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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for mycn

Z-value: 1.61

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Transcription factors associated with mycn

Gene Symbol Gene ID Gene Info
ENSDARG00000006837 MYCN proto-oncogene, bHLH transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
mycndr11_v1_chr20_+_33294428_33294428-0.929.8e-08Click!

Activity profile of mycn motif

Sorted Z-values of mycn motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_17099560 5.95 ENSDART00000101724
v-mos Moloney murine sarcoma viral oncogene homolog
chr13_-_35907768 4.59 ENSDART00000147522
MYCL proto-oncogene, bHLH transcription factor a
chr3_+_24595922 3.45 ENSDART00000169405
si:dkey-68o6.5
chr12_-_33359654 3.10 ENSDART00000001907
solute carrier family 16 (monocarboxylate transporter), member 3
chr12_-_33359052 3.06 ENSDART00000135943
solute carrier family 16 (monocarboxylate transporter), member 3
chr6_+_21001264 2.85 ENSDART00000044519
ENSDART00000151278
connexin 44.2
chr21_-_19919918 2.65 ENSDART00000137307
ENSDART00000142523
ENSDART00000065670
protein phosphatase 1, regulatory subunit 3B
chr22_-_26834043 2.61 ENSDART00000087202
si:dkey-44g23.5
chr25_+_17689565 2.50 ENSDART00000171965
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 18a
chr7_+_22801465 2.45 ENSDART00000052862
ENSDART00000173633
RNA binding motif protein 4.1
chr22_-_28777557 2.35 ENSDART00000135214
ENSDART00000131761
ENSDART00000005112
si:dkeyp-34c12.1
chr15_-_26089012 2.31 ENSDART00000152243
ENSDART00000140214
diphthamide biosynthesis 1
chr21_-_14832369 2.29 ENSDART00000144859
pseudouridylate synthase 1
chr8_-_13678415 2.29 ENSDART00000134153
ENSDART00000143331
si:dkey-258f14.3
chr8_+_26396552 2.26 ENSDART00000087151
aminomethyltransferase
chr19_+_20201254 2.26 ENSDART00000010140
insulin-like growth factor 2 mRNA binding protein 3
chr13_-_35908275 2.23 ENSDART00000013961
MYCL proto-oncogene, bHLH transcription factor a
chr2_-_49860723 2.22 ENSDART00000083690
biliverdin reductase A
chr7_-_49801183 2.22 ENSDART00000052083
four jointed box 1
chr19_-_30800004 2.21 ENSDART00000128560
ENSDART00000045504
ENSDART00000125893
tRNA isopentenyltransferase 1
chr5_-_54714525 2.21 ENSDART00000150138
ENSDART00000150070
cyclin B1
chr9_-_12888082 2.21 ENSDART00000133135
ENSDART00000134415
si:ch211-167j6.3
chr16_+_13860299 2.21 ENSDART00000121998
glutamate-rich WD repeat containing 1
chr22_-_28777374 2.20 ENSDART00000188206
si:dkeyp-34c12.1
chr18_+_14645568 2.18 ENSDART00000138995
ENSDART00000147351
VPS9 domain containing 1
chr14_+_22076596 2.17 ENSDART00000106147
ENSDART00000100278
ENSDART00000131489
solute carrier family 43 (amino acid system L transporter), member 1a
chr1_-_19648227 2.15 ENSDART00000054574
polymerase (RNA) I polypeptide E
chr7_+_30779761 2.15 ENSDART00000066806
ENSDART00000173671
methylmalonyl CoA epimerase
chr17_+_24318753 2.09 ENSDART00000064083
orthodenticle homeobox 1
chr21_-_22122312 2.09 ENSDART00000101726
solute carrier family 35, member F2
chr5_-_54714789 2.06 ENSDART00000063357
cyclin B1
chr13_-_25408387 2.06 ENSDART00000002741
inositol 1,4,5-trisphosphate receptor interacting protein
chr4_-_2945306 2.03 ENSDART00000128934
ENSDART00000019518
AE binding protein 2
chr10_+_29770120 2.00 ENSDART00000100032
ENSDART00000193205
hypoxia up-regulated 1
chr13_-_12021566 1.99 ENSDART00000125430
peroxisome proliferator-activated receptor gamma, coactivator-related 1
chr13_-_15142280 1.96 ENSDART00000163132
RAB11 family interacting protein 5a (class I)
chr2_+_12255568 1.95 ENSDART00000184164
ENSDART00000013454
phosphoribosyl transferase domain containing 1
chr10_+_16036573 1.95 ENSDART00000188757
lamin B1
chr3_-_16010968 1.94 ENSDART00000080672
mitochondrial ribosomal protein S34
chr5_-_26247215 1.94 ENSDART00000136806
endoplasmic reticulum aminopeptidase 1b
chr7_-_49800755 1.93 ENSDART00000180072
four jointed box 1
chr24_+_34069675 1.91 ENSDART00000143995
si:ch211-190p8.2
chr20_+_48116476 1.91 ENSDART00000043938
translocation associated membrane protein 2
chr14_+_8940326 1.89 ENSDART00000159920
ribosomal protein S6 kinase a, like
chr5_-_32338866 1.89 ENSDART00000017956
ENSDART00000047670
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr19_+_20201593 1.88 ENSDART00000163026
insulin-like growth factor 2 mRNA binding protein 3
chr23_+_30730121 1.87 ENSDART00000134141
additional sex combs like transcriptional regulator 1
chr24_+_36317544 1.87 ENSDART00000048640
ENSDART00000156096
pseudouridylate synthase 3
chr2_-_39036604 1.83 ENSDART00000129963
retinol binding protein 1b, cellular
chr20_-_25626428 1.82 ENSDART00000136475
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr12_-_31724198 1.81 ENSDART00000153056
ENSDART00000165299
ENSDART00000137464
ENSDART00000080173
serine/arginine-rich splicing factor 2a
chr20_-_25626198 1.78 ENSDART00000126716
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr2_-_11027258 1.78 ENSDART00000081072
ENSDART00000193824
ENSDART00000187036
ENSDART00000097741
single stranded DNA binding protein 3a
chr5_-_30080332 1.68 ENSDART00000140049
beta-carotene oxygenase 2a
chr16_-_42175617 1.67 ENSDART00000084715
alkB homolog 8, tRNA methyltransferase
chr21_+_34119759 1.66 ENSDART00000024750
ENSDART00000128242
high mobility group box 3b
chr22_-_20695237 1.65 ENSDART00000112722
oogenesis-related gene
chr5_-_10082244 1.64 ENSDART00000036421
checkpoint kinase 2
chr5_-_3927692 1.60 ENSDART00000146840
ENSDART00000058346
complement component 1, q subcomponent binding protein
chr3_-_34753605 1.59 ENSDART00000000160
thyroid hormone receptor alpha a
chr5_-_43859148 1.59 ENSDART00000162746
ENSDART00000128763
si:ch211-204c21.1
chr8_+_21114338 1.59 ENSDART00000002186
uridine-cytidine kinase 2a
chr23_+_17522867 1.57 ENSDART00000002714
solute carrier family 17 (vesicular nucleotide transporter), member 9b
chr9_-_11676491 1.57 ENSDART00000022358
zinc finger CCCH-type containing 15
chr17_+_22760126 1.55 ENSDART00000151999
ENSDART00000190442
tetratricopeptide repeat domain 27
chr20_+_38458084 1.55 ENSDART00000020153
ENSDART00000135912
coenzyme Q8A
chr1_+_5485799 1.54 ENSDART00000022307
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr17_-_48705993 1.53 ENSDART00000030934
potassium channel, subfamily K, member 5a
chr9_-_11587070 1.53 ENSDART00000030995
uridine monophosphate synthetase
chr13_+_32454262 1.53 ENSDART00000057421
retinol dehydrogenase 14a
chr25_-_14424406 1.53 ENSDART00000073609
protein arginine methyltransferase 7
chr3_+_34120191 1.50 ENSDART00000020017
ENSDART00000151700
aldehyde dehydrogenase 3 family, member B1
chr8_+_26059677 1.49 ENSDART00000009178
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr1_-_8917902 1.47 ENSDART00000137900
glutamate receptor, ionotropic, N-methyl D-aspartate 2A, b
chr20_-_45772306 1.47 ENSDART00000062092
tRNA methyltransferase 6 homolog (S. cerevisiae)
chr6_-_15065376 1.46 ENSDART00000087797
transforming growth factor, beta receptor associated protein 1
chr8_-_38317914 1.44 ENSDART00000125920
PDZ and LIM domain 2 (mystique)
chr22_+_5120033 1.44 ENSDART00000169200
muscle-specific beta 1 integrin binding protein
chr23_+_2906031 1.42 ENSDART00000109304
c23h20orf24 homolog (H. sapiens)
chr9_-_27391908 1.41 ENSDART00000135221
nucleolus and neural progenitor protein
chr25_-_35101673 1.41 ENSDART00000140864
zgc:162611
chr4_-_16824231 1.40 ENSDART00000014007
glycogen synthase 2
chr20_+_25626479 1.39 ENSDART00000143883
phosphoribosyl pyrophosphate amidotransferase
chr25_-_35101396 1.38 ENSDART00000138865
zgc:162611
chr7_-_55539738 1.36 ENSDART00000168721
ENSDART00000013796
ENSDART00000148514
adenine phosphoribosyltransferase
chr3_+_42126062 1.36 ENSDART00000154052
mitochondrial rRNA methyltransferase 2
chr9_+_38158570 1.35 ENSDART00000059549
ENSDART00000133060
nucleolar protein interacting with the FHA domain of MKI67
chr25_-_32869794 1.34 ENSDART00000162784
transmembrane protein 266
chr15_-_30857350 1.34 ENSDART00000138988
A kinase (PRKA) anchor protein 1b
chr3_-_15131438 1.34 ENSDART00000131720
exportin 6
chr15_+_44250335 1.33 ENSDART00000186162
ENSDART00000193503
ENSDART00000180275
zgc:162962
chr7_+_55292959 1.32 ENSDART00000147539
ENSDART00000073555
cytosolic thiouridylase subunit 2 homolog (S. pombe)
chr4_-_16824556 1.32 ENSDART00000165289
ENSDART00000185839
glycogen synthase 2
chr3_-_57762247 1.30 ENSDART00000156522
calcium activated nucleotidase 1a
chr12_+_3571770 1.30 ENSDART00000164707
ENSDART00000189819
cytochrome C oxidase assembly factor 3a
chr18_+_14277003 1.28 ENSDART00000006628
zgc:173742
chr2_+_37815687 1.28 ENSDART00000166352
short chain dehydrogenase/reductase family 39U, member 1
chr10_+_21434649 1.28 ENSDART00000193938
ENSDART00000064558
eukaryotic translation termination factor 1b
chr14_+_24935131 1.27 ENSDART00000170871
peroxisome proliferator-activated receptor gamma, coactivator 1 beta
chr5_-_63644938 1.27 ENSDART00000050865
surfeit gene 4, like
chr17_+_17764979 1.26 ENSDART00000105013
alkB homolog 1, histone H2A dioxygenase
chr2_-_32512648 1.26 ENSDART00000170674
ATP-binding cassette, sub-family F (GCN20), member 2a
chr2_+_205763 1.26 ENSDART00000160164
ENSDART00000101071
zgc:113293
chr6_-_39080630 1.26 ENSDART00000021520
ENSDART00000128308
eukaryotic translation initiation factor 4Bb
chr6_-_25952848 1.25 ENSDART00000076997
ENSDART00000148748
LIM domain only 4b
chr22_+_5118361 1.25 ENSDART00000168371
ENSDART00000170222
ENSDART00000158846
muscle-specific beta 1 integrin binding protein
chr21_+_39462520 1.25 ENSDART00000114825
MAX network transcriptional repressor b
chr16_-_21489514 1.24 ENSDART00000149525
ENSDART00000148517
ENSDART00000146914
ENSDART00000186493
ENSDART00000193081
ENSDART00000186017
membrane protein, palmitoylated 6a (MAGUK p55 subfamily member 6)
chr9_-_12652984 1.24 ENSDART00000052256
small ubiquitin-like modifier 3b
chr14_+_35414632 1.23 ENSDART00000191516
ENSDART00000084914
tRNA methyltransferase 12 homolog (S. cerevisiae)
chr14_+_16287968 1.23 ENSDART00000106593
pre-mRNA processing factor 19
chr5_+_3927989 1.23 ENSDART00000030125
zinc finger, HIT-type containing 3
chr7_+_38717624 1.23 ENSDART00000132522
synaptotagmin XIII
chr3_+_23029934 1.22 ENSDART00000110343
N-acetylglutamate synthase
chr6_+_3717613 1.22 ENSDART00000184330
Sjogren syndrome antigen B (autoantigen La)
chr7_-_8961941 1.22 ENSDART00000111002
si:ch211-74f19.2
chr25_+_16945348 1.22 ENSDART00000016591
fibroblast growth factor 6a
chr20_-_25631256 1.20 ENSDART00000048164
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr3_+_19665319 1.20 ENSDART00000007857
ENSDART00000193509
methyltransferase like 2A
chr2_-_6065416 1.19 ENSDART00000037698
uridine-cytidine kinase 2b
chr11_-_12800945 1.18 ENSDART00000191178
taxilin gamma
chr21_-_4539899 1.18 ENSDART00000112460
dolichol kinase
chr2_-_48826707 1.17 ENSDART00000134711
supervillin b
chr4_-_20232974 1.17 ENSDART00000193353
serine/threonine kinase 38 like
chr17_-_29249258 1.15 ENSDART00000031458
TNF receptor-associated factor 3
chr5_-_13167097 1.14 ENSDART00000149700
ENSDART00000030213
mitogen-activated protein kinase 1
chr12_-_9516981 1.13 ENSDART00000106285
si:ch211-207i20.3
chr5_-_1999417 1.13 ENSDART00000155437
ENSDART00000145781
si:ch211-160e1.5
chr11_-_12801157 1.12 ENSDART00000103449
taxilin gamma
chr20_-_38827623 1.10 ENSDART00000153310
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr19_-_8940068 1.10 ENSDART00000043507
circadian associated repressor of transcription a
chr23_+_32101361 1.10 ENSDART00000138849
zgc:56699
chr1_+_40613297 1.09 ENSDART00000040798
ENSDART00000168067
ENSDART00000130490
N(alpha)-acetyltransferase 15, NatA auxiliary subunit b
chr11_+_17984354 1.09 ENSDART00000179986
RNA pseudouridylate synthase domain containing 4
chr17_+_6535694 1.08 ENSDART00000191681
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
chr4_-_2727491 1.08 ENSDART00000141760
ENSDART00000039083
ENSDART00000134442
solute carrier organic anion transporter family, member 1C1
chr24_-_10394277 1.08 ENSDART00000127568
ANKH inorganic pyrophosphate transport regulator a
chr5_+_872299 1.07 ENSDART00000130042
far upstream element (FUSE) binding protein 3
chr17_+_51682429 1.07 ENSDART00000004379
nucleolar protein 10
chr4_+_17642731 1.06 ENSDART00000026509
CWF19-like 1, cell cycle control
chr21_+_6114709 1.06 ENSDART00000065858
folylpolyglutamate synthase
chr19_-_34979837 1.06 ENSDART00000044838
N-myc downstream regulated 1a
chr20_-_51656512 1.05 ENSDART00000129965

chr13_-_31370184 1.05 ENSDART00000034829
ribosomal RNA processing 12 homolog
chr11_+_17984167 1.05 ENSDART00000020283
ENSDART00000188329
RNA pseudouridylate synthase domain containing 4
chr17_+_53428092 1.04 ENSDART00000192509
serine/arginine-rich splicing factor 10b
chr5_+_43470544 1.04 ENSDART00000111587
Rho-related BTB domain containing 2a
chr22_+_438714 1.03 ENSDART00000136491
cadherin, EGF LAG seven-pass G-type receptor 2
chr18_+_6126506 1.03 ENSDART00000125725
si:ch1073-390k14.1
chr23_-_36441693 1.03 ENSDART00000024354
cysteine sulfinic acid decarboxylase
chr2_-_10386738 1.03 ENSDART00000016369
wntless Wnt ligand secretion mediator
chr14_+_46118834 1.02 ENSDART00000124417
ENSDART00000017785
N(alpha)-acetyltransferase 15, NatA auxiliary subunit a
chr14_+_52408619 1.02 ENSDART00000163856
nitric oxide associated 1
chr18_+_27489595 1.02 ENSDART00000182018
tumor protein p53 inducible protein 11b
chr9_-_3519717 1.01 ENSDART00000145043
ddb1 and cul4 associated factor 17
chr10_+_29850330 1.01 ENSDART00000168898
heat shock protein 8
chr24_-_20208474 1.00 ENSDART00000139329
cryptochrome DASH
chr6_+_296130 1.00 ENSDART00000073985
RNA binding fox-1 homolog 2
chr10_-_17587832 0.99 ENSDART00000113101
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 b
chr5_+_31791001 0.99 ENSDART00000043010
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25b
chr17_-_49407091 0.99 ENSDART00000021950
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b
chr14_+_28432737 0.98 ENSDART00000026846
protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)
chr24_-_38644937 0.97 ENSDART00000170194
solute carrier family 6, member 16b
chr10_+_35002786 0.97 ENSDART00000099552
exosome component 8
chr20_-_25626693 0.95 ENSDART00000132247
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr21_-_31252131 0.95 ENSDART00000121946
calcitonin gene-related peptide-receptor component protein
chr17_-_31819837 0.95 ENSDART00000160281
abraxas 2b, BRISC complex subunit
chr3_-_32290096 0.94 ENSDART00000148763
carnitine palmitoyltransferase 1Cb
chr20_-_154989 0.94 ENSDART00000064542
ribosome production factor 2 homolog
chr12_+_3262564 0.94 ENSDART00000184264
transmembrane protein 101
chr1_+_9860381 0.94 ENSDART00000054848
phosphomannomutase 2
chr12_-_34827477 0.94 ENSDART00000153026
si:dkey-21c1.6
chr11_-_26375575 0.93 ENSDART00000079255
UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
chr21_+_19330774 0.93 ENSDART00000109412
helicase, POLQ like
chr25_-_6011034 0.92 ENSDART00000075197
ENSDART00000136054
sorting nexin 22
chr10_+_29849977 0.92 ENSDART00000180242
heat shock protein 8
chr4_-_26032741 0.92 ENSDART00000188058
ubiquitin specific peptidase 44
chr3_-_32362872 0.92 ENSDART00000035545
ENSDART00000012630
protein arginine methyltransferase 1
chr21_-_32036597 0.89 ENSDART00000114964
zgc:165573
chr21_-_2958422 0.89 ENSDART00000174091
zgc:194215
chr5_-_55914268 0.89 ENSDART00000014049
WD repeat domain 36
chr9_+_145093 0.89 ENSDART00000162764
ribosomal RNA processing 1
chr10_-_45029041 0.89 ENSDART00000167878
polymerase (DNA directed), mu
chr8_+_41647539 0.88 ENSDART00000136492
ENSDART00000138799
ENSDART00000134404
si:ch211-158d24.4
chr11_-_26832685 0.88 ENSDART00000153519
IQ motif and Sec7 domain 1b
chr23_+_24598910 0.87 ENSDART00000126510
ENSDART00000078796
KAT8 regulatory NSL complex subunit 2
chr6_-_11812224 0.87 ENSDART00000150989
membrane-associated ring finger (C3HC4) 7
chr7_+_13684012 0.87 ENSDART00000056893
programmed cell death 7
chr23_-_18668836 0.87 ENSDART00000138792
ENSDART00000051182
Rho GTPase activating protein 4b
chr19_+_2685779 0.85 ENSDART00000160533
ENSDART00000097531
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr10_-_35002731 0.85 ENSDART00000131279
asparagine-linked glycosylation 5 (dolichyl-phosphate beta-glucosyltransferase)
chr3_+_28939759 0.85 ENSDART00000141904
lectin, galactoside-binding, soluble, 1 (galectin 1)-like 1
chr3_-_36458143 0.84 ENSDART00000168733
ENSDART00000167741
ENSDART00000167143
glyoxylate reductase 1 homolog (Arabidopsis)
chr13_+_6189203 0.83 ENSDART00000109665
protein phosphatase, Mg2+/Mn2+ dependent, 1G
chr8_+_7316568 0.83 ENSDART00000140874
selenoprotein H
chr13_-_45022301 0.83 ENSDART00000183589
ENSDART00000125633
ENSDART00000074787
KH domain containing, RNA binding, signal transduction associated 1a
chr5_+_29726428 0.82 ENSDART00000143183
DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
chr6_-_28222592 0.82 ENSDART00000131126
B-cell CLL/lymphoma 6a (zinc finger protein 51)
chr7_+_17973269 0.81 ENSDART00000079969
potassium channel, subfamily K, member 7
chr5_-_12560569 0.81 ENSDART00000133587
WD repeat and SOCS box containing 2

Network of associatons between targets according to the STRING database.

First level regulatory network of mycn

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 5.9 GO:1901993 meiotic cell cycle phase transition(GO:0044771) metaphase/anaphase transition of meiotic cell cycle(GO:0044785) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902102) negative regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902103) regulation of meiotic chromosome separation(GO:1905132) negative regulation of meiotic chromosome separation(GO:1905133)
1.0 9.7 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.9 2.7 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.8 4.2 GO:1990481 mRNA pseudouridine synthesis(GO:1990481)
0.7 2.9 GO:0070129 regulation of mitochondrial translation(GO:0070129) positive regulation of mitochondrial translation(GO:0070131)
0.6 2.3 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.5 2.6 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
0.5 1.5 GO:0071514 genetic imprinting(GO:0071514)
0.5 3.0 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.5 4.3 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.4 1.8 GO:0046084 adenine salvage(GO:0006168) adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084)
0.4 2.2 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.4 1.7 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.4 1.6 GO:0034969 histone arginine methylation(GO:0034969)
0.4 1.9 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:0006978) DNA damage response, signal transduction resulting in transcription(GO:0042772)
0.4 2.1 GO:0000455 enzyme-directed rRNA pseudouridine synthesis(GO:0000455)
0.3 2.8 GO:0044211 CTP salvage(GO:0044211)
0.3 1.0 GO:0061355 Wnt protein secretion(GO:0061355)
0.3 2.0 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143) protein urmylation(GO:0032447)
0.3 1.0 GO:0021693 cerebellar Purkinje cell layer structural organization(GO:0021693) cerebellar cortex structural organization(GO:0021698) U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047)
0.3 1.9 GO:1902946 positive regulation of receptor-mediated endocytosis(GO:0048260) protein localization to early endosome(GO:1902946)
0.3 1.2 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.3 1.2 GO:0006526 arginine biosynthetic process(GO:0006526)
0.3 2.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.3 0.6 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.3 2.2 GO:0009303 rRNA transcription(GO:0009303)
0.3 1.1 GO:0015887 biotin transport(GO:0015878) pantothenate transmembrane transport(GO:0015887) coenzyme transport(GO:0051182)
0.3 3.2 GO:0045807 positive regulation of endocytosis(GO:0045807)
0.3 1.3 GO:0002184 cytoplasmic translational termination(GO:0002184)
0.3 1.3 GO:0035513 oxidative RNA demethylation(GO:0035513)
0.3 0.8 GO:0006290 pyrimidine dimer repair(GO:0006290)
0.2 1.9 GO:0046149 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.2 0.7 GO:0002522 leukocyte migration involved in immune response(GO:0002522)
0.2 0.9 GO:0051444 negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.2 2.0 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154)
0.2 3.5 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.2 0.8 GO:0006404 RNA import into nucleus(GO:0006404) snRNA import into nucleus(GO:0061015)
0.2 1.9 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.2 0.8 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.2 0.9 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.2 1.7 GO:0046247 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.2 1.5 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.2 1.3 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.2 1.2 GO:0046037 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.2 0.8 GO:0010828 positive regulation of glucose transport(GO:0010828)
0.2 1.1 GO:0008063 Toll signaling pathway(GO:0008063)
0.2 0.8 GO:0031053 primary miRNA processing(GO:0031053)
0.2 1.4 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.2 0.9 GO:0006013 mannose metabolic process(GO:0006013) GDP-mannose biosynthetic process(GO:0009298)
0.2 1.1 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.1 0.7 GO:0044209 AMP salvage(GO:0044209)
0.1 1.0 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.1 0.5 GO:0014743 regulation of muscle hypertrophy(GO:0014743)
0.1 0.5 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.1 2.1 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 0.5 GO:0018343 protein farnesylation(GO:0018343)
0.1 1.4 GO:0006611 protein export from nucleus(GO:0006611)
0.1 2.1 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 0.5 GO:0070084 protein initiator methionine removal(GO:0070084)
0.1 2.2 GO:0015936 coenzyme A metabolic process(GO:0015936)
0.1 0.7 GO:0015961 diadenosine polyphosphate metabolic process(GO:0015959) diadenosine polyphosphate catabolic process(GO:0015961)
0.1 2.5 GO:0009749 response to glucose(GO:0009749)
0.1 2.1 GO:0071456 cellular response to hypoxia(GO:0071456)
0.1 0.6 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.1 0.7 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.1 2.3 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 0.7 GO:1900117 regulation of execution phase of apoptosis(GO:1900117) negative regulation of execution phase of apoptosis(GO:1900118) regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001270) negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.1 1.2 GO:0006415 translational termination(GO:0006415)
0.1 6.6 GO:0006400 tRNA modification(GO:0006400)
0.1 1.0 GO:0019885 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1 0.5 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.1 0.7 GO:0006102 isocitrate metabolic process(GO:0006102)
0.1 0.6 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.1 2.7 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 0.3 GO:0098957 anterograde axonal transport of mitochondrion(GO:0098957)
0.1 0.6 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.1 1.0 GO:0000729 DNA double-strand break processing(GO:0000729)
0.1 2.5 GO:0032543 mitochondrial translation(GO:0032543)
0.1 0.5 GO:0048011 neurotrophin TRK receptor signaling pathway(GO:0048011)
0.1 0.4 GO:0009052 pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.1 2.8 GO:0072310 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.1 1.4 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.1 1.5 GO:0060079 excitatory postsynaptic potential(GO:0060079)
0.1 1.3 GO:0006265 DNA topological change(GO:0006265)
0.1 0.7 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.1 0.9 GO:0021754 facial nucleus development(GO:0021754)
0.1 1.6 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.1 1.7 GO:0001510 RNA methylation(GO:0001510)
0.1 1.6 GO:0044773 mitotic DNA damage checkpoint(GO:0044773)
0.1 1.1 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 0.3 GO:0032528 microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.1 0.5 GO:0001522 pseudouridine synthesis(GO:0001522)
0.1 3.0 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.0 0.1 GO:1903358 regulation of Golgi organization(GO:1903358)
0.0 0.8 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.0 0.2 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.7 GO:0040033 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.4 GO:1900407 regulation of cellular response to oxidative stress(GO:1900407)
0.0 3.8 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.7 GO:0016486 peptide hormone processing(GO:0016486)
0.0 3.2 GO:0051028 mRNA transport(GO:0051028)
0.0 0.1 GO:0001961 positive regulation of cytokine-mediated signaling pathway(GO:0001961) positive regulation of response to cytokine stimulus(GO:0060760)
0.0 0.6 GO:0006405 RNA export from nucleus(GO:0006405)
0.0 2.9 GO:0006364 rRNA processing(GO:0006364)
0.0 0.8 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.9 GO:0016180 snRNA processing(GO:0016180)
0.0 0.9 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 0.4 GO:0018216 peptidyl-arginine methylation(GO:0018216)
0.0 0.4 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.6 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.0 1.2 GO:0008033 tRNA processing(GO:0008033)
0.0 0.8 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.7 GO:0035675 neuromast hair cell development(GO:0035675)
0.0 0.8 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 1.0 GO:0043652 engulfment of apoptotic cell(GO:0043652)
0.0 0.9 GO:0048264 determination of ventral identity(GO:0048264)
0.0 1.5 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.0 0.1 GO:1900060 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.0 0.1 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0 0.2 GO:0032228 regulation of synaptic transmission, GABAergic(GO:0032228)
0.0 0.1 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.6 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 1.2 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.2 GO:0017145 stem cell division(GO:0017145)
0.0 0.6 GO:0001757 somite specification(GO:0001757)
0.0 0.6 GO:0006298 mismatch repair(GO:0006298)
0.0 2.4 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.4 GO:0002115 store-operated calcium entry(GO:0002115)
0.0 0.8 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 0.4 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.2 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.0 0.1 GO:0086013 membrane repolarization during cardiac muscle cell action potential(GO:0086013)
0.0 0.6 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214)
0.0 0.6 GO:0014866 skeletal myofibril assembly(GO:0014866)
0.0 0.1 GO:0015862 uridine transport(GO:0015862) pyrimidine nucleoside transport(GO:0015864)
0.0 0.9 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.8 GO:0006171 cAMP biosynthetic process(GO:0006171)
0.0 0.1 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.6 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.6 GO:0050821 protein stabilization(GO:0050821)
0.0 0.1 GO:0006585 dopamine biosynthetic process from tyrosine(GO:0006585) dopamine biosynthetic process(GO:0042416)
0.0 1.0 GO:0044272 sulfur compound biosynthetic process(GO:0044272)
0.0 0.6 GO:1902593 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.0 0.4 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.4 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 0.2 GO:0045117 azole transport(GO:0045117)
0.0 3.2 GO:0000377 RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 0.5 GO:0060972 left/right pattern formation(GO:0060972)
0.0 0.2 GO:0006094 gluconeogenesis(GO:0006094)
0.0 0.2 GO:0015800 acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490)
0.0 0.3 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 1.4 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.7 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.0 0.5 GO:0051209 release of sequestered calcium ion into cytosol(GO:0051209)
0.0 0.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.1 GO:0031294 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 0.2 GO:1900006 positive regulation of dendrite development(GO:1900006)
0.0 0.1 GO:0046473 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.8 GO:0030336 negative regulation of cell migration(GO:0030336)
0.0 0.3 GO:0032526 response to retinoic acid(GO:0032526)
0.0 0.5 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 1.5 GO:0045055 regulated exocytosis(GO:0045055)
0.0 0.1 GO:0009409 response to cold(GO:0009409)
0.0 0.3 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 2.9 GO:0009101 glycoprotein biosynthetic process(GO:0009101)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.3 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.7 2.0 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.5 0.5 GO:0070938 contractile ring(GO:0070938)
0.4 2.1 GO:0031415 NatA complex(GO:0031415)
0.3 3.6 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.3 1.9 GO:0035517 PR-DUB complex(GO:0035517)
0.3 1.3 GO:0018444 translation release factor complex(GO:0018444)
0.2 0.7 GO:0034457 Mpp10 complex(GO:0034457)
0.2 1.1 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
0.2 1.4 GO:0030681 ribonuclease MRP complex(GO:0000172) multimeric ribonuclease P complex(GO:0030681)
0.2 1.1 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.2 2.7 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 2.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.8 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 0.6 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.1 1.2 GO:0000974 Prp19 complex(GO:0000974)
0.1 3.0 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 0.8 GO:1902555 endoribonuclease complex(GO:1902555)
0.1 0.5 GO:0097268 cytoophidium(GO:0097268)
0.1 0.5 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.1 0.5 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 2.4 GO:0032040 small-subunit processome(GO:0032040)
0.1 0.3 GO:0031362 intrinsic component of external side of plasma membrane(GO:0031233) anchored component of external side of plasma membrane(GO:0031362)
0.1 0.4 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 1.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 1.1 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.1 0.7 GO:0031332 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.1 1.5 GO:0000178 exosome (RNase complex)(GO:0000178)
0.1 0.6 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.1 0.9 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 0.3 GO:0016460 myosin II complex(GO:0016460)
0.1 1.8 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 2.6 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 0.6 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.1 1.5 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 0.8 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 0.6 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1 0.3 GO:0000818 nuclear MIS12/MIND complex(GO:0000818)
0.1 2.7 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.1 GO:0090443 FAR/SIN/STRIPAK complex(GO:0090443)
0.0 0.4 GO:0071007 U2-type catalytic step 2 spliceosome(GO:0071007)
0.0 0.7 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.6 GO:0000124 SAGA complex(GO:0000124)
0.0 0.1 GO:0033391 chromatoid body(GO:0033391)
0.0 0.9 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.3 GO:0031526 brush border membrane(GO:0031526)
0.0 0.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.8 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.3 GO:0032300 mismatch repair complex(GO:0032300)
0.0 1.0 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.9 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.1 GO:0035339 SPOTS complex(GO:0035339)
0.0 1.4 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 7.0 GO:0005730 nucleolus(GO:0005730)
0.0 3.8 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.4 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.3 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.4 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 2.5 GO:0000786 nucleosome(GO:0000786)
0.0 2.7 GO:0016607 nuclear speck(GO:0016607)
0.0 0.4 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.5 GO:0030667 secretory granule membrane(GO:0030667)
0.0 2.5 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 0.2 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.1 GO:0033165 interphotoreceptor matrix(GO:0033165)
0.0 14.2 GO:0005739 mitochondrion(GO:0005739)
0.0 0.1 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.7 GO:0016592 mediator complex(GO:0016592)
0.0 0.3 GO:0005771 multivesicular body(GO:0005771)
0.0 0.2 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.8 GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639)
0.7 2.2 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.7 2.7 GO:0004373 glycogen (starch) synthase activity(GO:0004373)
0.6 1.7 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.5 6.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.5 1.4 GO:0003999 adenine phosphoribosyltransferase activity(GO:0003999)
0.5 1.4 GO:0016436 rRNA (uridine) methyltransferase activity(GO:0016436)
0.4 1.3 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.4 1.2 GO:0034618 arginine binding(GO:0034618)
0.4 1.9 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.4 1.1 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.4 2.5 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262)
0.4 6.8 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.3 2.8 GO:0004849 uridine kinase activity(GO:0004849)
0.3 1.0 GO:0003913 DNA photolyase activity(GO:0003913)
0.3 1.3 GO:0035516 oxidative DNA demethylase activity(GO:0035516)
0.3 1.2 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.3 1.1 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.2 1.1 GO:0016429 tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
0.2 0.7 GO:0048030 disaccharide binding(GO:0048030)
0.2 1.3 GO:0030331 estrogen receptor binding(GO:0030331)
0.2 1.2 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.2 5.1 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.2 1.7 GO:0003834 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.2 0.6 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.2 1.3 GO:0033592 RNA strand annealing activity(GO:0033592) RNA strand-exchange activity(GO:0034057)
0.2 1.6 GO:0008494 translation activator activity(GO:0008494)
0.2 2.7 GO:2001069 glycogen binding(GO:2001069)
0.2 1.5 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.2 2.1 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.2 1.9 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.2 0.8 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.2 2.0 GO:0016783 sulfurtransferase activity(GO:0016783)
0.1 1.5 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.1 0.7 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.1 0.7 GO:0004001 adenosine kinase activity(GO:0004001)
0.1 0.4 GO:0004422 hypoxanthine phosphoribosyltransferase activity(GO:0004422)
0.1 0.7 GO:0030504 inorganic diphosphate transmembrane transporter activity(GO:0030504)
0.1 1.4 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 0.5 GO:0003883 CTP synthase activity(GO:0003883)
0.1 1.9 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 0.5 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.1 0.3 GO:0031752 D5 dopamine receptor binding(GO:0031752)
0.1 0.7 GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
0.1 1.3 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.1 1.3 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.1 2.2 GO:0016854 racemase and epimerase activity(GO:0016854)
0.1 2.3 GO:0022841 leak channel activity(GO:0022840) potassium ion leak channel activity(GO:0022841) narrow pore channel activity(GO:0022842)
0.1 1.7 GO:0008301 DNA binding, bending(GO:0008301)
0.1 0.5 GO:0022889 serine transmembrane transporter activity(GO:0022889)
0.1 0.3 GO:0032034 myosin head/neck binding(GO:0032028) myosin II head/neck binding(GO:0032034) myosin II heavy chain binding(GO:0032038)
0.1 0.3 GO:0033745 L-methionine-(R)-S-oxide reductase activity(GO:0033745)
0.1 2.2 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 0.2 GO:0004736 pyruvate carboxylase activity(GO:0004736)
0.1 0.7 GO:0035198 miRNA binding(GO:0035198)
0.1 0.5 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 2.3 GO:0008483 transaminase activity(GO:0008483)
0.1 1.2 GO:0031386 protein tag(GO:0031386)
0.1 1.3 GO:0045134 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.1 0.3 GO:0016842 amidine-lyase activity(GO:0016842)
0.1 2.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 1.3 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 1.5 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 1.4 GO:0051371 muscle alpha-actinin binding(GO:0051371) alpha-actinin binding(GO:0051393)
0.1 6.8 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 1.1 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1 0.8 GO:0004526 ribonuclease P activity(GO:0004526)
0.1 1.7 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 0.4 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.1 2.6 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 2.0 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 1.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 1.1 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1 0.2 GO:0004427 inorganic diphosphatase activity(GO:0004427)
0.1 0.7 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 1.2 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.5 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.0 3.1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.7 GO:0070628 proteasome binding(GO:0070628)
0.0 0.2 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.5 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.7 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.0 0.5 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.6 GO:0015923 mannosidase activity(GO:0015923)
0.0 0.6 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.3 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.0 1.2 GO:0000049 tRNA binding(GO:0000049)
0.0 0.1 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.0 0.6 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.3 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 2.5 GO:0051536 iron-sulfur cluster binding(GO:0051536) metal cluster binding(GO:0051540)
0.0 1.1 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.3 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.0 0.8 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.4 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.0 0.6 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.4 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.6 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.6 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.2 GO:1901474 azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0 1.2 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 0.4 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.5 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.0 1.8 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.5 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.1 GO:0046592 polyamine oxidase activity(GO:0046592)
0.0 0.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.9 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.1 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.0 0.4 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.1 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.1 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0 0.3 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.4 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 9.6 GO:0046983 protein dimerization activity(GO:0046983)
0.0 0.9 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.0 0.2 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 0.8 GO:0050661 NADP binding(GO:0050661)
0.0 0.1 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.0 0.1 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 1.3 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.1 GO:0036122 BMP binding(GO:0036122)
0.0 0.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 2.3 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.6 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.9 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.1 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 0.2 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.0 0.1 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.0 1.4 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0 0.5 GO:0032451 demethylase activity(GO:0032451)
0.0 0.3 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.1 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 8.2 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.1 5.9 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 1.5 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 2.1 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.1 1.7 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 0.5 PID ALK2 PATHWAY ALK2 signaling events
0.1 0.8 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 2.9 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.9 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.9 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.8 PID BARD1 PATHWAY BARD1 signaling events
0.0 1.1 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.6 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.4 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 1.2 PID TNF PATHWAY TNF receptor signaling pathway
0.0 0.5 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.5 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.9 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.1 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.7 PID E2F PATHWAY E2F transcription factor network
0.0 0.1 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.1 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.3 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.3 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 11.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.5 5.9 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.4 6.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.3 1.9 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.2 1.1 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.2 3.5 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.2 2.2 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 2.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 1.9 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.1 1.4 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 0.8 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 1.1 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.1 2.6 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.1 1.6 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.1 1.6 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.1 1.8 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 1.1 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.1 0.9 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 1.4 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.1 2.7 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 1.9 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 4.1 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.1 0.5 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 0.6 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 0.8 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.1 2.8 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.0 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 2.1 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.0 0.7 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.7 REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS Genes involved in TGF-beta receptor signaling activates SMADs
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.7 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.7 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.2 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.4 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 0.6 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 0.5 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.6 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.0 0.3 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.1 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.1 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.0 0.4 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.0 0.2 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway