ISMARA results: mef2d

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for mef2d

Z-value: 0.82

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Transcription factors associated with mef2d

Gene Symbol	Gene ID	Gene Info
mef2d NCBI UniProt	ENSDARG00000040237	myocyte enhancer factor 2d

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
mef2d	dr11_v1_chr16_-_29164379_29164379	0.74	4.2e-04	Click!

Activity profile of mef2d motif

Sorted Z-values of mef2d motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_-_36948586 Show fit	2.26	ENSDART00000193606	h3f3c NCBI UniProt Show fit	H3 histone, family 3C
chr3_+_28953274 Show fit	2.11	ENSDART00000133528 ENSDART00000103602	lgals2a NCBI UniProt Show fit	lectin, galactoside-binding, soluble, 2a
chr22_-_906757 Show fit	2.05	ENSDART00000193182	FP016205.1 NCBI UniProt Show fit
chr10_-_22845485 Show fit	1.89	ENSDART00000079454	vamp2 NCBI UniProt Show fit	vesicle-associated membrane protein 2
chr5_-_38643188 Show fit	1.89	ENSDART00000144972	si:ch211-271e10.1 NCBI UniProt Show fit	si:ch211-271e10.1
chr16_+_34523515 Show fit	1.74	ENSDART00000041007	stmn1b NCBI UniProt Show fit	stathmin 1b
chr17_-_5769196 Show fit	1.70	ENSDART00000113885	si:dkey-100n19.2 NCBI UniProt Show fit	si:dkey-100n19.2
chr10_-_29816467 Show fit	1.51	ENSDART00000055913	hist2h2l NCBI UniProt Show fit	histone 2, H2, like
chr20_-_22778394 Show fit	1.49	ENSDART00000152645	fip1l1a NCBI UniProt Show fit	FIP1 like 1a (S. cerevisiae)
chr12_-_36521767 Show fit	1.46	ENSDART00000110290	unc13d NCBI UniProt Show fit	unc-13 homolog D (C. elegans)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of mef2d

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.1	GO:0090303	positive regulation of wound healing(GO:0090303)
0.0	2.0	GO:0007019	microtubule depolymerization(GO:0007019)
0.1	1.9	GO:0045824	negative regulation of innate immune response(GO:0045824)
0.0	1.6	GO:0006334	nucleosome assembly(GO:0006334)
0.4	1.5	GO:0042985	negative regulation of glycoprotein biosynthetic process(GO:0010561) negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) negative regulation of glycoprotein metabolic process(GO:1903019)
0.2	1.5	GO:0098787	mRNA cleavage involved in mRNA processing(GO:0098787) pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.1	1.5	GO:0035493	SNARE complex assembly(GO:0035493)
0.0	1.5	GO:0048634	regulation of muscle organ development(GO:0048634)
0.2	1.4	GO:0032367	intracellular cholesterol transport(GO:0032367)
0.1	1.3	GO:0030240	skeletal muscle thin filament assembly(GO:0030240)

Showing 1 to 10 of 115 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.3	GO:0031430	M band(GO:0031430)
0.3	2.1	GO:0042612	MHC class I protein complex(GO:0042612)
0.0	1.9	GO:0097610	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1	1.5	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0	1.4	GO:0005758	mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0	1.3	GO:0005861	troponin complex(GO:0005861)
0.0	1.3	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.0	1.3	GO:0000786	nucleosome(GO:0000786)
0.0	1.0	GO:0030672	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0	0.8	GO:0097546	ciliary base(GO:0097546)

Showing 1 to 10 of 43 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.4	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	2.4	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0	2.3	GO:0015485	cholesterol binding(GO:0015485)
0.2	2.1	GO:0016936	galactoside binding(GO:0016936)
0.0	2.0	GO:0003735	structural constituent of ribosome(GO:0003735)
0.4	1.5	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1	1.5	GO:0001540	beta-amyloid binding(GO:0001540)
0.1	1.4	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.1	1.3	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.1	1.1	GO:0003993	acid phosphatase activity(GO:0003993)

Showing 1 to 10 of 72 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.7	PID CD8 TCR DOWNSTREAM PATHWAY	Downstream signaling in naïve CD8+ T cells
0.1	1.7	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.1	1.6	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	1.3	NABA COLLAGENS	Genes encoding collagen proteins
0.0	1.0	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	0.8	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.0	0.8	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.0	0.7	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	0.7	PID P73PATHWAY	p73 transcription factor network
0.0	0.5	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction

Showing 1 to 10 of 16 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	2.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.6	1.9	REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0	1.3	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0	0.9	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.1	0.8	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.1	0.7	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	0.7	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.7	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.1	0.6	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.0	0.6	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP

Showing 1 to 10 of 23 entries

Results for mef2d

Z-value: 0.82

Motif logo

Transcription factors associated with mef2d

Activity-expression correlation:

Activity profile of mef2d motif

Sorted Z-values of mef2d motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of mef2d

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: