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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for nfkb1_rela

Z-value: 0.70

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Transcription factors associated with nfkb1_rela

Gene Symbol Gene ID Gene Info
nfkb1
ENSDARG00000105261 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
rela
ENSDARG00000098696 v-rel avian reticuloendotheliosis viral oncogene homolog A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nfkb1dr11_v1_chr14_-_49859747_498598230.989.9e-13Click!
reladr11_v1_chr7_-_804515_8045150.223.8e-01Click!

Activity profile of nfkb1_rela motif

Sorted Z-values of nfkb1_rela motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_51001985 1.32 ENSDART00000074638
ankrd31
ankyrin repeat domain 31
chr4_-_12795436 1.31 ENSDART00000131026
ENSDART00000075127
b2m
beta-2-microglobulin
chr1_-_37377509 1.29 ENSDART00000113542
tnip2
TNFAIP3 interacting protein 2
chr4_+_3389866 1.18 ENSDART00000153834
sypl1
synaptophysin-like 1
chr5_-_29780752 1.17 ENSDART00000137400
ENSDART00000145021
cfap77
cilia and flagella associated protein 77
chr14_-_49859747 1.17 ENSDART00000169456
ENSDART00000164967
nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr12_+_7445595 1.14 ENSDART00000103536
ENSDART00000152524
phyhiplb
phytanoyl-CoA 2-hydroxylase interacting protein-like b
chr12_+_26471712 1.08 ENSDART00000162115
ndel1a
nudE neurodevelopment protein 1-like 1a
chr14_+_3038473 1.06 ENSDART00000026021
ENSDART00000150000
cd74a
CD74 molecule, major histocompatibility complex, class II invariant chain a
chr23_-_38054 1.02 ENSDART00000170393
CABZ01074076.1

chr22_+_110158 0.99 ENSDART00000143698
prkar2ab
protein kinase, cAMP-dependent, regulatory, type II, alpha, B
chr8_-_48770603 0.96 ENSDART00000159712
pimr184
Pim proto-oncogene, serine/threonine kinase, related 184
chr23_-_45319592 0.92 ENSDART00000189861
ccdc171
coiled-coil domain containing 171
chr25_+_16646113 0.91 ENSDART00000110426
cecr2
cat eye syndrome chromosome region, candidate 2
chr13_+_31497236 0.86 ENSDART00000146752
lrrc9
leucine rich repeat containing 9
chr14_+_21007957 0.86 ENSDART00000162316
pimr194
Pim proto-oncogene, serine/threonine kinase, related 194
chr2_-_879800 0.77 ENSDART00000019733
irf4a
interferon regulatory factor 4a
chr1_-_30039331 0.76 ENSDART00000086935
ENSDART00000143800
MARCH4 (1 of many)
zgc:153256
chr19_+_46259619 0.75 ENSDART00000158032
grinaa
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1a (glutamate binding)
chr14_-_4121052 0.71 ENSDART00000167074
irf2
interferon regulatory factor 2
chr10_-_27196093 0.71 ENSDART00000185282
auts2a
autism susceptibility candidate 2a
chr14_+_21042178 0.69 ENSDART00000168551
pimr192
Pim proto-oncogene, serine/threonine kinase, related 192
chr4_-_149334 0.69 ENSDART00000163280
tbk1
TANK-binding kinase 1
chr23_+_31815423 0.68 ENSDART00000075730
ENSDART00000075726
myb
v-myb avian myeloblastosis viral oncogene homolog
chr6_-_436658 0.67 ENSDART00000191515
grap2b
GRB2-related adaptor protein 2b
chr20_+_22045089 0.65 ENSDART00000063564
ENSDART00000187013
ENSDART00000161552
ENSDART00000174478
ENSDART00000063568
ENSDART00000152247
nmu
neuromedin U
chr20_+_48100261 0.64 ENSDART00000158604
xkr5a
XK related 5a
chr16_-_22225295 0.64 ENSDART00000163519
LO017682.1

chr8_+_53269657 0.61 ENSDART00000184212
gnb1a
guanine nucleotide binding protein (G protein), beta polypeptide 1a
chr3_-_31619463 0.60 ENSDART00000124559
moto
minamoto
chr25_-_7723685 0.59 ENSDART00000146882
phf21ab
PHD finger protein 21Ab
chr23_-_12423778 0.59 ENSDART00000124091
wfdc2
WAP four-disulfide core domain 2
chr14_-_31080183 0.56 ENSDART00000173282
mbnl3
muscleblind-like splicing regulator 3
chr25_+_5288665 0.56 ENSDART00000169540
CABZ01039861.1

chr17_+_42027969 0.55 ENSDART00000147563
kiz
kizuna centrosomal protein
chr3_+_46459540 0.54 ENSDART00000188150
si:ch211-66e2.5
si:ch211-66e2.5
chr6_-_55254786 0.54 ENSDART00000113805
nfatc2b
nuclear factor of activated T cells 2b
chr8_-_7475917 0.54 ENSDART00000082157
gata1b
GATA binding protein 1b
chr20_+_16881883 0.53 ENSDART00000130107
nfkbiaa
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a
chr25_+_3347461 0.52 ENSDART00000104888
slc35b4
solute carrier family 35, member B4
chr25_-_13188214 0.52 ENSDART00000187298
si:ch211-147m6.1
si:ch211-147m6.1
chr9_+_993477 0.51 ENSDART00000182045
CABZ01066921.1

chr5_+_13385837 0.51 ENSDART00000191190
ccl19a.1
chemokine (C-C motif) ligand 19a, tandem duplicate 1
chr23_-_43609595 0.50 ENSDART00000172222
CABZ01117603.1

chr9_+_26103814 0.50 ENSDART00000026011
efnb2a
ephrin-B2a
chr10_+_7029664 0.49 ENSDART00000166206
psd3l
pleckstrin and Sec7 domain containing 3, like
chr5_-_65968957 0.49 ENSDART00000161004
ttc16
tetratricopeptide repeat domain 16
chr16_-_41004731 0.49 ENSDART00000102591
KCNV1
si:dkey-201i6.2
chr8_-_38477817 0.49 ENSDART00000075989
inpp5l
inositol polyphosphate-5-phosphatase L
chr14_-_4120636 0.49 ENSDART00000059230
irf2
interferon regulatory factor 2
chr2_+_16780643 0.48 ENSDART00000125647
ENSDART00000108611
ENSDART00000181245
ENSDART00000163194
tfa
transferrin-a
chr15_-_25010400 0.48 ENSDART00000155236
si:ch211-198e20.10
si:ch211-198e20.10
chr15_-_25083200 0.48 ENSDART00000156053
pimr191
Pim proto-oncogene, serine/threonine kinase, related 191
chr24_+_41273252 0.47 ENSDART00000105526
nub1
negative regulator of ubiquitin-like proteins 1
chr1_-_59232267 0.47 ENSDART00000169658
ENSDART00000163257
akap8l
A kinase (PRKA) anchor protein 8-like
chr11_-_35763323 0.47 ENSDART00000026017
bhlhe40
basic helix-loop-helix family, member e40
chr19_+_7124337 0.46 ENSDART00000031380
tap2a
transporter associated with antigen processing, subunit type a
chr6_-_53160459 0.46 ENSDART00000128127
slc38a3b
solute carrier family 38, member 3b
chr22_+_508290 0.45 ENSDART00000135403
nuak2
NUAK family, SNF1-like kinase, 2
chr2_+_36004381 0.44 ENSDART00000098706
lamc2
laminin, gamma 2
chr17_+_14425219 0.43 ENSDART00000153994
ccdc175
coiled-coil domain containing 175
chr19_-_7144548 0.42 ENSDART00000147177
ENSDART00000134850
psmb8a
psmb13a
proteasome subunit beta 8A
proteasome subunit beta 13a
chr8_+_25302172 0.42 ENSDART00000046182
ENSDART00000145316
gstm.3
glutathione S-transferase mu tandem duplicate 3
chr12_+_20641102 0.42 ENSDART00000152964
calcoco2
calcium binding and coiled-coil domain 2
chr5_+_37032038 0.41 ENSDART00000045036
nfkbib
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr11_-_27917730 0.40 ENSDART00000173219
eif4g3a
eukaryotic translation initiation factor 4 gamma, 3a
chr7_+_1383027 0.40 ENSDART00000143762
khnyn
KH and NYN domain containing
chr17_-_51195651 0.40 ENSDART00000191205
ENSDART00000088185
paplna
papilin a, proteoglycan-like sulfated glycoprotein
chr22_+_38301365 0.40 ENSDART00000137339
traf5
Tnf receptor-associated factor 5
chr14_+_36889893 0.40 ENSDART00000124159
si:ch211-132p1.3
si:ch211-132p1.3
chr5_+_28308774 0.40 ENSDART00000087708
si:dkeyp-86b9.1
si:dkeyp-86b9.1
chr16_-_24819860 0.38 ENSDART00000183874
kcnn4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr17_-_10315644 0.38 ENSDART00000168572
ttc6
tetratricopeptide repeat domain 6
chr5_+_24086227 0.38 ENSDART00000051549
ENSDART00000177458
ENSDART00000135934
tp53
tumor protein p53
chr19_+_770300 0.37 ENSDART00000062518
gstr
glutathione S-transferase rho
chr5_-_63425428 0.37 ENSDART00000163246
cntrl
centriolin
chr18_-_4957022 0.36 ENSDART00000101686
zbbx
zinc finger, B-box domain containing
chr18_-_18543358 0.36 ENSDART00000126460
il34
interleukin 34
chr25_-_1333676 0.35 ENSDART00000183182
ENSDART00000188907
cln6b
CLN6, transmembrane ER protein b
chr16_-_24832038 0.35 ENSDART00000153731
si:dkey-79d12.5
si:dkey-79d12.5
chr23_+_19701587 0.35 ENSDART00000104425
dnase1l1
deoxyribonuclease I-like 1
chr11_+_8129536 0.34 ENSDART00000158112
ENSDART00000011183
prkacba
protein kinase, cAMP-dependent, catalytic, beta a
chr22_-_16180467 0.33 ENSDART00000171331
ENSDART00000185607
vcam1b
vascular cell adhesion molecule 1b
chr4_+_2059692 0.32 ENSDART00000067427
yeats4
YEATS domain containing 4
chr9_-_889567 0.32 ENSDART00000155921
si:ch73-250a16.5
si:ch73-250a16.5
chr22_-_651719 0.32 ENSDART00000148692
apobec2a
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2a
chr12_-_19151708 0.32 ENSDART00000057124
tefa
thyrotrophic embryonic factor a
chr23_-_31974060 0.31 ENSDART00000168087
BX927210.1

chr13_-_31452516 0.31 ENSDART00000193268
rtn1a
reticulon 1a
chr4_-_12914163 0.30 ENSDART00000140002
ENSDART00000145917
ENSDART00000141355
ENSDART00000067135
msrb3
methionine sulfoxide reductase B3
chr16_+_10346277 0.30 ENSDART00000081092
si:dkeyp-77h1.4
si:dkeyp-77h1.4
chr19_+_19767567 0.30 ENSDART00000169074
hoxa3a
homeobox A3a
chr17_-_51893123 0.30 ENSDART00000103350
ENSDART00000017329
numb
numb homolog (Drosophila)
chr23_-_32162810 0.30 ENSDART00000155905
nr4a1
nuclear receptor subfamily 4, group A, member 1
chr7_-_38861741 0.30 ENSDART00000173629
ENSDART00000037361
ENSDART00000173953
phf21aa
PHD finger protein 21Aa
chr14_+_50937757 0.30 ENSDART00000163865
rnf44
ring finger protein 44
chr1_+_12135129 0.29 ENSDART00000126020
spink4
serine peptidase inhibitor, Kazal type 4
chr20_-_6196989 0.29 ENSDART00000013343
b4galt6
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6
chr11_+_35050253 0.29 ENSDART00000124800
fam212aa
family with sequence similarity 212, member Aa
chr14_-_30967284 0.28 ENSDART00000149435
il2rgb
interleukin 2 receptor, gamma b
chr8_+_10823069 0.28 ENSDART00000081341
mapk13
mitogen-activated protein kinase 13
chr15_+_27364394 0.28 ENSDART00000122101
tbx2b
T-box 2b
chr25_-_1235457 0.27 ENSDART00000093093
coro2bb
coronin, actin binding protein, 2Bb
chr19_-_44801918 0.27 ENSDART00000108507
CSMD3 (1 of many)
si:ch211-233f16.1
chr19_-_7043355 0.27 ENSDART00000104845
tapbp.1
TAP binding protein (tapasin), tandem duplicate 1
chr17_-_26604946 0.27 ENSDART00000087062
fam149b1
family with sequence similarity 149, member B1
chr3_-_2591942 0.26 ENSDART00000127971
si:dkey-217f16.5
si:dkey-217f16.5
chr3_+_35406395 0.26 ENSDART00000055266
ENSDART00000150918
rbbp6
retinoblastoma binding protein 6
chr2_-_2642476 0.26 ENSDART00000124032
serbp1b
SERPINE1 mRNA binding protein 1b
chr6_-_442163 0.26 ENSDART00000163564
ENSDART00000189134
ENSDART00000169789
grap2b
GRB2-related adaptor protein 2b
chr22_+_28969071 0.26 ENSDART00000163427
pimr95
Pim proto-oncogene, serine/threonine kinase, related 95
chr3_-_39695856 0.26 ENSDART00000148247
b9d1
B9 protein domain 1
chr23_-_29003864 0.26 ENSDART00000148257
casz1
castor zinc finger 1
chr2_+_2737422 0.25 ENSDART00000032459
aqp1a.1
aquaporin 1a (Colton blood group), tandem duplicate 1
chr21_+_45223194 0.25 ENSDART00000150902
si:ch73-269m14.3
si:ch73-269m14.3
chr10_+_31646020 0.25 ENSDART00000115251
esama
endothelial cell adhesion molecule a
chr9_+_41156287 0.24 ENSDART00000189195
ENSDART00000186270
stat4
signal transducer and activator of transcription 4
chr25_+_10458990 0.24 ENSDART00000130354
ENSDART00000044738
ric8a
RIC8 guanine nucleotide exchange factor A
chr16_+_13855039 0.24 ENSDART00000113764
ENSDART00000143983
zgc:174888
zgc:174888
chr8_+_25629722 0.24 ENSDART00000026807
wasa
Wiskott-Aldrich syndrome (eczema-thrombocytopenia) a
chr3_+_13190012 0.24 ENSDART00000179747
ENSDART00000109876
ENSDART00000124824
ENSDART00000130261
sun1
Sad1 and UNC84 domain containing 1
chr22_+_30184039 0.24 ENSDART00000049075
add3a
adducin 3 (gamma) a
chr22_-_34591295 0.24 ENSDART00000044429
rnf123
ring finger protein 123
chr23_+_10347851 0.23 ENSDART00000127667
krt18
keratin 18
chr25_-_6557854 0.23 ENSDART00000181740
cspg4
chondroitin sulfate proteoglycan 4
chr13_+_27316934 0.23 ENSDART00000164533
eef1a1a
eukaryotic translation elongation factor 1 alpha 1a
chr7_-_28696556 0.23 ENSDART00000148822
adgrg1
adhesion G protein-coupled receptor G1
chr4_-_22311610 0.23 ENSDART00000137814
hcls1
hematopoietic cell-specific Lyn substrate 1
chr20_-_35076387 0.23 ENSDART00000019196
lft1
lefty1
chr3_-_2592350 0.23 ENSDART00000192325
si:dkey-217f16.5
si:dkey-217f16.5
chr21_+_30937690 0.22 ENSDART00000022562
rhogb
ras homolog family member Gb
chr9_+_41156818 0.22 ENSDART00000105764
ENSDART00000147052
stat4
signal transducer and activator of transcription 4
chr14_+_49382180 0.22 ENSDART00000158329
tnip1
TNFAIP3 interacting protein 1
chr15_+_32727848 0.22 ENSDART00000161361
postnb
periostin, osteoblast specific factor b
chr6_-_19333947 0.22 ENSDART00000160887
gga3
ggolgi-associated, gamma adaptin ear containing, ARF binding protein 3
chr5_+_30608057 0.22 ENSDART00000133583
si:ch211-117m20.4
si:ch211-117m20.4
chr23_-_36418059 0.22 ENSDART00000135232
znf740b
zinc finger protein 740b
chr13_-_10727550 0.22 ENSDART00000190925
ppm1ba
protein phosphatase, Mg2+/Mn2+ dependent, 1Ba
chr13_-_7474324 0.22 ENSDART00000162550
si:dkey-196h17.9
si:dkey-196h17.9
chr7_+_22585447 0.21 ENSDART00000149144
chrnb1l
cholinergic receptor, nicotinic, beta 1 (muscle) like
chr5_+_15819651 0.21 ENSDART00000081230
ENSDART00000186969
ENSDART00000134206
hspb8
heat shock protein b8
chr12_-_18961491 0.21 ENSDART00000172574
ep300a
E1A binding protein p300 a
chr7_+_19835569 0.21 ENSDART00000149812
ovol1a
ovo-like zinc finger 1a
chr11_+_8565828 0.21 ENSDART00000126523
tbl1xr1a
transducin (beta)-like 1 X-linked receptor 1a
chr17_+_23255365 0.21 ENSDART00000180277
AL935174.5

chr2_-_5836116 0.21 ENSDART00000142545
mier1b
mesoderm induction early response 1b, transcriptional regulator
chr5_+_24882633 0.21 ENSDART00000111302
rhbdd3
rhomboid domain containing 3
chr6_-_21616659 0.20 ENSDART00000074256
ppp1r12c
protein phosphatase 1, regulatory subunit 12C
chr21_-_22693730 0.20 ENSDART00000158342
gig2d
grass carp reovirus (GCRV)-induced gene 2d
chr13_+_32148338 0.20 ENSDART00000188591
osr1
odd-skipped related transciption factor 1
chr3_+_35406998 0.20 ENSDART00000102994
rbbp6
retinoblastoma binding protein 6
chr10_-_10969444 0.20 ENSDART00000138041
exd3
exonuclease 3'-5' domain containing 3
chr1_+_17892944 0.20 ENSDART00000013021
tlr3
toll-like receptor 3
chr12_-_30760971 0.20 ENSDART00000066257
entpd1
ectonucleoside triphosphate diphosphohydrolase 1
chr15_-_21678634 0.20 ENSDART00000061139
bco2b
beta-carotene oxygenase 2b
chr25_-_3469576 0.19 ENSDART00000186738
hbp1
HMG-box transcription factor 1
chr9_+_13733468 0.19 ENSDART00000165954
ENSDART00000160355
ENSDART00000081040
ENSDART00000138254
ENSDART00000081015
ENSDART00000141314
abi2a
abl-interactor 2a
chr3_-_32170850 0.19 ENSDART00000055307
ENSDART00000157366
tnnt1
troponin T type 1 (skeletal, slow)
chr24_-_33703504 0.19 ENSDART00000079292
cavin4b
caveolae associated protein 4b
chr2_-_51772438 0.19 ENSDART00000170241
BX908782.2
Danio rerio three-finger protein 5 (LOC100003647), mRNA.
chr20_+_46371458 0.18 ENSDART00000152912
adgrg11
adhesion G protein-coupled receptor G11
chr13_+_30692669 0.18 ENSDART00000187818
CR762483.1

chr16_+_23403602 0.18 ENSDART00000159848
s100w
S100 calcium binding protein W
chr24_+_25919809 0.18 ENSDART00000006615
map3k15
mitogen-activated protein kinase kinase kinase 15
chr4_-_22519516 0.18 ENSDART00000130409
ENSDART00000186258
ENSDART00000002851
ENSDART00000123801
kdm7aa
lysine (K)-specific demethylase 7Aa
chr8_+_22355909 0.18 ENSDART00000146457
ENSDART00000142883
zgc:153631
zgc:153631
chr14_+_49376011 0.18 ENSDART00000020961
tnip1
TNFAIP3 interacting protein 1
chr3_-_26524934 0.18 ENSDART00000087118
xylt1
xylosyltransferase I
chr18_+_27738349 0.18 ENSDART00000187816
tspan18b
tetraspanin 18b
chr2_-_50966124 0.18 ENSDART00000170470
ghrhra
growth hormone releasing hormone receptor a
chr18_+_27821856 0.18 ENSDART00000131712
si:ch211-222m18.4
si:ch211-222m18.4
chr16_+_50006872 0.18 ENSDART00000157100
ube2e2
ubiquitin-conjugating enzyme E2E 2
chr14_+_45028062 0.18 ENSDART00000184717
ENSDART00000185481
ATP8A1
ATPase phospholipid transporting 8A1
chr23_+_42819221 0.17 ENSDART00000180495
myl9a
myosin, light chain 9a, regulatory
chr7_+_56472585 0.17 ENSDART00000135259
ENSDART00000073596
ist1
increased sodium tolerance 1 homolog (yeast)
chr6_+_58915889 0.17 ENSDART00000083628
ddit3
DNA-damage-inducible transcript 3
chr12_+_49100365 0.17 ENSDART00000171905
CABZ01075125.1

chr6_-_35310224 0.17 ENSDART00000148997
nos1apa
nitric oxide synthase 1 (neuronal) adaptor protein a
chr6_-_10305918 0.17 ENSDART00000090994
scn1lab
sodium channel, voltage-gated, type I like, alpha b
chr13_-_25819825 0.17 ENSDART00000077612
rel
v-rel avian reticuloendotheliosis viral oncogene homolog
chr6_-_49078263 0.17 ENSDART00000032982
slc5a8l
solute carrier family 5 (iodide transporter), member 8-like
chr16_+_26766423 0.17 ENSDART00000048036
gem
GTP binding protein overexpressed in skeletal muscle
chr5_-_42883761 0.17 ENSDART00000167374
BX323596.2

chr4_+_20263097 0.16 ENSDART00000138820
lrtm2a
leucine-rich repeats and transmembrane domains 2a
chr22_+_3045495 0.16 ENSDART00000164061
LO017843.1

chr3_-_40976288 0.16 ENSDART00000193553
cyp3c1
cytochrome P450, family 3, subfamily c, polypeptide 1
chr5_+_41143563 0.16 ENSDART00000011229
sub1b
SUB1 homolog, transcriptional regulator b
chr16_+_32995882 0.15 ENSDART00000170157
prss35
protease, serine, 35
chr7_-_40082053 0.15 ENSDART00000083719
ENSDART00000173687
shrprbck1r
sharpin and rbck1 related
chr16_+_54829293 0.15 ENSDART00000024729
pabpc1a
poly(A) binding protein, cytoplasmic 1a
chr20_-_39367895 0.15 ENSDART00000136476
ENSDART00000021788
ENSDART00000180784
pbk
PDZ binding kinase
chr19_+_19412692 0.15 ENSDART00000113580
wu:fc38h03
wu:fc38h03
chr5_+_13373593 0.15 ENSDART00000051668
ENSDART00000183883
ccl19a.2
chemokine (C-C motif) ligand 19a, tandem duplicate 2
chr9_-_52999318 0.15 ENSDART00000176601
CABZ01054965.1

chr23_+_4483083 0.15 ENSDART00000092389
nup210
nucleoporin 210
chr7_-_37812176 0.14 ENSDART00000164485
adcy7
adenylate cyclase 7
chr10_+_3965565 0.14 ENSDART00000185405
TTC28
tetratricopeptide repeat domain 28
chr2_+_33052169 0.14 ENSDART00000180008
rnf220a
ring finger protein 220a
chr8_+_53452681 0.14 ENSDART00000166705
cacna1db
calcium channel, voltage-dependent, L type, alpha 1D subunit, b
chr2_+_3044992 0.14 ENSDART00000020463
zgc:63882
zgc:63882

Network of associatons between targets according to the STRING database.

First level regulatory network of nfkb1_rela

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0034138 toll-like receptor 3 signaling pathway(GO:0034138)
0.4 1.1 GO:1902230 macrophage cytokine production(GO:0010934) regulation of macrophage cytokine production(GO:0010935) positive regulation of macrophage cytokine production(GO:0060907) negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.2 0.8 GO:0002320 lymphoid progenitor cell differentiation(GO:0002320)
0.2 1.1 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.2 0.5 GO:1901533 negative regulation of hematopoietic progenitor cell differentiation(GO:1901533)
0.1 0.7 GO:0045658 regulation of granulocyte differentiation(GO:0030852) regulation of neutrophil differentiation(GO:0045658)
0.1 0.4 GO:0010526 regulation of transposition, RNA-mediated(GO:0010525) negative regulation of transposition, RNA-mediated(GO:0010526) transposition, RNA-mediated(GO:0032197) positive regulation of neuron apoptotic process(GO:0043525) positive regulation of neuron death(GO:1901216)
0.1 0.4 GO:0045649 regulation of macrophage differentiation(GO:0045649)
0.1 0.5 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787) regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.1 0.5 GO:0006867 asparagine transport(GO:0006867)
0.1 0.3 GO:0043388 positive regulation of DNA binding(GO:0043388)
0.1 0.5 GO:0007412 axon target recognition(GO:0007412)
0.1 1.1 GO:0019731 antibacterial humoral response(GO:0019731)
0.1 1.3 GO:0034122 regulation of toll-like receptor signaling pathway(GO:0034121) negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.1 0.3 GO:0072025 distal convoluted tubule development(GO:0072025) late distal convoluted tubule development(GO:0072068)
0.1 0.6 GO:0045475 locomotor rhythm(GO:0045475)
0.1 0.1 GO:0001562 response to protozoan(GO:0001562) defense response to protozoan(GO:0042832)
0.1 0.6 GO:0007141 male meiosis I(GO:0007141)
0.1 0.3 GO:0003097 renal water homeostasis(GO:0003091) renal water transport(GO:0003097)
0.1 1.3 GO:0048016 inositol phosphate-mediated signaling(GO:0048016)
0.1 0.3 GO:0030091 protein repair(GO:0030091)
0.1 0.8 GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902108)
0.1 0.2 GO:0048389 intermediate mesoderm development(GO:0048389)
0.1 1.0 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 0.3 GO:0060017 parathyroid gland development(GO:0060017)
0.1 0.6 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.1 0.3 GO:0010737 protein kinase A signaling(GO:0010737)
0.1 0.7 GO:0006940 regulation of smooth muscle contraction(GO:0006940)
0.0 0.2 GO:0070445 regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.0 0.1 GO:0070314 G1 to G0 transition(GO:0070314)
0.0 0.4 GO:1902624 positive regulation of neutrophil migration(GO:1902624)
0.0 0.2 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway(GO:2001244)
0.0 0.1 GO:0035994 response to muscle stretch(GO:0035994)
0.0 0.7 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.7 GO:0060324 face development(GO:0060324)
0.0 0.1 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.2 GO:1901841 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.0 0.3 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0 0.2 GO:0071405 response to methanol(GO:0033986) cellular response to methanol(GO:0071405)
0.0 0.2 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.0 0.2 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.2 GO:0070285 pigment cell development(GO:0070285)
0.0 0.3 GO:0035462 determination of left/right asymmetry in diencephalon(GO:0035462) determination of left/right asymmetry in nervous system(GO:0035545)
0.0 0.1 GO:0072003 kidney rudiment formation(GO:0072003) pronephros formation(GO:0072116)
0.0 0.2 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.0 0.2 GO:0033292 T-tubule organization(GO:0033292)
0.0 0.1 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.3 GO:0019883 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.2 GO:0051601 exocyst localization(GO:0051601)
0.0 0.2 GO:0016119 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.0 0.1 GO:1903400 L-arginine import(GO:0043091) amino acid import across plasma membrane(GO:0089718) arginine import(GO:0090467) L-arginine import across plasma membrane(GO:0097638) L-arginine transport(GO:1902023) L-arginine import into cell(GO:1902765) amino acid import into cell(GO:1902837) L-arginine transmembrane transport(GO:1903400) arginine transmembrane transport(GO:1903826)
0.0 0.5 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.3 GO:0016203 muscle attachment(GO:0016203)
0.0 0.4 GO:0000737 DNA catabolic process, endonucleolytic(GO:0000737)
0.0 0.1 GO:0035477 regulation of angioblast cell migration involved in selective angioblast sprouting(GO:0035477)
0.0 0.1 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.0 0.4 GO:0046686 response to cadmium ion(GO:0046686)
0.0 0.1 GO:0015677 copper ion import(GO:0015677)
0.0 0.1 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.0 0.1 GO:0006953 acute-phase response(GO:0006953)
0.0 0.7 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.1 GO:0002676 granuloma formation(GO:0002432) chronic inflammatory response(GO:0002544) regulation of granuloma formation(GO:0002631) regulation of chronic inflammatory response(GO:0002676)
0.0 0.4 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 0.2 GO:2000403 positive regulation of lymphocyte migration(GO:2000403) positive regulation of T cell migration(GO:2000406)
0.0 0.2 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.2 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.2 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.1 GO:0048662 regulation of smooth muscle cell proliferation(GO:0048660) negative regulation of smooth muscle cell proliferation(GO:0048662)
0.0 0.0 GO:0030857 negative regulation of epithelial cell differentiation(GO:0030857)
0.0 0.4 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.5 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.2 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.0 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.1 GO:0061056 sclerotome development(GO:0061056)
0.0 0.3 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.0 0.5 GO:0008643 carbohydrate transport(GO:0008643)
0.0 0.2 GO:1902622 regulation of neutrophil migration(GO:1902622)
0.0 0.0 GO:0035971 peptidyl-histidine dephosphorylation(GO:0035971)
0.0 0.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.4 GO:0006749 glutathione metabolic process(GO:0006749)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 1.1 GO:0042611 MHC protein complex(GO:0042611) MHC class II protein complex(GO:0042613)
0.1 1.0 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.9 GO:0031010 ISWI-type complex(GO:0031010)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:0060171 stereocilium membrane(GO:0060171)
0.0 0.2 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.2 GO:0071797 LUBAC complex(GO:0071797)
0.0 0.3 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.3 GO:0036038 MKS complex(GO:0036038)
0.0 0.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 1.2 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.4 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.1 GO:0061673 mitotic spindle astral microtubule(GO:0061673)
0.0 1.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1 0.5 GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity(GO:0005462)
0.1 0.3 GO:0008489 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity(GO:0008489)
0.1 1.4 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 0.4 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.1 0.5 GO:0005290 L-histidine transmembrane transporter activity(GO:0005290) L-asparagine transmembrane transporter activity(GO:0015182)
0.1 0.4 GO:0043295 glutathione binding(GO:0043295)
0.1 0.3 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 0.5 GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659)
0.1 0.3 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.1 1.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.3 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.2 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0 0.2 GO:0035575 histone demethylase activity (H4-K20 specific)(GO:0035575)
0.0 0.3 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.3 GO:0008158 hedgehog receptor activity(GO:0008158)
0.0 0.4 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.0 0.3 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.3 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
0.0 1.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.4 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.0 0.2 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0030504 inorganic diphosphate transmembrane transporter activity(GO:0030504)
0.0 0.1 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.2 GO:0035252 UDP-xylosyltransferase activity(GO:0035252)
0.0 0.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.2 GO:0003834 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.0 0.2 GO:0043495 protein anchor(GO:0043495)
0.0 0.2 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.1 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.0 0.1 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0 0.7 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.4 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.5 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.4 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.6 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.1 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.0 0.1 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.2 GO:0004382 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.0 1.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.2 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 0.1 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.0 GO:0005153 interleukin-8 receptor binding(GO:0005153)
0.0 0.2 GO:0048495 Roundabout binding(GO:0048495)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 PID IL23 PATHWAY IL23-mediated signaling events
0.0 1.4 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 1.4 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.4 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.5 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.7 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.4 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.3 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.3 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.1 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.2 PID ARF 3PATHWAY Arf1 pathway
0.0 0.3 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.1 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.4 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.4 PID BCR 5PATHWAY BCR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.2 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 0.2 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.3 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.4 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.1 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 1.3 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.5 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.2 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.1 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.5 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.3 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.1 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.1 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.2 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.1 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.0 0.3 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.3 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 0.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.8 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production