Project

PRJNA438478: RNAseq of wild type zebrafish germline

Navigation
Downloads

Results for nkx2.1

Z-value: 0.22

Motif logo

logo of

Transcription factors associated with nkx2.1

Gene Symbol Gene ID Gene Info
nkx2.1
ENSDARG00000019835 NK2 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx2.1dr11_v1_chr17_+_38262408_38262408-0.341.7e-01Click!

Activity profile of nkx2.1 motif

Sorted Z-values of nkx2.1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_26237322 0.45 ENSDART00000030520
palm1b
paralemmin 1b
chr5_-_54712159 0.41 ENSDART00000149207
ccnb1
cyclin B1
chr12_+_30788912 0.40 ENSDART00000160422
aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr20_-_38827623 0.37 ENSDART00000153310
cad
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr14_-_33478963 0.36 ENSDART00000132813
lamp2
lysosomal-associated membrane protein 2
chr23_-_33558161 0.36 ENSDART00000018301
itga5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr1_-_23294753 0.35 ENSDART00000013263
ugdh
UDP-glucose 6-dehydrogenase
chr2_+_26240339 0.35 ENSDART00000191006
palm1b
paralemmin 1b
chr17_-_12249990 0.33 ENSDART00000177889
ENSDART00000155545
ahctf1
AT hook containing transcription factor 1
chr21_+_34132747 0.33 ENSDART00000148115
trpc5b
transient receptor potential cation channel, subfamily C, member 5b
chr3_-_30888415 0.32 ENSDART00000124458
kmt5c
lysine methyltransferase 5C
chr19_-_6983002 0.31 ENSDART00000104891
znf384l
zinc finger protein 384 like
chr3_+_17933132 0.30 ENSDART00000104299
ENSDART00000162144
ENSDART00000162242
ENSDART00000166289
ENSDART00000171101
ENSDART00000164853
cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
chr21_+_34088377 0.28 ENSDART00000170070
mtmr1b
myotubularin related protein 1b
chr4_-_14531687 0.25 ENSDART00000182093
ENSDART00000159447
plxnb2a
plexin b2a
chr7_+_34602991 0.24 ENSDART00000073447
fhod1
formin homology 2 domain containing 1
chr1_+_27977297 0.22 ENSDART00000180692
ENSDART00000166819
sugt1
SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
chr2_+_19195841 0.21 ENSDART00000163137
ENSDART00000161095
elovl1a
ELOVL fatty acid elongase 1a
chr7_-_64770456 0.21 ENSDART00000192618
zdhhc21
zinc finger, DHHC-type containing 21
chr6_+_38880166 0.21 ENSDART00000019939
ENSDART00000144286
bin2b
bridging integrator 2b
chr3_+_17846890 0.21 ENSDART00000193384
znf385c
zinc finger protein 385C
chr7_-_24875421 0.21 ENSDART00000173920
adad2
adenosine deaminase domain containing 2
chr6_+_38879961 0.20 ENSDART00000184798
bin2b
bridging integrator 2b
chr22_-_5724085 0.20 ENSDART00000110526
ENSDART00000140905
pgbd4
piggyBac transposable element derived 4
chr19_+_7292654 0.19 ENSDART00000140459
ccdc127b
coiled-coil domain containing 127b
chr19_+_7292445 0.18 ENSDART00000026634
ccdc127b
coiled-coil domain containing 127b
chr11_-_24063196 0.18 ENSDART00000036513
trib3
tribbles pseudokinase 3
chr7_-_59123066 0.17 ENSDART00000175438
dennd4c
DENN/MADD domain containing 4C
chr17_+_24597001 0.17 ENSDART00000191834
rlf
rearranged L-myc fusion
chr4_-_9054947 0.17 ENSDART00000109764
si:dkey-48p11.3
si:dkey-48p11.3
chr15_-_23482088 0.16 ENSDART00000185823
ENSDART00000185523
nlrx1
NLR family member X1
chr25_+_25124684 0.16 ENSDART00000167542
ldha
lactate dehydrogenase A4
chr22_+_28818291 0.16 ENSDART00000136032
tp53bp2b
tumor protein p53 binding protein, 2b
chr3_+_17933553 0.16 ENSDART00000167731
ENSDART00000165644
cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
chr2_-_37401600 0.15 ENSDART00000015723
prkci
protein kinase C, iota
chr22_+_8753092 0.15 ENSDART00000140720
si:dkey-182g1.2
si:dkey-182g1.2
chr20_+_9128829 0.14 ENSDART00000064144
ENSDART00000137450
bpnt1
bisphosphate nucleotidase 1
chr14_-_16476863 0.14 ENSDART00000089021
canx
calnexin
chr4_-_2052687 0.13 ENSDART00000138291
ENSDART00000150844
cpsf6
cleavage and polyadenylation specific factor 6
chr7_-_48733662 0.13 ENSDART00000191675
traf6
TNF receptor-associated factor 6
chr21_-_2162850 0.12 ENSDART00000159731
gb:ai877918
expressed sequence AI877918
chr6_-_18531760 0.12 ENSDART00000167167
utp6
UTP6, small subunit (SSU) processome component, homolog (yeast)
chr1_-_53756851 0.12 ENSDART00000122445
akt3b
v-akt murine thymoma viral oncogene homolog 3b
chr7_+_1442059 0.12 ENSDART00000173391
si:cabz01090193.1
si:cabz01090193.1
chr17_+_33999630 0.11 ENSDART00000167085
ENSDART00000155030
ENSDART00000168522
ENSDART00000191799
ENSDART00000189684
ENSDART00000153942
ENSDART00000187272
ENSDART00000127692
gphna
gephyrin a
chr12_+_34953038 0.10 ENSDART00000187022
ENSDART00000123988
ENSDART00000027034
qki2
QKI, KH domain containing, RNA binding 2
chr2_-_11119303 0.10 ENSDART00000135450
ENSDART00000131836
cryz
crystallin, zeta (quinone reductase)
chr3_+_22335030 0.10 ENSDART00000055676
zgc:103564
zgc:103564
chr9_-_7089303 0.09 ENSDART00000146609
coa5
cytochrome C oxidase assembly factor 5
chr15_-_18429550 0.08 ENSDART00000136208
ncam1b
neural cell adhesion molecule 1b
chr15_-_434503 0.08 ENSDART00000122286
CABZ01056629.1

chr7_+_25825667 0.08 ENSDART00000149835
mtm1
myotubularin 1
chr21_-_2348838 0.08 ENSDART00000160337
si:ch73-299h12.8
si:ch73-299h12.8
chr11_+_25596038 0.07 ENSDART00000140856
ccdc120
coiled-coil domain containing 120
chr3_+_39600562 0.07 ENSDART00000134309
ENSDART00000007170
prpsap2
phosphoribosyl pyrophosphate synthetase-associated protein 2
chr13_+_27040887 0.07 ENSDART00000132714
soul2
heme-binding protein soul2
chr25_-_17590971 0.07 ENSDART00000189942
mmp15a
matrix metallopeptidase 15a
chr7_-_23777445 0.07 ENSDART00000173527
si:ch211-200p22.4
si:ch211-200p22.4
chr7_+_48555626 0.06 ENSDART00000125483
ENSDART00000083514
kcnq1
potassium voltage-gated channel, KQT-like subfamily, member 1
chr7_+_24390939 0.06 ENSDART00000087494
ENSDART00000125463
haus3
HAUS augmin-like complex, subunit 3
chr22_-_24248420 0.06 ENSDART00000165433
rgs2
regulator of G protein signaling 2
chr17_+_48314724 0.06 ENSDART00000125617
smoc1
SPARC related modular calcium binding 1
chr22_+_39096911 0.05 ENSDART00000157127
ENSDART00000153841
lmcd1
LIM and cysteine-rich domains 1
chr7_+_48555400 0.05 ENSDART00000174474
kcnq1
potassium voltage-gated channel, KQT-like subfamily, member 1
chr14_+_10656975 0.05 ENSDART00000127594
ENSDART00000125865
atrx
alpha thalassemia/mental retardation syndrome X-linked homolog (human)
chr5_-_64511428 0.05 ENSDART00000016321
rxrab
retinoid x receptor, alpha b
chr17_+_23975762 0.04 ENSDART00000155941
xpo1b
exportin 1 (CRM1 homolog, yeast) b
chr5_-_35456269 0.04 ENSDART00000051312
ttc33
tetratricopeptide repeat domain 33
chr19_-_10394931 0.04 ENSDART00000191549
zgc:194578
zgc:194578
chr4_+_76403698 0.04 ENSDART00000184821
ENSDART00000169373
FP074874.2
FP074874.1


chr11_+_37909654 0.04 ENSDART00000172211
si:ch211-112f3.4
si:ch211-112f3.4
chr18_-_46020138 0.03 ENSDART00000027772
pcyt1ab
phosphate cytidylyltransferase 1, choline, alpha b
chr14_-_10321851 0.03 ENSDART00000143382
il1rapl2
interleukin 1 receptor accessory protein-like 2
chr15_-_31357634 0.03 ENSDART00000127485
or111-2
odorant receptor, family D, subfamily 111, member 2
chr1_+_57040472 0.03 ENSDART00000181365
si:ch211-1f22.16
si:ch211-1f22.16
chr2_+_314249 0.03 ENSDART00000082086
zgc:113452
zgc:113452
chr3_-_23461954 0.03 ENSDART00000040065
casc3
cancer susceptibility candidate 3
chr25_-_28674739 0.03 ENSDART00000067073
lrrc10
leucine rich repeat containing 10
chr1_+_16621345 0.03 ENSDART00000149026
pcm1
pericentriolar material 1
chr8_-_44298964 0.02 ENSDART00000098520
fzd10
frizzled class receptor 10
chr25_-_20691075 0.02 ENSDART00000067373
edc3
enhancer of mRNA decapping 3 homolog (S. cerevisiae)
chr12_-_19862912 0.02 ENSDART00000145788
shisa9a
shisa family member 9a
chr7_-_32833153 0.02 ENSDART00000099871
ENSDART00000099872
slc17a6b
solute carrier family 17 (vesicular glutamate transporter), member 6b
chr7_+_16991711 0.02 ENSDART00000173660
nav2a
neuron navigator 2a
chr4_-_3805992 0.02 ENSDART00000190125
si:dkey-61f9.1
si:dkey-61f9.1
chr20_+_46255057 0.02 ENSDART00000100536
taar14i
trace amine associated receptor 14i
chr14_-_11507211 0.02 ENSDART00000186873
ENSDART00000109181
ENSDART00000186166
ENSDART00000186986
zgc:174917
zgc:174917
chr8_-_20243389 0.02 ENSDART00000184904
acer1
alkaline ceramidase 1
chr11_+_43403525 0.02 ENSDART00000180683
vipb
vasoactive intestinal peptide b
chr4_-_50926767 0.02 ENSDART00000183430
si:ch211-208f21.3
si:ch211-208f21.3
chr16_+_5539189 0.01 ENSDART00000178106
CR848788.2

chr7_-_30639385 0.01 ENSDART00000173618
myo1ea
myosin IE, a
chr2_-_59345920 0.01 ENSDART00000134662
ftr37
finTRIM family, member 37
chr4_-_75812937 0.01 ENSDART00000125096
si:ch211-203c5.3
si:ch211-203c5.3
chr15_-_4053149 0.01 ENSDART00000189076
CR626884.4

chr18_-_22701800 0.01 ENSDART00000135098
si:ch73-113g13.3
si:ch73-113g13.3
chr1_+_8304904 0.01 ENSDART00000168631
cacna1hb
calcium channel, voltage-dependent, T type, alpha 1H subunit b
chr1_-_43862638 0.01 ENSDART00000145044
tacr3a
tachykinin receptor 3a
chr15_-_23508214 0.01 ENSDART00000115051
abcg4b
ATP-binding cassette, sub-family G (WHITE), member 4b
chr13_+_25412307 0.01 ENSDART00000175339
calhm1
calcium homeostasis modulator 1
chr7_-_3895071 0.01 ENSDART00000175200
si:dkey-88n24.11
si:dkey-88n24.11
chr7_-_3894831 0.00 ENSDART00000172921
si:dkey-88n24.11
si:dkey-88n24.11
chr2_-_9646857 0.00 ENSDART00000056901
zgc:153615
zgc:153615
chr22_+_38762693 0.00 ENSDART00000015016
ENSDART00000150187
alpi.1
alkaline phosphatase, intestinal, tandem duplicate 1

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx2.1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0021563 glossopharyngeal nerve development(GO:0021563)
0.1 0.3 GO:0034773 histone H4-K20 methylation(GO:0034770) histone H4-K20 trimethylation(GO:0034773)
0.1 0.4 GO:0071800 podosome assembly(GO:0071800)
0.1 0.3 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.1 0.4 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
0.1 0.4 GO:0003188 heart valve formation(GO:0003188) atrioventricular valve formation(GO:0003190)
0.0 0.4 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.0 0.4 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.0 0.1 GO:0046833 regulation of nucleobase-containing compound transport(GO:0032239) positive regulation of nucleobase-containing compound transport(GO:0032241) positive regulation of nucleocytoplasmic transport(GO:0046824) regulation of RNA export from nucleus(GO:0046831) positive regulation of RNA export from nucleus(GO:0046833) messenger ribonucleoprotein complex assembly(GO:1990120)
0.0 0.1 GO:0071470 cellular response to osmotic stress(GO:0071470)
0.0 0.2 GO:0045217 establishment or maintenance of polarity of embryonic epithelium(GO:0016332) cell-cell junction maintenance(GO:0045217)
0.0 0.1 GO:0072579 establishment of synaptic specificity at neuromuscular junction(GO:0007529) molybdenum incorporation into molybdenum-molybdopterin complex(GO:0018315) metal incorporation into metallo-molybdopterin complex(GO:0042040) glycine receptor clustering(GO:0072579)
0.0 0.4 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 0.1 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.5 GO:0009214 cyclic nucleotide catabolic process(GO:0009214)
0.0 0.2 GO:0006382 adenosine to inosine editing(GO:0006382)
0.0 0.1 GO:0090299 regulation of neural crest formation(GO:0090299)
0.0 0.1 GO:0070498 interleukin-1-mediated signaling pathway(GO:0070498)
0.0 0.2 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.0 0.2 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 0.3 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.1 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.2 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.2 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.1 0.4 GO:0031310 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.1 0.4 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.1 GO:0042382 paraspeckles(GO:0042382)
0.0 0.2 GO:0005915 cell-cell adherens junction(GO:0005913) zonula adherens(GO:0005915)
0.0 0.1 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.0 0.1 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.2 GO:0000813 ESCRT I complex(GO:0000813)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113)
0.1 0.4 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.1 0.3 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.1 0.4 GO:0003979 UDP-glucose 6-dehydrogenase activity(GO:0003979)
0.1 0.4 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 0.2 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 0.4 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.1 GO:0061598 molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599)
0.0 0.1 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.0 0.2 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.2 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.4 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.2 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.9 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.4 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.1 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.2 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.3 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 0.4 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.4 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.0 0.2 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.4 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1