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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for msx1a

Z-value: 1.01

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Transcription factors associated with msx1a

Gene Symbol Gene ID Gene Info
msx1a
ENSDARG00000116118 muscle segment homeobox 1a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
msx1adr11_v1_chr14_-_12822_12847-0.617.5e-03Click!

Activity profile of msx1a motif

Sorted Z-values of msx1a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_6452444 4.98 ENSDART00000137879
ENSDART00000134957
ENSDART00000004483
larp6b
La ribonucleoprotein domain family, member 6b
chr10_-_21362071 4.97 ENSDART00000125167
avd
avidin
chr10_-_21362320 4.64 ENSDART00000189789
avd
avidin
chr21_+_25777425 3.78 ENSDART00000021620
cldnd
claudin d
chr9_-_35633827 3.75 ENSDART00000077745
zp2l1
zona pellucida glycoprotein 2, like 1
chr20_-_23426339 3.52 ENSDART00000004625
zar1
zygote arrest 1
chr14_+_34490445 3.49 ENSDART00000132193
ENSDART00000148044
wnt8a
wingless-type MMTV integration site family, member 8a
chr18_-_40708537 3.30 ENSDART00000077577
si:ch211-132b12.8
si:ch211-132b12.8
chr10_-_25217347 3.10 ENSDART00000036906
kpna7
karyopherin alpha 7 (importin alpha 8)
chr8_+_45334255 2.93 ENSDART00000126848
ENSDART00000134161
ENSDART00000142322
ENSDART00000145011
ENSDART00000183560
pabpc1l
poly(A) binding protein, cytoplasmic 1-like
chr11_+_18183220 2.81 ENSDART00000113468
LO018315.10

chr6_+_21001264 2.72 ENSDART00000044519
ENSDART00000151278
cx44.2
connexin 44.2
chr17_+_16046132 2.63 ENSDART00000155005
si:ch73-204p21.2
si:ch73-204p21.2
chr17_+_16046314 2.60 ENSDART00000154554
ENSDART00000154338
ENSDART00000155336
si:ch73-204p21.2
si:ch73-204p21.2
chr11_+_18130300 2.57 ENSDART00000169146
zgc:175135
zgc:175135
chr1_-_18811517 2.56 ENSDART00000142026
si:dkey-167i21.2
si:dkey-167i21.2
chr10_-_34002185 2.56 ENSDART00000046599
zar1l
zygote arrest 1-like
chr7_-_48263516 2.40 ENSDART00000006619
ENSDART00000142370
ENSDART00000148273
ENSDART00000147968
rbpms2b
RNA binding protein with multiple splicing 2b
chr16_+_39159752 2.30 ENSDART00000122081
sybu
syntabulin (syntaxin-interacting)
chr11_+_18157260 2.30 ENSDART00000144659
zgc:173545
zgc:173545
chr11_-_44801968 2.30 ENSDART00000161846
map1lc3c
microtubule-associated protein 1 light chain 3 gamma
chr10_-_34915886 2.08 ENSDART00000141201
ENSDART00000002166
ccna1
cyclin A1
chr1_-_55248496 2.06 ENSDART00000098615
nanos3
nanos homolog 3
chr2_+_6253246 2.03 ENSDART00000058256
ENSDART00000076700
zp3b
zona pellucida glycoprotein 3b
chr15_-_25099679 1.99 ENSDART00000154628
rflnb
refilin B
chr3_-_32337653 1.97 ENSDART00000156918
ENSDART00000156551
si:dkey-16p21.8
si:dkey-16p21.8
chr10_-_34916208 1.93 ENSDART00000187371
ccna1
cyclin A1
chr16_-_17197546 1.91 ENSDART00000139939
ENSDART00000135146
ENSDART00000063800
ENSDART00000163606
gapdh
glyceraldehyde-3-phosphate dehydrogenase
chr3_+_28860283 1.78 ENSDART00000077235
alg1
ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
chr19_-_8768564 1.75 ENSDART00000170416
si:ch73-350k19.1
si:ch73-350k19.1
chr24_+_12835935 1.67 ENSDART00000114762
nanog
nanog homeobox
chr7_+_27603211 1.51 ENSDART00000148782
cyp2r1
cytochrome P450, family 2, subfamily R, polypeptide 1
chr4_-_27099224 1.50 ENSDART00000048383
creld2
cysteine-rich with EGF-like domains 2
chr2_-_21167652 1.46 ENSDART00000185792
bmi1b
bmi1 polycomb ring finger oncogene 1b
chr19_-_25119443 1.45 ENSDART00000148953
ptp4a3
protein tyrosine phosphatase type IVA, member 3
chr8_-_20230559 1.34 ENSDART00000193677
mllt1a
MLLT1, super elongation complex subunit a
chr13_-_36911118 1.25 ENSDART00000048739
trim9
tripartite motif containing 9
chr3_+_56366395 1.18 ENSDART00000154367
cacng5b
calcium channel, voltage-dependent, gamma subunit 5b
chr21_+_34088110 1.17 ENSDART00000145123
ENSDART00000029599
ENSDART00000147519
mtmr1b
myotubularin related protein 1b
chr8_-_20230802 1.13 ENSDART00000063400
mllt1a
MLLT1, super elongation complex subunit a
chr25_-_32869794 1.08 ENSDART00000162784
tmem266
transmembrane protein 266
chr19_+_28187480 1.06 ENSDART00000183825
irx4b
iroquois homeobox 4b
chr15_-_26931541 1.06 ENSDART00000027563
ccdc9
coiled-coil domain containing 9
chr5_+_60590796 1.05 ENSDART00000159859
tmem132e
transmembrane protein 132E
chr19_+_15441022 1.04 ENSDART00000098970
ENSDART00000140276
lin28a
lin-28 homolog A (C. elegans)
chr20_-_40758410 0.99 ENSDART00000183031
cx34.5
connexin 34.5
chr6_-_37744430 0.94 ENSDART00000150177
ENSDART00000149722
nipa2
non imprinted in Prader-Willi/Angelman syndrome 2 (human)
chr3_-_26806032 0.88 ENSDART00000143710
pigq
phosphatidylinositol glycan anchor biosynthesis, class Q
chr8_-_25034411 0.86 ENSDART00000135973
nfyal
nuclear transcription factor Y, alpha, like
chr24_-_25144441 0.84 ENSDART00000152104
phldb2b
pleckstrin homology-like domain, family B, member 2b
chr19_+_15440841 0.83 ENSDART00000182329
lin28a
lin-28 homolog A (C. elegans)
chr12_+_22580579 0.82 ENSDART00000171725
ENSDART00000192290
capgb
capping protein (actin filament), gelsolin-like b
chr10_+_43039947 0.80 ENSDART00000193434
atg10
ATG10 autophagy related 10 homolog (S. cerevisiae)
chr16_+_33163858 0.79 ENSDART00000101943
rragca
Ras-related GTP binding Ca
chr9_-_21460164 0.78 ENSDART00000133469
zmym2
zinc finger, MYM-type 2
chr19_-_19871211 0.77 ENSDART00000170980
evx1
even-skipped homeobox 1
chr3_+_18807006 0.74 ENSDART00000180091
tnpo2
transportin 2 (importin 3, karyopherin beta 2b)
chr20_-_28800999 0.71 ENSDART00000049462
rab15
RAB15, member RAS oncogene family
chr2_-_57076687 0.69 ENSDART00000161523
slc25a42
solute carrier family 25, member 42
chr10_-_13343831 0.67 ENSDART00000135941
il11ra
interleukin 11 receptor, alpha
chr12_+_21298317 0.67 ENSDART00000178562
ca10a
carbonic anhydrase Xa
chr3_-_26805455 0.64 ENSDART00000180648
pigq
phosphatidylinositol glycan anchor biosynthesis, class Q
chr20_-_45060241 0.63 ENSDART00000185227
klhl29
kelch-like family member 29
chr4_-_72638972 0.62 ENSDART00000193312
CABZ01054394.1

chr9_+_43799829 0.56 ENSDART00000186240
ube2e3
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chr25_-_27621268 0.55 ENSDART00000146205
ENSDART00000073511
hyal6
hyaluronoglucosaminidase 6
chr20_+_28803977 0.55 ENSDART00000153351
ENSDART00000038149
fntb
farnesyltransferase, CAAX box, beta
chr18_-_22094102 0.54 ENSDART00000100904
pard6a
par-6 family cell polarity regulator alpha
chr21_-_28640316 0.54 ENSDART00000128237
nrg2a
neuregulin 2a
chr17_+_25856671 0.53 ENSDART00000064817
wapla
WAPL cohesin release factor a
chr2_-_38206034 0.52 ENSDART00000144518
ENSDART00000137395
acin1a
apoptotic chromatin condensation inducer 1a
chr24_-_30843250 0.51 ENSDART00000162920
ptbp2a
polypyrimidine tract binding protein 2a
chr13_+_2625150 0.51 ENSDART00000164177
plpp4
phospholipid phosphatase 4
chr18_+_15644559 0.50 ENSDART00000061794
nr1h4
nuclear receptor subfamily 1, group H, member 4
chr23_+_33963619 0.48 ENSDART00000140666
ENSDART00000084792
plpbp
pyridoxal phosphate binding protein
chr17_-_11439815 0.46 ENSDART00000130105
psma3
proteasome subunit alpha 3
chr19_-_15855427 0.44 ENSDART00000133059
cited4a
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4a
chr10_-_32494499 0.43 ENSDART00000129395
uvrag
UV radiation resistance associated gene
chr7_+_38089650 0.41 ENSDART00000052365
cebpg
CCAAT/enhancer binding protein (C/EBP), gamma
chr21_-_36396334 0.40 ENSDART00000183627
mrpl22
mitochondrial ribosomal protein L22
chr16_+_31827502 0.40 ENSDART00000045210
mlf2
myeloid leukemia factor 2
chr16_-_17347727 0.38 ENSDART00000144392
zyx
zyxin
chr11_+_31864921 0.38 ENSDART00000180252
diaph3
diaphanous-related formin 3
chr23_+_38957472 0.36 ENSDART00000193836
ATP9A
ATPase phospholipid transporting 9A (putative)
chr21_-_11654422 0.35 ENSDART00000081614
ENSDART00000132699
cast
calpastatin
chr2_+_37227011 0.34 ENSDART00000126587
ENSDART00000084958
samd7
sterile alpha motif domain containing 7
chr10_-_32494304 0.34 ENSDART00000028161
uvrag
UV radiation resistance associated gene
chr16_+_31827653 0.34 ENSDART00000187261
mlf2
myeloid leukemia factor 2
chr5_+_60928576 0.33 ENSDART00000131041
doc2b
double C2-like domains, beta
chr9_+_34331368 0.31 ENSDART00000147913
pou2f1b
POU class 2 homeobox 1b
chr14_-_32631013 0.31 ENSDART00000176815
atp11c
ATPase phospholipid transporting 11C
chr23_-_40194732 0.31 ENSDART00000164931
tgm1l2
transglutaminase 1 like 2
chr25_+_10410620 0.30 ENSDART00000151886
ehf
ets homologous factor
chr20_+_41021054 0.30 ENSDART00000146052
man1a1
mannosidase, alpha, class 1A, member 1
chr12_+_6195191 0.29 ENSDART00000043236
ENSDART00000186420
prkg1b
protein kinase, cGMP-dependent, type Ib
chr19_-_19556778 0.27 ENSDART00000164060
tax1bp1a
Tax1 (human T-cell leukemia virus type I) binding protein 1a
chr23_-_31913069 0.25 ENSDART00000135526
mtfr2
mitochondrial fission regulator 2
chr2_+_50626476 0.24 ENSDART00000018150
neurod6b
neuronal differentiation 6b
chr21_-_3853204 0.24 ENSDART00000188829
st6galnac4
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
chr12_-_20120702 0.24 ENSDART00000153387
ENSDART00000158412
ENSDART00000112768
ubald1a
UBA-like domain containing 1a
chr20_-_19511016 0.23 ENSDART00000168521
snx17
sorting nexin 17
chr5_+_68807170 0.21 ENSDART00000017849
her7
hairy and enhancer of split related-7
chr22_-_7129631 0.20 ENSDART00000171359
asic1b
acid-sensing (proton-gated) ion channel 1b
chr17_+_31914877 0.20 ENSDART00000177801
FAM196A (1 of many)
family with sequence similarity 196 member A
chr16_+_35661771 0.19 ENSDART00000161393
map7d1a
MAP7 domain containing 1a
chr17_+_24821627 0.19 ENSDART00000112389
wdr43
WD repeat domain 43
chr8_+_25034544 0.19 ENSDART00000123300
ngrn
neugrin, neurite outgrowth associated
chr14_-_3381303 0.19 ENSDART00000171601
im:7150988
im:7150988
chr13_+_38430466 0.18 ENSDART00000132691
adgrb3
adhesion G protein-coupled receptor B3
chr7_-_12464412 0.18 ENSDART00000178723
adamtsl3
ADAMTS-like 3
chr18_+_9362455 0.18 ENSDART00000187025
sema3ab
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ab
chr3_+_32365811 0.17 ENSDART00000155967
ap2a1
adaptor-related protein complex 2, alpha 1 subunit
chr15_+_9053059 0.16 ENSDART00000012039
ppm1na
protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative)
chr8_-_10961991 0.16 ENSDART00000139603
trim33
tripartite motif containing 33
chr23_+_30967686 0.15 ENSDART00000144485
si:ch211-197l9.2
si:ch211-197l9.2
chr20_-_32110882 0.14 ENSDART00000030324
grm1a
glutamate receptor, metabotropic 1a
chr19_-_38830582 0.14 ENSDART00000189966
ENSDART00000183055
adgrb2
adhesion G protein-coupled receptor B2
chr25_+_11456696 0.14 ENSDART00000171408
AGBL1
si:ch73-141f14.1
chr15_-_25518084 0.13 ENSDART00000158594
hif1al
hypoxia-inducible factor 1, alpha subunit, like
chr8_+_26125218 0.13 ENSDART00000145095
celsr3
cadherin, EGF LAG seven-pass G-type receptor 3
chr2_+_50608099 0.12 ENSDART00000185805
ENSDART00000111135
neurod6b
neuronal differentiation 6b
chr18_-_29896367 0.11 ENSDART00000191303
cmc2
C-x(9)-C motif containing 2
chr20_-_29864390 0.11 ENSDART00000161834
ENSDART00000132278
rnf144ab
ring finger protein 144ab
chr13_-_36184476 0.10 ENSDART00000057185
map3k9
mitogen-activated protein kinase kinase kinase 9
chr15_-_12270857 0.10 ENSDART00000170093
si:dkey-36i7.3
si:dkey-36i7.3
chr22_-_10486477 0.10 ENSDART00000184366
aspn
asporin (LRR class 1)
chr3_-_50443607 0.09 ENSDART00000074036
rcvrna
recoverin a
chr23_-_1348933 0.09 ENSDART00000168981
CABZ01078120.1

chr3_+_45365098 0.09 ENSDART00000052746
ENSDART00000156555
ube2ia
ubiquitin-conjugating enzyme E2Ia
chr11_-_29563437 0.09 ENSDART00000163958
arhgef10la
Rho guanine nucleotide exchange factor (GEF) 10-like a
chr19_-_20403318 0.09 ENSDART00000136826
dazl
deleted in azoospermia-like
chr18_-_33979422 0.08 ENSDART00000136535
ENSDART00000167698
si:ch211-203b20.7
si:ch211-203b20.7
chr14_-_2364761 0.08 ENSDART00000167322
PCDHGC3 (1 of many)
si:ch73-233f7.3
chr10_+_40660772 0.08 ENSDART00000148007
taar19l
trace amine associated receptor 19l
chr19_+_46237665 0.07 ENSDART00000159391
vps28
vacuolar protein sorting 28 (yeast)
chr16_-_27628994 0.07 ENSDART00000157407
nacad
NAC alpha domain containing
chr13_+_38990939 0.07 ENSDART00000145979
col19a1
collagen, type XIX, alpha 1
chr7_-_23768234 0.06 ENSDART00000173981
si:ch211-200p22.4
si:ch211-200p22.4
chr11_+_33312601 0.04 ENSDART00000188024
cntnap5l
contactin associated protein-like 5 like
chr6_-_14292307 0.04 ENSDART00000177852
ENSDART00000061745
inpp4ab
inositol polyphosphate-4-phosphatase type I Ab
chr15_-_6247775 0.04 ENSDART00000148350
dscamb
Down syndrome cell adhesion molecule b
chr16_+_42471455 0.03 ENSDART00000166640
si:ch211-215k15.5
si:ch211-215k15.5
chr15_-_8665662 0.03 ENSDART00000090675
arhgap35a
Rho GTPase activating protein 35a
chr10_+_40756352 0.03 ENSDART00000156210
ENSDART00000144576
taar19f
trace amine associated receptor 19f
chr10_-_36253958 0.03 ENSDART00000126288
or110-2
odorant receptor, family D, subfamily 110, member 2
chr6_+_23887314 0.03 ENSDART00000163188
znf648
zinc finger protein 648
chr15_+_30323491 0.03 ENSDART00000048847
nos2b
nitric oxide synthase 2b, inducible
chr12_-_33579873 0.03 ENSDART00000184661
tdrkh
tudor and KH domain containing
chr20_+_30490682 0.02 ENSDART00000184871
myt1la
myelin transcription factor 1-like, a
chr18_-_25568994 0.02 ENSDART00000133029
si:ch211-13k12.2
si:ch211-13k12.2
chr21_+_28478663 0.02 ENSDART00000077887
ENSDART00000134150
slc22a6l
solute carrier family 22 (organic anion transporter), member 6, like
chr17_-_44247707 0.02 ENSDART00000126097
otx2b
orthodenticle homeobox 2b
chr6_-_44711942 0.01 ENSDART00000055035
cntn3b
contactin 3b
chr19_-_19379084 0.01 ENSDART00000165206
smarcc1b
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1b
chr9_+_24008879 0.01 ENSDART00000190419
ENSDART00000191843
ENSDART00000148226
mlphb
melanophilin b
chr15_-_5172170 0.00 ENSDART00000062830
or126-5
odorant receptor, family E, subfamily 126, member 5

Network of associatons between targets according to the STRING database.

First level regulatory network of msx1a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0039015 spinal cord anterior/posterior patterning(GO:0021512) cell proliferation involved in pronephros development(GO:0039015) cell proliferation involved in kidney development(GO:0072111)
0.8 3.8 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.7 2.0 GO:1900157 negative regulation of chondrocyte differentiation(GO:0032331) negative regulation of cartilage development(GO:0061037) negative regulation of chondrocyte development(GO:0061182) regulation of bone mineralization involved in bone maturation(GO:1900157) negative regulation of bone mineralization involved in bone maturation(GO:1900158) negative regulation of bone development(GO:1903011)
0.6 2.3 GO:0060074 synapse maturation(GO:0060074)
0.5 2.1 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.5 2.4 GO:0051145 smooth muscle cell differentiation(GO:0051145) negative regulation of muscle cell differentiation(GO:0051148)
0.3 3.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.3 1.5 GO:0071305 vitamin D3 metabolic process(GO:0070640) cellular response to vitamin D(GO:0071305)
0.2 0.5 GO:0060623 regulation of chromosome condensation(GO:0060623)
0.1 0.5 GO:0018343 protein farnesylation(GO:0018343)
0.1 2.3 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 2.0 GO:0035803 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.1 1.5 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.1 1.0 GO:0035677 posterior lateral line neuromast hair cell development(GO:0035677)
0.1 4.0 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.1 0.5 GO:0003222 ventricular trabecula myocardium morphogenesis(GO:0003222) trabecula formation(GO:0060343) heart trabecula formation(GO:0060347) skin epidermis development(GO:0098773)
0.1 1.5 GO:0006825 copper ion transport(GO:0006825)
0.1 1.2 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.1 0.9 GO:0015693 magnesium ion transport(GO:0015693)
0.1 1.9 GO:0050821 protein stabilization(GO:0050821)
0.1 0.8 GO:0035493 SNARE complex assembly(GO:0035493)
0.1 1.5 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 0.6 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 0.4 GO:0097340 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.0 2.3 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 0.6 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 0.5 GO:0060573 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.0 0.2 GO:0016322 neuron remodeling(GO:0016322)
0.0 0.3 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.0 0.5 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.0 0.2 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.0 0.8 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.2 GO:0070207 protein homotrimerization(GO:0070207)
0.0 1.7 GO:0001706 endoderm formation(GO:0001706)
0.0 0.8 GO:0051014 actin filament severing(GO:0051014)
0.0 0.7 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 0.1 GO:0036306 embryonic heart tube elongation(GO:0036306)
0.0 2.5 GO:0017148 negative regulation of translation(GO:0017148)
0.0 2.6 GO:0048545 response to steroid hormone(GO:0048545)
0.0 0.5 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.7 GO:0007006 mitochondrial membrane organization(GO:0007006)
0.0 0.3 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.3 GO:0006491 N-glycan processing(GO:0006491)
0.0 0.7 GO:0044744 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.0 0.7 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.8 GO:0006497 protein lipidation(GO:0006497)
0.0 0.5 GO:0001841 neural tube formation(GO:0001841)
0.0 0.2 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.9 GO:0046839 phospholipid dephosphorylation(GO:0046839)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 4.0 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
1.2 3.5 GO:0097189 apoptotic body(GO:0097189)
0.3 1.5 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.2 0.8 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 0.5 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.1 0.9 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 0.7 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 2.3 GO:0000421 autophagosome membrane(GO:0000421)
0.1 1.5 GO:0035102 PRC1 complex(GO:0035102)
0.1 0.8 GO:0045180 basal cortex(GO:0045180)
0.1 2.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 2.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 2.0 GO:0031970 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 0.5 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 2.4 GO:0032432 actin filament bundle(GO:0032432)
0.0 4.2 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.2 GO:0043083 synaptic cleft(GO:0043083)
0.0 1.3 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 0.6 GO:0043186 P granule(GO:0043186)
0.0 0.2 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.1 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.0 0.8 GO:0001726 ruffle(GO:0001726)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 9.6 GO:0009374 biotin binding(GO:0009374)
0.5 2.0 GO:0031005 filamin binding(GO:0031005)
0.5 1.9 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.4 2.0 GO:0016531 copper chaperone activity(GO:0016531)
0.3 0.8 GO:0019777 Atg12 transferase activity(GO:0019777)
0.2 0.7 GO:0071077 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.2 3.8 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.2 1.5 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.2 2.9 GO:0008266 poly(U) RNA binding(GO:0008266)
0.2 2.0 GO:0035804 structural constituent of egg coat(GO:0035804)
0.1 2.3 GO:0031729 CCR1 chemokine receptor binding(GO:0031726) CCR4 chemokine receptor binding(GO:0031729)
0.1 0.5 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.1 1.2 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 2.3 GO:0019894 kinesin binding(GO:0019894)
0.1 0.5 GO:0032052 bile acid binding(GO:0032052)
0.1 3.3 GO:0005109 frizzled binding(GO:0005109)
0.1 4.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 1.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.8 GO:0000030 mannosyltransferase activity(GO:0000030)
0.1 0.4 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 0.3 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 0.9 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.6 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.2 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 2.1 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 7.4 GO:0042802 identical protein binding(GO:0042802)
0.0 2.3 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 0.2 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.3 GO:0015924 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0 0.5 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.7 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 1.5 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.1 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.0 0.1 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.0 0.5 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 4.7 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 1.2 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.1 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.0 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 5.4 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 1.5 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.5 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.5 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.4 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.5 PID AURORA B PATHWAY Aurora B signaling
0.0 0.2 PID ARF 3PATHWAY Arf1 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.0 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 0.5 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 1.9 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 1.5 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 1.5 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 1.8 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.8 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.2 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.2 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.5 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 1.8 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation