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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for nr2f1b+nr2f5

Z-value: 0.95

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Transcription factors associated with nr2f1b+nr2f5

Gene Symbol Gene ID Gene Info
nr2f1b
ENSDARG00000017168 nuclear receptor subfamily 2, group F, member 1b
nr2f5
ENSDARG00000033172 nuclear receptor subfamily 2, group F, member 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr2f1bdr11_v1_chr10_+_43797130_43797130-0.931.5e-08Click!
nr2f5dr11_v1_chr16_+_46294337_462943370.735.7e-04Click!

Activity profile of nr2f1b+nr2f5 motif

Sorted Z-values of nr2f1b+nr2f5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr20_-_16906623 2.60 ENSDART00000012859
ENSDART00000171628
psma6b
proteasome subunit alpha 6b
chr11_+_6010177 2.14 ENSDART00000170047
ENSDART00000022526
ENSDART00000161001
ENSDART00000188999
gtpbp3
GTP binding protein 3, mitochondrial
chr22_-_26834043 1.91 ENSDART00000087202
si:dkey-44g23.5
si:dkey-44g23.5
chr18_+_1145571 1.88 ENSDART00000135055
rec114
REC114 meiotic recombination protein
chr24_+_42149453 1.69 ENSDART00000128766
serpinb1l3
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 3
chr8_-_13442871 1.58 ENSDART00000144887
pimr106
Pim proto-oncogene, serine/threonine kinase, related 106
chr24_+_42127983 1.56 ENSDART00000190157
ENSDART00000176032
ENSDART00000175790
wwp1
WW domain containing E3 ubiquitin protein ligase 1
chr1_-_40132831 1.50 ENSDART00000135647
si:ch211-113e8.10
si:ch211-113e8.10
chr24_+_42149296 1.50 ENSDART00000154231
serpinb1l3
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 3
chr24_+_42132962 1.49 ENSDART00000187739
wwp1
WW domain containing E3 ubiquitin protein ligase 1
chr1_-_55785722 1.45 ENSDART00000142069
ENSDART00000043933
ndufb7
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7
chr8_-_13471916 1.44 ENSDART00000146558
pimr105
Pim proto-oncogene, serine/threonine kinase, related 105
chr22_-_31788170 1.44 ENSDART00000170925
pimr207
Pim proto-oncogene, serine/threonine kinase, related 207
chr14_-_24391424 1.36 ENSDART00000113376
ENSDART00000126894
fam13b
family with sequence similarity 13, member B
chr8_-_13454281 1.28 ENSDART00000141959
CR354547.2

chr8_-_13486258 1.26 ENSDART00000137459
pimr104
Pim proto-oncogene, serine/threonine kinase, related 104
chr8_-_13428740 1.26 ENSDART00000131826
CR354547.3

chr11_-_25324534 1.24 ENSDART00000158598
si:ch211-232b12.5
si:ch211-232b12.5
chr5_+_64856666 1.24 ENSDART00000050863
zgc:101858
zgc:101858
chr2_+_21605547 1.14 ENSDART00000112014
mplkip
M-phase specific PLK1 interacting protein
chr2_+_2904080 1.14 ENSDART00000110416
eif2b5
eukaryotic translation initiation factor 2B, subunit 5 epsilon
chr8_-_41273461 1.13 ENSDART00000190598
rnf10
ring finger protein 10
chr12_-_14922955 1.06 ENSDART00000002078
neurod2
neurogenic differentiation 2
chr8_-_13419049 1.06 ENSDART00000133656
pimr101
Pim proto-oncogene, serine/threonine kinase, related 101
chr23_+_31245395 1.05 ENSDART00000053588
irak1bp1
interleukin-1 receptor-associated kinase 1 binding protein 1
chr1_-_26544268 1.02 ENSDART00000152117
si:ch211-202n12.2
si:ch211-202n12.2
chr22_+_37888249 0.99 ENSDART00000076082
fetub
fetuin B
chr19_+_8606883 0.96 ENSDART00000054469
ENSDART00000185264
s100a10a
S100 calcium binding protein A10a
chr12_+_7491690 0.94 ENSDART00000152564
phyhiplb
phytanoyl-CoA 2-hydroxylase interacting protein-like b
chr25_+_1591964 0.89 ENSDART00000093277
ppm1h
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr13_-_23007813 0.85 ENSDART00000057638
hk1
hexokinase 1
chr5_+_54400971 0.84 ENSDART00000169695
bspry
B-box and SPRY domain containing
chr1_-_55840105 0.82 ENSDART00000137909
samd1b
sterile alpha motif domain containing 1b
chr21_+_28445052 0.82 ENSDART00000077871
pygma
phosphorylase, glycogen, muscle A
chr2_+_52847049 0.73 ENSDART00000121980
creb3l3b
cAMP responsive element binding protein 3-like 3b
chr6_+_13806466 0.70 ENSDART00000043522
tmem198b
transmembrane protein 198b
chr19_+_26828502 0.67 ENSDART00000183654
ENSDART00000126006
ENSDART00000185341
FP085398.1

chr24_-_21989406 0.67 ENSDART00000032963
apoob
apolipoprotein O, b
chr17_-_53282539 0.65 ENSDART00000164953
FO704905.1

chr18_-_11729 0.65 ENSDART00000159781
WHAMM
WAS protein homolog associated with actin, golgi membranes and microtubules
chr2_+_43750899 0.65 ENSDART00000135836
arhgap12a
Rho GTPase activating protein 12a
chr1_+_144284 0.64 ENSDART00000064061
prozb
protein Z, vitamin K-dependent plasma glycoprotein b
chr25_-_10791437 0.63 ENSDART00000127054
BX572619.1

chr1_+_59154521 0.58 ENSDART00000130089
ENSDART00000152456
soul5l
heme-binding protein soul5, like
chr3_+_41917499 0.57 ENSDART00000028673
lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr18_+_3338228 0.54 ENSDART00000161520
gdpd4a
glycerophosphodiester phosphodiesterase domain containing 4a
chr7_+_29153018 0.52 ENSDART00000138065
tmppe
transmembrane protein with metallophosphoesterase domain
chr3_-_12970418 0.51 ENSDART00000158747
pdgfab
platelet-derived growth factor alpha polypeptide b
chr24_-_21991770 0.50 ENSDART00000147296
si:rp71-1f1.4
si:rp71-1f1.4
chr15_+_27364394 0.49 ENSDART00000122101
tbx2b
T-box 2b
chr15_+_34933552 0.49 ENSDART00000155368
zgc:66024
zgc:66024
chr21_+_5882300 0.47 ENSDART00000165065
uqcr10
ubiquinol-cytochrome c reductase, complex III subunit X
chr8_-_41273768 0.47 ENSDART00000108518
rnf10
ring finger protein 10
chr2_+_56213694 0.47 ENSDART00000162582
upf1
upf1 regulator of nonsense transcripts homolog (yeast)
chr7_-_28565230 0.43 ENSDART00000028887
tmem9b
TMEM9 domain family, member B
chr23_+_25822742 0.41 ENSDART00000184436
r3hdml
R3H domain containing-like
chr4_-_2440175 0.39 ENSDART00000058059
OSBPL8
oxysterol binding protein like 8
chr23_-_3703569 0.38 ENSDART00000143731
pacsin1a
protein kinase C and casein kinase substrate in neurons 1a
chr19_+_5291935 0.35 ENSDART00000141237
si:dkeyp-113d7.10
si:dkeyp-113d7.10
chr2_+_3696038 0.33 ENSDART00000150499
ENSDART00000136906
ENSDART00000164152
ENSDART00000128514
ENSDART00000108964
egfra
epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
chr14_-_51855047 0.33 ENSDART00000088912
cplx1
complexin 1
chr15_+_1199407 0.33 ENSDART00000163827
mfsd1
major facilitator superfamily domain containing 1
chr20_-_11178022 0.32 ENSDART00000152246
flrt2
fibronectin leucine rich transmembrane protein 2
chr8_+_23711842 0.32 ENSDART00000128783
ppardb
peroxisome proliferator-activated receptor delta b
chr12_-_7807298 0.29 ENSDART00000191355
ank3b
ankyrin 3b
chr18_-_49283058 0.29 ENSDART00000076554
si:zfos-464b6.2
si:zfos-464b6.2
chr13_+_24834199 0.29 ENSDART00000101274
zgc:153981
zgc:153981
chr15_-_41756454 0.28 ENSDART00000139498
ENSDART00000099302
ftr72
finTRIM family, member 72
chr20_+_43925266 0.27 ENSDART00000037379
clic5b
chloride intracellular channel 5b
chr14_-_5817039 0.25 ENSDART00000131820
kazald2
Kazal-type serine peptidase inhibitor domain 2
chr8_-_52594111 0.24 ENSDART00000167667
si:ch73-199g24.2
si:ch73-199g24.2
chr24_-_22015751 0.23 ENSDART00000147055
si:rp71-1f1.6
si:rp71-1f1.6
chr23_-_30076950 0.23 ENSDART00000180139
camta1a
calmodulin binding transcription activator 1a
chr1_-_47771742 0.22 ENSDART00000101079
neurl1aa
neuralized E3 ubiquitin protein ligase 1Aa
chr20_+_25581627 0.20 ENSDART00000030229
cyp2p9
cytochrome P450, family 2, subfamily P, polypeptide 9
chr24_-_22003031 0.18 ENSDART00000133627
si:rp71-1f1.5
si:rp71-1f1.5
chr7_-_26446726 0.18 ENSDART00000173607
zgc:172079
zgc:172079
chr18_+_8340886 0.18 ENSDART00000081132
cpt1b
carnitine palmitoyltransferase 1B (muscle)
chr4_+_1530287 0.18 ENSDART00000067446
slc38a4
solute carrier family 38, member 4
chr17_+_17955063 0.17 ENSDART00000104999
ccdc85ca
coiled-coil domain containing 85C, a
chr16_+_20895904 0.15 ENSDART00000052662
hoxa13b
homeobox A13b
chr13_-_13754091 0.14 ENSDART00000131255
ky
kyphoscoliosis peptidase
chr7_+_27251376 0.13 ENSDART00000173521
ENSDART00000173962
sox6
SRY (sex determining region Y)-box 6
chr17_+_5351922 0.13 ENSDART00000105394
runx2a
runt-related transcription factor 2a
chr7_-_2039060 0.12 ENSDART00000173879
si:cabz01007794.1
si:cabz01007794.1
chr17_+_14711765 0.11 ENSDART00000012889
cx28.6
connexin 28.6
chr17_+_389218 0.10 ENSDART00000162898
si:rp71-62i8.1
si:rp71-62i8.1
chr25_+_1549838 0.09 ENSDART00000115001
avpr1aa
arginine vasopressin receptor 1Aa
chr8_+_36803415 0.08 ENSDART00000111680
iqsec2b
IQ motif and Sec7 domain 2b
chr5_-_8910703 0.07 ENSDART00000097221
adamts12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
chr24_+_42117231 0.07 ENSDART00000067734
snx16
sorting nexin 16
chr4_-_71983381 0.06 ENSDART00000169130
ftr64
finTRIM family, member 64
chr1_-_20824411 0.04 ENSDART00000182810
tll1
tolloid-like 1
chr10_-_21054059 0.04 ENSDART00000139733
pcdh1a
protocadherin 1a
chr18_+_7073130 0.02 ENSDART00000101216
ENSDART00000148947
si:dkey-88e18.2
si:dkey-88e18.2
chr13_+_22249636 0.02 ENSDART00000108472
ENSDART00000173123
synpo2la
synaptopodin 2-like a
chr14_+_41518257 0.02 ENSDART00000050037
chrnb3b
cholinergic receptor, nicotinic, beta 3b (neuronal)
chr22_-_4398069 0.01 ENSDART00000181893
kdm4b
lysine (K)-specific demethylase 4B

Network of associatons between targets according to the STRING database.

First level regulatory network of nr2f1b+nr2f5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0052575 carbohydrate localization(GO:0052575) carbohydrate storage(GO:0052576)
0.3 1.1 GO:0060074 synapse maturation(GO:0060074)
0.2 1.6 GO:0031643 positive regulation of myelination(GO:0031643)
0.2 0.5 GO:0072068 distal convoluted tubule development(GO:0072025) late distal convoluted tubule development(GO:0072068)
0.1 0.6 GO:0055016 hypochord development(GO:0055016)
0.1 2.1 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 2.6 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 0.8 GO:0001678 cellular glucose homeostasis(GO:0001678)
0.1 0.5 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 4.2 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.5 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.3 GO:0010887 negative regulation of cholesterol storage(GO:0010887)
0.0 3.0 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.0 0.3 GO:0072554 endothelial tube morphogenesis(GO:0061154) blood vessel lumenization(GO:0072554)
0.0 6.9 GO:0046777 protein autophosphorylation(GO:0046777)
0.0 0.4 GO:0097320 membrane tubulation(GO:0097320)
0.0 0.7 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 0.5 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.1 GO:0060612 adipose tissue development(GO:0060612)
0.0 0.4 GO:0061462 protein localization to lysosome(GO:0061462)
0.0 0.0 GO:0035124 embryonic caudal fin morphogenesis(GO:0035124)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.6 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.2 1.1 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.1 0.7 GO:0061617 MICOS complex(GO:0061617)
0.1 1.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.5 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.4 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 0.3 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.1 GO:0031313 extrinsic component of endosome membrane(GO:0031313)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0004645 phosphorylase activity(GO:0004645) glycogen phosphorylase activity(GO:0008184)
0.2 0.9 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.1 0.6 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.8 GO:0004396 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) glucose binding(GO:0005536) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 0.3 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 1.4 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.5 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.1 0.9 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.1 1.1 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.7 GO:0035497 cAMP response element binding(GO:0035497)
0.0 1.0 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 3.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.2 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 1.0 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.3 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.0 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.8 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.0 REACTOME SIGNALING BY ERBB4 Genes involved in Signaling by ERBB4
0.0 0.6 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 1.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.8 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.2 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 1.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases