000173904
tpma
alpha-tropomyosin
chr18_-_15932704 1.02 ENSDART00000127769
plekhg7
pleckstrin homology domain containing, family G (with RhoGef domain) member 7
chr25_+_7671640 1.02 ENSDART00000145367
kcnj11l
potassium inwardly-rectifying channel, subfamily J, member 11, like
chr22_+_16535575 1.01 ENSDART00000083063
tal1
T-cell acute lymphocytic leukemia 1
chr22_-_22416337 1.01 ENSDART00000142947
ENSDART00000089569
camsap2a
calmodulin regulated spectrin-associated protein family, member 2a
chr3_+_46635527 1.00 ENSDART00000153971
si:dkey-248g21.1
si:dkey-248g21.1
chr9_+_38481780 1.00 ENSDART00000087241
lss
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
chr16_-_10053049 1.00 ENSDART00000081152
cep76
centrosomal protein 76
chr7_+_72003301 0.98 ENSDART00000012918
ENSDART00000182268
ENSDART00000185750
psmd9
proteasome 26S subunit, non-ATPase 9
chr22_-_5252005 0.98 ENSDART00000132942
ENSDART00000081801
ncln
nicalin
chr14_-_46070802 0.98 ENSDART00000038670
elf2a
E74-like factor 2a (ets domain transcription factor)
chr18_-_43884044 0.97 ENSDART00000087382
ddx6
DEAD (Asp-Glu-Ala-Asp) box helicase 6
chr22_+_19366866 0.97 ENSDART00000137301
si:dkey-21e2.12
si:dkey-21e2.12
chr23_-_18024543 0.97 ENSDART00000139695
pm20d1.1
peptidase M20 domain containing 1, tandem duplicate 1
chr15_-_14625373 0.96 ENSDART00000171841
slc5a2
solute carrier family 5 (sodium/glucose cotransporter), member 2
chr13_+_22295905 0.96 ENSDART00000180133
ENSDART00000181125
usp54a
ubiquitin specific peptidase 54a
chr8_+_18830759 0.95 ENSDART00000089079
mpnd
MPN domain containing
chr19_-_11106315 0.95 ENSDART00000059102
arhgef1a
Rho guanine nucleotide exchange factor (GEF) 1a
chr22_-_31060579 0.94 ENSDART00000182376
cand2
cullin-associated and neddylation-dissociated 2 (putative)
chr2_+_38373272 0.94 ENSDART00000113111
psmb5
proteasome subunit beta 5
chr1_+_15204633 0.93 ENSDART00000188410
itln1
intelectin 1
chr10_-_17222083 0.93 ENSDART00000134059
depdc5
DEP domain containing 5
chr19_-_5699703 0.92 ENSDART00000082050
zgc:174904
zgc:174904
chr9_-_31278048 0.91 ENSDART00000022204
zic5
zic family member 5 (odd-paired homolog, Drosophila)
chr13_-_12006007 0.91 ENSDART00000111438
mgea5
meningioma expressed antigen 5 (hyaluronidase)
chr7_-_25895189 0.91 ENSDART00000173599
ENSDART00000079235
ENSDART00000173786
ENSDART00000173602
ENSDART00000079245
ENSDART00000187568
ENSDART00000173505
cd99l2
CD99 molecule-like 2
chr14_+_4807207 0.90 ENSDART00000167145
ap1ar
adaptor-related protein complex 1 associated regulatory protein
chr11_+_45436703 0.89 ENSDART00000168295
ENSDART00000173293
sos1
son of sevenless homolog 1 (Drosophila)
chr5_+_21144269 0.89 ENSDART00000028087
cds2
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
chr4_+_16715267 0.88 ENSDART00000143849
pkp2
plakophilin 2
chr9_+_30112423 0.87 ENSDART00000112398
ENSDART00000013591
tfg
trk-fused gene
chr6_-_51386656 0.87 ENSDART00000154732
ENSDART00000177990
ENSDART00000184928
ENSDART00000180197
ptprt
protein tyrosine phosphatase, receptor type, t
chr20_-_48485354 0.87 ENSDART00000124040
ENSDART00000148437
insm1a
insulinoma-associated 1a
chr16_-_45178430 0.86 ENSDART00000165186
si:dkey-33i11.9
si:dkey-33i11.9

Network of associatons between targets according to the STRING database.

First level regulatory network of lhx3+lhx4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.2 GO:0061037 negative regulation of chondrocyte differentiation(GO:0032331) negative regulation of cartilage development(GO:0061037) negative regulation of chondrocyte development(GO:0061182) regulation of bone mineralization involved in bone maturation(GO:1900157) negative regulation of bone mineralization involved in bone maturation(GO:1900158) negative regulation of bone development(GO:1903011)
1.5 4.4 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.9 3.6 GO:0031448 regulation of twitch skeletal muscle contraction(GO:0014724) regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) negative regulation of striated muscle contraction(GO:0045988) relaxation of skeletal muscle(GO:0090076)
0.7 4.0 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.6 2.2 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.5 2.7 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
0.5 3.4 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.5 5.3 GO:0034605 cellular response to heat(GO:0034605)
0.4 1.3 GO:0060092 regulation of synaptic transmission, glycinergic(GO:0060092)
0.4 1.7 GO:0038093 Fc receptor signaling pathway(GO:0038093)
0.4 1.7 GO:0015871 choline transport(GO:0015871)
0.4 2.5 GO:0006788 heme oxidation(GO:0006788)
0.4 2.4 GO:0006572 tyrosine catabolic process(GO:0006572)
0.4 3.1 GO:0097477 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
0.4 2.2 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.4 1.1 GO:0035971 peptidyl-histidine dephosphorylation(GO:0035971)
0.3 1.0 GO:0045601 positive regulation of epithelial cell differentiation(GO:0030858) regulation of endothelial cell differentiation(GO:0045601)
0.3 0.9 GO:0010265 SCF complex assembly(GO:0010265)
0.3 1.2 GO:0021730 trigeminal sensory nucleus development(GO:0021730)
0.3 1.2 GO:0048308 organelle inheritance(GO:0048308) Golgi inheritance(GO:0048313)
0.3 2.2 GO:1990845 adaptive thermogenesis(GO:1990845)
0.3 3.5 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.3 2.8 GO:0097105 presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105)
0.2 2.0 GO:0043584 nose development(GO:0043584)
0.2 4.1 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.2 0.9 GO:0098908 regulation of neuronal action potential(GO:0098908)
0.2 0.9 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
0.2 4.4 GO:0006415 translational termination(GO:0006415)
0.2 1.5 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.2 1.2 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108) negative regulation of mesoderm development(GO:2000381)
0.2 2.7 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.2 0.6 GO:0007414 axonal defasciculation(GO:0007414)
0.2 0.6 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.2 0.7 GO:0048618 post-embryonic foregut morphogenesis(GO:0048618)
0.2 0.9 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.2 0.7 GO:0015677 copper ion import(GO:0015677)
0.2 1.2 GO:0032732 positive regulation of interleukin-1 production(GO:0032732)
0.2 1.9 GO:0030719 P granule organization(GO:0030719)
0.2 0.7 GO:0071926 endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921)
0.2 5.0 GO:0006695 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.2 0.6 GO:0051876 pigment granule dispersal(GO:0051876)
0.2 1.4 GO:1902038 positive regulation of hematopoietic stem cell differentiation(GO:1902038)
0.1 0.6 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.1 1.2 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.1 1.4 GO:0040014 regulation of multicellular organism growth(GO:0040014)
0.1 0.7 GO:0003261 cardiac muscle progenitor cell migration to the midline involved in heart field formation(GO:0003261)
0.1 3.9 GO:0010508 positive regulation of autophagy(GO:0010508)
0.1 2.0 GO:0043248 proteasome assembly(GO:0043248)
0.1 1.3 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 1.1 GO:0002934 desmosome organization(GO:0002934)
0.1 0.7 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 0.9 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.1 1.0 GO:0034063 stress granule assembly(GO:0034063)
0.1 4.2 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.1 1.5 GO:0016126 sterol biosynthetic process(GO:0016126)
0.1 0.5 GO:0099563 modification of synaptic structure(GO:0099563)
0.1 0.9 GO:0060118 vestibular receptor cell differentiation(GO:0060114) vestibular receptor cell development(GO:0060118)
0.1 3.0 GO:0003323 type B pancreatic cell development(GO:0003323)
0.1 1.3 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.1 0.4 GO:0021564 vagus nerve development(GO:0021564)
0.1 0.9 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.9 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.1 1.9 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.1 0.3 GO:0045226 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.1 0.5 GO:0003210 cardiac atrium formation(GO:0003210)
0.1 0.3 GO:0035773 insulin secretion involved in cellular response to glucose stimulus(GO:0035773) regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.1 0.5 GO:0030279 negative regulation of ossification(GO:0030279)
0.1 0.6 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.1 1.1 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.1 1.2 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 1.0 GO:0031111 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.1 0.7 GO:0030497 fatty acid elongation(GO:0030497)
0.1 0.2 GO:0009750 response to fructose(GO:0009750)
0.1 0.7 GO:1901998 toxin transport(GO:1901998)
0.1 1.5 GO:0099565 chemical synaptic transmission, postsynaptic(GO:0099565)
0.1 0.5 GO:0021703 locus ceruleus development(GO:0021703)
0.1 0.6 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.1 0.4 GO:0030326 embryonic limb morphogenesis(GO:0030326)
0.1 1.0 GO:0046599 regulation of centriole replication(GO:0046599)
0.1 3.6 GO:0042738 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.1 1.2 GO:0043114 regulation of vascular permeability(GO:0043114)
0.1 0.5 GO:1900052 regulation of isoprenoid metabolic process(GO:0019747) regulation of vitamin metabolic process(GO:0030656) regulation of retinoic acid biosynthetic process(GO:1900052)
0.1 1.3 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.1 5.6 GO:0033339 pectoral fin development(GO:0033339)
0.1 3.5 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.1 2.0 GO:0000302 response to reactive oxygen species(GO:0000302)
0.1 1.3 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.1 0.4 GO:0042983 amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.1 0.6 GO:0015810 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.1 0.3 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.1 0.6 GO:0001765 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.1 3.2 GO:0006414 translational elongation(GO:0006414)
0.1 19.1 GO:0046777 protein autophosphorylation(GO:0046777)
0.1 2.1 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.1 0.2 GO:0021530 spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 0.7 GO:0031937 methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 1.7 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 0.7 GO:0003181 atrioventricular valve morphogenesis(GO:0003181)
0.0 2.4 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.3 GO:1902915 negative regulation of histone ubiquitination(GO:0033183) regulation of protein K63-linked ubiquitination(GO:1900044) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) regulation of protein polyubiquitination(GO:1902914) negative regulation of protein polyubiquitination(GO:1902915)
0.0 0.4 GO:0030216 keratinocyte differentiation(GO:0030216)
0.0 1.3 GO:0055064 chloride ion homeostasis(GO:0055064)
0.0 1.3 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 5.4 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.6 GO:0009251 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 0.7 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.8 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.2 GO:0060967 negative regulation of posttranscriptional gene silencing(GO:0060149) negative regulation of gene silencing by miRNA(GO:0060965) negative regulation of gene silencing by RNA(GO:0060967)
0.0 0.1 GO:0060898 eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
0.0 0.3 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.0 3.9 GO:0007283 spermatogenesis(GO:0007283)
0.0 0.5 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.8 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.3 GO:0007608 sensory perception of smell(GO:0007608)
0.0 1.3 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636)
0.0 1.9 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.0 2.1 GO:0007030 Golgi organization(GO:0007030)
0.0 3.1 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 0.1 GO:0050957 equilibrioception(GO:0050957)
0.0 1.7 GO:0007596 blood coagulation(GO:0007596)
0.0 0.3 GO:0042119 granulocyte activation(GO:0036230) neutrophil activation(GO:0042119)
0.0 0.2 GO:0034394 protein localization to cell surface(GO:0034394)
0.0 0.6 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.6 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.3 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.2 GO:0006707 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 1.1 GO:0061515 myeloid cell development(GO:0061515)
0.0 0.5 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 1.0 GO:0009142 nucleoside triphosphate biosynthetic process(GO:0009142)
0.0 0.7 GO:0030050 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 1.1 GO:0051051 negative regulation of transport(GO:0051051)
0.0 0.2 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 1.4 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.0 0.4 GO:0002548 monocyte chemotaxis(GO:0002548)
0.0 0.5 GO:0008643 carbohydrate transport(GO:0008643)
0.0 0.4 GO:0036269 swimming behavior(GO:0036269)
0.0 0.5 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 1.1 GO:0045666 positive regulation of neuron differentiation(GO:0045666)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:0060077 inhibitory synapse(GO:0060077)
0.9 3.6 GO:0031673 H zone(GO:0031673)
0.9 3.4 GO:0097255 R2TP complex(GO:0097255)
0.2 4.0 GO:0005903 brush border(GO:0005903)
0.2 0.6 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.2 1.3 GO:0016012 sarcoglycan complex(GO:0016012)
0.2 4.1 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.2 2.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.2 2.7 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 4.4 GO:0044447 axoneme part(GO:0044447)
0.1 0.9 GO:1990130 Iml1 complex(GO:1990130)
0.1 4.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 2.2 GO:0043209 myelin sheath(GO:0043209)
0.1 1.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 1.0 GO:0036449 microtubule minus-end(GO:0036449)
0.1 4.4 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 3.9 GO:0016605 PML body(GO:0016605)
0.1 1.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 1.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 1.1 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 6.2 GO:0032432 actin filament bundle(GO:0032432)
0.1 4.0 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 0.4 GO:0005673 transcription factor TFIIE complex(GO:0005673)
0.1 0.6 GO:0071914 prominosome(GO:0071914)
0.1 0.9 GO:0014704 intercalated disc(GO:0014704)
0.1 0.7 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 1.9 GO:0043186 P granule(GO:0043186)
0.1 0.7 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 0.4 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.1 2.7 GO:0016592 mediator complex(GO:0016592)
0.1 1.1 GO:0032420 stereocilium(GO:0032420)
0.0 1.2 GO:0005921 gap junction(GO:0005921)
0.0 0.2 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.5 GO:1990246 uniplex complex(GO:1990246)
0.0 0.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.6 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 3.2 GO:0005814 centriole(GO:0005814)
0.0 0.2 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0 1.7 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.3 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.9 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.8 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.2 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.4 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 4.8 GO:0005769 early endosome(GO:0005769)
0.0 0.9 GO:0005902 microvillus(GO:0005902)
0.0 0.8 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 1.6 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.5 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.6 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.3 GO:0030057 desmosome(GO:0030057)
0.0 1.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 2.2 GO:0005635 nuclear envelope(GO:0005635)
0.0 1.0 GO:0005871 kinesin complex(GO:0005871)
0.0 1.0 GO:0005884 actin filament(GO:0005884)
0.0 1.4 GO:0014069 postsynaptic density(GO:0014069)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 6.2 GO:0031005 filamin binding(GO:0031005)
0.8 2.4 GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity(GO:0003868)
0.7 4.0 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.6 4.1 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.5 3.8 GO:0036122 BMP binding(GO:0036122)
0.5 6.8 GO:0005504 fatty acid binding(GO:0005504)
0.4 4.4 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.4 1.7 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.4 2.5 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.4 1.9 GO:0039706 co-receptor binding(GO:0039706)
0.3 1.1 GO:0101006 protein histidine phosphatase activity(GO:0101006)
0.2 0.9 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.2 1.5 GO:0000254 C-4 methylsterol oxidase activity(GO:0000254)
0.2 3.6 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.2 2.7 GO:0010484 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.2 0.7 GO:0048407 platelet-derived growth factor-activated receptor activity(GO:0005017) platelet-derived growth factor binding(GO:0048407)
0.2 0.7 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.2 2.4 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.2 2.4 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.2 0.7 GO:0102345 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.2 1.0 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.2 4.0 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 0.9 GO:0019215 intermediate filament binding(GO:0019215)
0.1 0.6 GO:0004134 glycogen debranching enzyme activity(GO:0004133) 4-alpha-glucanotransferase activity(GO:0004134) amylo-alpha-1,6-glucosidase activity(GO:0004135)
0.1 0.7 GO:0098634 C-X3-C chemokine binding(GO:0019960) protein binding involved in cell-matrix adhesion(GO:0098634) collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.9 GO:0042834 peptidoglycan binding(GO:0042834)
0.1 1.4 GO:0031994 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)
0.1 2.0 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 2.8 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 1.4 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 0.8 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 0.3 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 1.8 GO:0070122 isopeptidase activity(GO:0070122)
0.1 1.0 GO:0004046 aminoacylase activity(GO:0004046)
0.1 1.3 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 1.4 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 1.0 GO:0030507 spectrin binding(GO:0030507) microtubule minus-end binding(GO:0051011)
0.1 0.2 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.1 0.3 GO:0005153 interleukin-8 receptor binding(GO:0005153)
0.1 1.5 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 3.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 1.2 GO:0008301 DNA binding, bending(GO:0008301)
0.1 0.7 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 3.6 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.1 0.2 GO:0072571 ADP-D-ribose binding(GO:0072570) mono-ADP-D-ribose binding(GO:0072571)
0.0 1.8 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.9 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.3 GO:0070698 type I activin receptor binding(GO:0070698)
0.0 1.2 GO:0022829 wide pore channel activity(GO:0022829)
0.0 0.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.6 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 5.8 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 1.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.7 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.0 0.5 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 0.9 GO:0019894 kinesin binding(GO:0019894)
0.0 3.3 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.3 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 3.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 3.5 GO:0051082 unfolded protein binding(GO:0051082)
0.0 1.6 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 1.2 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.3 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 1.0 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.6 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.2 GO:0033781 cholesterol 24-hydroxylase activity(GO:0033781)
0.0 0.2 GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity(GO:0003977)
0.0 0.5 GO:0016208 AMP binding(GO:0016208)
0.0 1.2 GO:0019956 chemokine binding(GO:0019956)
0.0 0.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.6 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.9 GO:0005518 collagen binding(GO:0005518)
0.0 0.4 GO:0002020 protease binding(GO:0002020)
0.0 0.6 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 1.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.1 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 0.2 GO:0008494 translation activator activity(GO:0008494)
0.0 0.2 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.4 GO:0008417 fucosyltransferase activity(GO:0008417)
0.0 0.7 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 3.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.9 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.2 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.2 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.1 GO:0015172 L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172)
0.0 0.3 GO:0015026 coreceptor activity(GO:0015026)
0.0 0.9 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.3 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 1.0 GO:0019955 cytokine binding(GO:0019955)
0.0 0.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.4 GO:0045296 cadherin binding(GO:0045296)
0.0 0.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 14.3 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 1.7 GO:0005179 hormone activity(GO:0005179)
0.0 0.1 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 0.4 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 1.0 GO:0003777 microtubule motor activity(GO:0003777)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.3 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.9 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.5 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 1.3 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.8 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.7 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 4.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.6 PID AURORA A PATHWAY Aurora A signaling
0.0 1.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.3 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.5 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.5 PID ATR PATHWAY ATR signaling pathway
0.0 0.6 PID REG GR PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 3.6 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.2 3.0 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.2 0.8 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 1.3 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 1.9 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1 1.1 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 0.7 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 1.3 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 1.3 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 0.6 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 1.0 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 0.7 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 1.6 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.9 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.3 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.0 REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
0.0 0.6 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.5 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 1.0 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.3 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.2 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.2 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.0 0.9 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.1 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors