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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for lhx5

Z-value: 0.42

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Transcription factors associated with lhx5

Gene Symbol Gene ID Gene Info
lhx5
ENSDARG00000057936 LIM homeobox 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
lhx5dr11_v1_chr21_-_15929041_159290410.292.4e-01Click!

Activity profile of lhx5 motif

Sorted Z-values of lhx5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_43340995 1.36 ENSDART00000038566
rflna
refilin A
chr8_+_25569903 1.31 ENSDART00000062375
si:dkey-48j7.3
si:dkey-48j7.3
chr18_+_46382484 1.21 ENSDART00000024202
ENSDART00000142790
daw1
dynein assembly factor with WDR repeat domains 1
chr15_-_20939579 1.08 ENSDART00000152371
usp2a
ubiquitin specific peptidase 2a
chr24_-_26328721 1.07 ENSDART00000125468
apodb
apolipoprotein Db
chr3_+_39853788 1.02 ENSDART00000154869
cacna1ha
calcium channel, voltage-dependent, T type, alpha 1H subunit a
chr2_+_49799470 0.99 ENSDART00000146325
si:ch211-190k17.19
si:ch211-190k17.19
chr17_+_15433518 0.95 ENSDART00000026180
fabp7a
fatty acid binding protein 7, brain, a
chr18_-_17485419 0.95 ENSDART00000018764
foxl1
forkhead box L1
chr5_+_38040407 0.92 ENSDART00000139936
si:dkey-111e8.4
si:dkey-111e8.4
chr12_+_45200744 0.90 ENSDART00000098932
wbp2
WW domain binding protein 2
chr15_-_18162647 0.89 ENSDART00000012064
pih1d2
PIH1 domain containing 2
chr19_+_43297546 0.88 ENSDART00000168002
laptm5
lysosomal protein transmembrane 5
chr9_+_7732714 0.88 ENSDART00000145853
si:ch1073-349o24.2
si:ch1073-349o24.2
chr17_+_15433671 0.86 ENSDART00000149568
fabp7a
fatty acid binding protein 7, brain, a
chr11_-_2838699 0.82 ENSDART00000066189
lhfpl5a
LHFPL tetraspan subfamily member 5a
chr3_+_26145013 0.82 ENSDART00000162546
ENSDART00000129561
atp2a1
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
chr23_-_39666519 0.81 ENSDART00000110868
ENSDART00000190961
vwa1
von Willebrand factor A domain containing 1
chr5_-_54672763 0.79 ENSDART00000159009
spag8
sperm associated antigen 8
chr8_-_13046089 0.73 ENSDART00000137784
si:dkey-208b23.5
si:dkey-208b23.5
chr16_-_28856112 0.73 ENSDART00000078543
syt11b
synaptotagmin XIb
chr3_-_39180048 0.72 ENSDART00000049720
cdk21
cyclin-dependent kinase 21
chr5_+_69747417 0.70 ENSDART00000153717
si:ch211-275j6.5
si:ch211-275j6.5
chr22_-_24285432 0.69 ENSDART00000164083
si:ch211-117l17.4
si:ch211-117l17.4
chr4_+_72723304 0.69 ENSDART00000186791
ENSDART00000158902
ENSDART00000191925
rab3ip
RAB3A interacting protein (rabin3)
chr25_-_16157776 0.69 ENSDART00000138453
si:dkey-80c24.5
si:dkey-80c24.5
chr6_-_21582444 0.68 ENSDART00000151339
si:dkey-43k4.3
si:dkey-43k4.3
chr20_+_25586099 0.67 ENSDART00000063122
ENSDART00000134047
cyp2p10
cytochrome P450, family 2, subfamily P, polypeptide 10
chr7_+_20471315 0.65 ENSDART00000173714
si:dkey-19b23.13
si:dkey-19b23.13
chr5_-_41494831 0.64 ENSDART00000051081
eef2l2
eukaryotic translation elongation factor 2, like 2
chr24_-_38657683 0.63 ENSDART00000154843
si:ch1073-164k15.3
si:ch1073-164k15.3
chr6_+_6797520 0.62 ENSDART00000150967
si:ch211-85n16.3
si:ch211-85n16.3
chr25_+_16189044 0.62 ENSDART00000143975
si:dkey-80c24.1
si:dkey-80c24.1
chr20_-_53981626 0.61 ENSDART00000023550
hsp90aa1.2
heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2
chr2_+_19578079 0.61 ENSDART00000144413
pimr50
Pim proto-oncogene, serine/threonine kinase, related 50
chr12_+_7497882 0.61 ENSDART00000134608
phyhiplb
phytanoyl-CoA 2-hydroxylase interacting protein-like b
chr15_-_39955785 0.60 ENSDART00000154556
msh5
mutS homolog 5
chr4_+_9669717 0.59 ENSDART00000004604
si:dkey-153k10.9
si:dkey-153k10.9
chr6_+_52350443 0.57 ENSDART00000151612
ENSDART00000151349
si:ch211-239j9.1
si:ch211-239j9.1
chr10_+_39084354 0.56 ENSDART00000158245
si:ch73-1a9.3
si:ch73-1a9.3
chr2_+_19522082 0.56 ENSDART00000146098
pimr49
Pim proto-oncogene, serine/threonine kinase, related 49
chr24_+_12989727 0.54 ENSDART00000126842
ENSDART00000129309
flj11011l
hypothetical protein FLJ11011-like (H. sapiens)
chr16_-_41004731 0.54 ENSDART00000102591
KCNV1
si:dkey-201i6.2
chr6_+_49551614 0.54 ENSDART00000022581
rab22a
RAB22A, member RAS oncogene family
chr24_-_26310854 0.53 ENSDART00000080113
apodb
apolipoprotein Db
chr2_-_30668580 0.53 ENSDART00000087270
ctnnd2b
catenin (cadherin-associated protein), delta 2b
chr1_-_55785722 0.52 ENSDART00000142069
ENSDART00000043933
ndufb7
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7
chr12_-_35830625 0.51 ENSDART00000180028
CU459056.1

chr4_+_57881965 0.50 ENSDART00000162234
si:dkeyp-44b5.4
si:dkeyp-44b5.4
chr6_-_59942335 0.50 ENSDART00000168416
fbxl3b
F-box and leucine-rich repeat protein 3b
chr21_-_25801956 0.49 ENSDART00000101219
mettl27
methyltransferase like 27
chr1_-_669717 0.48 ENSDART00000160564
cyyr1
cysteine/tyrosine-rich 1
chr12_+_25600685 0.47 ENSDART00000077157
six3b
SIX homeobox 3b
chr23_+_42810055 0.47 ENSDART00000186647
myl9a
myosin, light chain 9a, regulatory
chr15_-_46779934 0.47 ENSDART00000085136
clcn2c
chloride channel 2c
chr14_-_1355544 0.47 ENSDART00000060417
cetn4
centrin 4
chr14_-_7137808 0.46 ENSDART00000054803
trpt1
tRNA phosphotransferase 1
chr2_+_19578446 0.45 ENSDART00000164758
pimr50
Pim proto-oncogene, serine/threonine kinase, related 50
chr17_+_12285285 0.45 ENSDART00000154336
pimr174
Pim proto-oncogene, serine/threonine kinase, related 174
chr22_+_508290 0.44 ENSDART00000135403
nuak2
NUAK family, SNF1-like kinase, 2
chr5_+_2815021 0.44 ENSDART00000020472
hpda
4-hydroxyphenylpyruvate dioxygenase a
chr21_+_45502773 0.42 ENSDART00000160059
ENSDART00000165704
si:dkey-223p19.2
si:dkey-223p19.2
chr20_+_19512727 0.42 ENSDART00000063696
atraid
all-trans retinoic acid-induced differentiation factor
chr3_+_45687266 0.41 ENSDART00000131652
gpr146
G protein-coupled receptor 146
chr4_-_9891874 0.40 ENSDART00000067193
adm2a
adrenomedullin 2a
chr11_-_1509773 0.40 ENSDART00000050762
phactr3b
phosphatase and actin regulator 3b
chr13_-_9450210 0.40 ENSDART00000133768
pimr152
Pim proto-oncogene, serine/threonine kinase, related 152
chr14_+_44794936 0.39 ENSDART00000128881
zgc:195212
zgc:195212
chr3_-_15999501 0.38 ENSDART00000160668
nme3
NME/NM23 nucleoside diphosphate kinase 3
chr15_+_9861973 0.37 ENSDART00000170945
si:dkey-13m3.2
si:dkey-13m3.2
chr7_-_71531846 0.37 ENSDART00000111797
acer2
alkaline ceramidase 2
chr18_-_6766354 0.37 ENSDART00000132611
adm2b
adrenomedullin 2b
chr9_-_9415000 0.37 ENSDART00000146210
si:ch211-214p13.9
si:ch211-214p13.9
chr14_-_42231293 0.37 ENSDART00000185486
BX890543.1

chr23_-_16485190 0.36 ENSDART00000155038
si:dkeyp-100a5.4
si:dkeyp-100a5.4
chr10_-_31015535 0.35 ENSDART00000146116
panx3
pannexin 3
chr13_-_9467944 0.35 ENSDART00000136582
pimr152
Pim proto-oncogene, serine/threonine kinase, related 152
chr15_+_9327252 0.35 ENSDART00000144381
sgcg
sarcoglycan, gamma
chr18_-_15932704 0.35 ENSDART00000127769
plekhg7
pleckstrin homology domain containing, family G (with RhoGef domain) member 7
chr12_-_28363111 0.34 ENSDART00000016283
ENSDART00000164156
psmd11b
proteasome 26S subunit, non-ATPase 11b
chr9_+_28598577 0.34 ENSDART00000142623
ENSDART00000135947
si:ch73-7i4.1
si:ch73-7i4.1
chr2_-_9059955 0.34 ENSDART00000022768
ak5
adenylate kinase 5
chr5_-_67911111 0.33 ENSDART00000051833
gsx1
GS homeobox 1
chr4_-_948776 0.33 ENSDART00000023483
sim1b
single-minded family bHLH transcription factor 1b
chr20_+_11731039 0.33 ENSDART00000152215
ENSDART00000152585
si:ch211-155o21.3
si:ch211-155o21.3
chr6_+_25257728 0.33 ENSDART00000162581
kyat3
kynurenine aminotransferase 3
chr11_+_45436703 0.32 ENSDART00000168295
ENSDART00000173293
sos1
son of sevenless homolog 1 (Drosophila)
chr7_+_6652967 0.32 ENSDART00000102681
pnp5a
purine nucleoside phosphorylase 5a
chr25_+_20715950 0.32 ENSDART00000180223
ergic2
ERGIC and golgi 2
chr23_+_31405497 0.32 ENSDART00000053546
sh3bgrl2
SH3 domain binding glutamate-rich protein like 2
chr22_+_19552987 0.32 ENSDART00000105315
hsd11b1la
hydroxysteroid (11-beta) dehydrogenase 1-like a
chr20_-_45812144 0.31 ENSDART00000147897
ENSDART00000147637
fermt1
fermitin family member 1
chr4_-_52165969 0.31 ENSDART00000171130
si:dkeyp-44b5.4
si:dkeyp-44b5.4
chr22_-_5252005 0.30 ENSDART00000132942
ENSDART00000081801
ncln
nicalin
chr15_-_21014270 0.30 ENSDART00000154019
si:ch211-212c13.10
si:ch211-212c13.10
chr11_+_30057762 0.30 ENSDART00000164139
nhsb
Nance-Horan syndrome b (congenital cataracts and dental anomalies)
chr20_-_9095105 0.29 ENSDART00000140792
oma1
OMA1 zinc metallopeptidase
chr22_-_19552796 0.28 ENSDART00000148088
ENSDART00000105485
si:dkey-78l4.14
si:dkey-78l4.14
chr12_-_6880694 0.28 ENSDART00000171846
pcdh15b
protocadherin-related 15b
chr6_+_7444899 0.28 ENSDART00000053775
arf3b
ADP-ribosylation factor 3b
chr14_-_413273 0.28 ENSDART00000163976
ENSDART00000179907
FAT4
FAT atypical cadherin 4
chr25_-_1126311 0.28 ENSDART00000161863
spg11
spastic paraplegia 11
chr2_+_38373272 0.28 ENSDART00000113111
psmb5
proteasome subunit beta 5
chr22_-_31060579 0.26 ENSDART00000182376
cand2
cullin-associated and neddylation-dissociated 2 (putative)
chr23_-_18024543 0.26 ENSDART00000139695
pm20d1.1
peptidase M20 domain containing 1, tandem duplicate 1
chr2_+_42072231 0.26 ENSDART00000084517
vcpip1
valosin containing protein (p97)/p47 complex interacting protein 1
chr7_+_59020972 0.25 ENSDART00000157873
hacd1
3-hydroxyacyl-CoA dehydratase 1
chr6_+_35362225 0.25 ENSDART00000133783
ENSDART00000102483
rgs4
regulator of G protein signaling 4
chr22_+_19366866 0.25 ENSDART00000137301
si:dkey-21e2.12
si:dkey-21e2.12
chr9_+_34641237 0.24 ENSDART00000133996
shox
short stature homeobox
chr10_-_43771447 0.24 ENSDART00000052307
arrdc3b
arrestin domain containing 3b
chr10_-_43568239 0.24 ENSDART00000131731
ENSDART00000097433
ENSDART00000131309
mef2ca
myocyte enhancer factor 2ca
chr20_+_6035427 0.24 ENSDART00000054086
tshr
thyroid stimulating hormone receptor
chr11_-_22371105 0.24 ENSDART00000146873
tmem183a
transmembrane protein 183A
chr8_+_52637507 0.24 ENSDART00000163830
si:dkey-90l8.3
si:dkey-90l8.3
chr24_-_21847945 0.24 ENSDART00000189097
CR352265.4

chr6_+_11989537 0.23 ENSDART00000190817
baz2ba
bromodomain adjacent to zinc finger domain, 2Ba
chr19_+_32158010 0.23 ENSDART00000005255
mrpl53
mitochondrial ribosomal protein L53
chr5_+_13427826 0.22 ENSDART00000083359
sec14l8
SEC14-like lipid binding 8
chr11_+_40812590 0.22 ENSDART00000186690
errfi1a
ERBB receptor feedback inhibitor 1a
chr9_+_37152564 0.22 ENSDART00000189497
gli2a
GLI family zinc finger 2a
chr4_-_75158035 0.22 ENSDART00000174353
CABZ01066312.1

chr22_+_37631234 0.21 ENSDART00000007346
psmd1
proteasome 26S subunit, non-ATPase 1
chr1_+_10318089 0.21 ENSDART00000029774
pip4p1b
phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1b
chr19_-_26869103 0.21 ENSDART00000089699
prrt1
proline-rich transmembrane protein 1
chr7_+_19495905 0.20 ENSDART00000125584
ENSDART00000173774
si:ch211-212k18.8
si:ch211-212k18.8
chr23_-_4409668 0.20 ENSDART00000081823
si:ch73-142c19.1
si:ch73-142c19.1
chr22_+_37631034 0.20 ENSDART00000159016
ENSDART00000193346
psmd1
proteasome 26S subunit, non-ATPase 1
chr19_-_5699703 0.20 ENSDART00000082050
zgc:174904
zgc:174904
chr24_-_31425799 0.20 ENSDART00000157998
cngb3.1
cyclic nucleotide gated channel beta 3, tandem duplicate 1
chr2_+_2223837 0.19 ENSDART00000101038
ENSDART00000129354
tmie
transmembrane inner ear
chr24_-_40860603 0.19 ENSDART00000188032
CU633479.7

chr3_-_7546740 0.18 ENSDART00000128960
zmp:0000001003
zmp:0000001003
chr4_+_77943184 0.18 ENSDART00000159094
pacsin2
protein kinase C and casein kinase substrate in neurons 2
chr2_-_16217344 0.18 ENSDART00000152031
arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr7_+_19495379 0.18 ENSDART00000180514
si:ch211-212k18.8
si:ch211-212k18.8
chr21_-_20939488 0.18 ENSDART00000039043
rgs7bpb
regulator of G protein signaling 7 binding protein b
chr21_+_30502002 0.17 ENSDART00000043727
slc7a3a
solute carrier family 7 (cationic amino acid transporter, y+ system), member 3a
chr22_-_28226948 0.17 ENSDART00000147686
si:dkey-222p3.1
si:dkey-222p3.1
chr22_-_36530902 0.17 ENSDART00000056188
polr2h
info polymerase (RNA) II (DNA directed) polypeptide H
chr14_-_52583021 0.17 ENSDART00000166924
CU469526.1

chr15_-_20949692 0.16 ENSDART00000185548
tbcela
tubulin folding cofactor E-like a
chr15_-_22074315 0.16 ENSDART00000149830
drd2a
dopamine receptor D2a
chr3_-_48716422 0.15 ENSDART00000164979
si:ch211-114m9.1
si:ch211-114m9.1
chr3_-_49566364 0.15 ENSDART00000161507
zgc:153426
zgc:153426
chr6_-_57539141 0.14 ENSDART00000156967
itcha
itchy E3 ubiquitin protein ligase a
chr5_-_6377865 0.14 ENSDART00000031775
zgc:73226
zgc:73226
chr15_-_40267485 0.14 ENSDART00000152253
kcnj13
potassium inwardly-rectifying channel, subfamily J, member 13
chr20_+_52389858 0.14 ENSDART00000185863
ENSDART00000166651
arhgap39
Rho GTPase activating protein 39
chr23_+_41800052 0.14 ENSDART00000141484
pdyn
prodynorphin
chr20_-_48485354 0.14 ENSDART00000124040
ENSDART00000148437
insm1a
insulinoma-associated 1a
chr6_+_14980761 0.14 ENSDART00000087782
mrps9
mitochondrial ribosomal protein S9
chr5_-_21422390 0.14 ENSDART00000144198
tenm1
teneurin transmembrane protein 1
chr24_-_7995960 0.13 ENSDART00000186594
bloc1s5
biogenesis of lysosomal organelles complex-1, subunit 5, muted
chr12_+_18681477 0.13 ENSDART00000127981
ENSDART00000143979
rgs9b
regulator of G protein signaling 9b
chr1_-_9195629 0.13 ENSDART00000143587
ENSDART00000192174
ern2
endoplasmic reticulum to nucleus signaling 2
chr6_-_43677125 0.13 ENSDART00000150128
foxp1b
forkhead box P1b
chr5_+_21144269 0.13 ENSDART00000028087
cds2
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
chr17_+_45405821 0.13 ENSDART00000189482
ENSDART00000177422
tagapa
T cell activation RhoGTPase activating protein a
chr24_+_9475809 0.13 ENSDART00000132688
si:ch211-285f17.1
si:ch211-285f17.1
chr4_-_18309917 0.13 ENSDART00000189084
plxnc1
plexin C1
chr25_-_19420949 0.12 ENSDART00000181338
map1ab
microtubule-associated protein 1Ab
chr19_+_31771270 0.11 ENSDART00000147474
stmn2b
stathmin 2b
chr6_-_35046735 0.11 ENSDART00000143649
uap1
UDP-N-acetylglucosamine pyrophosphorylase 1
chr23_+_4689626 0.11 ENSDART00000131532
gp9
glycoprotein IX (platelet)
chr23_-_1660708 0.11 ENSDART00000175138
CU693481.1

chr10_+_17776981 0.11 ENSDART00000141693
ccl19b
chemokine (C-C motif) ligand 19b
chr22_-_11614973 0.10 ENSDART00000063135
pcyt2
phosphate cytidylyltransferase 2, ethanolamine
chr19_+_5480327 0.10 ENSDART00000148794
jupb
junction plakoglobin b
chr17_+_43595692 0.10 ENSDART00000156271
cfap99
cilia and flagella associated protein 99
chr3_-_19368435 0.10 ENSDART00000132987
s1pr5a
sphingosine-1-phosphate receptor 5a
chr17_-_16965809 0.10 ENSDART00000153697
nrxn3a
neurexin 3a
chr6_+_39905021 0.10 ENSDART00000064904
endou
endonuclease, polyU-specific
chr2_+_9990491 0.10 ENSDART00000011906
slc35a3b
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3b
chr3_-_5361959 0.09 ENSDART00000081894
trim35-7
tripartite motif containing 35-7
chr2_+_20406399 0.09 ENSDART00000006817
ENSDART00000137848
palmda
palmdelphin a
chr25_-_13490744 0.09 ENSDART00000056721
ldhd
lactate dehydrogenase D
chr5_-_42904329 0.09 ENSDART00000112807
cxcl20
chemokine (C-X-C motif) ligand 20
chr3_-_36839115 0.09 ENSDART00000154553
ramp2
receptor (G protein-coupled) activity modifying protein 2
chr6_-_39649504 0.09 ENSDART00000179960
ENSDART00000190951
larp4ab
La ribonucleoprotein domain family, member 4Ab
chr16_-_25829779 0.08 ENSDART00000086301
irge4
immunity-related GTPase family, e4
chr10_-_11261565 0.08 ENSDART00000146727
ptbp3
polypyrimidine tract binding protein 3
chr1_-_45616470 0.08 ENSDART00000150165
atf7ip
activating transcription factor 7 interacting protein
chr14_-_4145594 0.08 ENSDART00000077348
casp3b
caspase 3, apoptosis-related cysteine peptidase b
chr21_-_35419486 0.08 ENSDART00000138529
si:dkeyp-23e4.3
si:dkeyp-23e4.3
chr21_-_39327223 0.08 ENSDART00000115097
aifm5
apoptosis-inducing factor, mitochondrion-associated, 5
chr5_-_38094130 0.08 ENSDART00000131831
si:ch211-284e13.4
si:ch211-284e13.4
chr13_-_12602920 0.08 ENSDART00000102311
lrit3b
leucine-rich repeat, immunoglobulin-like and transmembrane domains 3b
chr4_+_20536120 0.08 ENSDART00000125685
zmp:0000000650
zmp:0000000650
chr20_-_2949028 0.07 ENSDART00000104667
ENSDART00000193151
ENSDART00000131946
cdk19
cyclin-dependent kinase 19
chr11_+_11974708 0.07 ENSDART00000125060
zgc:64002
zgc:64002
chr5_-_13251907 0.07 ENSDART00000176774
ENSDART00000030553
top3b
DNA topoisomerase III beta
chr1_+_51721851 0.07 ENSDART00000040397
prdx2
peroxiredoxin 2
chr15_-_14552101 0.06 ENSDART00000171169
numbl
numb homolog (Drosophila)-like
chr11_-_6069081 0.06 ENSDART00000008980
babam1
BRISC and BRCA1 A complex member 1
chr10_+_16584382 0.06 ENSDART00000112039
CR790388.1

chr24_+_21540842 0.06 ENSDART00000091529
wasf3b
WAS protein family, member 3b
chr10_+_38417512 0.06 ENSDART00000112457
samsn1b
SAM domain, SH3 domain and nuclear localisation signals 1b
chr20_-_5291012 0.06 ENSDART00000122892
cyp46a1.3
cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 3
chr1_+_6172786 0.06 ENSDART00000126468
prkag3a
protein kinase, AMP-activated, gamma 3a non-catalytic subunit

Network of associatons between targets according to the STRING database.

First level regulatory network of lhx5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:1900157 negative regulation of chondrocyte differentiation(GO:0032331) negative regulation of cartilage development(GO:0061037) negative regulation of chondrocyte development(GO:0061182) regulation of bone mineralization involved in bone maturation(GO:1900157) negative regulation of bone mineralization involved in bone maturation(GO:1900158) negative regulation of bone development(GO:1903011)
0.2 0.7 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.2 0.8 GO:0031446 regulation of twitch skeletal muscle contraction(GO:0014724) regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) negative regulation of striated muscle contraction(GO:0045988) relaxation of skeletal muscle(GO:0090076)
0.1 0.9 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.1 0.4 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.1 0.5 GO:0046677 response to antibiotic(GO:0046677)
0.1 0.3 GO:0010265 SCF complex assembly(GO:0010265)
0.1 0.2 GO:0036076 ligamentous ossification(GO:0036076)
0.1 0.5 GO:0021846 cell proliferation in forebrain(GO:0021846)
0.1 0.2 GO:1904088 regulation of convergent extension involved in axis elongation(GO:1901232) positive regulation of epiboly involved in gastrulation with mouth forming second(GO:1904088)
0.1 0.4 GO:0006572 tyrosine catabolic process(GO:0006572)
0.1 0.7 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.1 0.5 GO:1990845 adaptive thermogenesis(GO:1990845)
0.1 0.3 GO:0048308 organelle inheritance(GO:0048308) Golgi inheritance(GO:0048313)
0.1 1.2 GO:0060285 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.1 1.0 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.1 0.6 GO:0000710 meiotic mismatch repair(GO:0000710)
0.1 0.3 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108) negative regulation of mesoderm development(GO:2000381)
0.1 0.4 GO:0032732 positive regulation of interleukin-1 production(GO:0032732)
0.1 1.6 GO:0007568 aging(GO:0007568)
0.0 0.4 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.0 0.5 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.2 GO:0099563 modification of synaptic structure(GO:0099563)
0.0 0.1 GO:0051876 pigment granule dispersal(GO:0051876)
0.0 0.7 GO:0006415 translational termination(GO:0006415)
0.0 0.2 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.0 0.1 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.2 GO:0043091 L-arginine import(GO:0043091) amino acid import across plasma membrane(GO:0089718) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine transport(GO:1902023) L-arginine import into cell(GO:1902765) amino acid import into cell(GO:1902837) L-arginine transmembrane transport(GO:1903400) arginine transmembrane transport(GO:1903826)
0.0 1.0 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.0 0.1 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.0 0.9 GO:0045815 positive regulation of gene expression, epigenetic(GO:0045815)
0.0 0.5 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.3 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.4 GO:0006228 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.0 0.3 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.9 GO:0035138 pectoral fin morphogenesis(GO:0035138)
0.0 0.9 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.1 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.1 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.0 0.5 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.0 0.2 GO:0045762 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.0 0.2 GO:0044857 membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.0 0.7 GO:0051904 melanosome transport(GO:0032402) pigment granule transport(GO:0051904)
0.0 0.4 GO:0030183 B cell differentiation(GO:0030183)
0.0 0.0 GO:0070589 cell wall biogenesis(GO:0042546) cell wall macromolecule biosynthetic process(GO:0044038) cellular component macromolecule biosynthetic process(GO:0070589)
0.0 0.1 GO:0097345 mitochondrial outer membrane permeabilization(GO:0097345)
0.0 0.2 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.1 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.5 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.7 GO:0042738 drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738)
0.0 0.3 GO:0001966 thigmotaxis(GO:0001966)
0.0 4.0 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 0.6 GO:0006414 translational elongation(GO:0006414)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0097255 R2TP complex(GO:0097255)
0.2 0.8 GO:0031673 H zone(GO:0031673)
0.2 0.7 GO:0070319 Golgi to plasma membrane transport vesicle(GO:0070319)
0.1 0.4 GO:0034515 proteasome storage granule(GO:0034515)
0.1 0.4 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.3 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.1 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 1.0 GO:0001518 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.6 GO:0043209 myelin sheath(GO:0043209)
0.0 0.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.7 GO:0044447 axoneme part(GO:0044447)
0.0 0.9 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.2 GO:0032432 actin filament bundle(GO:0032432)
0.0 0.2 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.8 GO:0016592 mediator complex(GO:0016592)
0.0 0.4 GO:0005921 gap junction(GO:0005921)
0.0 0.3 GO:0032420 stereocilium(GO:0032420)
0.0 0.5 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 0.3 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0031005 filamin binding(GO:0031005)
0.1 1.0 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 0.4 GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity(GO:0003868)
0.1 1.8 GO:0005504 fatty acid binding(GO:0005504)
0.1 0.7 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 0.2 GO:0018812 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.1 0.8 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.8 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.3 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 0.6 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.1 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.0 0.2 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.0 0.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 0.2 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.0 0.7 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.3 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.1 GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity(GO:0003977)
0.0 0.1 GO:0005153 interleukin-8 receptor binding(GO:0005153)
0.0 1.0 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.7 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.2 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.7 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.2 GO:0005222 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.1 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.2 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.1 GO:0004457 lactate dehydrogenase activity(GO:0004457)
0.0 0.3 GO:0016229 steroid dehydrogenase activity(GO:0016229)
0.0 0.7 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.1 GO:0031628 opioid receptor binding(GO:0031628)
0.0 1.3 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.3 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.1 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 0.7 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.3 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.1 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.6 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.2 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis