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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for nr2e1

Z-value: 0.90

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Transcription factors associated with nr2e1

Gene Symbol Gene ID Gene Info
nr2e1
ENSDARG00000017107 nuclear receptor subfamily 2, group E, member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr2e1dr11_v1_chr20_-_32446406_324464060.806.6e-05Click!

Activity profile of nr2e1 motif

Sorted Z-values of nr2e1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_14272083 2.93 ENSDART00000169986
tctex1d1
Tctex1 domain containing 1
chr12_+_18533198 2.54 ENSDART00000189729
meiob
meiosis specific with OB domains
chr25_-_12515741 2.44 ENSDART00000159487
si:ch211-280a23.2
si:ch211-280a23.2
chr2_-_14271874 2.38 ENSDART00000189390
tctex1d1
Tctex1 domain containing 1
chr23_+_3731375 2.36 ENSDART00000141782
smim29
small integral membrane protein 29
chr18_+_31016379 2.35 ENSDART00000172461
ENSDART00000163471
uraha
urate (5-hydroxyiso-) hydrolase a
chr18_-_41232297 2.28 ENSDART00000036928
fbxo36a
F-box protein 36a
chr7_-_30367650 2.27 ENSDART00000075519
aldh1a2
aldehyde dehydrogenase 1 family, member A2
chr14_-_858985 2.25 ENSDART00000148687
ENSDART00000149375
slc34a1a
solute carrier family 34 (type II sodium/phosphate cotransporter), member 1a
chr4_-_73709502 2.21 ENSDART00000170308
BX855614.3

chr16_-_35392926 2.07 ENSDART00000164482
si:dkey-34d22.3
si:dkey-34d22.3
chr6_-_31364475 1.96 ENSDART00000145715
ENSDART00000134370
ak4
adenylate kinase 4
chr17_-_12408109 1.95 ENSDART00000155509
ankef1b
ankyrin repeat and EF-hand domain containing 1b
chr12_-_23128746 1.89 ENSDART00000170018
armc4
armadillo repeat containing 4
chr25_-_16160494 1.87 ENSDART00000146880
si:dkey-80c24.4
si:dkey-80c24.4
chr7_+_73332486 1.86 ENSDART00000174119
ENSDART00000092051
ENSDART00000192388
CABZ01081780.1

chr1_+_44003654 1.64 ENSDART00000131337
si:dkey-22i16.10
si:dkey-22i16.10
chr23_+_44497701 1.63 ENSDART00000149903
si:ch73-375g18.1
si:ch73-375g18.1
chr10_+_10351685 1.62 ENSDART00000109432
cercam
cerebral endothelial cell adhesion molecule
chr16_-_39178979 1.43 ENSDART00000158894
si:dkey-99n20.6
si:dkey-99n20.6
chr24_+_35827766 1.43 ENSDART00000144700
si:dkeyp-7a3.1
si:dkeyp-7a3.1
chr25_-_15507523 1.40 ENSDART00000134166
si:dkeyp-67e1.3
si:dkeyp-67e1.3
chr18_-_37407235 1.39 ENSDART00000132315
cep126
centrosomal protein 126
chr1_+_44336897 1.39 ENSDART00000157578
si:ch211-165a10.1
si:ch211-165a10.1
chr1_+_7546259 1.36 ENSDART00000015732
mylz3
myosin, light polypeptide 3, skeletal muscle
chr7_+_26029672 1.30 ENSDART00000101126
alox12
arachidonate 12-lipoxygenase
chr1_+_57311901 1.28 ENSDART00000149397
mycbpap
mycbp associated protein
chr15_-_39948635 1.25 ENSDART00000114836
msh5
mutS homolog 5
chr15_-_1822548 1.24 ENSDART00000082026
ENSDART00000180230
mmp28
matrix metallopeptidase 28
chr20_-_46554440 1.19 ENSDART00000043298
ENSDART00000060680
fosab
v-fos FBJ murine osteosarcoma viral oncogene homolog Ab
chr13_-_12660318 1.19 ENSDART00000008498
adh8a
alcohol dehydrogenase 8a
chr17_+_21760032 1.19 ENSDART00000190425
ikzf5
IKAROS family zinc finger 5
chr17_+_14784275 1.16 ENSDART00000005355
rtraf
RNA transcription, translation and transport factor
chr1_-_46244523 1.10 ENSDART00000143908
si:ch211-138g9.3
si:ch211-138g9.3
chr15_-_1822166 1.10 ENSDART00000156883
mmp28
matrix metallopeptidase 28
chr22_+_28969071 1.10 ENSDART00000163427
pimr95
Pim proto-oncogene, serine/threonine kinase, related 95
chr20_+_30725778 1.10 ENSDART00000062532
nhsl1b
NHS-like 1b
chr2_+_17524278 1.09 ENSDART00000165633
pimr196
Pim proto-oncogene, serine/threonine kinase, related 196
chr24_+_23742690 1.08 ENSDART00000130162
TCF24
transcription factor 24
chr6_-_52723901 1.08 ENSDART00000033949
oser1
oxidative stress responsive serine-rich 1
chr18_+_3530769 1.07 ENSDART00000163469
si:ch73-338a16.3
si:ch73-338a16.3
chr21_-_25801956 1.07 ENSDART00000101219
mettl27
methyltransferase like 27
chr5_-_48285756 1.03 ENSDART00000183495
mef2cb
myocyte enhancer factor 2cb
chr19_+_29798064 1.02 ENSDART00000167803
ENSDART00000051804
marcksl1b
MARCKS-like 1b
chr20_-_1176631 0.98 ENSDART00000152255
gabrr2b
gamma-aminobutyric acid (GABA) A receptor, rho 2b
chr9_+_3388099 0.95 ENSDART00000019910
dlx1a
distal-less homeobox 1a
chr12_+_7491690 0.95 ENSDART00000152564
phyhiplb
phytanoyl-CoA 2-hydroxylase interacting protein-like b
chr19_+_9533008 0.91 ENSDART00000104607
fam131ba
family with sequence similarity 131, member Ba
chr5_+_30680804 0.90 ENSDART00000078049
pdzd3b
PDZ domain containing 3b
chr1_-_9130136 0.88 ENSDART00000113013
palb2
partner and localizer of BRCA2
chr1_+_12009673 0.84 ENSDART00000080100
slc24a2
solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
chr7_-_29571615 0.81 ENSDART00000019140
rorab
RAR-related orphan receptor A, paralog b
chr20_+_33294428 0.80 ENSDART00000024104
mycn
MYCN proto-oncogene, bHLH transcription factor
chr17_+_12408188 0.79 ENSDART00000105218
khk
ketohexokinase
chr9_-_6380653 0.73 ENSDART00000078523
ecrg4a
esophageal cancer related gene 4a
chr14_-_40389699 0.72 ENSDART00000181581
ENSDART00000173398
pcdh19
protocadherin 19
chr3_-_62393449 0.72 ENSDART00000101870
ENSDART00000140782
ENSDART00000181704
proza
protein Z, vitamin K-dependent plasma glycoprotein a
chr1_+_14348399 0.71 ENSDART00000064468
crmp1
collapsin response mediator protein 1
chr2_+_21486529 0.70 ENSDART00000047468
inhbab
inhibin, beta Ab
chr3_-_26017592 0.70 ENSDART00000030890
hmox1a
heme oxygenase 1a
chr14_-_45604667 0.70 ENSDART00000167016
si:ch211-276i12.9
si:ch211-276i12.9
chr15_-_4485828 0.66 ENSDART00000062868
tfdp2
transcription factor Dp-2
chr7_-_41693004 0.65 ENSDART00000121509
malrd1
MAM and LDL receptor class A domain containing 1
chr3_-_26017831 0.64 ENSDART00000179982
hmox1a
heme oxygenase 1a
chr20_+_30578163 0.61 ENSDART00000159485
fgfr1op
FGFR1 oncogene partner
chr4_-_8060962 0.56 ENSDART00000146622
wnk1b
WNK lysine deficient protein kinase 1b
chr14_-_17575764 0.55 ENSDART00000123145
rnf4
ring finger protein 4
chr24_+_26895748 0.54 ENSDART00000089351
nceh1b.1
neutral cholesterol ester hydrolase 1b, tandem duplicate 1
chr3_-_36606884 0.54 ENSDART00000172003
si:dkeyp-72e1.6
si:dkeyp-72e1.6
chr8_+_4838114 0.54 ENSDART00000146667
es1
es1 protein
chr12_+_7865470 0.53 ENSDART00000161683
BX548028.1

chr23_-_16485190 0.50 ENSDART00000155038
si:dkeyp-100a5.4
si:dkeyp-100a5.4
chr19_-_46775562 0.49 ENSDART00000187144
abrab
actin binding Rho activating protein b
chr20_+_38257766 0.48 ENSDART00000147485
ENSDART00000149160
ccl38.6
chemokine (C-C motif) ligand 38, duplicate 6
chr4_-_2868112 0.48 ENSDART00000133843
pde3a
phosphodiesterase 3A, cGMP-inhibited
chr15_-_33834577 0.48 ENSDART00000163354
mmp13b
matrix metallopeptidase 13b
chr5_-_45877387 0.48 ENSDART00000183714
ENSDART00000041503
slc4a4a
solute carrier family 4 (sodium bicarbonate cotransporter), member 4a
chr6_+_3828560 0.47 ENSDART00000185273
ENSDART00000179091
gad1b
glutamate decarboxylase 1b
chr20_+_11731039 0.45 ENSDART00000152215
ENSDART00000152585
si:ch211-155o21.3
si:ch211-155o21.3
chr17_+_43843536 0.45 ENSDART00000164097
FO704777.1

chr16_+_20915319 0.43 ENSDART00000079383
hoxa9b
homeobox A9b
chr23_-_19682971 0.43 ENSDART00000048891
zgc:193598
zgc:193598
chr7_+_13382852 0.42 ENSDART00000166318
dagla
diacylglycerol lipase, alpha
chr12_+_9551667 0.42 ENSDART00000048493
ENSDART00000166178
p4ha1a
prolyl 4-hydroxylase, alpha polypeptide I a
chr7_-_3693536 0.42 ENSDART00000126381
si:ch211-282j17.13
si:ch211-282j17.13
chr1_-_38538284 0.42 ENSDART00000009777
glra3
glycine receptor, alpha 3
chr9_+_51147380 0.38 ENSDART00000003913
ifih1
interferon induced with helicase C domain 1
chr9_+_51265283 0.38 ENSDART00000137426
gcgb
glucagon b
chr14_-_26377044 0.38 ENSDART00000022236
emx3
empty spiracles homeobox 3
chr25_+_12640211 0.38 ENSDART00000165108
jph3
junctophilin 3
chr18_-_5542351 0.38 ENSDART00000129459
spata5l1
spermatogenesis associated 5-like 1
chr4_+_40953320 0.37 ENSDART00000151912
znf1136
zinc finger protein 1136
chr16_-_26855936 0.37 ENSDART00000167320
ENSDART00000078119
ino80c
INO80 complex subunit C
chr17_-_48743076 0.36 ENSDART00000173117
kcnk17
potassium channel, subfamily K, member 17
chr5_-_38197080 0.36 ENSDART00000140708
si:ch211-284e13.9
si:ch211-284e13.9
chr10_-_20669635 0.35 ENSDART00000131361
kcnip3b
Kv channel interacting protein 3b, calsenilin
chr7_+_57108823 0.35 ENSDART00000184943
ENSDART00000055956
enosf1
enolase superfamily member 1
chr4_-_71983381 0.34 ENSDART00000169130
ftr64
finTRIM family, member 64
chr1_+_41465771 0.34 ENSDART00000010211
paip2b
poly(A) binding protein interacting protein 2B
chr2_+_10771787 0.33 ENSDART00000187782
gfi1aa
growth factor independent 1A transcription repressor a
chr17_+_29345606 0.32 ENSDART00000086164
kctd3
potassium channel tetramerization domain containing 3
chr15_+_42599501 0.31 ENSDART00000177646
grik1b
glutamate receptor, ionotropic, kainate 1b
chr6_-_29007493 0.31 ENSDART00000065139
gfi1ab
growth factor independent 1A transcription repressor b
chr19_-_38539670 0.31 ENSDART00000136775
col16a1
collagen, type XVI, alpha 1
chr19_-_27196090 0.29 ENSDART00000045616
gabbr1b
gamma-aminobutyric acid (GABA) B receptor, 1b
chr7_-_70665965 0.29 ENSDART00000097710
ppargc1a
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr22_+_24646339 0.29 ENSDART00000183865
lpar3
lysophosphatidic acid receptor 3
chr5_-_19861766 0.29 ENSDART00000088904
gltpa
glycolipid transfer protein a
chr5_+_9246018 0.28 ENSDART00000081769
ENSDART00000183189
susd1
sushi domain containing 1
chr17_+_12408405 0.28 ENSDART00000154827
ENSDART00000048440
ENSDART00000156429
khk
ketohexokinase
chr18_+_44631789 0.28 ENSDART00000144271
bicra
BRD4 interacting chromatin remodeling complex associated protein
chr10_-_15644904 0.28 ENSDART00000138389
ENSDART00000101191
ENSDART00000186559
ENSDART00000122170
smc5
structural maintenance of chromosomes 5
chr15_+_37545855 0.27 ENSDART00000099456
psenen
presenilin enhancer gamma secretase subunit
chr5_+_13870340 0.27 ENSDART00000160690
hk2
hexokinase 2
chr15_+_15314189 0.26 ENSDART00000156830
camkk1b
calcium/calmodulin-dependent protein kinase kinase 1, alpha b
chr2_-_30249746 0.25 ENSDART00000124153
ENSDART00000142575
elocb
elongin C paralog b
chr1_+_41466011 0.25 ENSDART00000135280
paip2b
poly(A) binding protein interacting protein 2B
chr10_-_20650302 0.25 ENSDART00000142028
ENSDART00000064662
rassf2b
Ras association (RalGDS/AF-6) domain family member 2b
chr24_+_20658942 0.24 ENSDART00000142848
sec22c
SEC22 homolog C, vesicle trafficking protein
chr19_+_28284120 0.23 ENSDART00000103862
mrpl36
mitochondrial ribosomal protein L36
chr19_+_48176745 0.23 ENSDART00000164963
prdm1b
PR domain containing 1b, with ZNF domain
chr10_-_1625080 0.22 ENSDART00000137285
nup155
nucleoporin 155
chr17_+_28073062 0.22 ENSDART00000182021
AL844186.1

chr13_-_15986871 0.22 ENSDART00000189394
ikzf1
IKAROS family zinc finger 1 (Ikaros)
chr20_+_27020201 0.22 ENSDART00000126919
ENSDART00000016014
chga
chromogranin A
chr9_-_23944470 0.21 ENSDART00000138754
col6a3
collagen, type VI, alpha 3
chr13_+_8958438 0.21 ENSDART00000165721
ENSDART00000169398
haao
3-hydroxyanthranilate 3,4-dioxygenase
chr15_-_16098531 0.21 ENSDART00000080377
aldoca
aldolase C, fructose-bisphosphate, a
chr23_+_2669 0.20 ENSDART00000011146
twist3
twist3
chr2_-_38141997 0.20 ENSDART00000143469
trim110
tripartite motif containing 110
chr21_+_37411547 0.20 ENSDART00000076320
mrps17
mitochondrial ribosomal protein S17
chr8_-_50287949 0.20 ENSDART00000023639
nkx2.7
NK2 transcription factor related 7
chr1_+_14073891 0.19 ENSDART00000021693
ank2a
ankyrin 2a, neuronal
chr21_-_22547496 0.19 ENSDART00000166835
ENSDART00000089030
myo5b
myosin VB
chr20_+_51006362 0.18 ENSDART00000028084
mpp5b
membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5)
chr25_-_31433512 0.18 ENSDART00000067028
zgc:172145
zgc:172145
chr21_-_28901095 0.18 ENSDART00000180820
cxxc5a
CXXC finger protein 5a
chr24_+_27511734 0.18 ENSDART00000105771
cxcl32b.1
chemokine (C-X-C motif) ligand 32b, duplicate 1
chr4_+_43392655 0.18 ENSDART00000150797
znf1073
zinc finger protein 1073
chr19_-_3886991 0.18 ENSDART00000162085
thrap3b
thyroid hormone receptor associated protein 3b
chr24_-_7699356 0.17 ENSDART00000013117
syt5b
synaptotagmin Vb
chr5_-_39474235 0.17 ENSDART00000171557
antxr2a
anthrax toxin receptor 2a
chr16_+_38360002 0.16 ENSDART00000087346
ENSDART00000148101
zgc:113232
zgc:113232
chr5_-_50781623 0.15 ENSDART00000114950
zgc:194908
zgc:194908
chr15_+_37546391 0.15 ENSDART00000186625
psenen
presenilin enhancer gamma secretase subunit
chr16_+_20947439 0.15 ENSDART00000137344
skap2
src kinase associated phosphoprotein 2
chr14_+_44774089 0.14 ENSDART00000098643
tomm5
translocase of outer mitochondrial membrane 5 homolog (yeast)
chr4_+_59748607 0.14 ENSDART00000108499
znf1068
zinc finger protein 1068
chr17_+_5985933 0.12 ENSDART00000190844
zgc:194275
zgc:194275
chr5_-_63663811 0.10 ENSDART00000111403
ciz1b
cdkn1a interacting zinc finger protein 1b
chr2_-_55861351 0.10 ENSDART00000059003
rx2
retinal homeobox gene 2
chr16_+_28932038 0.10 ENSDART00000149480
npr1b
natriuretic peptide receptor 1b
chr24_+_20658760 0.10 ENSDART00000188362
sec22c
SEC22 homolog C, vesicle trafficking protein
chr10_-_11203164 0.09 ENSDART00000040308
ptbp3
polypyrimidine tract binding protein 3
chr11_-_18601955 0.08 ENSDART00000180565
zmynd8
zinc finger, MYND-type containing 8
chr22_-_22301672 0.08 ENSDART00000111711
chaf1a
chromatin assembly factor 1, subunit A (p150)
chr25_-_16724913 0.08 ENSDART00000157075
galnt8a.2
polypeptide N-acetylgalactosaminyltransferase 8a, tandem duplicate 2
chr22_+_2409175 0.07 ENSDART00000141776
zgc:113220
zgc:113220
chr4_+_60381608 0.07 ENSDART00000167351
znf1130
zinc finger protein 1130
chr9_-_31135901 0.06 ENSDART00000113027
ENSDART00000193210
ENSDART00000128896
si:ch211-184m13.4
si:ch211-184m13.4
chr11_-_29946640 0.05 ENSDART00000079175
zgc:113276
zgc:113276
chr25_-_16742438 0.05 ENSDART00000156091
galnt8a.1
polypeptide N-acetylgalactosaminyltransferase 8a, tandem duplicate 1
chr22_+_13977772 0.05 ENSDART00000080313
arl4ca
ADP-ribosylation factor-like 4Ca
chr6_+_46668717 0.04 ENSDART00000064853
oxtrl
oxytocin receptor like
chr4_+_69577362 0.04 ENSDART00000160913
znf1030
zinc finger protein 1030
chr6_-_49655879 0.04 ENSDART00000191594
apcdd1l
adenomatosis polyposis coli down-regulated 1-like
chr4_-_59159690 0.03 ENSDART00000164706
znf1149
zinc finger protein 1149
chr23_+_37185247 0.03 ENSDART00000146269
vwa5b1
von Willebrand factor A domain containing 5B1
chr18_+_13236255 0.03 ENSDART00000091560
tldc1
TBC/LysM-associated domain containing 1
chr4_-_43071336 0.02 ENSDART00000150773
znf1072
zinc finger protein 1072
chr21_+_28535203 0.02 ENSDART00000184950
CR749775.2

chr6_-_21534301 0.02 ENSDART00000126186
psmd12
proteasome 26S subunit, non-ATPase 12
chr17_+_5895500 0.02 ENSDART00000019905
fndc4b
fibronectin type III domain containing 4b
chr1_-_52292235 0.01 ENSDART00000132638
si:dkey-121b10.7
si:dkey-121b10.7
chr12_-_43982343 0.01 ENSDART00000161539
CR385054.1

chr4_-_39942347 0.01 ENSDART00000124410
znf979
zinc finger protein 979
chr4_+_39055027 0.01 ENSDART00000150397
znf977
zinc finger protein 977
chr12_-_26423439 0.00 ENSDART00000113978
synpo2lb
synaptopodin 2-like b

Network of associatons between targets according to the STRING database.

First level regulatory network of nr2e1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0046415 urate catabolic process(GO:0019628) urate metabolic process(GO:0046415)
0.6 2.3 GO:0061113 pancreas morphogenesis(GO:0061113)
0.4 1.3 GO:0043576 respiratory gaseous exchange(GO:0007585) regulation of respiratory gaseous exchange(GO:0043576)
0.4 2.3 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.4 1.1 GO:0009750 response to fructose(GO:0009750)
0.3 2.0 GO:0009136 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180)
0.3 0.8 GO:0060292 long term synaptic depression(GO:0060292)
0.2 0.7 GO:0070314 G1 to G0 transition(GO:0070314)
0.2 1.2 GO:0071908 determination of intestine left/right asymmetry(GO:0071908)
0.2 1.2 GO:0046294 formaldehyde metabolic process(GO:0046292) formaldehyde catabolic process(GO:0046294)
0.2 0.9 GO:0035881 amacrine cell differentiation(GO:0035881)
0.2 0.5 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.1 2.5 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.1 1.2 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1 1.3 GO:0000710 meiotic mismatch repair(GO:0000710)
0.1 1.3 GO:0051122 lipoxygenase pathway(GO:0019372) linoleic acid metabolic process(GO:0043651) hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.1 0.4 GO:0098921 endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921)
0.1 1.1 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)
0.1 0.3 GO:0072068 proximal straight tubule development(GO:0072020) distal convoluted tubule development(GO:0072025) late distal convoluted tubule development(GO:0072068)
0.1 0.3 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
0.1 2.8 GO:0044243 collagen catabolic process(GO:0030574) multicellular organism catabolic process(GO:0044243)
0.1 1.2 GO:0061026 cardiac muscle tissue regeneration(GO:0061026)
0.1 0.5 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.1 0.5 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.1 0.2 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228) protein localization to nuclear envelope(GO:0090435)
0.1 0.3 GO:0035095 behavioral response to nicotine(GO:0035095)
0.1 0.2 GO:0090278 negative regulation of peptide secretion(GO:0002792) negative regulation of peptide hormone secretion(GO:0090278)
0.1 0.4 GO:0032728 interferon-beta production(GO:0032608) regulation of interferon-beta production(GO:0032648) positive regulation of interferon-beta production(GO:0032728)
0.1 0.6 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.1 1.1 GO:0097475 motor neuron migration(GO:0097475)
0.1 0.2 GO:0043420 anthranilate metabolic process(GO:0043420)
0.0 0.2 GO:0003242 growth involved in heart morphogenesis(GO:0003241) cardiac chamber ballooning(GO:0003242) cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.0 0.4 GO:0042987 Notch receptor processing(GO:0007220) beta-amyloid formation(GO:0034205) amyloid precursor protein catabolic process(GO:0042987)
0.0 0.4 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 14.7 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 1.0 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.7 GO:0006208 pyrimidine nucleobase catabolic process(GO:0006208)
0.0 0.4 GO:1900407 regulation of cellular response to oxidative stress(GO:1900407)
0.0 0.6 GO:1903288 positive regulation of sodium ion transport(GO:0010765) positive regulation of sodium ion transmembrane transport(GO:1902307) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.0 0.4 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 0.2 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0 1.4 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 0.4 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471)
0.0 0.5 GO:0015701 bicarbonate transport(GO:0015701)
0.0 1.0 GO:0060914 heart formation(GO:0060914)
0.0 0.2 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.2 GO:0060038 cardiac muscle cell proliferation(GO:0060038)
0.0 0.2 GO:1901998 toxin transport(GO:1901998)
0.0 0.3 GO:0001678 cellular glucose homeostasis(GO:0001678)
0.0 0.7 GO:0001841 neural tube formation(GO:0001841)
0.0 0.5 GO:0035775 pronephric glomerulus morphogenesis(GO:0035775)
0.0 0.7 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.4 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.2 GO:1901222 regulation of NIK/NF-kappaB signaling(GO:1901222)
0.0 0.4 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.7 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 0.0 GO:0060137 parturition(GO:0007567) maternal process involved in parturition(GO:0060137)
0.0 1.0 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.5 GO:0030851 granulocyte differentiation(GO:0030851)
0.0 0.2 GO:0071594 T cell differentiation in thymus(GO:0033077) thymocyte aggregation(GO:0071594)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.1 2.3 GO:0005903 brush border(GO:0005903)
0.1 1.4 GO:0097546 ciliary base(GO:0097546)
0.1 0.2 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 0.4 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.3 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.3 GO:0038039 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.0 1.0 GO:1902711 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0 0.3 GO:0070449 elongin complex(GO:0070449)
0.0 0.2 GO:0031045 dense core granule(GO:0031045)
0.0 0.4 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.2 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.2 GO:0070938 contractile ring(GO:0070938)
0.0 1.6 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.4 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 1.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 1.1 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.5 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.4 1.6 GO:0050211 procollagen galactosyltransferase activity(GO:0050211)
0.4 2.3 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.3 0.9 GO:0030251 cyclase inhibitor activity(GO:0010852) guanylate cyclase inhibitor activity(GO:0030251)
0.2 1.2 GO:0051903 alcohol dehydrogenase activity, zinc-dependent(GO:0004024) S-(hydroxymethyl)glutathione dehydrogenase activity(GO:0051903)
0.2 1.3 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.2 2.3 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.2 3.1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.2 0.5 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.2 2.0 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 0.4 GO:0005252 open rectifier potassium channel activity(GO:0005252)
0.1 0.8 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 0.4 GO:0031769 glucagon receptor binding(GO:0031769)
0.1 1.3 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 1.2 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.4 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.3 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) glucose binding(GO:0005536) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.4 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.0 1.9 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.3 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.6 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.6 GO:0019869 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.0 0.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 1.1 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 1.0 GO:0016917 GABA-A receptor activity(GO:0004890) GABA receptor activity(GO:0016917)
0.0 0.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 1.3 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.3 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.3 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 15.8 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 0.7 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.2 GO:0008199 ferric iron binding(GO:0008199)
0.0 0.0 GO:0004990 oxytocin receptor activity(GO:0004990)
0.0 0.2 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 0.1 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 1.6 GO:0004222 metalloendopeptidase activity(GO:0004222)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.9 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 2.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.5 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.4 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.3 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 0.4 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.9 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.4 REACTOME SIGNALING BY NOTCH4 Genes involved in Signaling by NOTCH4
0.0 1.3 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.4 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.4 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.6 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.1 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.2 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.4 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.4 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.3 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.8 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.5 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation