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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for nr4a1

Z-value: 0.18

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Transcription factors associated with nr4a1

Gene Symbol Gene ID Gene Info
ENSDARG00000000796 nuclear receptor subfamily 4, group A, member 1
ENSDARG00000109473 nuclear receptor subfamily 4, group A, member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr4a1dr11_v1_chr23_-_32156278_321562780.859.2e-06Click!

Activity profile of nr4a1 motif

Sorted Z-values of nr4a1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr22_+_29113796 0.36 ENSDART00000150264
phospholipase A2, group VI (cytosolic, calcium-independent)
chr5_+_6670945 0.35 ENSDART00000185686
paxillin a
chr11_-_44999858 0.35 ENSDART00000167759
ENSDART00000126845
LIM-domain binding 1b
chr8_-_22542467 0.34 ENSDART00000182588
ENSDART00000134542
cold shock domain containing E1, RNA-binding
chr24_-_26820698 0.34 ENSDART00000147788
fibronectin type III domain containing 3Bb
chr5_-_10082244 0.32 ENSDART00000036421
checkpoint kinase 2
chr3_+_33745014 0.32 ENSDART00000159966
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing a
chr18_+_27515640 0.31 ENSDART00000181593
tumor protein p53 inducible protein 11b
chr8_+_21114338 0.30 ENSDART00000002186
uridine-cytidine kinase 2a
chr13_+_7241170 0.26 ENSDART00000109434
apoptosis-inducing factor, mitochondrion-associated, 2
chr12_-_33568174 0.26 ENSDART00000142329
tudor and KH domain containing
chr23_+_30730121 0.26 ENSDART00000134141
additional sex combs like transcriptional regulator 1
chr13_-_24260609 0.25 ENSDART00000138747
URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
chr25_+_16214854 0.25 ENSDART00000109672
ENSDART00000190093
microtubule associated monooxygenase, calponin and LIM domain containing 2b
chr22_-_11833317 0.25 ENSDART00000125423
ENSDART00000000192
protein tyrosine phosphatase, non-receptor type 4b
chr20_-_36917670 0.25 ENSDART00000046716
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr7_+_22792132 0.24 ENSDART00000135207
ENSDART00000146801
RNA binding motif protein 4.3
chr6_-_41135215 0.24 ENSDART00000001861
solute carrier family 6 member 22, tandem duplicate 1
chr17_+_17764979 0.24 ENSDART00000105013
alkB homolog 1, histone H2A dioxygenase
chr14_+_35428152 0.24 ENSDART00000172597
synaptotagmin-like 4
chr7_-_42206720 0.24 ENSDART00000110907
integrin alpha FG-GAP repeat containing 1
chr20_-_48701593 0.24 ENSDART00000132835
paired box 1b
chr7_-_51775688 0.23 ENSDART00000149793
bone morphogenetic protein 15
chr15_-_16946124 0.22 ENSDART00000154923
huntingtin interacting protein 1
chr10_+_11265387 0.21 ENSDART00000038888
hydroxysteroid dehydrogenase like 2
chr24_+_25822999 0.20 ENSDART00000109809
SH3-domain kinase binding protein 1
chr14_+_30413312 0.20 ENSDART00000186864
CCR4-NOT transcription complex, subunit 7
chr24_-_6024466 0.20 ENSDART00000040865
prenyl (decaprenyl) diphosphate synthase, subunit 1
chr6_-_31348999 0.19 ENSDART00000153734
DnaJ (Hsp40) homolog, subfamily C, member 6
chr6_+_13206516 0.19 ENSDART00000036927
NADH dehydrogenase (ubiquinone) Fe-S protein 1
chr7_+_42206847 0.19 ENSDART00000149250
phosphorylase kinase, beta
chr3_-_54500354 0.19 ENSDART00000124215
thyroid hormone receptor interactor 10a
chr16_-_39195318 0.19 ENSDART00000058546
estrogen receptor binding site associated, antigen, 9
chr3_-_27915270 0.18 ENSDART00000115370
methyltransferase like 22
chr15_+_24676905 0.18 ENSDART00000078014
ENSDART00000143137
polymerase (DNA-directed), delta interacting protein 2
chr6_+_40952031 0.18 ENSDART00000189219
POZ (BTB) and AT hook containing zinc finger 1
chr16_-_25680666 0.17 ENSDART00000132693
ENSDART00000140539
ENSDART00000015302
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr6_+_30533504 0.17 ENSDART00000155842
WWC family member 3
chr7_+_38667066 0.16 ENSDART00000013394
mitochondrial carrier homolog 2
chr1_-_23110740 0.16 ENSDART00000171848
ENSDART00000086797
ENSDART00000189344
ENSDART00000190858
adhesion G protein-coupled receptor L3.1
chr7_+_56253914 0.16 ENSDART00000073594
ankyrin repeat domain 11
chr10_+_36441124 0.15 ENSDART00000185626
ubiquitin specific peptidase like 1
chr2_-_4787566 0.15 ENSDART00000160663
ENSDART00000157808
tyrosine kinase, non-receptor, 2b
chr12_+_45238292 0.15 ENSDART00000057983
mitochondrial ribosomal protein L38
chr20_-_26060154 0.15 ENSDART00000151950
serine active site containing 1
chr12_+_21525496 0.15 ENSDART00000152974
carbonic anhydrase Xa
chr12_+_9817440 0.14 ENSDART00000137081
ENSDART00000123712
RUN domain containing 3Ab
chr11_+_5681762 0.14 ENSDART00000179139
AT rich interactive domain 3A (BRIGHT-like)
chr6_-_45995401 0.14 ENSDART00000154392
carbonic anhydrase XVI b
chr5_+_62611400 0.14 ENSDART00000132054
active BCR-related
chr6_+_3343834 0.13 ENSDART00000160290
ST3 beta-galactoside alpha-2,3-sialyltransferase 3a
chr4_-_2975461 0.13 ENSDART00000150794
pleckstrin homology domain containing, family A member 5
chr3_+_24050043 0.13 ENSDART00000151788
chromobox homolog 1a (HP1 beta homolog Drosophila)
chr2_+_26655744 0.13 ENSDART00000174928
aspartate beta-hydroxylase
chr23_+_20640875 0.13 ENSDART00000147382
ubiquitin-like modifier activating enzyme 1
chr11_-_31226578 0.13 ENSDART00000109698
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing b
chr5_-_14509137 0.13 ENSDART00000180742
si:ch211-244o22.2
chr22_+_30184039 0.12 ENSDART00000049075
adducin 3 (gamma) a
chr8_+_10823069 0.11 ENSDART00000081341
mitogen-activated protein kinase 13
chr19_+_34169055 0.11 ENSDART00000135592
ENSDART00000186043
POC1 centriolar protein homolog B (Chlamydomonas), like
chr13_-_42673978 0.10 ENSDART00000133848
ENSDART00000099738
ENSDART00000099729
ENSDART00000169083
leucine rich repeat (in FLII) interacting protein 2
chr25_+_22017182 0.10 ENSDART00000156517
si:dkey-217l24.1
chr8_-_25566347 0.10 ENSDART00000138289
ENSDART00000078022
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
chr6_-_10912424 0.10 ENSDART00000036456
cytochrome c, somatic b
chr20_+_13883131 0.10 ENSDART00000003248
ENSDART00000152611
NIMA-related kinase 2
chr5_+_24156170 0.10 ENSDART00000136570
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15b
chr19_-_5332784 0.10 ENSDART00000010373
keratin, type 1, gene 19d
chr15_-_6946286 0.10 ENSDART00000019330
enoyl CoA hydratase 1, peroxisomal
chr18_+_44769027 0.10 ENSDART00000145190
ilvB (bacterial acetolactate synthase)-like
chr2_-_41562868 0.09 ENSDART00000084597
D-2-hydroxyglutarate dehydrogenase
chr7_+_38267136 0.09 ENSDART00000173613
G patch domain containing 1
chr3_-_45250924 0.09 ENSDART00000109017
ubiquitin specific peptidase 31
chr5_+_19448078 0.09 ENSDART00000088968
ubiquitin protein ligase E3B
chr19_-_3056235 0.09 ENSDART00000137020
block of proliferation 1
chr2_+_34767171 0.09 ENSDART00000145451
astrotactin 1
chr24_+_39641991 0.09 ENSDART00000142182
LUC7-like (S. cerevisiae)
chr2_+_13710439 0.09 ENSDART00000155712
EBNA1 binding protein 2
chr3_+_32842825 0.08 ENSDART00000122228
proline rich 14
chr20_+_13883353 0.08 ENSDART00000188006
NIMA-related kinase 2
chr13_+_24263049 0.07 ENSDART00000135992
ENSDART00000088005
ATP-binding cassette, sub-family B (MDR/TAP), member 10
chr11_-_40647190 0.07 ENSDART00000173217
ENSDART00000173276
ENSDART00000147264
family with sequence similarity 213, member B
chr12_-_45238759 0.07 ENSDART00000154859
tripartite motif containing 65
chr7_+_38588866 0.07 ENSDART00000015682
NADH dehydrogenase (ubiquinone) Fe-S protein 3, (NADH-coenzyme Q reductase)
chr5_-_32890807 0.06 ENSDART00000007512
polymerase (DNA directed), epsilon 3 (p17 subunit)
chr13_-_11679486 0.06 ENSDART00000108694
si:ch211-195e19.1
chr7_+_34296789 0.06 ENSDART00000052471
ENSDART00000173798
ENSDART00000173778
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr3_-_37351225 0.06 ENSDART00000174685
si:ch211-278a6.1
chr3_-_5829501 0.06 ENSDART00000091017
protein kinase N1b
chr6_-_53204808 0.06 ENSDART00000160955
solute carrier family 38, member 3b
chr20_+_21391181 0.06 ENSDART00000185158
ENSDART00000049586
ENSDART00000024922
jagged 2b
chr20_-_31743817 0.05 ENSDART00000137679
SAM and SH3 domain containing 1a
chr13_-_21739142 0.05 ENSDART00000078460
si:dkey-191g9.5
chr1_+_38153944 0.05 ENSDART00000135666
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr18_-_42333428 0.05 ENSDART00000034225
contactin 5
chr15_-_11341635 0.05 ENSDART00000055220
RAB30, member RAS oncogene family
chr7_+_31132588 0.05 ENSDART00000173702
tight junction protein 1a
chr7_+_65398161 0.05 ENSDART00000166109
ENSDART00000157399
ubiquitin specific peptidase 47
chr14_-_7409364 0.04 ENSDART00000036463
DND microRNA-mediated repression inhibitor 1
chr13_-_41155472 0.04 ENSDART00000160588
si:dkeyp-86d6.2
chr21_-_43527198 0.04 ENSDART00000126092
insulin receptor substrate 4a
chr10_-_11385155 0.04 ENSDART00000064214
placenta-specific 8, tandem duplicate 1
chr13_+_31603988 0.04 ENSDART00000030646
SIX homeobox 6a
chr24_-_8214253 0.04 ENSDART00000160432

chr7_+_30202104 0.04 ENSDART00000173525
WD repeat domain 76
chr2_-_8688759 0.03 ENSDART00000010257
mitoguardin 1
chr14_+_36246726 0.03 ENSDART00000105602
ELOVL fatty acid elongase 6
chr6_-_13206255 0.03 ENSDART00000065373
eukaryotic translation elongation factor 1 beta 2
chr11_-_15090118 0.03 ENSDART00000171118
solute carrier family 1 (glutamate transporter), member 8a
chr8_+_53120278 0.03 ENSDART00000125232
nuclear receptor subfamily 2, group C, member 2
chr13_+_29193649 0.02 ENSDART00000045951
unc-5 netrin receptor B
chr9_-_30346279 0.02 ENSDART00000089488
synaptotagmin-like 5
chr22_+_21317597 0.02 ENSDART00000132605
SHC (Src homology 2 domain containing) transforming protein 2
chr8_+_8699085 0.02 ENSDART00000021209
ubiquitously-expressed, prefoldin-like chaperone
chr21_+_4320769 0.02 ENSDART00000168553
si:dkey-84o3.4
chr17_-_1705013 0.02 ENSDART00000182864

chr13_+_24853578 0.02 ENSDART00000145865
si:dkey-24f15.2
chr25_-_31898552 0.02 ENSDART00000156128
si:ch73-330k17.3
chr20_+_49081967 0.02 ENSDART00000112689
crooked neck pre-mRNA splicing factor 1
chr13_+_43050562 0.01 ENSDART00000016602
cadherin-related 23
chr2_-_42827336 0.01 ENSDART00000140913
adenylate cyclase 8 (brain)
chr16_-_16619854 0.01 ENSDART00000150512
ENSDART00000191306
ENSDART00000181773
ENSDART00000183231
cytochrome P450, family 21, subfamily A, polypeptide 2
chr8_+_10404310 0.01 ENSDART00000185573
TBC1 domain family, member 22B
chr16_-_11859309 0.01 ENSDART00000145754
chemokine (C-X-C motif) receptor 3, tandem duplicate 1
chr1_+_44826367 0.01 ENSDART00000146962
zgc:165520
chr5_+_65493699 0.01 ENSDART00000161567
si:dkey-21e5.1
chr8_-_14052349 0.01 ENSDART00000135811
ATPase plasma membrane Ca2+ transporting 3a
chr18_+_9382847 0.01 ENSDART00000061886
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ab
chr5_+_24282570 0.01 ENSDART00000041905
zinc finger, DHHC-type containing 23a
chr5_-_26323137 0.01 ENSDART00000133823
ARVCF, delta catenin family member b
chr19_-_703898 0.01 ENSDART00000181096
ENSDART00000121462
solute carrier family 6 (neutral amino acid transporter), member 19a, tandem duplicate 2
chr23_+_21544227 0.01 ENSDART00000140253
Rho guanine nucleotide exchange factor (GEF) 10-like b
chr19_+_2275019 0.01 ENSDART00000136138
integrin, beta 8
chr8_+_26125218 0.01 ENSDART00000145095
cadherin, EGF LAG seven-pass G-type receptor 3
chr1_+_44826593 0.01 ENSDART00000162200
zgc:165520
chr7_-_31794476 0.00 ENSDART00000142385
nucleosome assembly protein 1-like 4b
chr5_-_26330313 0.00 ENSDART00000148656
ARVCF, delta catenin family member b
chr7_+_34297271 0.00 ENSDART00000180342
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr15_+_14154174 0.00 ENSDART00000161234
chloride channel accessory 5, tandem duplicate 1
chr1_-_58868306 0.00 ENSDART00000166615
dynamin 2b
chr23_+_3538463 0.00 ENSDART00000172758
si:dkey-9l20.3
chr1_-_40208237 0.00 ENSDART00000191987

chr20_+_40150612 0.00 ENSDART00000143680
ENSDART00000109681
ENSDART00000101041
ENSDART00000121818
triadin
chr23_+_26003187 0.00 ENSDART00000147271
WNT1 inducible signaling pathway protein 2
chr2_+_10127762 0.00 ENSDART00000100726
insulin-like 5b
chr7_+_15871408 0.00 ENSDART00000014572
paired box 6b

Network of associatons between targets according to the STRING database.

First level regulatory network of nr4a1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0060283 negative regulation of oocyte development(GO:0060283)
0.0 0.2 GO:0035513 oxidative RNA demethylation(GO:0035513)
0.0 0.2 GO:0070987 error-free translesion synthesis(GO:0070987)
0.0 0.3 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.2 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.3 GO:0044211 CTP salvage(GO:0044211)
0.0 0.1 GO:0000066 mitochondrial ornithine transport(GO:0000066) mitochondrial L-ornithine transmembrane transport(GO:1990575)
0.0 0.2 GO:0030576 nuclear body organization(GO:0030575) Cajal body organization(GO:0030576) protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) protein localization to nucleoplasm(GO:1990173)
0.0 0.1 GO:0018197 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.1 GO:0006549 isoleucine metabolic process(GO:0006549) isoleucine biosynthetic process(GO:0009097)
0.0 0.4 GO:0061055 myotome development(GO:0061055)
0.0 0.2 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 0.2 GO:0045444 fat cell differentiation(GO:0045444)
0.0 0.2 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.1 GO:0006272 leading strand elongation(GO:0006272)
0.0 0.1 GO:0006867 asparagine transport(GO:0006867)
0.0 0.2 GO:0061154 endothelial tube morphogenesis(GO:0061154) blood vessel lumenization(GO:0072554)
0.0 0.3 GO:0044773 mitotic DNA damage checkpoint(GO:0044773)
0.0 0.1 GO:0035307 positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0098890 extrinsic component of postsynaptic membrane(GO:0098890)
0.0 0.3 GO:0035517 PR-DUB complex(GO:0035517)
0.0 0.1 GO:0005948 acetolactate synthase complex(GO:0005948)
0.0 0.1 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.2 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.2 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.0 GO:0043073 germ cell nucleus(GO:0043073)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0035516 oxidative DNA demethylase activity(GO:0035516)
0.1 0.3 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.3 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.3 GO:0043914 NADPH:sulfur oxidoreductase activity(GO:0043914)
0.0 0.3 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.2 GO:0070698 type I activin receptor binding(GO:0070698)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.1 GO:0003984 acetolactate synthase activity(GO:0003984)
0.0 0.2 GO:0032183 SUMO binding(GO:0032183)
0.0 0.1 GO:0004174 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0 0.1 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 0.2 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.1 GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
0.0 0.1 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.2 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.1 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.2 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.3 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.2 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.0 0.1 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.5 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.2 PID HIF2PATHWAY HIF-2-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.0 0.3 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.1 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.2 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA