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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for meis1a+meis1b

Z-value: 0.68

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Transcription factors associated with meis1a+meis1b

Gene Symbol Gene ID Gene Info
meis1a
ENSDARG00000002937 Meis homeobox 1 a
meis1b
ENSDARG00000012078 Meis homeobox 1 b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
meis1bdr11_v1_chr13_-_5569562_5569562-0.097.2e-01Click!
meis1adr11_v1_chr1_+_51475094_514750940.087.5e-01Click!

Activity profile of meis1a+meis1b motif

Sorted Z-values of meis1a+meis1b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_53092509 1.12 ENSDART00000062081
lpar2a
lysophosphatidic acid receptor 2a
chr6_-_39199070 1.02 ENSDART00000131793
c1galt1b
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1b
chr24_+_10027902 0.90 ENSDART00000175961
ENSDART00000172773
si:ch211-146l10.8
si:ch211-146l10.8
chr21_+_22330005 0.87 ENSDART00000140751
ENSDART00000157839
ENSDART00000140468
nadk2
NAD kinase 2, mitochondrial
chr24_-_10006158 0.80 ENSDART00000106244
zgc:171750
zgc:171750
chr5_+_35744623 0.78 ENSDART00000148213
ENSDART00000076627
yipf6
Yip1 domain family, member 6
chr24_-_9985019 0.75 ENSDART00000193536
ENSDART00000189595
zgc:171977
zgc:171977
chr4_-_18851365 0.75 ENSDART00000021782
mcat
malonyl CoA:ACP acyltransferase (mitochondrial)
chr8_-_17167819 0.74 ENSDART00000135042
ENSDART00000143920
mrps36
mitochondrial ribosomal protein S36
chr11_-_544187 0.70 ENSDART00000173161
CU695207.1

chr22_+_39084829 0.70 ENSDART00000002826
gmppb
GDP-mannose pyrophosphorylase B
chr24_-_9979342 0.69 ENSDART00000138576
ENSDART00000191206
zgc:171977
zgc:171977
chr5_-_2721686 0.64 ENSDART00000169404
hspa5
heat shock protein 5
chr24_-_10014512 0.62 ENSDART00000124341
ENSDART00000191630
zgc:171474
zgc:171474
chr12_+_46543572 0.61 ENSDART00000167510
hid1b
HID1 domain containing b
chr2_+_7557912 0.58 ENSDART00000160053
ripk2
receptor-interacting serine-threonine kinase 2
chr6_-_7052595 0.57 ENSDART00000081761
ENSDART00000181351
bin1b
bridging integrator 1b
chr7_-_16034324 0.52 ENSDART00000002498
ENSDART00000162962
elp4
elongator acetyltransferase complex subunit 4
chr7_-_19369002 0.51 ENSDART00000165680
ntn4
netrin 4
chr19_+_20778011 0.51 ENSDART00000024208
nutf2l
nuclear transport factor 2, like
chr13_-_8692860 0.50 ENSDART00000058107
mcfd2
multiple coagulation factor deficiency 2
chr2_+_27855346 0.50 ENSDART00000175159
ENSDART00000192645
buc
bucky ball
chr10_-_26512742 0.49 ENSDART00000135951
si:dkey-5g14.1
si:dkey-5g14.1
chr9_+_38399912 0.49 ENSDART00000022246
ENSDART00000145892
bcs1l
BC1 (ubiquinol-cytochrome c reductase) synthesis-like
chr20_-_30035326 0.49 ENSDART00000141068
sox11b
SRY (sex determining region Y)-box 11b
chr13_-_8692432 0.49 ENSDART00000058106
mcfd2
multiple coagulation factor deficiency 2
chr17_+_33375469 0.47 ENSDART00000032827
zgc:162964
zgc:162964
chr11_+_1796426 0.47 ENSDART00000173330
lrp1aa
low density lipoprotein receptor-related protein 1Aa
chr6_-_7052408 0.47 ENSDART00000150033
ENSDART00000149232
bin1b
bridging integrator 1b
chr4_-_5332814 0.46 ENSDART00000144225
osgep
O-sialoglycoprotein endopeptidase
chr4_-_18850799 0.46 ENSDART00000151844
mcat
malonyl CoA:ACP acyltransferase (mitochondrial)
chr21_+_17024002 0.45 ENSDART00000080628
arpc3
actin related protein 2/3 complex, subunit 3
chr4_-_15603511 0.45 ENSDART00000122520
ENSDART00000162356
chchd3a
coiled-coil-helix-coiled-coil-helix domain containing 3a
chr3_-_20793655 0.44 ENSDART00000163473
ENSDART00000159457
spop
speckle-type POZ protein
chr14_-_24251057 0.43 ENSDART00000114169
bnip1a
BCL2 interacting protein 1a
chr25_-_37314700 0.43 ENSDART00000017807
igl4v8
immunoglobulin light 4 variable 8
chr21_-_2958422 0.43 ENSDART00000174091
zgc:194215
zgc:194215
chr1_-_53880639 0.42 ENSDART00000010543
ltv1
LTV1 ribosome biogenesis factor
chr13_+_33246150 0.42 ENSDART00000136356
ENSDART00000132834
ENSDART00000144379
ENSDART00000131985
ENSDART00000148368
ENSDART00000035940
ENSDART00000141912
ndufaf1
NADH dehydrogenase (ubiquinone) complex I, assembly factor 1
chr22_-_38034852 0.42 ENSDART00000104613
pex6
peroxisomal biogenesis factor 6
chr10_-_45029041 0.42 ENSDART00000167878
polm
polymerase (DNA directed), mu
chr7_-_18881358 0.41 ENSDART00000021502
mllt3
MLLT3, super elongation complex subunit
chr8_-_45838277 0.41 ENSDART00000046064
ogdha
oxoglutarate (alpha-ketoglutarate) dehydrogenase a (lipoamide)
chr22_-_38035084 0.41 ENSDART00000145029
pex6
peroxisomal biogenesis factor 6
chr3_+_17537352 0.41 ENSDART00000104549
hcrt
hypocretin (orexin) neuropeptide precursor
chr7_+_55292959 0.40 ENSDART00000147539
ENSDART00000073555
ctu2
cytosolic thiouridylase subunit 2 homolog (S. pombe)
chr12_+_4220353 0.40 ENSDART00000133675
mapk7
mitogen-activated protein kinase 7
chr8_+_53051701 0.40 ENSDART00000131514
nadka
NAD kinase a
chr8_-_45838481 0.40 ENSDART00000148206
ENSDART00000170485
ogdha
oxoglutarate (alpha-ketoglutarate) dehydrogenase a (lipoamide)
chr15_-_24588649 0.38 ENSDART00000060469
gemin4
gem (nuclear organelle) associated protein 4
chr24_-_2736809 0.38 ENSDART00000171805
fars2
phenylalanyl-tRNA synthetase 2, mitochondrial
chr15_-_684911 0.37 ENSDART00000161685
zgc:171901
zgc:171901
chr10_-_42776344 0.37 ENSDART00000190653
ENSDART00000130229
wdr45
WD repeat domain 45
chr7_-_7676186 0.36 ENSDART00000091105
mfap3l
microfibril associated protein 3 like
chr20_-_37813863 0.36 ENSDART00000147529
batf3
basic leucine zipper transcription factor, ATF-like 3
chr10_+_24692076 0.35 ENSDART00000181600
tpte
transmembrane phosphatase with tensin homology
chr16_+_4695075 0.34 ENSDART00000039054
mecr
mitochondrial trans-2-enoyl-CoA reductase
chr20_-_26391958 0.34 ENSDART00000078062
armt1
acidic residue methyltransferase 1
chr5_-_21030934 0.34 ENSDART00000133461
ENSDART00000098667
camk2b1
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1
chr13_+_24584401 0.34 ENSDART00000057599
fuom
fucose mutarotase
chr17_+_24809221 0.33 ENSDART00000082251
ENSDART00000147871
ENSDART00000130871
spdya
speedy/RINGO cell cycle regulator family member A
chr14_+_2243 0.33 ENSDART00000191193
CYTL1
cytokine like 1
chr14_-_28473639 0.33 ENSDART00000173007
nxt2
nuclear transport factor 2-like export factor 2
chr20_+_3339248 0.31 ENSDART00000108955
mfsd4b
major facilitator superfamily domain containing 4B
chr5_-_54497319 0.31 ENSDART00000160492
alad
aminolevulinate dehydratase
chr10_-_26512993 0.30 ENSDART00000188549
ENSDART00000193316
si:dkey-5g14.1
si:dkey-5g14.1
chr24_-_26369185 0.30 ENSDART00000080039
lrrc31
leucine rich repeat containing 31
chr4_-_14191717 0.30 ENSDART00000147928
pus7l
pseudouridylate synthase 7-like
chr3_-_1400309 0.30 ENSDART00000159893
wbp11
WW domain binding protein 11
chr5_+_55984270 0.30 ENSDART00000047358
ENSDART00000138191
fkbp6
FK506 binding protein 6
chr13_-_7031033 0.29 ENSDART00000193211
CABZ01061524.1

chr4_-_14192254 0.29 ENSDART00000143804
pus7l
pseudouridylate synthase 7-like
chr12_-_31461219 0.29 ENSDART00000148954
acsl5
acyl-CoA synthetase long chain family member 5
chr7_-_19526721 0.29 ENSDART00000114203
man2b2
mannosidase, alpha, class 2B, member 2
chr2_+_51645164 0.28 ENSDART00000169600
abhd4
abhydrolase domain containing 4
chr10_-_43117607 0.28 ENSDART00000148293
ENSDART00000089965
tmem167a
transmembrane protein 167A
chr4_-_14191434 0.28 ENSDART00000142374
ENSDART00000136730
pus7l
pseudouridylate synthase 7-like
chr15_-_25365319 0.27 ENSDART00000152651
cluha
clustered mitochondria (cluA/CLU1) homolog a
chr4_+_16768961 0.27 ENSDART00000143926
BX649500.1

chr5_-_66215928 0.27 ENSDART00000082797
coq2
coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
chr20_-_7176809 0.26 ENSDART00000012247
ENSDART00000125019
dhcr24
24-dehydrocholesterol reductase
chr4_+_16777715 0.26 ENSDART00000148344
BX649476.1

chr2_-_41861040 0.26 ENSDART00000045763
keap1a
kelch-like ECH-associated protein 1a
chr6_-_16493516 0.26 ENSDART00000022499
psmb3
proteasome subunit beta 3
chr5_-_67750907 0.25 ENSDART00000172097
b4galt4
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4
chr3_-_7134113 0.25 ENSDART00000180849
BX005085.6

chr8_-_31384607 0.25 ENSDART00000164134
ENSDART00000024872
creb3l3l
cAMP responsive element binding protein 3-like 3 like
chr8_-_13972626 0.25 ENSDART00000144296
serping1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr2_+_19236969 0.24 ENSDART00000163875
ENSDART00000168644
cc2d1b
coiled-coil and C2 domain containing 1B
chr2_-_44971551 0.24 ENSDART00000018818
mul1a
mitochondrial E3 ubiquitin protein ligase 1a
chr19_+_619200 0.24 ENSDART00000050125
nupl2
nucleoporin like 2
chr19_+_33850705 0.24 ENSDART00000160356
pex1
peroxisomal biogenesis factor 1
chr1_+_58628165 0.24 ENSDART00000158654
si:ch73-221f6.4
si:ch73-221f6.4
chr14_+_22172047 0.23 ENSDART00000114750
ENSDART00000148259
gabrb2
gamma-aminobutyric acid (GABA) A receptor, beta 2
chr23_+_40410644 0.23 ENSDART00000056328
elovl4b
ELOVL fatty acid elongase 4b
chr25_+_37297659 0.23 ENSDART00000086733
si:dkey-234i14.13
si:dkey-234i14.13
chr23_+_23183449 0.22 ENSDART00000132296
klhl17
kelch-like family member 17
chr6_+_54154807 0.22 ENSDART00000061735
nudt3b
nudix (nucleoside diphosphate linked moiety X)-type motif 3b
chr20_+_26987416 0.22 ENSDART00000012816
sel1l
sel-1 suppressor of lin-12-like (C. elegans)
chr23_+_23182037 0.22 ENSDART00000137353
klhl17
kelch-like family member 17
chr13_+_24287093 0.22 ENSDART00000058628
ccsapb
centriole, cilia and spindle-associated protein b
chr9_+_33222911 0.22 ENSDART00000135387
si:ch211-125e6.14
si:ch211-125e6.14
chr16_-_30826712 0.22 ENSDART00000122474
ptk2ab
protein tyrosine kinase 2ab
chr14_-_5546497 0.21 ENSDART00000054877
fgf24
fibroblast growth factor 24
chr2_-_26469065 0.21 ENSDART00000099247
ENSDART00000099248
rabggtb
Rab geranylgeranyltransferase, beta subunit
chr21_+_11749097 0.21 ENSDART00000102408
ENSDART00000102404
ell2
elongation factor, RNA polymerase II, 2
chr20_+_38910214 0.21 ENSDART00000047362
msra
methionine sulfoxide reductase A
chr19_+_7453996 0.21 ENSDART00000147491
ENSDART00000136502
mindy1
MINDY lysine 48 deubiquitinase 1
chr12_+_34273240 0.20 ENSDART00000037904
socs3b
suppressor of cytokine signaling 3b
chr3_-_55104310 0.20 ENSDART00000101713
hbba1
hemoglobin, beta adult 1
chr19_+_48111285 0.19 ENSDART00000169420
nme2b.2
NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 2
chr18_-_19006634 0.19 ENSDART00000060731
ints14
integrator complex subunit 14
chr4_+_7876197 0.19 ENSDART00000111986
ENSDART00000189601
cdc123
cell division cycle 123 homolog (S. cerevisiae)
chr7_-_41013575 0.19 ENSDART00000150139
insig1
insulin induced gene 1
chr2_-_22993601 0.19 ENSDART00000125049
ENSDART00000099735
mllt1b
MLLT1, super elongation complex subunit b
chr3_+_25990052 0.19 ENSDART00000007398
gcat
glycine C-acetyltransferase
chr5_+_37744625 0.18 ENSDART00000014031
dpf2
D4, zinc and double PHD fingers family 2
chr1_+_58614897 0.18 ENSDART00000167354
ENSDART00000162849
si:ch73-221f6.3
si:ch73-221f6.3
chr6_+_49926115 0.18 ENSDART00000018523
ahcy
adenosylhomocysteinase
chr1_-_19648227 0.18 ENSDART00000054574
polr1e
polymerase (RNA) I polypeptide E
chr10_-_45210184 0.18 ENSDART00000167128
pargl
poly (ADP-ribose) glycohydrolase, like
chr23_-_10254288 0.18 ENSDART00000081215
krt8
keratin 8
chr14_-_26425416 0.18 ENSDART00000088690
lman2
lectin, mannose-binding 2
chr10_+_39476600 0.18 ENSDART00000135756
kirrel3a
kirre like nephrin family adhesion molecule 3a
chr2_-_8609653 0.18 ENSDART00000193354
ENSDART00000189489
ENSDART00000186144
si:ch211-71m22.1
si:ch211-71m22.1
chr12_+_11167870 0.17 ENSDART00000052537
vps35l
zgc:163107
chr17_-_43594864 0.17 ENSDART00000139980
zfyve28
zinc finger, FYVE domain containing 28
chr3_+_29641181 0.17 ENSDART00000151517
eif3d
eukaryotic translation initiation factor 3, subunit D
chr17_-_30839338 0.17 ENSDART00000139707
gdf7
growth differentiation factor 7
chr5_-_26284276 0.17 ENSDART00000148608
arvcfb
ARVCF, delta catenin family member b
chr22_-_24791505 0.17 ENSDART00000136837
vtg4
vitellogenin 4
chr10_-_24765988 0.16 ENSDART00000064463
timm10b
translocase of inner mitochondrial membrane 10 homolog B (yeast)
chr25_+_19670273 0.16 ENSDART00000073472
zgc:113426
zgc:113426
chr8_-_22508055 0.16 ENSDART00000101616
si:ch211-261n11.5
si:ch211-261n11.5
chr11_+_41540862 0.16 ENSDART00000173210
kcnab2a
potassium voltage-gated channel, shaker-related subfamily, beta member 2 a
chr5_-_18446483 0.16 ENSDART00000180027
si:dkey-215k6.1
si:dkey-215k6.1
chr7_-_55292116 0.16 ENSDART00000122603
rnf166
ring finger protein 166
chr25_+_34641536 0.16 ENSDART00000167033
CABZ01079011.1

chr5_-_33298352 0.16 ENSDART00000015076
zgc:103692
zgc:103692
chr22_+_35275468 0.15 ENSDART00000189516
ENSDART00000181572
ENSDART00000165353
ENSDART00000185352
rubcn
RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein
chr15_+_24588963 0.15 ENSDART00000155075
zgc:198241
zgc:198241
chr10_-_39011514 0.15 ENSDART00000075123
pcp4a
Purkinje cell protein 4a
chr11_+_27347076 0.14 ENSDART00000173383
fbln2
fibulin 2
chr4_-_77561679 0.14 ENSDART00000180809
AL935186.9

chr21_-_26483237 0.14 ENSDART00000169072
ENSDART00000147947
ankhd1
ankyrin repeat and KH domain containing 1
chr6_+_9107063 0.14 ENSDART00000083820
vps16
vacuolar protein sorting protein 16
chr8_+_41413919 0.14 ENSDART00000142590
si:ch211-152p23.2
si:ch211-152p23.2
chr9_+_38168012 0.14 ENSDART00000102445
clasp1a
cytoplasmic linker associated protein 1a
chr5_+_50898849 0.14 ENSDART00000083317
arsk
arylsulfatase family, member K
chr10_+_29770120 0.14 ENSDART00000100032
ENSDART00000193205
hyou1
hypoxia up-regulated 1
chr22_+_1006573 0.14 ENSDART00000123458
pparda
peroxisome proliferator-activated receptor delta a
chr1_+_39859782 0.14 ENSDART00000149984
irf2a
interferon regulatory factor 2a
chr5_+_51248784 0.14 ENSDART00000159571
ENSDART00000189513
ENSDART00000092285
msh3
mutS homolog 3 (E. coli)
chr25_-_17852944 0.14 ENSDART00000155169
si:ch211-176l24.4
si:ch211-176l24.4
chr16_-_33817828 0.14 ENSDART00000188395
rspo1
R-spondin 1
chr25_-_3192405 0.14 ENSDART00000104835
hps5
Hermansky-Pudlak syndrome 5
chr5_+_56119975 0.14 ENSDART00000083137
mrm1
mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
chr4_-_20208166 0.14 ENSDART00000066891
gsap
gamma-secretase activating protein
chr1_+_35473397 0.13 ENSDART00000158799
usp38
ubiquitin specific peptidase 38
chr1_+_58609885 0.13 ENSDART00000186199
si:ch73-236c18.9
si:ch73-236c18.9
chr11_-_18557277 0.13 ENSDART00000103950
dido1
death inducer-obliterator 1
chr1_+_34496855 0.13 ENSDART00000012873
klf12a
Kruppel-like factor 12a
chr23_+_22335407 0.13 ENSDART00000147696
rap1gap
RAP1 GTPase activating protein
chr1_-_49919042 0.13 ENSDART00000050603
hadh
hydroxyacyl-CoA dehydrogenase
chr8_+_41453691 0.13 ENSDART00000061144
arpc5la
actin related protein 2/3 complex, subunit 5-like, a
chr2_+_11028923 0.13 ENSDART00000076725
acot11a
acyl-CoA thioesterase 11a
chr22_+_35275206 0.13 ENSDART00000112234
rubcn
RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein
chr24_+_2736815 0.13 ENSDART00000184009
LYRM4
si:ch211-152c8.4
chr2_+_24374669 0.13 ENSDART00000133818
nr2f6a
nuclear receptor subfamily 2, group F, member 6a
chr15_-_9294929 0.13 ENSDART00000155717
si:ch211-261a10.5
si:ch211-261a10.5
chr7_-_17814118 0.13 ENSDART00000179688
ecsit
ECSIT signalling integrator
chr24_+_9881219 0.13 ENSDART00000036204
cdv3
carnitine deficiency-associated gene expressed in ventricle 3
chr7_+_40205394 0.13 ENSDART00000173742
ENSDART00000148390
ncapg2
non-SMC condensin II complex, subunit G2
chr24_-_13272842 0.12 ENSDART00000146790
ENSDART00000066703
rdh10a
retinol dehydrogenase 10a
chr17_+_39741926 0.12 ENSDART00000154996
ENSDART00000154599
si:dkey-229e3.2
si:dkey-229e3.2
chr6_+_33881372 0.12 ENSDART00000165710
gpbp1l1
GC-rich promoter binding protein 1-like 1
chr15_+_41027466 0.12 ENSDART00000075940
mtnr1ba
melatonin receptor type 1Ba
chr5_+_26079178 0.12 ENSDART00000145920
si:dkey-201c13.2
si:dkey-201c13.2
chr20_+_23855025 0.12 ENSDART00000032393
ginm1
glycoprotein integral membrane 1
chr14_+_29941266 0.12 ENSDART00000112757
fam149a
family with sequence similarity 149 member A
chr3_-_40162843 0.12 ENSDART00000129664
ENSDART00000025285
drg2
developmentally regulated GTP binding protein 2
chr20_-_44460789 0.12 ENSDART00000085442
mut
methylmalonyl CoA mutase
chr21_-_28523548 0.12 ENSDART00000077910
epdl2
ependymin-like 2
chr13_+_40692804 0.12 ENSDART00000109822
hps1
Hermansky-Pudlak syndrome 1
chr22_+_1276680 0.12 ENSDART00000169230
si:ch73-138e16.2
si:ch73-138e16.2
chr21_+_37357578 0.12 ENSDART00000143621
nsd1b
nuclear receptor binding SET domain protein 1b
chr4_-_15420452 0.12 ENSDART00000016230
plxna4
plexin A4
chr3_-_55099272 0.12 ENSDART00000130869
hbba1
hemoglobin, beta adult 1
chr11_-_21303946 0.11 ENSDART00000185786
RASSF5
si:dkey-85p17.3
chr12_+_48841419 0.11 ENSDART00000125331
dlg5b.1
discs, large homolog 5b (Drosophila), tandem duplicate 1
chr12_+_18768021 0.11 ENSDART00000153111
mkl1b
megakaryoblastic leukemia (translocation) 1b
chr20_-_5267600 0.11 ENSDART00000099258
cyp46a1.4
cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 4
chr23_-_4930229 0.11 ENSDART00000189456
ngfa
nerve growth factor a (beta polypeptide)
chr23_-_31555696 0.11 ENSDART00000053539
tcf21
transcription factor 21
chr11_-_13151841 0.11 ENSDART00000161983
elovl1b
ELOVL fatty acid elongase 1b
chr2_+_6127593 0.11 ENSDART00000184007
fzr1b
fizzy/cell division cycle 20 related 1b
chr11_+_31558207 0.11 ENSDART00000140204
egln1b
egl-9 family hypoxia-inducible factor 1b
chr19_+_10855158 0.11 ENSDART00000172219
ENSDART00000170826
apoea
apolipoprotein Ea
chr4_-_20235904 0.11 ENSDART00000146621
ENSDART00000193655
stk38l
serine/threonine kinase 38 like
chr8_-_25605537 0.11 ENSDART00000005906
stk38a
serine/threonine kinase 38a

Network of associatons between targets according to the STRING database.

First level regulatory network of meis1a+meis1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.2 1.3 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 0.4 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.1 0.7 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.1 0.4 GO:0042755 eating behavior(GO:0042755)
0.1 0.5 GO:0051204 protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979) protein insertion into mitochondrial membrane(GO:0051204)
0.1 0.3 GO:2000193 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) plasma membrane long-chain fatty acid transport(GO:0015911) regulation of organic acid transport(GO:0032890) positive regulation of organic acid transport(GO:0032892) fatty acid transmembrane transport(GO:1902001) positive regulation of anion transport(GO:1903793) positive regulation of anion transmembrane transport(GO:1903961) regulation of fatty acid transport(GO:2000191) positive regulation of fatty acid transport(GO:2000193)
0.1 0.3 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) negative regulation of lipid kinase activity(GO:0090219)
0.1 0.5 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.1 0.5 GO:0060832 oocyte animal/vegetal axis specification(GO:0060832)
0.1 0.2 GO:2000257 regulation of protein activation cascade(GO:2000257)
0.1 0.4 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143) protein urmylation(GO:0032447)
0.1 0.2 GO:0036316 response to sterol(GO:0036314) cellular response to sterol(GO:0036315) SREBP-SCAP complex retention in endoplasmic reticulum(GO:0036316) regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 1.1 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.1 0.3 GO:0006013 mannose metabolic process(GO:0006013)
0.1 0.2 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.1 0.3 GO:0006004 fucose metabolic process(GO:0006004)
0.0 0.4 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.1 GO:0051096 regulation of helicase activity(GO:0051095) positive regulation of helicase activity(GO:0051096)
0.0 0.2 GO:1901911 diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.0 0.5 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.6 GO:0042026 protein refolding(GO:0042026)
0.0 0.1 GO:0007414 axonal defasciculation(GO:0007414)
0.0 0.1 GO:0030521 androgen receptor signaling pathway(GO:0030521) regulation of androgen receptor signaling pathway(GO:0060765)
0.0 0.2 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.0 0.9 GO:0001522 pseudouridine synthesis(GO:0001522)
0.0 0.2 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
0.0 0.4 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 0.2 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.2 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.1 GO:1903232 melanosome assembly(GO:1903232)
0.0 0.2 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.1 GO:0080182 histone H3-K4 trimethylation(GO:0080182) histone H3-K36 dimethylation(GO:0097676)
0.0 0.1 GO:0097242 regulation of nitric-oxide synthase activity(GO:0050999) positive regulation of nitric-oxide synthase activity(GO:0051000) beta-amyloid clearance(GO:0097242) regulation of beta-amyloid clearance(GO:1900221)
0.0 0.6 GO:0007257 activation of JUN kinase activity(GO:0007257) positive regulation of JUN kinase activity(GO:0043507)
0.0 0.3 GO:0071379 cellular response to prostaglandin stimulus(GO:0071379)
0.0 0.4 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.3 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.1 GO:0042373 vitamin K metabolic process(GO:0042373)
0.0 0.2 GO:0006566 threonine metabolic process(GO:0006566) threonine catabolic process(GO:0006567)
0.0 0.2 GO:0070309 lens fiber cell development(GO:0070307) lens fiber cell morphogenesis(GO:0070309)
0.0 0.3 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.2 GO:0042664 negative regulation of endodermal cell fate specification(GO:0042664)
0.0 0.1 GO:0048069 eye pigmentation(GO:0048069)
0.0 0.3 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.0 0.5 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.1 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0 0.1 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0 0.1 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.1 GO:0009146 dGTP catabolic process(GO:0006203) purine nucleoside triphosphate catabolic process(GO:0009146) purine deoxyribonucleoside triphosphate catabolic process(GO:0009217) dGTP metabolic process(GO:0046070)
0.0 0.5 GO:0007007 inner mitochondrial membrane organization(GO:0007007)
0.0 0.6 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.3 GO:0046473 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.3 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.1 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.0 0.7 GO:0043648 dicarboxylic acid metabolic process(GO:0043648)
0.0 0.3 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.1 GO:0006707 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.1 GO:0010888 negative regulation of cholesterol storage(GO:0010887) negative regulation of lipid storage(GO:0010888)
0.0 0.1 GO:0034205 beta-amyloid formation(GO:0034205) amyloid precursor protein catabolic process(GO:0042987)
0.0 0.3 GO:0015671 oxygen transport(GO:0015671)
0.0 0.2 GO:0098900 regulation of action potential(GO:0098900)
0.0 1.5 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.0 0.6 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.1 GO:0071908 determination of intestine left/right asymmetry(GO:0071908)
0.0 0.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 0.3 GO:0071456 cellular response to hypoxia(GO:0071456)
0.0 0.0 GO:2000405 response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869) negative regulation of lymphocyte migration(GO:2000402) negative regulation of T cell migration(GO:2000405)
0.0 0.1 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.0 0.4 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.1 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress(GO:0043618) regulation of DNA-templated transcription in response to stress(GO:0043620)
0.0 0.2 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 0.2 GO:0046051 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.0 0.0 GO:1901052 sarcosine metabolic process(GO:1901052)
0.0 0.8 GO:0060048 cardiac muscle contraction(GO:0060048)
0.0 0.1 GO:0010517 regulation of phospholipase activity(GO:0010517) lipid digestion(GO:0044241)
0.0 0.8 GO:1902593 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.0 0.1 GO:0070587 regulation of cell-cell adhesion involved in gastrulation(GO:0070587)
0.0 0.1 GO:0045299 otolith mineralization(GO:0045299)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0005797 Golgi medial cisterna(GO:0005797)
0.3 0.8 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.2 0.7 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.1 0.8 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.1 0.9 GO:0045240 dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.1 0.5 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.1 0.5 GO:0032019 mitochondrial cloud(GO:0032019)
0.1 0.2 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.2 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.1 0.2 GO:0061673 mitotic spindle astral microtubule(GO:0061673)
0.1 0.2 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719) mitochondrial inner membrane protein insertion complex(GO:0042721)
0.1 0.2 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.4 GO:0032797 SMN complex(GO:0032797)
0.0 0.1 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.2 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.5 GO:0061617 MICOS complex(GO:0061617)
0.0 0.4 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.4 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.3 GO:0016234 inclusion body(GO:0016234)
0.0 0.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.1 GO:0031085 BLOC-3 complex(GO:0031085)
0.0 0.1 GO:0033263 CORVET complex(GO:0033263)
0.0 0.1 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 0.5 GO:0043256 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 0.1 GO:1990745 EARP complex(GO:1990745)
0.0 0.3 GO:0005833 hemoglobin complex(GO:0005833)
0.0 1.0 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.2 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.2 GO:0045095 keratin filament(GO:0045095)
0.0 0.1 GO:0000796 condensin complex(GO:0000796)
0.0 0.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.1 GO:0032300 mismatch repair complex(GO:0032300)
0.0 0.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0008905 mannose-1-phosphate guanylyltransferase activity(GO:0004475) mannose-phosphate guanylyltransferase activity(GO:0008905)
0.2 1.0 GO:0048156 tau protein binding(GO:0048156)
0.2 0.5 GO:0061711 N(6)-L-threonylcarbamoyladenine synthase(GO:0061711)
0.1 0.3 GO:0042806 fucose binding(GO:0042806)
0.1 0.8 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 0.4 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.1 0.3 GO:0002094 polyprenyltransferase activity(GO:0002094)
0.1 0.6 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.1 0.9 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.2 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 1.5 GO:0004312 fatty acid synthase activity(GO:0004312)
0.1 0.4 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1 0.2 GO:0098808 mRNA cap binding(GO:0098808)
0.1 0.2 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.0 0.2 GO:0016453 C-acetyltransferase activity(GO:0016453)
0.0 0.9 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.2 GO:0004649 poly(ADP-ribose) glycohydrolase activity(GO:0004649)
0.0 0.2 GO:0000298 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432)
0.0 0.6 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.3 GO:0010340 carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.0 1.3 GO:0003951 NAD+ kinase activity(GO:0003951)
0.0 0.2 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.1 GO:0032135 DNA insertion or deletion binding(GO:0032135)
0.0 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.4 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 0.2 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.0 0.2 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.3 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.0 0.1 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.0 0.2 GO:0045735 nutrient reservoir activity(GO:0045735)
0.0 0.1 GO:0016793 dGTPase activity(GO:0008832) triphosphoric monoester hydrolase activity(GO:0016793)
0.0 0.1 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0 0.1 GO:1990757 anaphase-promoting complex binding(GO:0010997) ubiquitin ligase activator activity(GO:1990757)
0.0 0.6 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.1 GO:0008502 melatonin receptor activity(GO:0008502)
0.0 0.3 GO:0005355 glucose transmembrane transporter activity(GO:0005355) monosaccharide transmembrane transporter activity(GO:0015145) hexose transmembrane transporter activity(GO:0015149)
0.0 0.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.1 GO:0033781 cholesterol 24-hydroxylase activity(GO:0033781)
0.0 0.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.2 GO:0005537 mannose binding(GO:0005537)
0.0 0.2 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.1 GO:0070888 E-box binding(GO:0070888)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.1 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.3 GO:0019825 oxygen transporter activity(GO:0005344) oxygen binding(GO:0019825)
0.0 0.3 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.3 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.0 0.1 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 0.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.2 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0 0.2 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.4 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.1 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.0 0.1 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)
0.0 0.2 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.3 ST GA12 PATHWAY G alpha 12 Pathway
0.0 0.6 PID IL12 2PATHWAY IL12-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 0.6 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 0.7 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.3 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.1 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.4 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.4 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.3 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.2 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.2 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.8 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.1 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.5 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.7 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.4 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.2 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.1 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.1 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway