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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for nkx2.4a+nkx2.4b

Z-value: 0.32

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Transcription factors associated with nkx2.4a+nkx2.4b

Gene Symbol Gene ID Gene Info
nkx2.4a
ENSDARG00000075107 NK2 homeobox 4a
nkx2.4b
ENSDARG00000104107 NK2 homeobox 4b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx2.4bdr11_v1_chr20_+_48803248_48803248-0.643.9e-03Click!
nkx2.4adr11_v1_chr17_-_42097267_42097267-0.039.2e-01Click!

Activity profile of nkx2.4a+nkx2.4b motif

Sorted Z-values of nkx2.4a+nkx2.4b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_23294753 0.89 ENSDART00000013263
ugdh
UDP-glucose 6-dehydrogenase
chr1_+_31657842 0.78 ENSDART00000057880
poll
polymerase (DNA directed), lambda
chr1_+_31658011 0.74 ENSDART00000192203
poll
polymerase (DNA directed), lambda
chr15_-_28569786 0.68 ENSDART00000127845
ssh2a
slingshot protein phosphatase 2a
chr8_-_39884359 0.67 ENSDART00000131372
mlec
malectin
chr16_+_25259313 0.60 ENSDART00000058938
fbxo32
F-box protein 32
chr8_-_22558773 0.58 ENSDART00000074309
porcnl
porcupine O-acyltransferase like
chr1_-_38171648 0.53 ENSDART00000137451
ENSDART00000047159
hmgb2a
high mobility group box 2a
chr22_-_18241390 0.52 ENSDART00000083879
tmem161a
transmembrane protein 161A
chr22_-_18240968 0.50 ENSDART00000027605
tmem161a
transmembrane protein 161A
chr23_+_27778670 0.49 ENSDART00000053863
kmt2d
lysine (K)-specific methyltransferase 2D
chr7_+_13830052 0.48 ENSDART00000191360
abhd2a
abhydrolase domain containing 2a
chr9_+_2762270 0.47 ENSDART00000123342
ENSDART00000001795
ENSDART00000177563
sp3a
sp3a transcription factor
chr7_+_39416336 0.47 ENSDART00000171783
CT030188.1

chr24_+_19210001 0.46 ENSDART00000179373
ENSDART00000139299
zgc:162928
zgc:162928
chr8_-_39859688 0.45 ENSDART00000019907
unc119.1
unc-119 homolog 1
chr15_-_28904371 0.45 ENSDART00000155154
eml2
echinoderm microtubule associated protein like 2
chr19_-_38419575 0.44 ENSDART00000087639
smap2
small ArfGAP2
chr24_-_205275 0.44 ENSDART00000108762
vopp1
VOPP1, WBP1/VOPP1 family member
chr9_+_22634073 0.42 ENSDART00000181822
etv5a
ets variant 5a
chr19_-_25113660 0.42 ENSDART00000035538
ptp4a3
protein tyrosine phosphatase type IVA, member 3
chr24_-_5691956 0.41 ENSDART00000189112
dia1b
deleted in autism 1b
chr10_-_10018120 0.41 ENSDART00000132375
strbp
spermatid perinuclear RNA binding protein
chr20_+_23742574 0.40 ENSDART00000050559
sh3rf1
SH3 domain containing ring finger 1
chr10_+_5268054 0.39 ENSDART00000114491
ror2
receptor tyrosine kinase-like orphan receptor 2
chr3_-_26805455 0.39 ENSDART00000180648
pigq
phosphatidylinositol glycan anchor biosynthesis, class Q
chr22_-_21897203 0.38 ENSDART00000158501
ENSDART00000105566
ENSDART00000136795
gna11a
guanine nucleotide binding protein (G protein), alpha 11a (Gq class)
chr9_+_4378153 0.36 ENSDART00000191264
ENSDART00000182384
kalrna
kalirin RhoGEF kinase a
chr15_+_34963316 0.36 ENSDART00000153840
si:ch73-95l15.5
si:ch73-95l15.5
chr1_+_22654875 0.36 ENSDART00000019698
ENSDART00000161874
anxa5b
annexin A5b
chr2_+_47754419 0.34 ENSDART00000188221
mbnl1
muscleblind-like splicing regulator 1
chr14_+_16083818 0.34 ENSDART00000168462
rnf103
ring finger protein 103
chr7_+_29163762 0.33 ENSDART00000173762
slc38a8b
solute carrier family 38, member 8b
chr2_+_36608387 0.32 ENSDART00000159541
pak2a
p21 protein (Cdc42/Rac)-activated kinase 2a
chr5_-_54554583 0.31 ENSDART00000158865
ENSDART00000158069
ssna1
Sjogren syndrome nuclear autoantigen 1
chr1_-_28950366 0.31 ENSDART00000110270
pwp2h
PWP2 periodic tryptophan protein homolog (yeast)
chr14_+_23709134 0.30 ENSDART00000191162
ENSDART00000179754
ENSDART00000054266
gnpda1
glucosamine-6-phosphate deaminase 1
chr13_-_4018888 0.30 ENSDART00000058238
tjap1
tight junction associated protein 1 (peripheral)
chr7_+_7630409 0.30 ENSDART00000172934
clcn3
chloride channel 3
chr18_+_50669456 0.29 ENSDART00000163005
si:dkey-151j17.4
si:dkey-151j17.4
chr1_+_45671687 0.28 ENSDART00000146101
mcoln1a
mucolipin 1a
chr5_-_39171302 0.28 ENSDART00000020808
paqr3a
progestin and adipoQ receptor family member IIIa
chr14_+_23709543 0.28 ENSDART00000136909
gnpda1
glucosamine-6-phosphate deaminase 1
chr15_-_14193926 0.28 ENSDART00000162707
pnkp
polynucleotide kinase 3'-phosphatase
chr23_-_33709964 0.28 ENSDART00000143333
ENSDART00000130338
pou6f1
POU class 6 homeobox 1
chr7_+_42206847 0.28 ENSDART00000149250
phkb
phosphorylase kinase, beta
chr15_-_14194208 0.28 ENSDART00000188237
ENSDART00000183155
ENSDART00000165520
pnkp
polynucleotide kinase 3'-phosphatase
chr10_-_15048781 0.28 ENSDART00000038401
ENSDART00000155674
si:ch211-95j8.2
si:ch211-95j8.2
chr15_-_23485752 0.27 ENSDART00000152706
nlrx1
NLR family member X1
chr12_+_27243059 0.27 ENSDART00000066269
arl4d
ADP-ribosylation factor-like 4D
chr2_-_38284648 0.27 ENSDART00000148281
ENSDART00000132621
si:ch211-14a17.7
si:ch211-14a17.7
chr12_-_22238004 0.27 ENSDART00000038310
ormdl3
ORMDL sphingolipid biosynthesis regulator 3
chr23_+_4348265 0.26 ENSDART00000136287
mybl2a
v-myb avian myeloblastosis viral oncogene homolog-like 2a
chr19_+_32401278 0.26 ENSDART00000184353
atxn1a
ataxin 1a
chr23_+_4348479 0.26 ENSDART00000182425
mybl2a
v-myb avian myeloblastosis viral oncogene homolog-like 2a
chr7_+_39664055 0.25 ENSDART00000146171
zgc:158564
zgc:158564
chr13_-_48388726 0.25 ENSDART00000169473
fbxo11a
F-box protein 11a
chr23_+_39346774 0.22 ENSDART00000190985
src
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr13_-_51846224 0.22 ENSDART00000184663
LT631684.2

chr19_-_17303500 0.22 ENSDART00000162355
sf3a3
splicing factor 3a, subunit 3
chr8_-_23776399 0.21 ENSDART00000114800
INAVA
si:ch211-163l21.4
chr19_+_40250682 0.21 ENSDART00000102888
cdk6
cyclin-dependent kinase 6
chr25_-_14424406 0.21 ENSDART00000073609
prmt7
protein arginine methyltransferase 7
chr5_-_28915130 0.20 ENSDART00000078592
npdc1b
neural proliferation, differentiation and control, 1b
chr2_-_11648731 0.20 ENSDART00000080925
impad1
inositol monophosphatase domain containing 1
chr17_-_8673567 0.20 ENSDART00000192714
ENSDART00000012546
ctbp2a
C-terminal binding protein 2a
chr3_-_39305291 0.19 ENSDART00000102674
plcd3a
phospholipase C, delta 3a
chr17_-_8673278 0.19 ENSDART00000171850
ENSDART00000017337
ENSDART00000148504
ENSDART00000148808
ctbp2a
C-terminal binding protein 2a
chr2_+_16652238 0.19 ENSDART00000091351
gk5
glycerol kinase 5 (putative)
chr23_-_35347714 0.19 ENSDART00000161770
ENSDART00000165615
cpne9
copine family member IX
chr4_+_23127104 0.19 ENSDART00000139543
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr17_-_22552678 0.19 ENSDART00000079401
si:ch211-125o16.4
si:ch211-125o16.4
chr7_+_26049818 0.19 ENSDART00000173611
si:dkey-6n21.12
si:dkey-6n21.12
chr1_+_29862074 0.18 ENSDART00000133905
ENSDART00000136786
ENSDART00000135252
pcca
propionyl CoA carboxylase, alpha polypeptide
chr2_+_23731194 0.18 ENSDART00000155747
slc22a13a
solute carrier family 22 member 13a
chr6_+_18367388 0.18 ENSDART00000163394
dgke
diacylglycerol kinase, epsilon
chr25_-_1079417 0.17 ENSDART00000163134
FO907089.1

chr22_+_8753092 0.17 ENSDART00000140720
si:dkey-182g1.2
si:dkey-182g1.2
chr19_+_23982466 0.16 ENSDART00000080673
syt11a
synaptotagmin XIa
chr23_+_39346930 0.16 ENSDART00000102843
src
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr20_-_43079478 0.16 ENSDART00000060982
snx9b
sorting nexin 9b
chr3_-_29891456 0.16 ENSDART00000151677
ENSDART00000014021
slc25a39
solute carrier family 25, member 39
chr5_+_36896933 0.16 ENSDART00000151984
srsf7a
serine/arginine-rich splicing factor 7a
chr14_-_30876708 0.16 ENSDART00000147597
ubl3b
ubiquitin-like 3b
chr4_-_22335247 0.14 ENSDART00000192781
golgb1
golgin B1
chr3_+_32571929 0.14 ENSDART00000151025
si:ch73-248e21.1
si:ch73-248e21.1
chr8_-_51293265 0.14 ENSDART00000127875
ENSDART00000181145
bmp1a
bone morphogenetic protein 1a
chr24_-_28259127 0.14 ENSDART00000149589
prkag2a
protein kinase, AMP-activated, gamma 2 non-catalytic subunit a
chr8_+_23485079 0.14 ENSDART00000026316
sema3gb
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Gb
chr12_+_32199651 0.14 ENSDART00000153027
si:ch211-277e21.1
si:ch211-277e21.1
chr20_-_27190393 0.14 ENSDART00000149024
btbd7
BTB (POZ) domain containing 7
chr7_+_13639473 0.13 ENSDART00000157870
ENSDART00000032899
clpxa
caseinolytic mitochondrial matrix peptidase chaperone subunit a
chr14_-_30876299 0.13 ENSDART00000180305
ubl3b
ubiquitin-like 3b
chr6_+_49028874 0.13 ENSDART00000175254
slc16a1a
solute carrier family 16 (monocarboxylate transporter), member 1a
chr8_-_30316436 0.13 ENSDART00000111358
ENSDART00000167065
zgc:162939
zgc:162939
chr8_-_22698651 0.13 ENSDART00000181411
iqsec2a
IQ motif and Sec7 domain 2a
chr4_+_23126558 0.12 ENSDART00000162859
mdm2
MDM2 oncogene, E3 ubiquitin protein ligase
chr3_-_11008532 0.12 ENSDART00000165086
CR382337.3

chr10_+_9346383 0.12 ENSDART00000064975
ENSDART00000141869
rbm18
RNA binding motif protein 18
chr10_+_31244619 0.12 ENSDART00000145562
ENSDART00000184412
robo4
roundabout, axon guidance receptor, homolog 4 (Drosophila)
chr17_+_8184649 0.12 ENSDART00000091818
tulp4b
tubby like protein 4b
chr2_-_6292510 0.12 ENSDART00000092182
ppm1la
protein phosphatase, Mg2+/Mn2+ dependent, 1La
chr5_+_63767376 0.12 ENSDART00000138898
rgs3b
regulator of G protein signaling 3b
chr13_-_13294847 0.11 ENSDART00000125883
ENSDART00000013534
fgfr3
fibroblast growth factor receptor 3
chr5_+_56119975 0.10 ENSDART00000083137
mrm1
mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
chr24_+_33392698 0.10 ENSDART00000122579
si:ch73-173p19.1
si:ch73-173p19.1
chr10_-_9086716 0.09 ENSDART00000140095
arl15b
ADP-ribosylation factor-like 15b
chr5_-_33825465 0.09 ENSDART00000110645
dab2ipb
DAB2 interacting protein b
chr24_+_3307857 0.09 ENSDART00000106527
gyg1b
glycogenin 1b
chr16_-_49505275 0.09 ENSDART00000160784
satb1b
SATB homeobox 1b
chr10_+_573667 0.09 ENSDART00000110384
smad4a
SMAD family member 4a
chr19_+_26424734 0.08 ENSDART00000187402
npr1a
natriuretic peptide receptor 1a
chr2_-_32668668 0.08 ENSDART00000190450
puf60a
poly-U binding splicing factor a
chr5_+_36611128 0.07 ENSDART00000097684
nova1
neuro-oncological ventral antigen 1
chr11_+_22109887 0.07 ENSDART00000122136
MDFI
si:dkey-91m3.1
chr14_+_23158021 0.07 ENSDART00000084664
enox2
ecto-NOX disulfide-thiol exchanger 2
chr22_-_7457247 0.06 ENSDART00000106081
BX511034.2

chr7_-_26049282 0.06 ENSDART00000136389
ENSDART00000101124
rnaseka
ribonuclease, RNase K a
chr19_+_7938121 0.06 ENSDART00000140053
ENSDART00000146649
si:dkey-266f7.5
si:dkey-266f7.5
chr14_-_32486757 0.05 ENSDART00000148830
mcf2a
MCF.2 cell line derived transforming sequence a
chr21_+_17110598 0.05 ENSDART00000101282
ENSDART00000191864
bcr
breakpoint cluster region
chr8_+_53120278 0.05 ENSDART00000125232
nr2c2
nuclear receptor subfamily 2, group C, member 2
chr17_-_28097760 0.05 ENSDART00000149861
kdm1a
lysine (K)-specific demethylase 1a
chr4_+_1146346 0.05 ENSDART00000166467
chrm2a
cholinergic receptor, muscarinic 2a
chr12_+_19208338 0.05 ENSDART00000110415
sh3bp1
SH3-domain binding protein 1
chr18_-_7481036 0.05 ENSDART00000101292
si:dkey-238c7.16
si:dkey-238c7.16
chr13_-_42530656 0.05 ENSDART00000084327
btaf1
BTAF1 RNA polymerase II, B-TFIID transcription factor-associated
chr24_-_13272842 0.04 ENSDART00000146790
ENSDART00000066703
rdh10a
retinol dehydrogenase 10a
chr23_+_34321237 0.04 ENSDART00000173272
plxna1a
plexin A1a
chr7_-_18601206 0.04 ENSDART00000111636
DTX4
si:ch211-119e14.2
chr9_+_25832329 0.04 ENSDART00000130059
zeb2a
zinc finger E-box binding homeobox 2a
chr23_+_42254960 0.04 ENSDART00000102980
zcchc11
zinc finger, CCHC domain containing 11
chr13_-_2112008 0.04 ENSDART00000110814
fam83b
family with sequence similarity 83, member B
chr3_+_33340939 0.04 ENSDART00000128786
pyya
peptide YYa
chr1_-_59232267 0.03 ENSDART00000169658
ENSDART00000163257
akap8l
A kinase (PRKA) anchor protein 8-like
chr1_-_34612613 0.03 ENSDART00000004361
klf5a
Kruppel-like factor 5a
chr12_-_11768889 0.03 ENSDART00000057866
atoh1c
atonal bHLH transcription factor 1c
chr17_+_27456804 0.03 ENSDART00000017756
ENSDART00000181461
ENSDART00000180178
ctsl.1
cathepsin L.1
chr23_-_18982499 0.03 ENSDART00000012507
bcl2l1
bcl2-like 1
chr2_-_24407732 0.03 ENSDART00000180612
ENSDART00000153688
ENSDART00000179913
si:dkey-208k22.6
si:dkey-208k22.6
chr16_+_23924040 0.02 ENSDART00000161124
si:dkey-7f3.14
si:dkey-7f3.14
chr16_-_34258931 0.02 ENSDART00000145485
phactr4b
phosphatase and actin regulator 4b
chr15_+_17441734 0.02 ENSDART00000153729
snx19b
sorting nexin 19b
chr8_-_49345388 0.02 ENSDART00000053203
plp2
proteolipid protein 2
chr1_-_14234076 0.02 ENSDART00000040049
camk2d2
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2
chr14_-_9982603 0.02 ENSDART00000054687
il1rapl2
interleukin 1 receptor accessory protein-like 2
chr15_-_8517555 0.02 ENSDART00000140213
npas1
neuronal PAS domain protein 1
chr21_+_30084823 0.02 ENSDART00000154573
prob1
proline-rich basic protein 1
chr17_-_32698503 0.01 ENSDART00000157175
ENSDART00000077439
kcnk2a
potassium channel, subfamily K, member 2a
chr8_-_47152001 0.01 ENSDART00000163922
ENSDART00000110512
ENSDART00000024320
ybx1
Y box binding protein 1
chr4_+_54618332 0.01 ENSDART00000171824
si:ch211-227e10.2
si:ch211-227e10.2
chr15_-_26552652 0.01 ENSDART00000152336
serpinf2b
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2b
chr6_-_46782176 0.01 ENSDART00000185559
igfn1.4
immunoglobulin-like and fibronectin type III domain containing 1, tandem duplicate 4
chr21_-_41147818 0.01 ENSDART00000167339
ENSDART00000192730
msx2b
muscle segment homeobox 2b
chr20_+_35484070 0.01 ENSDART00000026234
ENSDART00000141675
mep1a.2
meprin A, alpha (PABA peptide hydrolase), tandem duplicate 2
chr8_-_29658171 0.01 ENSDART00000147755
mpeg1.3
macrophage expressed 1, tandem duplicate 3
chr4_-_60312069 0.00 ENSDART00000167207
si:dkey-248e17.4
si:dkey-248e17.4
chr3_+_4047789 0.00 ENSDART00000148498
si:dkeyp-52c3.5
si:dkeyp-52c3.5
chr25_+_19485198 0.00 ENSDART00000156730
glsl
glutaminase like
chr6_-_42073367 0.00 ENSDART00000154304
grm2a
glutamate receptor, metabotropic 2a

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx2.4a+nkx2.4b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0006041 glucosamine metabolic process(GO:0006041) glucosamine catabolic process(GO:0006043)
0.2 0.6 GO:0061355 Wnt protein secretion(GO:0061355)
0.1 0.4 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
0.1 0.9 GO:0003188 heart valve formation(GO:0003188) atrioventricular valve formation(GO:0003190)
0.1 0.5 GO:0051792 medium-chain fatty acid biosynthetic process(GO:0051792)
0.1 0.4 GO:0036037 CD8-positive, alpha-beta T cell activation(GO:0036037)
0.1 0.2 GO:0071514 genetic imprinting(GO:0071514)
0.1 0.6 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.1 0.3 GO:1900060 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.1 0.3 GO:1904036 negative regulation of epithelial cell apoptotic process(GO:1904036)
0.1 0.4 GO:0070073 clustering of voltage-gated calcium channels(GO:0070073)
0.1 0.5 GO:0003422 growth plate cartilage morphogenesis(GO:0003422) chondrocyte intercalation involved in growth plate cartilage morphogenesis(GO:0003428)
0.1 1.5 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 0.1 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.0 0.4 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.0 0.2 GO:0019563 glycerol catabolic process(GO:0019563)
0.0 0.2 GO:0035332 positive regulation of hippo signaling(GO:0035332)
0.0 0.2 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.0 0.4 GO:0042953 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.0 0.1 GO:0032964 collagen biosynthetic process(GO:0032964)
0.0 0.2 GO:0050819 negative regulation of coagulation(GO:0050819)
0.0 0.4 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 0.3 GO:2000344 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.0 0.4 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.0 0.1 GO:0007624 ultradian rhythm(GO:0007624)
0.0 0.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.3 GO:0035675 neuromast hair cell development(GO:0035675)
0.0 0.4 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.1 GO:0010459 cardiac conduction system development(GO:0003161) negative regulation of heart rate(GO:0010459)
0.0 0.1 GO:0038026 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948) reelin-mediated signaling pathway(GO:0038026)
0.0 0.3 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 0.3 GO:0035339 SPOTS complex(GO:0035339)
0.1 0.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 0.2 GO:0043034 costamere(GO:0043034)
0.0 0.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0 0.5 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.3 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0003979 UDP-glucose 6-dehydrogenase activity(GO:0003979)
0.2 0.6 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.2 0.6 GO:0046403 polynucleotide 3'-phosphatase activity(GO:0046403)
0.1 0.5 GO:0008126 acetylesterase activity(GO:0008126)
0.1 0.2 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.1 1.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.4 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 0.4 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.3 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0 1.0 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.5 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.2 GO:0016421 CoA carboxylase activity(GO:0016421)
0.0 0.5 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.2 GO:0016530 metallochaperone activity(GO:0016530)
0.0 0.4 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.3 GO:0032190 acrosin binding(GO:0032190)
0.0 0.2 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.4 ST STAT3 PATHWAY STAT3 Pathway
0.0 0.3 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.4 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.6 PID FOXO PATHWAY FoxO family signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.9 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.0 0.7 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.0 0.4 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.3 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.3 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 0.1 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation