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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for mafb+mafba+nrl

Z-value: 0.85

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Transcription factors associated with mafb+mafba+nrl

Gene Symbol Gene ID Gene Info
mafba
ENSDARG00000017121 v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Ba
mafb
ENSDARG00000076520 v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog b (paralog b)
nrl
ENSDARG00000100466 neural retina leucine zipper

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
mafbdr11_v1_chr25_+_36674715_366747150.634.9e-03Click!
nrldr11_v1_chr20_+_661037_661037-0.272.8e-01Click!
mafbadr11_v1_chr23_-_3408777_3408777-0.107.1e-01Click!

Activity profile of mafb+mafba+nrl motif

Sorted Z-values of mafb+mafba+nrl motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr25_-_4482449 1.72 ENSDART00000056278
ENSDART00000149425
slc25a22a
solute carrier family 25 member 22a
chr24_+_13277573 1.60 ENSDART00000137886
si:ch211-171b20.3
si:ch211-171b20.3
chr5_-_71722257 1.42 ENSDART00000013404
ak1
adenylate kinase 1
chr16_-_54465271 1.16 ENSDART00000185978
cyp11c1
cytochrome P450, family 11, subfamily C, polypeptide 1
chr5_+_62723233 1.08 ENSDART00000183718
nanos2
nanos homolog 2
chr14_-_24397718 1.04 ENSDART00000110164
si:ch211-163m17.4
si:ch211-163m17.4
chr19_+_233143 1.01 ENSDART00000175273
syngap1a
synaptic Ras GTPase activating protein 1a
chr13_+_50375800 1.01 ENSDART00000099537
cox5b2
cytochrome c oxidase subunit Vb 2
chr25_-_19584735 0.91 ENSDART00000137930
sycp3
synaptonemal complex protein 3
chr1_-_59287410 0.90 ENSDART00000158011
ENSDART00000170580
col5a3b
collagen, type V, alpha 3b
chr25_+_245438 0.87 ENSDART00000004689
zgc:92481
zgc:92481
chr12_-_27242498 0.86 ENSDART00000152609
ENSDART00000152170
si:dkey-11c5.11
si:dkey-11c5.11
chr4_+_15819728 0.86 ENSDART00000101613
lrguk
leucine-rich repeats and guanylate kinase domain containing
chr15_-_106689 0.86 ENSDART00000185007
apoa1b
apolipoprotein A-Ib
chr6_-_39313027 0.84 ENSDART00000012644
krt4
keratin 4
chr19_+_9004256 0.79 ENSDART00000186401
ENSDART00000091443
si:ch211-81a5.1
si:ch211-81a5.1
chr11_+_39135050 0.77 ENSDART00000180571
ENSDART00000189685
cdc42
cell division cycle 42
chr6_+_120181 0.76 ENSDART00000151209
ENSDART00000185930
cdkn2d
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr2_-_14798295 0.74 ENSDART00000143430
ENSDART00000145869
si:ch73-366i20.1
si:ch73-366i20.1
chr19_-_5332784 0.74 ENSDART00000010373
krt1-19d
keratin, type 1, gene 19d
chrM_+_3803 0.71 ENSDART00000093596
mt-nd1
NADH dehydrogenase 1, mitochondrial
chr16_-_42969598 0.71 ENSDART00000156011
si:ch211-135n15.3
si:ch211-135n15.3
chr5_+_42467867 0.70 ENSDART00000172028
pimr58
Pim proto-oncogene, serine/threonine kinase, related 58
chr3_+_1209006 0.70 ENSDART00000158633
poldip3
polymerase (DNA-directed), delta interacting protein 3
chr23_-_45049044 0.67 ENSDART00000067630
SH3GL2 (1 of many)
SH3 domain containing GRB2 like 2, endophilin A1
chr23_+_6795531 0.66 ENSDART00000092131
si:ch211-117c9.5
si:ch211-117c9.5
chr15_-_19771981 0.65 ENSDART00000175502
ENSDART00000159475
picalmb
phosphatidylinositol binding clathrin assembly protein b
chr22_+_18816662 0.64 ENSDART00000132476
cbarpb
calcium channel, voltage-dependent, beta subunit associated regulatory protein b
chr21_+_40106448 0.61 ENSDART00000100166
serpinf1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr19_-_4023050 0.60 ENSDART00000162883
stpg1
sperm-tail PG-rich repeat containing 1
chr20_-_53981626 0.60 ENSDART00000023550
hsp90aa1.2
heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2
chr24_-_35707552 0.60 ENSDART00000165199
mapre2
microtubule-associated protein, RP/EB family, member 2
chr4_-_12795030 0.59 ENSDART00000150427
b2m
beta-2-microglobulin
chr21_+_26726936 0.59 ENSDART00000065392
calm2a
calmodulin 2a (phosphorylase kinase, delta)
chr9_-_105135 0.59 ENSDART00000180126
FQ377903.3

chr14_+_33329420 0.58 ENSDART00000171090
ENSDART00000164062
sowahd
sosondowah ankyrin repeat domain family d
chr17_-_39786222 0.57 ENSDART00000154515
pimr62
Pim proto-oncogene, serine/threonine kinase, related 62
chr18_+_7611298 0.57 ENSDART00000062156
odf3b
outer dense fiber of sperm tails 3B
chr5_+_42402536 0.57 ENSDART00000186754
BX548073.11

chr23_+_32011768 0.57 ENSDART00000053509
plagx
pleiomorphic adenoma gene X
chr23_+_44644911 0.55 ENSDART00000140799
zgc:85858
zgc:85858
chr5_-_67661102 0.55 ENSDART00000013605
zbtb20
zinc finger and BTB domain containing 20
chr13_+_24755049 0.55 ENSDART00000134102
col17a1b
collagen, type XVII, alpha 1b
chr2_-_10450784 0.54 ENSDART00000081196
scinlb
scinderin like b
chr8_+_53311965 0.54 ENSDART00000130104
gnb1a
guanine nucleotide binding protein (G protein), beta polypeptide 1a
chr5_-_33259079 0.54 ENSDART00000132223
ifitm1
interferon induced transmembrane protein 1
chr17_+_14425219 0.53 ENSDART00000153994
ccdc175
coiled-coil domain containing 175
chr21_+_244503 0.53 ENSDART00000162889
stard4
StAR-related lipid transfer (START) domain containing 4
chr22_-_193234 0.52 ENSDART00000131067
fbxo42
F-box protein 42
chr17_+_46739693 0.52 ENSDART00000097810
pimr22
Pim proto-oncogene, serine/threonine kinase, related 22
chr11_+_45347961 0.51 ENSDART00000172962
si:ch73-100l22.3
si:ch73-100l22.3
chr25_+_28823952 0.51 ENSDART00000067072
nfybb
nuclear transcription factor Y, beta b
chr4_-_12795436 0.50 ENSDART00000131026
ENSDART00000075127
b2m
beta-2-microglobulin
chr19_+_58954 0.49 ENSDART00000162379
col14a1b
collagen, type XIV, alpha 1b
chr4_+_38344 0.49 ENSDART00000170197
ENSDART00000175348
phtf2
putative homeodomain transcription factor 2
chr23_+_6795709 0.49 ENSDART00000149136
si:ch211-117c9.5
si:ch211-117c9.5
chr23_+_2542158 0.49 ENSDART00000182197
LO017835.1

chr18_+_30028135 0.49 ENSDART00000140825
ENSDART00000145306
ENSDART00000136810
si:ch211-220f16.1
si:ch211-220f16.1
chr16_+_1254390 0.48 ENSDART00000092627
ADAMTSL4
ADAMTS like 4
chr5_-_68022631 0.48 ENSDART00000143199
wasf3a
WAS protein family, member 3a
chr2_+_35728033 0.47 ENSDART00000002094
ankrd45
ankyrin repeat domain 45
chr9_-_42696408 0.47 ENSDART00000144744
col5a2a
collagen, type V, alpha 2a
chr25_-_27665978 0.46 ENSDART00000123590
si:ch211-91p5.3
si:ch211-91p5.3
chr17_+_10593398 0.45 ENSDART00000168897
ENSDART00000193989
ENSDART00000191664
ENSDART00000167188
mapkbp1
mitogen-activated protein kinase binding protein 1
chr5_+_20112032 0.45 ENSDART00000130554
isg15
ISG15 ubiquitin-like modifier
chr10_-_26744131 0.45 ENSDART00000020096
ENSDART00000162710
ENSDART00000179853
fgf13b
fibroblast growth factor 13b
chr4_-_890220 0.45 ENSDART00000022668
aim1b
crystallin beta-gamma domain containing 1b
chr25_-_22187397 0.44 ENSDART00000123211
ENSDART00000139110
pkp3a
plakophilin 3a
chr1_+_22003173 0.44 ENSDART00000054388
dnah6
dynein, axonemal, heavy chain 6
chr16_+_54588930 0.44 ENSDART00000159174
dennd4b
DENN/MADD domain containing 4B
chr20_-_1383916 0.44 ENSDART00000152373
scara5
scavenger receptor class A, member 5 (putative)
chr22_+_22021936 0.44 ENSDART00000149586
gna15.1
guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 1
chr8_+_19548985 0.44 ENSDART00000123104
notch2
notch 2
chr4_-_73190246 0.43 ENSDART00000170842
LO018260.1

chr11_+_26669724 0.43 ENSDART00000157157
si:dkey-57n24.6
si:dkey-57n24.6
chr5_-_56119028 0.43 ENSDART00000083134
mks1
Meckel syndrome, type 1
chr24_+_38522254 0.42 ENSDART00000156189
si:ch1073-66l23.1
si:ch1073-66l23.1
chr22_-_1079773 0.42 ENSDART00000136668
si:ch1073-15f12.3
si:ch1073-15f12.3
chr16_-_42894628 0.42 ENSDART00000045600
hfe2
hemochromatosis type 2
chr15_-_28095532 0.42 ENSDART00000191490
cryba1a
crystallin, beta A1a
chr25_-_3627130 0.41 ENSDART00000171863
si:ch211-272n13.3
si:ch211-272n13.3
chr3_+_40809892 0.41 ENSDART00000190803
arpc1b
actin related protein 2/3 complex, subunit 1B
chr17_+_51940768 0.41 ENSDART00000053422
ttll5
tubulin tyrosine ligase-like family, member 5
chr19_-_10081047 0.40 ENSDART00000128837
grin2da
glutamate receptor, ionotropic, N-methyl D-aspartate 2D, a
chr1_+_11711226 0.40 ENSDART00000147623
si:dkey-26i13.8
si:dkey-26i13.8
chr3_+_55100045 0.40 ENSDART00000113098
hbaa1
hemoglobin, alpha adult 1
chr16_+_19014886 0.40 ENSDART00000079298
si:ch211-254p10.2
si:ch211-254p10.2
chr18_-_48755037 0.40 ENSDART00000109673
tirap
toll-interleukin 1 receptor (TIR) domain containing adaptor protein
chr25_-_16600811 0.40 ENSDART00000011397
cpa2
carboxypeptidase A2 (pancreatic)
chr7_-_33130552 0.40 ENSDART00000127006
mns1
meiosis-specific nuclear structural 1
chr9_-_24985511 0.39 ENSDART00000141957
dnah7
dynein, axonemal, heavy chain 7
chr10_+_10351685 0.39 ENSDART00000109432
cercam
cerebral endothelial cell adhesion molecule
chr25_+_16601839 0.39 ENSDART00000008986
atp6v1e1a
ATPase H+ transporting V1 subunit E1a
chr15_+_46386261 0.39 ENSDART00000191793
igsf11
immunoglobulin superfamily member 11
chr4_-_191736 0.39 ENSDART00000169187
ENSDART00000192054
ptpro
protein tyrosine phosphatase, receptor type, O
chr2_+_31957554 0.39 ENSDART00000012413
ankhb
ANKH inorganic pyrophosphate transport regulator b
chr6_+_7250824 0.39 ENSDART00000177226
dzip1
DAZ interacting zinc finger protein 1
chr1_-_11878845 0.38 ENSDART00000163971
ENSDART00000123431
iqce
IQ motif containing E
chr16_-_29194517 0.38 ENSDART00000046114
ENSDART00000148899
mef2d
myocyte enhancer factor 2d
chr15_+_2559875 0.38 ENSDART00000178505
SH2B2
SH2B adaptor protein 2
chr21_-_45920 0.38 ENSDART00000040422
bhmt
betaine-homocysteine methyltransferase
chr8_+_53464216 0.38 ENSDART00000169514
cacna1db
calcium channel, voltage-dependent, L type, alpha 1D subunit, b
chr16_-_2558653 0.38 ENSDART00000110365
adcy3a
adenylate cyclase 3a
chr23_+_7710447 0.37 ENSDART00000168199
kif3b
kinesin family member 3B
chr4_-_8030583 0.37 ENSDART00000113628
si:ch211-240l19.8
si:ch211-240l19.8
chr12_-_49151326 0.37 ENSDART00000153244
bub3
BUB3 mitotic checkpoint protein
chr18_-_20869175 0.37 ENSDART00000090079
synm
synemin, intermediate filament protein
chr15_+_3284684 0.37 ENSDART00000179778
foxo1a
forkhead box O1 a
chr13_-_38792061 0.37 ENSDART00000162858
lmbrd1
LMBR1 domain containing 1
chr7_+_39166460 0.36 ENSDART00000052318
ENSDART00000146635
ENSDART00000173877
ENSDART00000173767
ENSDART00000173600
mdka
midkine a
chr15_-_45246911 0.36 ENSDART00000189557
ENSDART00000185291
CABZ01072607.1

chr6_+_24661736 0.36 ENSDART00000169283
znf644b
zinc finger protein 644b
chr3_+_55105066 0.36 ENSDART00000110848
si:ch211-5k11.8
si:ch211-5k11.8
chr16_+_10841163 0.36 ENSDART00000065467
dedd1
death effector domain-containing 1
chr12_+_466324 0.36 ENSDART00000169691
mprip
myosin phosphatase Rho interacting protein
chr13_+_22675802 0.36 ENSDART00000145538
ENSDART00000143312
zgc:193505
zgc:193505
chr1_-_59407322 0.36 ENSDART00000161661
si:ch211-188p14.5
si:ch211-188p14.5
chr8_-_15305528 0.35 ENSDART00000134794
spata6
spermatogenesis associated 6
chr1_-_59232267 0.35 ENSDART00000169658
ENSDART00000163257
akap8l
A kinase (PRKA) anchor protein 8-like
chr23_+_7710721 0.35 ENSDART00000186852
ENSDART00000161193
kif3b
kinesin family member 3B
chr14_+_23518110 0.34 ENSDART00000112930
si:ch211-221f10.2
si:ch211-221f10.2
chr7_-_25697285 0.34 ENSDART00000082620
dysf
dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)
chr8_-_43456025 0.34 ENSDART00000001092
ENSDART00000140618
ncor2
nuclear receptor corepressor 2
chr12_-_684200 0.34 ENSDART00000152122
si:ch211-176g6.2
si:ch211-176g6.2
chr4_-_149334 0.34 ENSDART00000163280
tbk1
TANK-binding kinase 1
chr25_-_36361697 0.34 ENSDART00000152388
si:ch211-113a14.22
si:ch211-113a14.22
chr18_+_14477740 0.34 ENSDART00000146472
kcng4a
potassium voltage-gated channel, subfamily G, member 4a
chr19_+_23982466 0.34 ENSDART00000080673
syt11a
synaptotagmin XIa
chr14_+_49135264 0.34 ENSDART00000084119
si:ch1073-44g3.1
si:ch1073-44g3.1
chr23_-_26077038 0.34 ENSDART00000126299
gdi1
GDP dissociation inhibitor 1
chr23_+_35713557 0.34 ENSDART00000123518
tuba1c
tubulin, alpha 1c
chr14_+_81919 0.34 ENSDART00000171444
stag3
stromal antigen 3
chr12_-_3840664 0.33 ENSDART00000160967
taok2b
TAO kinase 2b
chr8_+_52314542 0.33 ENSDART00000013059
ENSDART00000125241
dbnlb
drebrin-like b
chr23_-_45318760 0.33 ENSDART00000166883
ccdc171
coiled-coil domain containing 171
chr22_+_38192568 0.33 ENSDART00000126323
cp
ceruloplasmin
chr3_+_32425202 0.33 ENSDART00000156464
prr12b
proline rich 12b
chr19_+_56351 0.33 ENSDART00000168334
col14a1b
collagen, type XIV, alpha 1b
chr16_+_11242443 0.33 ENSDART00000024935
gsk3ab
glycogen synthase kinase 3 alpha b
chr1_+_54606354 0.33 ENSDART00000125227
si:ch211-202h22.10
si:ch211-202h22.10
chr16_+_23282655 0.33 ENSDART00000015956
efna1b
ephrin-A1b
chr21_+_30502002 0.32 ENSDART00000043727
slc7a3a
solute carrier family 7 (cationic amino acid transporter, y+ system), member 3a
chr15_-_19772372 0.32 ENSDART00000152729
picalmb
phosphatidylinositol binding clathrin assembly protein b
chr9_-_5916693 0.32 ENSDART00000115404
ENSDART00000148792
GPR89A
si:ch73-390b10.2
chr19_-_6134802 0.32 ENSDART00000140051
cica
capicua transcriptional repressor a
chr7_-_12968689 0.31 ENSDART00000173115
ENSDART00000013690
rplp2l
ribosomal protein, large P2, like
chr1_-_11973341 0.31 ENSDART00000159981
ENSDART00000066638
grk4
G protein-coupled receptor kinase 4
chr15_-_28094256 0.31 ENSDART00000142041
ENSDART00000132153
ENSDART00000146657
ENSDART00000048720
cryba1a
crystallin, beta A1a
chr1_-_55183088 0.31 ENSDART00000100619
LUC7L2
zgc:158803
chr22_+_38301365 0.31 ENSDART00000137339
traf5
Tnf receptor-associated factor 5
chr19_-_379750 0.31 ENSDART00000102725
tnfaip8l2a
tumor necrosis factor, alpha-induced protein 8-like 2a
chr1_+_10318089 0.31 ENSDART00000029774
pip4p1b
phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1b
chr24_+_3478871 0.31 ENSDART00000111491
ENSDART00000134598
ENSDART00000142407
wdr37
WD repeat domain 37
chr3_+_20012891 0.31 ENSDART00000078974
tmub2
transmembrane and ubiquitin-like domain containing 2
chr4_-_760560 0.31 ENSDART00000103601
agbl5
ATP/GTP binding protein-like 5
chr23_+_44157682 0.30 ENSDART00000164474
ENSDART00000149928
si:ch73-106g13.1
si:ch73-106g13.1
chr8_-_25074319 0.30 ENSDART00000134190
sort1b
sortilin 1b
chr16_+_6021908 0.30 ENSDART00000163786
BX511115.1

chr14_+_33329761 0.30 ENSDART00000161138
sowahd
sosondowah ankyrin repeat domain family d
chr11_+_30161168 0.29 ENSDART00000157385
cdkl5
cyclin-dependent kinase-like 5
chr21_-_43015383 0.29 ENSDART00000065097
dpysl3
dihydropyrimidinase-like 3
chr23_+_25210953 0.29 ENSDART00000132799
si:dkey-151g10.3
si:dkey-151g10.3
chr19_+_156757 0.29 ENSDART00000167717
carmil1
capping protein regulator and myosin 1 linker 1
chr24_-_12938922 0.29 ENSDART00000024084
pck2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr9_-_296169 0.29 ENSDART00000165228
kif5aa
kinesin family member 5A, a
chr10_-_42147318 0.28 ENSDART00000134890
dusp11
dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
chr17_-_30521043 0.28 ENSDART00000087111
itsn2b
intersectin 2b
chr10_+_31809226 0.28 ENSDART00000087898
foxo1b
forkhead box O1 b
chr15_+_3284416 0.28 ENSDART00000187665
ENSDART00000171723
foxo1a
forkhead box O1 a
chr21_-_20932603 0.27 ENSDART00000138155
ENSDART00000079709
c6
complement component 6
chr14_-_32089117 0.27 ENSDART00000158014
si:ch211-69b22.5
si:ch211-69b22.5
chr25_-_3503164 0.27 ENSDART00000191477
ENSDART00000186345
ENSDART00000180199
PRKAR2B
si:ch211-272n13.7
chr25_+_19999623 0.27 ENSDART00000026401
zgc:194665
zgc:194665
chr10_+_25355308 0.27 ENSDART00000100415
map3k7cl
map3k7 C-terminal like
chr18_-_12451772 0.27 ENSDART00000175083
si:ch211-1e14.1
si:ch211-1e14.1
chr15_+_15479442 0.27 ENSDART00000067095
nek8
NIMA-related kinase 8
chr19_-_15192638 0.27 ENSDART00000048151
phactr4a
phosphatase and actin regulator 4a
chr23_+_23658474 0.27 ENSDART00000162838
agrn
agrin
chr13_+_233482 0.27 ENSDART00000102511
cfap36
cilia and flagella associated protein 36
chr23_-_28141419 0.27 ENSDART00000133039
tac3a
tachykinin 3a
chr20_+_35086242 0.27 ENSDART00000114262
cdc42bpab
CDC42 binding protein kinase alpha (DMPK-like) b
chr22_+_28969071 0.26 ENSDART00000163427
pimr95
Pim proto-oncogene, serine/threonine kinase, related 95
chr1_+_10129099 0.26 ENSDART00000187740
rbm46
RNA binding motif protein 46
chr20_+_39685572 0.26 ENSDART00000050729
hddc2
HD domain containing 2
chr7_-_73848458 0.26 ENSDART00000041385
zgc:163061
zgc:163061
chr3_-_46410387 0.26 ENSDART00000156822
cdip1
cell death-inducing p53 target 1
chr7_-_26087807 0.26 ENSDART00000052989
ache
acetylcholinesterase
chr25_-_3503458 0.26 ENSDART00000173269
PRKAR2B
si:ch211-272n13.7
chr4_-_4592287 0.26 ENSDART00000155287
rassf3
Ras association (RalGDS/AF-6) domain family member 3
chr23_-_270847 0.26 ENSDART00000191867
anks1aa
ankyrin repeat and sterile alpha motif domain containing 1Aa
chr8_-_25011157 0.26 ENSDART00000078795
ahcyl1
adenosylhomocysteinase-like 1
chr22_-_7669624 0.25 ENSDART00000189617
AL929276.2

chr21_+_35215810 0.25 ENSDART00000135256
ubtd2
ubiquitin domain containing 2
chr21_-_22543611 0.25 ENSDART00000177084
myo5b
myosin VB
chr7_-_29200090 0.25 ENSDART00000173973
herc1
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
chr2_-_44720551 0.25 ENSDART00000146380
map6d1
MAP6 domain containing 1
chr4_+_16710001 0.25 ENSDART00000035899
pkp2
plakophilin 2
chr21_+_382400 0.25 ENSDART00000190785
ENSDART00000124615
rad23b
RAD23 homolog B, nucleotide excision repair protein
chr6_-_8311044 0.25 ENSDART00000129674
slc44a2
solute carrier family 44 (choline transporter), member 2
chr2_+_56139941 0.25 ENSDART00000164741
pgpep1
pyroglutamyl-peptidase I

Network of associatons between targets according to the STRING database.

First level regulatory network of mafb+mafba+nrl

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.2 1.4 GO:0006172 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180)
0.2 1.7 GO:0043490 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.2 0.9 GO:0010873 regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873)
0.1 0.5 GO:0035376 sterol import(GO:0035376) cholesterol import(GO:0070508)
0.1 0.5 GO:1903723 negative regulation of centriole elongation(GO:1903723)
0.1 0.4 GO:1902571 regulation of serine-type peptidase activity(GO:1902571)
0.1 0.6 GO:0046677 response to antibiotic(GO:0046677)
0.1 0.9 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.1 0.1 GO:2000402 response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869) negative regulation of lymphocyte migration(GO:2000402) negative regulation of T cell migration(GO:2000405)
0.1 0.3 GO:2000812 regulation of barbed-end actin filament capping(GO:2000812)
0.1 0.6 GO:0048745 smooth muscle tissue development(GO:0048745)
0.1 0.6 GO:0045955 negative regulation of calcium ion-dependent exocytosis(GO:0045955) negative regulation of regulated secretory pathway(GO:1903306)
0.1 0.7 GO:0043584 nose development(GO:0043584)
0.1 0.8 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.1 0.3 GO:0042117 plasma membrane repair(GO:0001778) monocyte activation(GO:0042117)
0.1 0.3 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.1 0.2 GO:0015871 choline transport(GO:0015871)
0.1 0.2 GO:0003156 regulation of organ formation(GO:0003156)
0.1 0.2 GO:0031642 negative regulation of myelination(GO:0031642) negative regulation of neurological system process(GO:0031645)
0.1 1.1 GO:0034122 negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.1 0.3 GO:0044003 modification by symbiont of host morphology or physiology(GO:0044003) modulation by symbiont of host cellular process(GO:0044068)
0.1 0.3 GO:0019626 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401) short-chain fatty acid catabolic process(GO:0019626) response to dexamethasone(GO:0071548)
0.1 0.3 GO:1990535 neuron projection maintenance(GO:1990535)
0.1 0.2 GO:0043388 positive regulation of DNA binding(GO:0043388)
0.1 0.9 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.3 GO:0072116 kidney rudiment formation(GO:0072003) pronephros formation(GO:0072116)
0.1 0.2 GO:0032757 interleukin-8 production(GO:0032637) regulation of interleukin-8 production(GO:0032677) positive regulation of interleukin-8 production(GO:0032757)
0.1 0.3 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.1 0.6 GO:0035372 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.1 0.3 GO:1900619 acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.1 0.4 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.1 0.3 GO:0003242 growth involved in heart morphogenesis(GO:0003241) cardiac chamber ballooning(GO:0003242) cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.1 0.2 GO:0032197 regulation of transposition, RNA-mediated(GO:0010525) negative regulation of transposition, RNA-mediated(GO:0010526) transposition, RNA-mediated(GO:0032197) positive regulation of neuron apoptotic process(GO:0043525) positive regulation of neuron death(GO:1901216)
0.1 0.3 GO:0035608 protein deglutamylation(GO:0035608)
0.1 0.6 GO:1902110 positive regulation of mitochondrial membrane permeability(GO:0035794) positive regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902110) mitochondrial outer membrane permeabilization involved in programmed cell death(GO:1902686)
0.1 0.2 GO:0032207 regulation of telomere maintenance via recombination(GO:0032207) negative regulation of telomere maintenance via recombination(GO:0032208)
0.1 0.3 GO:0097272 ammonia homeostasis(GO:0097272)
0.1 0.2 GO:0010633 negative regulation of epithelial cell migration(GO:0010633)
0.1 0.5 GO:1902624 positive regulation of neutrophil migration(GO:1902624)
0.1 0.2 GO:1902895 pri-miRNA transcription from RNA polymerase II promoter(GO:0061614) regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902893) positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.1 0.3 GO:1903826 L-arginine import(GO:0043091) amino acid import across plasma membrane(GO:0089718) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine transport(GO:1902023) L-arginine import into cell(GO:1902765) amino acid import into cell(GO:1902837) L-arginine transmembrane transport(GO:1903400) arginine transmembrane transport(GO:1903826)
0.1 0.3 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.1 0.2 GO:0006844 acyl carnitine transport(GO:0006844)
0.0 0.2 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.0 0.2 GO:0006116 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
0.0 0.1 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.0 0.1 GO:0015824 proline transport(GO:0015824)
0.0 0.3 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.4 GO:0071379 cellular response to prostaglandin stimulus(GO:0071379)
0.0 0.1 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.0 0.6 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.2 GO:0035909 aorta morphogenesis(GO:0035909) dorsal aorta morphogenesis(GO:0035912)
0.0 0.2 GO:0010807 regulation of synaptic vesicle priming(GO:0010807)
0.0 0.2 GO:0010755 regulation of plasminogen activation(GO:0010755)
0.0 0.2 GO:0032615 interleukin-12 production(GO:0032615) regulation of interleukin-12 production(GO:0032655)
0.0 0.2 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0 0.2 GO:0099509 regulation of presynaptic cytosolic calcium ion concentration(GO:0099509) regulation of long-term synaptic potentiation(GO:1900271)
0.0 0.1 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.3 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.4 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.2 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.0 0.0 GO:1903589 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587) positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903589)
0.0 1.0 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0 0.2 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.0 0.5 GO:0060351 cartilage development involved in endochondral bone morphogenesis(GO:0060351)
0.0 0.2 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.1 GO:0009098 leucine biosynthetic process(GO:0009098)
0.0 0.7 GO:0015671 oxygen transport(GO:0015671)
0.0 0.1 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0 0.2 GO:0019388 galactose catabolic process(GO:0019388) galactose catabolic process via UDP-galactose(GO:0033499)
0.0 0.1 GO:0000066 mitochondrial ornithine transport(GO:0000066) ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352) mitochondrial L-ornithine transmembrane transport(GO:1990575)
0.0 0.4 GO:0009086 methionine biosynthetic process(GO:0009086)
0.0 0.4 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 0.1 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.2 GO:0003096 renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294)
0.0 0.2 GO:0033183 negative regulation of histone ubiquitination(GO:0033183) regulation of protein K63-linked ubiquitination(GO:1900044) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) regulation of protein polyubiquitination(GO:1902914) negative regulation of protein polyubiquitination(GO:1902915)
0.0 0.4 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.0 0.2 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.3 GO:0019883 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.1 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.0 0.1 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.0 0.1 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.0 0.1 GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis(GO:0051563)
0.0 0.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.2 GO:0051969 regulation of transmission of nerve impulse(GO:0051969)
0.0 0.5 GO:0002574 thrombocyte differentiation(GO:0002574)
0.0 0.7 GO:0007286 spermatid development(GO:0007286)
0.0 0.2 GO:0061709 reticulophagy(GO:0061709)
0.0 0.1 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.0 0.2 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.1 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.0 0.2 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.3 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.3 GO:1902307 positive regulation of sodium ion transport(GO:0010765) positive regulation of sodium ion transmembrane transport(GO:1902307) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.0 0.4 GO:0060030 dorsal convergence(GO:0060030)
0.0 0.1 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.0 0.6 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.4 GO:0097324 melanocyte migration(GO:0097324)
0.0 0.4 GO:0045841 mitotic spindle assembly checkpoint(GO:0007094) spindle checkpoint(GO:0031577) negative regulation of mitotic metaphase/anaphase transition(GO:0045841) spindle assembly checkpoint(GO:0071173) mitotic spindle checkpoint(GO:0071174)
0.0 0.4 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.1 GO:0070166 enamel mineralization(GO:0070166)
0.0 0.1 GO:0090243 fibroblast growth factor receptor signaling pathway involved in somitogenesis(GO:0090243)
0.0 0.5 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.1 GO:0003322 pancreatic A cell development(GO:0003322)
0.0 0.4 GO:0070654 sensory epithelium regeneration(GO:0070654) epithelium regeneration(GO:1990399)
0.0 0.4 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 0.3 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.3 GO:0030225 macrophage differentiation(GO:0030225)
0.0 0.2 GO:0045634 regulation of melanocyte differentiation(GO:0045634)
0.0 0.1 GO:0009957 epidermal cell fate specification(GO:0009957)
0.0 0.4 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.3 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.0 0.1 GO:0071276 cellular response to cadmium ion(GO:0071276)
0.0 0.2 GO:0048385 regulation of retinoic acid receptor signaling pathway(GO:0048385)
0.0 0.5 GO:0051014 actin filament severing(GO:0051014)
0.0 0.9 GO:0009060 aerobic respiration(GO:0009060)
0.0 0.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0060832 oocyte animal/vegetal axis specification(GO:0060832)
0.0 0.4 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 0.2 GO:0030431 sleep(GO:0030431)
0.0 0.6 GO:0061462 protein localization to lysosome(GO:0061462)
0.0 0.1 GO:0010456 cell proliferation in dorsal spinal cord(GO:0010456)
0.0 0.1 GO:0006046 N-acetylglucosamine catabolic process(GO:0006046)
0.0 0.3 GO:0006825 copper ion transport(GO:0006825)
0.0 0.0 GO:0021530 spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 0.1 GO:0033137 negative regulation of peptidyl-serine phosphorylation(GO:0033137)
0.0 0.0 GO:0046902 regulation of mitochondrial membrane permeability(GO:0046902)
0.0 0.1 GO:0086013 membrane repolarization during cardiac muscle cell action potential(GO:0086013)
0.0 0.5 GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0 0.1 GO:0001887 selenium compound metabolic process(GO:0001887)
0.0 0.1 GO:0006543 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.0 0.2 GO:1990504 dense core granule exocytosis(GO:1990504)
0.0 0.1 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0 0.1 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 0.1 GO:0042438 melanin biosynthetic process(GO:0042438)
0.0 0.2 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.4 GO:0071910 determination of liver left/right asymmetry(GO:0071910)
0.0 0.3 GO:1903845 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0 0.2 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.0 0.3 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.2 GO:0042953 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.0 0.1 GO:0006561 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.0 0.2 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.0 0.1 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.0 0.1 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.2 GO:0060211 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213) regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.0 0.0 GO:0048923 posterior lateral line neuromast hair cell differentiation(GO:0048923)
0.0 0.3 GO:0038034 signal transduction in absence of ligand(GO:0038034) extrinsic apoptotic signaling pathway in absence of ligand(GO:0097192)
0.0 0.2 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.0 0.4 GO:0021587 cerebellum morphogenesis(GO:0021587)
0.0 0.3 GO:0072114 pronephros morphogenesis(GO:0072114)
0.0 0.1 GO:1900006 positive regulation of dendrite development(GO:1900006)
0.0 0.2 GO:0030223 neutrophil differentiation(GO:0030223)
0.0 0.1 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.6 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 0.0 GO:0006843 mitochondrial citrate transport(GO:0006843)
0.0 0.1 GO:0046686 response to cadmium ion(GO:0046686)
0.0 0.3 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.1 GO:0090178 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.0 0.0 GO:0090183 regulation of morphogenesis of a branching structure(GO:0060688) positive regulation of mesonephros development(GO:0061213) regulation of mesonephros development(GO:0061217) regulation of kidney development(GO:0090183) positive regulation of kidney development(GO:0090184) regulation of branching involved in ureteric bud morphogenesis(GO:0090189) positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0042612 MHC class I protein complex(GO:0042612)
0.2 0.6 GO:0043073 germ cell nucleus(GO:0043073)
0.1 0.5 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.5 GO:0097224 sperm connecting piece(GO:0097224)
0.1 0.3 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 1.1 GO:0042627 chylomicron(GO:0042627)
0.1 0.8 GO:0045095 keratin filament(GO:0045095)
0.1 0.7 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.5 GO:0098888 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.0 0.5 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.3 GO:0016234 inclusion body(GO:0016234)
0.0 0.9 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.2 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.6 GO:0031209 SCAR complex(GO:0031209)
0.0 0.6 GO:0043209 myelin sheath(GO:0043209)
0.0 0.2 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0 0.2 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 0.2 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.5 GO:0036038 MKS complex(GO:0036038)
0.0 0.5 GO:0098844 postsynaptic endocytic zone membrane(GO:0098844)
0.0 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.2 GO:0014704 intercalated disc(GO:0014704)
0.0 0.3 GO:0002102 podosome(GO:0002102)
0.0 0.4 GO:0030057 desmosome(GO:0030057)
0.0 0.4 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.3 GO:0030315 T-tubule(GO:0030315)
0.0 0.1 GO:0043198 dendritic shaft(GO:0043198)
0.0 0.2 GO:0005675 holo TFIIH complex(GO:0005675)
0.0 0.2 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.2 GO:0070449 elongin complex(GO:0070449)
0.0 0.3 GO:0008278 cohesin complex(GO:0008278)
0.0 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.9 GO:0030286 dynein complex(GO:0030286)
0.0 0.1 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.3 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.4 GO:0035371 microtubule plus-end(GO:0035371)
0.0 1.2 GO:0031514 motile cilium(GO:0031514)
0.0 0.2 GO:0070187 telosome(GO:0070187)
0.0 0.8 GO:0030496 midbody(GO:0030496)
0.0 0.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.1 GO:0070062 extracellular exosome(GO:0070062)
0.0 0.2 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.1 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 1.0 GO:0005814 centriole(GO:0005814)
0.0 0.1 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.3 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510) clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.3 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.4 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.0 1.3 GO:0030027 lamellipodium(GO:0030027)
0.0 0.1 GO:0016586 RSC complex(GO:0016586)
0.0 0.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.6 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.1 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.6 GO:0030426 growth cone(GO:0030426)
0.0 0.1 GO:0032019 mitochondrial cloud(GO:0032019)
0.0 0.2 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.3 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.2 GO:0000780 condensed nuclear chromosome kinetochore(GO:0000778) condensed nuclear chromosome, centromeric region(GO:0000780)
0.0 0.3 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.1 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.1 GO:0032797 SMN complex(GO:0032797)
0.0 0.1 GO:0000812 Swr1 complex(GO:0000812)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0032027 myosin light chain binding(GO:0032027)
0.2 0.9 GO:0004385 guanylate kinase activity(GO:0004385)
0.2 0.9 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.1 0.4 GO:0016920 pyroglutamyl-peptidase activity(GO:0016920)
0.1 0.3 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.1 1.4 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 1.2 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.1 0.4 GO:0050211 procollagen galactosyltransferase activity(GO:0050211)
0.1 0.3 GO:0000810 diacylglycerol diphosphate phosphatase activity(GO:0000810)
0.1 0.3 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087)
0.1 0.3 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.4 GO:0030504 inorganic diphosphate transmembrane transporter activity(GO:0030504)
0.1 0.6 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 0.2 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.1 0.2 GO:0046923 ER retention sequence binding(GO:0046923)
0.1 0.7 GO:0031720 haptoglobin binding(GO:0031720)
0.1 0.3 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.1 0.5 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.1 0.2 GO:0046978 TAP1 binding(GO:0046978)
0.1 0.2 GO:0015227 acyl carnitine transmembrane transporter activity(GO:0015227)
0.0 0.4 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 0.4 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.2 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0 0.4 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.3 GO:0004104 cholinesterase activity(GO:0004104)
0.0 0.1 GO:0030251 cyclase inhibitor activity(GO:0010852) guanylate cyclase inhibitor activity(GO:0030251)
0.0 0.4 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 0.2 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.3 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.0 0.5 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.0 0.1 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.0 0.2 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.2 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.2 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.2 GO:0042169 SH2 domain binding(GO:0042169)
0.0 1.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.1 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.9 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.5 GO:0031386 protein tag(GO:0031386)
0.0 0.1 GO:0004155 6,7-dihydropteridine reductase activity(GO:0004155) NADH binding(GO:0070404)
0.0 0.2 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.0 0.4 GO:0070740 protein-glutamic acid ligase activity(GO:0070739) tubulin-glutamic acid ligase activity(GO:0070740)
0.0 0.2 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 0.2 GO:0008158 hedgehog receptor activity(GO:0008158)
0.0 0.4 GO:0019869 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.0 0.6 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.2 GO:0001217 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.0 0.2 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.2 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
0.0 0.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.2 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.0 0.1 GO:0042974 estrogen receptor binding(GO:0030331) retinoic acid receptor binding(GO:0042974)
0.0 0.3 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.2 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.1 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114) type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.1 GO:0015228 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.0 0.4 GO:0019211 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.0 0.2 GO:0035252 UDP-xylosyltransferase activity(GO:0035252)
0.0 0.5 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0035197 siRNA binding(GO:0035197)
0.0 0.2 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.3 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.0 0.1 GO:0008384 IkappaB kinase activity(GO:0008384)
0.0 0.1 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.4 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.6 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.2 GO:0070628 proteasome binding(GO:0070628)
0.0 0.1 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.1 GO:0008430 selenium binding(GO:0008430)
0.0 0.1 GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
0.0 0.1 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.4 GO:0043236 laminin binding(GO:0043236)
0.0 0.7 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 2.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.1 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 0.5 GO:0051020 GTPase binding(GO:0051020)
0.0 0.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.0 0.2 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.9 GO:0044325 ion channel binding(GO:0044325)
0.0 0.3 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.1 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.0 0.2 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.2 GO:0005223 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.6 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.2 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.1 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.0 0.1 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.0 0.1 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.1 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.2 GO:0022884 macromolecule transmembrane transporter activity(GO:0022884)
0.0 0.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.1 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0 0.1 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.0 1.0 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.2 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.2 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.3 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.2 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.4 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.6 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.1 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.2 GO:0004382 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.0 0.1 GO:0045503 dynein light chain binding(GO:0045503)
0.0 0.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.0 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 1.0 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.8 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.5 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.3 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.4 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.4 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.2 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.4 PID BMP PATHWAY BMP receptor signaling
0.0 0.7 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.2 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.3 SIG CD40PATHWAYMAP Genes related to CD40 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 0.8 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 0.6 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 1.5 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.7 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.5 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.1 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.5 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.6 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.7 REACTOME KINESINS Genes involved in Kinesins
0.0 0.3 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0 0.6 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 1.0 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.2 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.3 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.2 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.4 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.2 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.5 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.2 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.5 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.2 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.3 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.5 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.2 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.4 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.1 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0 0.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.3 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.2 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.1 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.1 REACTOME SIGNALING BY NOTCH2 Genes involved in Signaling by NOTCH2
0.0 0.1 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.4 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.1 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.3 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade