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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for mtf1

Z-value: 0.35

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Transcription factors associated with mtf1

Gene Symbol Gene ID Gene Info
mtf1
ENSDARG00000102898 metal-regulatory transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
mtf1dr11_v1_chr16_+_4138331_41383790.911.5e-07Click!

Activity profile of mtf1 motif

Sorted Z-values of mtf1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_48397702 1.59 ENSDART00000147169
zgc:172182
zgc:172182
chr16_-_7692568 1.35 ENSDART00000148980
pimr209
Pim proto-oncogene, serine/threonine kinase, related 209
chr20_-_147574 1.19 ENSDART00000104762
ENSDART00000131635
slc16a10
solute carrier family 16 (aromatic amino acid transporter), member 10
chr11_-_497854 0.84 ENSDART00000104520
cnbpb
CCHC-type zinc finger, nucleic acid binding protein b
chr13_+_15682803 0.70 ENSDART00000188063
CR931980.1

chr8_+_31435452 0.63 ENSDART00000145282
selenop
selenoprotein P
chr1_-_35928942 0.63 ENSDART00000033566
smad1
SMAD family member 1
chr22_+_29067388 0.59 ENSDART00000133673
pimr100
Pim proto-oncogene, serine/threonine kinase, related 100
chr1_-_35929143 0.55 ENSDART00000185002
smad1
SMAD family member 1
chr7_-_74090168 0.53 ENSDART00000050528
tyrp1a
tyrosinase-related protein 1a
chr17_+_37215820 0.53 ENSDART00000104009
slc30a1b
solute carrier family 30 (zinc transporter), member 1b
chr6_+_3280939 0.51 ENSDART00000151359
kdm4aa
lysine (K)-specific demethylase 4A, genome duplicate a
chr25_+_17313568 0.51 ENSDART00000125459
cnot1
CCR4-NOT transcription complex, subunit 1
chr20_+_27298783 0.50 ENSDART00000013861
ppp4r4
protein phosphatase 4, regulatory subunit 4
chr23_-_20309505 0.48 ENSDART00000130856
lamb2l
laminin, beta 2-like
chr12_+_20149707 0.47 ENSDART00000181942
foxj1b
forkhead box J1b
chr11_-_497680 0.47 ENSDART00000154888
cnbpb
CCHC-type zinc finger, nucleic acid binding protein b
chr19_+_10832092 0.47 ENSDART00000191851
tomm40l
translocase of outer mitochondrial membrane 40 homolog, like
chr10_-_26997344 0.46 ENSDART00000146595
zgc:193742
zgc:193742
chr3_-_56933578 0.45 ENSDART00000192185
hid1a
HID1 domain containing a
chr20_-_46362606 0.43 ENSDART00000153087
bmf2
BCL2 modifying factor 2
chr20_+_13894123 0.40 ENSDART00000007744
slc30a1a
solute carrier family 30 (zinc transporter), member 1a
chr25_-_23526058 0.37 ENSDART00000191331
ENSDART00000062930
phlda2
pleckstrin homology-like domain, family A, member 2
chr22_-_38607504 0.36 ENSDART00000164609
si:ch211-126j24.1
si:ch211-126j24.1
chr1_+_44906517 0.36 ENSDART00000142820
wu:fc21g02
wu:fc21g02
chr3_+_23221047 0.36 ENSDART00000009393
col1a1a
collagen, type I, alpha 1a
chr22_+_29009541 0.36 ENSDART00000169449
pimr97
Pim proto-oncogene, serine/threonine kinase, related 97
chr22_+_29027037 0.33 ENSDART00000170071
pimr97
Pim proto-oncogene, serine/threonine kinase, related 97
chr16_-_19026733 0.32 ENSDART00000104826
pimr98
Pim proto-oncogene, serine/threonine kinase, related 98
chr16_+_11029762 0.32 ENSDART00000091183
erfl3
Ets2 repressor factor like 3
chr12_+_41510492 0.32 ENSDART00000170976
ENSDART00000176164
kif5bb
kinesin family member 5B, b
chr16_-_19026414 0.32 ENSDART00000141208
pimr98
Pim proto-oncogene, serine/threonine kinase, related 98
chr22_+_28995391 0.31 ENSDART00000164486
pimr99
Pim proto-oncogene, serine/threonine kinase, related 99
chr24_-_4450238 0.31 ENSDART00000066835
fzd8a
frizzled class receptor 8a
chr7_+_74150839 0.31 ENSDART00000160195
ppp1cbl
protein phosphatase 1, catalytic subunit, beta isoform, like
chr4_+_23223881 0.31 ENSDART00000133056
ENSDART00000089126
trhde.1
thyrotropin releasing hormone degrading enzyme, tandem duplicate 1
chr7_-_38861741 0.30 ENSDART00000173629
ENSDART00000037361
ENSDART00000173953
phf21aa
PHD finger protein 21Aa
chr3_+_30500968 0.30 ENSDART00000103447
si:dkey-13n23.3
si:dkey-13n23.3
chr14_+_15257658 0.29 ENSDART00000161625
ENSDART00000193577
si:dkey-77g12.4
si:dkey-203a12.5
si:dkey-77g12.4
si:dkey-203a12.5
chr20_-_54259780 0.28 ENSDART00000172631
fkbp3
FK506 binding protein 3
chr3_+_1211242 0.28 ENSDART00000171287
ENSDART00000165769
poldip3
polymerase (DNA-directed), delta interacting protein 3
chr4_-_23643272 0.28 ENSDART00000112301
ENSDART00000133184
trhde.2
thyrotropin releasing hormone degrading enzyme, tandem duplicate 2
chr22_+_26703026 0.27 ENSDART00000158756
crebbpa
CREB binding protein a
chr11_-_3334248 0.27 ENSDART00000154314
ENSDART00000121861
prph
peripherin
chr20_-_1314537 0.26 ENSDART00000144288
pcmt
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr23_+_23485858 0.25 ENSDART00000114067
agrn
agrin
chr6_+_31684 0.25 ENSDART00000188853
ENSDART00000184553
CZQB01141835.2

chr22_+_28888781 0.24 ENSDART00000145629
pimr98
Pim proto-oncogene, serine/threonine kinase, related 98
chr7_-_50604626 0.23 ENSDART00000073903
ENSDART00000174031
crtc3
CREB regulated transcription coactivator 3
chr20_-_5267600 0.22 ENSDART00000099258
cyp46a1.4
cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 4
chr6_+_10450000 0.22 ENSDART00000151288
ENSDART00000187431
ENSDART00000192474
ENSDART00000188214
ENSDART00000184766
ENSDART00000190082
kcnh7
potassium channel, voltage gated eag related subfamily H, member 7
chr17_-_12385308 0.22 ENSDART00000080927
snap25b
synaptosomal-associated protein, 25b
chr2_+_41876595 0.21 ENSDART00000112243
crlf1a
cytokine receptor-like factor 1a
chr7_+_49715750 0.21 ENSDART00000019446
ascl1b
achaete-scute family bHLH transcription factor 1b
chr20_-_1314355 0.20 ENSDART00000152436
pcmt
protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr19_-_35400819 0.20 ENSDART00000148080
rnf19b
ring finger protein 19B
chr14_-_33177935 0.20 ENSDART00000180583
ENSDART00000078856
dlg3
discs, large homolog 3 (Drosophila)
chr16_+_26449615 0.19 ENSDART00000039746
epb41b
erythrocyte membrane protein band 4.1b
chr24_+_10397865 0.18 ENSDART00000155557
si:ch211-69l10.4
si:ch211-69l10.4
chr4_-_68564988 0.17 ENSDART00000191212
BX548011.3

chr20_-_48470599 0.17 ENSDART00000166857
CABZ01059120.1

chr12_+_22745618 0.17 ENSDART00000181024
ENSDART00000183993
ENSDART00000077548
ablim2
actin binding LIM protein family, member 2
chr2_+_33457310 0.16 ENSDART00000056657
zgc:113531
zgc:113531
chr1_-_59251874 0.15 ENSDART00000168919
olfm2b
olfactomedin 2b
chr1_-_12278522 0.15 ENSDART00000142122
ENSDART00000003825
cplx2l
complexin 2, like
chr1_-_12278056 0.15 ENSDART00000139336
ENSDART00000137463
cplx2l
complexin 2, like
chr2_+_54641644 0.15 ENSDART00000027313
ndufv2
NADH dehydrogenase (ubiquinone) flavoprotein 2
chr24_-_3477103 0.15 ENSDART00000143723
idi1
isopentenyl-diphosphate delta isomerase 1
chr11_+_575665 0.14 ENSDART00000122133
mkrn2os.1
MKRN2 opposite strand, tandem duplicate 1
chr23_-_3681026 0.13 ENSDART00000192128
ENSDART00000040086
pacsin1a
protein kinase C and casein kinase substrate in neurons 1a
chr6_+_10094061 0.12 ENSDART00000150998
ENSDART00000162236
atp7b
ATPase copper transporting beta
chr13_+_52006253 0.11 ENSDART00000181259
CABZ01080135.1

chr9_+_156142 0.11 ENSDART00000171501
cldn10b
claudin 10b
chr8_+_22355909 0.11 ENSDART00000146457
ENSDART00000142883
zgc:153631
zgc:153631
chr14_+_597532 0.10 ENSDART00000159805
LO018568.2

chr12_+_48851381 0.10 ENSDART00000187241
ENSDART00000187796
dlg5b.1
discs, large homolog 5b (Drosophila), tandem duplicate 1
chr15_-_44275069 0.10 ENSDART00000124980
CU929391.2

chr2_+_327081 0.10 ENSDART00000155595
zgc:174263
zgc:174263
chr6_+_7553085 0.10 ENSDART00000150939
ENSDART00000151114
myh10
myosin, heavy chain 10, non-muscle
chr19_+_37701450 0.10 ENSDART00000087694
thsd7aa
thrombospondin, type I, domain containing 7Aa
chr19_-_11336782 0.09 ENSDART00000131014
sept7a
septin 7a
chr15_-_30816370 0.09 ENSDART00000142982
ENSDART00000050649
ENSDART00000136901
ENSDART00000100194
msi2b
musashi RNA-binding protein 2b
chr23_-_45705525 0.09 ENSDART00000148959
ednrab
endothelin receptor type Ab
chr4_-_28334464 0.08 ENSDART00000123617
celsr1a
cadherin EGF LAG seven-pass G-type receptor 1a
chr13_-_23756700 0.08 ENSDART00000057612
rgs17
regulator of G protein signaling 17
chr19_+_31183495 0.07 ENSDART00000088618
meox2b
mesenchyme homeobox 2b
chr4_-_28335184 0.07 ENSDART00000178149
ENSDART00000043737
celsr1a
cadherin EGF LAG seven-pass G-type receptor 1a
chr24_-_37877743 0.07 ENSDART00000105658
tmem204
transmembrane protein 204
chr14_-_45394704 0.07 ENSDART00000173078
ENSDART00000125970
si:ch211-168f7.5
si:ch211-168f7.5
chr16_-_29452039 0.07 ENSDART00000148960
si:ch211-113g11.6
si:ch211-113g11.6
chr4_+_8376362 0.07 ENSDART00000138653
ENSDART00000132647
erc1b
ELKS/RAB6-interacting/CAST family member 1b
chr14_+_5117072 0.07 ENSDART00000189628
nanos1
nanos homolog 1
chr7_+_25323742 0.07 ENSDART00000110347
cyp26b1
cytochrome P450, family 26, subfamily b, polypeptide 1
chr22_-_37349967 0.07 ENSDART00000104493
sox2
SRY (sex determining region Y)-box 2
chr17_-_125091 0.06 ENSDART00000158825
actc1b
actin, alpha, cardiac muscle 1b
chr12_-_25294096 0.06 ENSDART00000183398
hcar1-4
hydroxycarboxylic acid receptor 1-4
chr21_+_21621042 0.06 ENSDART00000134907
tgfb1b
transforming growth factor, beta 1b
chr17_+_25481466 0.06 ENSDART00000139451
aim1a
crystallin beta-gamma domain containing 1a
chr23_-_45682136 0.06 ENSDART00000164646
fam160a1b
family with sequence similarity 160, member A1b
chr10_+_22724059 0.06 ENSDART00000136123
kdm6bb
lysine (K)-specific demethylase 6B, b
chr23_+_45611649 0.05 ENSDART00000169521
dclk2b
doublecortin-like kinase 2b
chr10_+_5954787 0.05 ENSDART00000161887
ENSDART00000160345
ENSDART00000190046
map3k1
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
chr12_-_45876387 0.05 ENSDART00000043210
ENSDART00000149044
pax2b
paired box 2b
chr25_-_36020344 0.04 ENSDART00000181448
rbl2
retinoblastoma-like 2 (p130)
chr22_+_569565 0.04 ENSDART00000037069
usp49
ubiquitin specific peptidase 49
chr17_-_36988455 0.04 ENSDART00000187180
ENSDART00000126823
dnmt3ab
DNA (cytosine-5-)-methyltransferase 3 alpha b
chr1_-_16394814 0.03 ENSDART00000013024
fgf20a
fibroblast growth factor 20a
chr12_-_44070043 0.03 ENSDART00000180059
si:ch73-329n5.3
si:ch73-329n5.3
chr24_+_28525507 0.03 ENSDART00000191121
arhgap29a
Rho GTPase activating protein 29a
chr8_-_53926228 0.02 ENSDART00000015554
ubiad1
UbiA prenyltransferase domain containing 1
chr15_+_3219134 0.02 ENSDART00000113532
LO017656.1

chr1_+_50085440 0.02 ENSDART00000018469
ENSDART00000134988
npnt
nephronectin
chr9_-_128036 0.02 ENSDART00000165960
FQ377903.2

chr3_-_18756076 0.02 ENSDART00000055766
zgc:113333
zgc:113333
chr16_+_35395597 0.02 ENSDART00000158143
si:dkey-34d22.5
si:dkey-34d22.5
chr2_+_49246099 0.01 ENSDART00000179089
sema6ba
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba
chr6_-_20875111 0.01 ENSDART00000115118
ENSDART00000159916
tns1a
tensin 1a
chr4_+_31085014 0.01 ENSDART00000172541
si:dkey-47k16.4
si:dkey-47k16.4
chr4_+_38981587 0.00 ENSDART00000142713
si:dkey-66k12.3
si:dkey-66k12.3
chr17_+_3128273 0.00 ENSDART00000122453
zgc:136872
zgc:136872
chr23_+_20931030 0.00 ENSDART00000167014
pax7b
paired box 7b
chr3_+_30501135 0.00 ENSDART00000165869
si:dkey-13n23.3
si:dkey-13n23.3

Network of associatons between targets according to the STRING database.

First level regulatory network of mtf1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:1990359 detoxification of zinc ion(GO:0010312) stress response to zinc ion(GO:1990359)
0.3 1.3 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.1 0.5 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.1 0.6 GO:0001887 selenium compound metabolic process(GO:0001887)
0.1 0.3 GO:0021531 spinal cord radial glial cell differentiation(GO:0021531) eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
0.1 0.4 GO:0035630 bone mineralization involved in bone maturation(GO:0035630)
0.1 0.3 GO:1902571 regulation of serine-type peptidase activity(GO:1902571)
0.1 0.5 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.1 0.5 GO:0042438 melanin biosynthetic process(GO:0042438)
0.0 0.2 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 0.1 GO:0046490 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
0.0 0.5 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.5 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.1 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.1 GO:0035992 tendon formation(GO:0035992)
0.0 0.2 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 1.2 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.0 0.5 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.4 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.2 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.0 0.1 GO:0070650 actin filament bundle distribution(GO:0070650)
0.0 0.2 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.0 0.1 GO:0003319 cardioblast migration to the midline involved in heart rudiment formation(GO:0003319)
0.0 0.1 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.0 3.8 GO:0046777 protein autophosphorylation(GO:0046777)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 0.2 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 1.2 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.5 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.5 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.5 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.2 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0 0.5 GO:0043256 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 0.6 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.3 GO:0043195 terminal bouton(GO:0043195)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 0.6 GO:0008430 selenium binding(GO:0008430)
0.1 0.5 GO:0042974 estrogen receptor binding(GO:0030331) retinoic acid receptor binding(GO:0042974)
0.1 0.5 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.1 1.2 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.3 GO:0001130 bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217)
0.0 0.2 GO:0033781 cholesterol 24-hydroxylase activity(GO:0033781)
0.0 0.5 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.9 GO:0016248 ion channel inhibitor activity(GO:0008200) channel inhibitor activity(GO:0016248)
0.0 0.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.5 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.0 1.4 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.1 GO:0004962 endothelin receptor activity(GO:0004962)
0.0 0.3 GO:0043236 laminin binding(GO:0043236)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 PID ALK2 PATHWAY ALK2 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 1.2 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.3 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.2 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors