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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for mycn
Z-value: 1.61
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Transcription factors associated with mycn
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| mycn | dr11_v1_chr20_+_33294428_33294428 | -0.92 | 9.8e-08 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_-_17099560 Show fit | 5.95 |
ENSDART00000101724
|
v-mos Moloney murine sarcoma viral oncogene homolog |
|
| chr13_-_35907768 Show fit | 4.59 |
ENSDART00000147522
|
MYCL proto-oncogene, bHLH transcription factor a |
|
| chr3_+_24595922 Show fit | 3.45 |
ENSDART00000169405
|
si:dkey-68o6.5 |
|
| chr12_-_33359654 Show fit | 3.10 |
ENSDART00000001907
|
solute carrier family 16 (monocarboxylate transporter), member 3 |
|
| chr12_-_33359052 Show fit | 3.06 |
ENSDART00000135943
|
solute carrier family 16 (monocarboxylate transporter), member 3 |
|
| chr6_+_21001264 Show fit | 2.85 |
ENSDART00000044519
ENSDART00000151278 |
connexin 44.2 |
|
| chr21_-_19919918 Show fit | 2.65 |
ENSDART00000137307
ENSDART00000142523 ENSDART00000065670 |
protein phosphatase 1, regulatory subunit 3B |
|
| chr22_-_26834043 Show fit | 2.61 |
ENSDART00000087202
|
si:dkey-44g23.5 |
|
| chr25_+_17689565 Show fit | 2.50 |
ENSDART00000171965
|
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 18a |
|
| chr7_+_22801465 Show fit | 2.45 |
ENSDART00000052862
ENSDART00000173633 |
RNA binding motif protein 4.1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of mycn
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 9.7 | GO:0006189 | 'de novo' IMP biosynthetic process(GO:0006189) |
| 0.1 | 6.6 | GO:0006400 | tRNA modification(GO:0006400) |
| 2.0 | 5.9 | GO:1901993 | meiotic cell cycle phase transition(GO:0044771) metaphase/anaphase transition of meiotic cell cycle(GO:0044785) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902102) negative regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902103) regulation of meiotic chromosome separation(GO:1905132) negative regulation of meiotic chromosome separation(GO:1905133) |
| 0.5 | 4.3 | GO:0007080 | mitotic metaphase plate congression(GO:0007080) |
| 0.8 | 4.2 | GO:1990481 | mRNA pseudouridine synthesis(GO:1990481) |
| 0.0 | 3.8 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.2 | 3.5 | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) |
| 0.3 | 3.2 | GO:0045807 | positive regulation of endocytosis(GO:0045807) |
| 0.0 | 3.2 | GO:0051028 | mRNA transport(GO:0051028) |
| 0.0 | 3.2 | GO:0000377 | RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.2 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 7.0 | GO:0005730 | nucleolus(GO:0005730) |
| 1.4 | 4.3 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.0 | 3.8 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.3 | 3.6 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.1 | 3.0 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.2 | 2.7 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 2.7 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 2.7 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 2.6 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.6 | GO:0046983 | protein dimerization activity(GO:0046983) |
| 0.4 | 6.8 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.1 | 6.8 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.5 | 6.2 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 1.4 | 5.8 | GO:0004639 | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity(GO:0004639) |
| 0.2 | 5.1 | GO:0034062 | DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062) |
| 0.0 | 3.1 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.3 | 2.8 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.7 | 2.7 | GO:0004373 | glycogen (starch) synthase activity(GO:0004373) |
| 0.2 | 2.7 | GO:2001069 | glycogen binding(GO:2001069) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.2 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 5.9 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 2.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 2.1 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 1.9 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 1.7 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 1.5 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 1.5 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 1.2 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.0 | 1.1 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 11.2 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.4 | 6.2 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.5 | 5.9 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |
| 0.1 | 4.1 | REACTOME DIABETES PATHWAYS | Genes involved in Diabetes pathways |
| 0.2 | 3.5 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.1 | 2.8 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.1 | 2.7 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 2.6 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.2 | 2.2 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.2 | 2.2 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |