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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for nr3c2

Z-value: 0.23

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Transcription factors associated with nr3c2

Gene Symbol Gene ID Gene Info
nr3c2
ENSDARG00000102082 nuclear receptor subfamily 3, group C, member 2
nr3c2
ENSDARG00000115513 nuclear receptor subfamily 3, group C, member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr3c2dr11_v1_chr1_-_37087966_37087966-0.864.5e-06Click!

Activity profile of nr3c2 motif

Sorted Z-values of nr3c2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_40051425 0.79 ENSDART00000146700
llgl1
lethal giant larvae homolog 1 (Drosophila)
chr14_-_46113321 0.62 ENSDART00000169040
ENSDART00000161475
ENSDART00000124925
si:ch211-235e9.8
si:ch211-235e9.8
chr8_+_23034718 0.53 ENSDART00000184512
ythdf1
YTH N(6)-methyladenosine RNA binding protein 1
chr6_+_4255319 0.51 ENSDART00000170351
nbeal1
neurobeachin-like 1
chr2_-_32512648 0.44 ENSDART00000170674
abcf2a
ATP-binding cassette, sub-family F (GCN20), member 2a
chr10_+_20364009 0.43 ENSDART00000186139
ENSDART00000080395
golga7
golgin A7
chr7_-_51749683 0.42 ENSDART00000083190
hdac8
histone deacetylase 8
chr13_-_33700461 0.40 ENSDART00000160520
mad2l1bp
MAD2L1 binding protein
chr5_+_30518441 0.36 ENSDART00000132664
hmbsa
hydroxymethylbilane synthase a
chr11_-_43473824 0.32 ENSDART00000179561
tmem63bb
transmembrane protein 63Bb
chr15_+_40188076 0.30 ENSDART00000063779
efhd1
EF-hand domain family, member D1
chr22_-_34979139 0.28 ENSDART00000116455
ENSDART00000133537
arhgap19
Rho GTPase activating protein 19
chr18_-_20608025 0.27 ENSDART00000090156
ENSDART00000151980
bcl2l13
BCL2 like 13
chr17_-_6613458 0.26 ENSDART00000175024
si:ch211-189e2.3
si:ch211-189e2.3
chr18_-_20608300 0.23 ENSDART00000140632
bcl2l13
BCL2 like 13
chr15_+_23951560 0.23 ENSDART00000191133
myo18ab
myosin XVIIIAb
chr24_-_20641000 0.19 ENSDART00000166135
zbtb47b
zinc finger and BTB domain containing 47b
chr10_+_8554929 0.19 ENSDART00000190849
tbc1d10ab
TBC1 domain family, member 10Ab
chr3_+_13850163 0.18 ENSDART00000164872
ilf3b
interleukin enhancer binding factor 3b
chr25_+_10416583 0.15 ENSDART00000073907
ehf
ets homologous factor
chr11_+_34522554 0.15 ENSDART00000109833
zmat3
zinc finger, matrin-type 3
chr20_+_54336137 0.15 ENSDART00000113792
cipcb
CLOCK-interacting pacemaker b
chr10_+_29849497 0.15 ENSDART00000099994
ENSDART00000132212
hspa8
heat shock protein 8
chr18_-_19491162 0.15 ENSDART00000090413
snapc5
small nuclear RNA activating complex, polypeptide 5
chr1_-_28473350 0.14 ENSDART00000190608
ENSDART00000148175
si:ch1073-440b2.1
si:ch1073-440b2.1
chr8_+_39767915 0.14 ENSDART00000017153
hps4
Hermansky-Pudlak syndrome 4
chr24_-_23784701 0.12 ENSDART00000090368
sgk3
serum/glucocorticoid regulated kinase family, member 3
chr5_-_54792239 0.12 ENSDART00000056213
pik3r1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr11_+_34523132 0.10 ENSDART00000192257
zmat3
zinc finger, matrin-type 3
chr5_-_9540641 0.10 ENSDART00000124384
ENSDART00000160079
gak
cyclin G associated kinase
chr10_-_24689725 0.10 ENSDART00000079566
si:ch211-287a12.9
si:ch211-287a12.9
chr25_-_13408760 0.10 ENSDART00000154445
gins3
GINS complex subunit 3
chr9_+_22388686 0.10 ENSDART00000182731
ENSDART00000181462
dgkg
diacylglycerol kinase, gamma
chr17_+_6276559 0.09 ENSDART00000131075
dusp23b
dual specificity phosphatase 23b
chr24_-_38097305 0.09 ENSDART00000124321
crp2
C-reactive protein 2
chr15_-_18429550 0.07 ENSDART00000136208
ncam1b
neural cell adhesion molecule 1b
chr11_+_5880562 0.07 ENSDART00000129663
ENSDART00000130768
ENSDART00000160909
dazap1
DAZ associated protein 1
chr15_-_24883956 0.07 ENSDART00000113199
aipl1
aryl hydrocarbon receptor interacting protein-like 1
chr3_-_25275364 0.04 ENSDART00000163782
ENSDART00000145420
ENSDART00000133718
ENSDART00000055492
ddx5
DEAD (Asp-Glu-Ala-Asp) box helicase 5
chr22_-_16275236 0.04 ENSDART00000149051
cdc14ab
cell division cycle 14Ab
chr2_+_29257942 0.02 ENSDART00000184362
ENSDART00000025562
cdh18a
cadherin 18, type 2a
chr22_+_19538626 0.02 ENSDART00000189174
BX936298.2

chr18_-_44611252 0.02 ENSDART00000173095
spred3
sprouty-related, EVH1 domain containing 3
chr19_+_7916790 0.02 ENSDART00000081584
si:dkey-266f7.1
si:dkey-266f7.1
chr3_-_37476475 0.02 ENSDART00000148107
si:ch211-278a6.1
si:ch211-278a6.1
chr21_+_6291027 0.01 ENSDART00000180467
ENSDART00000184952
ENSDART00000184006
fnbp1b
formin binding protein 1b
chr11_-_34147205 0.01 ENSDART00000173216
atp13a3
ATPase 13A3
chr15_+_31462664 0.01 ENSDART00000174267
ENSDART00000185665
ENSDART00000060087
or102-1
odorant receptor, family C, subfamily 102, member 1
chr25_+_28772632 0.00 ENSDART00000160619
slc41a2a
solute carrier family 41 (magnesium transporter), member 2a

Network of associatons between targets according to the STRING database.

First level regulatory network of nr3c2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
0.1 0.8 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.1 0.4 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.5 GO:0050779 RNA destabilization(GO:0050779) mRNA destabilization(GO:0061157)
0.0 0.1 GO:0042754 negative regulation of circadian rhythm(GO:0042754)
0.0 0.6 GO:0008089 anterograde axonal transport(GO:0008089)
0.0 0.1 GO:1903232 melanosome assembly(GO:1903232)
0.0 0.1 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.4 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 0.4 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.1 GO:1902946 positive regulation of receptor-mediated endocytosis(GO:0048260) protein localization to early endosome(GO:1902946)
0.0 0.1 GO:0072319 clathrin coat disassembly(GO:0072318) vesicle uncoating(GO:0072319)
0.0 0.1 GO:1902315 cell cycle DNA replication initiation(GO:1902292) nuclear cell cycle DNA replication initiation(GO:1902315) mitotic DNA replication initiation(GO:1902975)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0031085 BLOC-3 complex(GO:0031085)
0.0 0.4 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.1 GO:0000811 GINS complex(GO:0000811)
0.0 0.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 0.4 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.0 0.8 GO:0045159 myosin II binding(GO:0045159)
0.0 0.4 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.2 GO:0017091 AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.1 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.3 GO:0005227 calcium activated cation channel activity(GO:0005227)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.1 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation