Project

PRJNA438478: RNAseq of wild type zebrafish germline

Navigation
Downloads

Results for nr4a2b

Z-value: 0.41

Motif logo

logo of

Transcription factors associated with nr4a2b

Gene Symbol Gene ID Gene Info
nr4a2b
ENSDARG00000044532 nuclear receptor subfamily 4, group A, member 2b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr4a2bdr11_v1_chr6_+_12462079_12462079-0.243.4e-01Click!

Activity profile of nr4a2b motif

Sorted Z-values of nr4a2b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_5332784 0.75 ENSDART00000010373
krt1-19d
keratin, type 1, gene 19d
chr22_+_30184039 0.59 ENSDART00000049075
add3a
adducin 3 (gamma) a
chr17_+_26753967 0.58 ENSDART00000025096
larp1b
La ribonucleoprotein domain family, member 1B
chr8_+_13106760 0.54 ENSDART00000029308
itgb4
integrin, beta 4
chr21_-_41369370 0.49 ENSDART00000159290
cpeb4b
cytoplasmic polyadenylation element binding protein 4b
chr22_+_29113796 0.43 ENSDART00000150264
pla2g6
phospholipase A2, group VI (cytosolic, calcium-independent)
chr8_-_22542467 0.42 ENSDART00000182588
ENSDART00000134542
csde1
cold shock domain containing E1, RNA-binding
chr7_+_22792132 0.41 ENSDART00000135207
ENSDART00000146801
rbm4.3
RNA binding motif protein 4.3
chr21_-_41369539 0.41 ENSDART00000187546
cpeb4b
cytoplasmic polyadenylation element binding protein 4b
chr22_-_11833317 0.39 ENSDART00000125423
ENSDART00000000192
ptpn4b
protein tyrosine phosphatase, non-receptor type 4b
chr18_+_27515640 0.37 ENSDART00000181593
tp53i11b
tumor protein p53 inducible protein 11b
chr3_+_33745014 0.35 ENSDART00000159966
nacc1a
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing a
chr11_-_44999858 0.34 ENSDART00000167759
ENSDART00000126845
ldb1b
LIM-domain binding 1b
chr6_-_41135215 0.34 ENSDART00000001861
slc6a22.1
solute carrier family 6 member 22, tandem duplicate 1
chr7_+_30202104 0.33 ENSDART00000173525
wdr76
WD repeat domain 76
chr5_-_13076779 0.32 ENSDART00000192826
ypel1
yippee-like 1
chr13_+_27298673 0.30 ENSDART00000142922
slc17a5
solute carrier family 17 (acidic sugar transporter), member 5
chr1_-_23110740 0.29 ENSDART00000171848
ENSDART00000086797
ENSDART00000189344
ENSDART00000190858
adgrl3.1
adhesion G protein-coupled receptor L3.1
chr14_+_30413312 0.29 ENSDART00000186864
cnot7
CCR4-NOT transcription complex, subunit 7
chr7_-_42206720 0.27 ENSDART00000110907
itfg1
integrin alpha FG-GAP repeat containing 1
chr10_+_11265387 0.27 ENSDART00000038888
hsdl2
hydroxysteroid dehydrogenase like 2
chr5_+_6670945 0.27 ENSDART00000185686
pxna
paxillin a
chr24_-_27256338 0.27 ENSDART00000105768
zmynd11
zinc finger, MYND-type containing 11
chr24_-_27256673 0.26 ENSDART00000181182
zmynd11
zinc finger, MYND-type containing 11
chr2_-_37312927 0.26 ENSDART00000141214
skila
SKI-like proto-oncogene a
chr1_-_40102836 0.26 ENSDART00000147317
cntf
ciliary neurotrophic factor
chr11_-_31226578 0.24 ENSDART00000109698
nacc1b
nucleus accumbens associated 1, BEN and BTB (POZ) domain containing b
chr13_-_24260609 0.24 ENSDART00000138747
urb2
URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
chr15_-_16946124 0.24 ENSDART00000154923
hip1
huntingtin interacting protein 1
chr2_+_16585549 0.23 ENSDART00000134135
si:dkeyp-13a3.10
si:dkeyp-13a3.10
chr17_-_15189397 0.23 ENSDART00000133710
ENSDART00000110507
wdhd1
WD repeat and HMG-box DNA binding protein 1
chr21_-_36571804 0.23 ENSDART00000138129
wwc1
WW and C2 domain containing 1
chr24_-_8214253 0.22 ENSDART00000160432
CABZ01077956.1

chr3_-_54500354 0.22 ENSDART00000124215
trip10a
thyroid hormone receptor interactor 10a
chr6_-_31348999 0.22 ENSDART00000153734
dnajc6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr5_-_10082244 0.21 ENSDART00000036421
chek2
checkpoint kinase 2
chr11_+_5681762 0.21 ENSDART00000179139
arid3a
AT rich interactive domain 3A (BRIGHT-like)
chr3_-_45250924 0.21 ENSDART00000109017
usp31
ubiquitin specific peptidase 31
chr5_-_68093169 0.21 ENSDART00000051849
slc25a11
solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
chr14_+_30413758 0.20 ENSDART00000092953
cnot7
CCR4-NOT transcription complex, subunit 7
chr12_-_850457 0.20 ENSDART00000022688
tob1b
transducer of ERBB2, 1b
chr8_-_8698607 0.19 ENSDART00000046712
zgc:86609
zgc:86609
chr5_+_24156170 0.19 ENSDART00000136570
slc25a15b
solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15b
chr7_+_38667066 0.19 ENSDART00000013394
mtch2
mitochondrial carrier homolog 2
chr4_+_11723852 0.18 ENSDART00000028820
mkln1
muskelin 1, intracellular mediator containing kelch motifs
chr23_-_45504991 0.18 ENSDART00000148761
col24a1
collagen type XXIV alpha 1
chr23_+_30730121 0.18 ENSDART00000134141
asxl1
additional sex combs like transcriptional regulator 1
chr8_-_49756171 0.18 ENSDART00000140609
hnrnpk
heterogeneous nuclear ribonucleoprotein K
chr8_+_53120278 0.18 ENSDART00000125232
nr2c2
nuclear receptor subfamily 2, group C, member 2
chr14_-_26482096 0.18 ENSDART00000187280
smad5
SMAD family member 5
chr3_+_17806213 0.17 ENSDART00000055890
znf385c
zinc finger protein 385C
chr11_-_38492564 0.17 ENSDART00000102850
elk4
ELK4, ETS-domain protein
chr13_+_7241170 0.16 ENSDART00000109434
aifm2
apoptosis-inducing factor, mitochondrion-associated, 2
chr9_+_24065855 0.16 ENSDART00000161468
ENSDART00000171577
ENSDART00000172743
ENSDART00000159324
ENSDART00000079689
ENSDART00000023196
ENSDART00000101577
lrrfip1a
leucine rich repeat (in FLII) interacting protein 1a
chr5_-_5669879 0.16 ENSDART00000191963
CABZ01075628.1

chr1_-_58868306 0.15 ENSDART00000166615
dnm2b
dynamin 2b
chr15_+_33691455 0.15 ENSDART00000170329
hdac12
histone deacetylase 12
chr24_+_22022109 0.14 ENSDART00000133686
ropn1l
rhophilin associated tail protein 1-like
chr4_-_2975461 0.14 ENSDART00000150794
plekha5
pleckstrin homology domain containing, family A member 5
chr7_+_42206847 0.13 ENSDART00000149250
phkb
phosphorylase kinase, beta
chr5_-_10007897 0.13 ENSDART00000109052
CR936408.1
Danio rerio uncharacterized LOC799523 (LOC799523), mRNA.
chr2_+_34767171 0.13 ENSDART00000145451
astn1
astrotactin 1
chr24_+_684924 0.12 ENSDART00000186103
si:ch211-188f17.1
si:ch211-188f17.1
chr13_-_27660955 0.12 ENSDART00000188651
ENSDART00000134494
rims1a
regulating synaptic membrane exocytosis 1a
chr5_-_41831646 0.12 ENSDART00000134326
si:dkey-65b12.6
si:dkey-65b12.6
chr14_+_30340251 0.11 ENSDART00000148448
mtus1a
microtubule associated tumor suppressor 1a
chr13_-_41155472 0.11 ENSDART00000160588
si:dkeyp-86d6.2
si:dkeyp-86d6.2
chr25_+_16214854 0.10 ENSDART00000109672
ENSDART00000190093
mical2b
microtubule associated monooxygenase, calponin and LIM domain containing 2b
chr15_+_31526225 0.10 ENSDART00000154456
wdr95
WD40 repeat domain 95
chr2_-_38282079 0.10 ENSDART00000145808
rnf212b
si:ch211-10e2.1
chr22_+_11153590 0.10 ENSDART00000188207
bcor
BCL6 corepressor
chr5_+_60928576 0.10 ENSDART00000131041
doc2b
double C2-like domains, beta
chr5_+_36611128 0.09 ENSDART00000097684
nova1
neuro-oncological ventral antigen 1
chr5_+_37406358 0.09 ENSDART00000162811
klhl13
kelch-like family member 13
chr7_-_24046999 0.09 ENSDART00000144616
ENSDART00000124653
ENSDART00000127813
dhrs4
dehydrogenase/reductase (SDR family) member 4
chr23_+_21544227 0.09 ENSDART00000140253
arhgef10lb
Rho guanine nucleotide exchange factor (GEF) 10-like b
chr24_+_26997798 0.09 ENSDART00000089506
larp4b
La ribonucleoprotein domain family, member 4B
chr1_-_20593778 0.08 ENSDART00000124770
ugt8
UDP glycosyltransferase 8
chr11_-_40647190 0.08 ENSDART00000173217
ENSDART00000173276
ENSDART00000147264
fam213b
family with sequence similarity 213, member B
chr4_-_8060962 0.08 ENSDART00000146622
wnk1b
WNK lysine deficient protein kinase 1b
chr25_+_22017182 0.08 ENSDART00000156517
si:dkey-217l24.1
si:dkey-217l24.1
chr18_-_17513426 0.08 ENSDART00000146725
b3gnt9
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9
chr6_+_13206516 0.07 ENSDART00000036927
ndufs1
NADH dehydrogenase (ubiquinone) Fe-S protein 1
chr7_+_25913225 0.07 ENSDART00000129924
hmgb3a
high mobility group box 3a
chr19_+_17358850 0.07 ENSDART00000123519
ube2e1
ubiquitin-conjugating enzyme E2E 1
chr18_-_42333428 0.07 ENSDART00000034225
cntn5
contactin 5
chr7_+_34620418 0.07 ENSDART00000081338
slc9a5
solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
chr18_-_4957022 0.07 ENSDART00000101686
zbbx
zinc finger, B-box domain containing
chr25_-_16969922 0.07 ENSDART00000111158
tigara
tp53-induced glycolysis and apoptosis regulator a
chr15_-_16884912 0.06 ENSDART00000062135
zgc:103681
zgc:103681
chr16_-_25680666 0.06 ENSDART00000132693
ENSDART00000140539
ENSDART00000015302
tomm40
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr3_-_25377163 0.06 ENSDART00000055490
kpna2
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
chr12_+_27156943 0.06 ENSDART00000153030
ENSDART00000001737
skap1
src kinase associated phosphoprotein 1
chr9_+_31795343 0.06 ENSDART00000139584
itgbl1
integrin, beta-like 1
chr9_-_21067971 0.06 ENSDART00000004333
tbx15
T-box 15
chr4_-_18775548 0.06 ENSDART00000141187
def6c
differentially expressed in FDCP 6c homolog
chr17_+_30545895 0.06 ENSDART00000076739
nhsl1a
NHS-like 1a
chr9_-_20853439 0.06 ENSDART00000028247
ENSDART00000133321
gdap2
ganglioside induced differentiation associated protein 2
chr15_+_20403903 0.06 ENSDART00000134182
cox7a1
cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
chr23_-_24488696 0.06 ENSDART00000155593
tmem82
transmembrane protein 82
chr6_+_3282809 0.06 ENSDART00000187444
ENSDART00000187407
ENSDART00000191883
kdm4aa
lysine (K)-specific demethylase 4A, genome duplicate a
chr1_-_30689004 0.06 ENSDART00000018827
dachc
dachshund c
chr14_+_35023923 0.05 ENSDART00000172171
ebf3a
early B cell factor 3a
chr24_-_1021318 0.05 ENSDART00000181403
ralaa
v-ral simian leukemia viral oncogene homolog Aa (ras related)
chr7_+_34296789 0.05 ENSDART00000052471
ENSDART00000173798
ENSDART00000173778
bbox1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr9_+_35860975 0.05 ENSDART00000134447
rcan1a
regulator of calcineurin 1a
chr10_-_25561751 0.05 ENSDART00000147089
grik1a
glutamate receptor, ionotropic, kainate 1a
chr3_+_24190207 0.05 ENSDART00000034762
prr15la
proline rich 15-like a
chr20_-_26937453 0.05 ENSDART00000139756
ftr97
finTRIM family, member 97
chr10_+_9561066 0.04 ENSDART00000136281
si:ch211-243g18.2
si:ch211-243g18.2
chr12_+_14084291 0.04 ENSDART00000189734
si:ch211-217a12.1
si:ch211-217a12.1
chr11_-_21363834 0.04 ENSDART00000080051
RASSF5
si:dkey-85p17.3
chr7_-_31794878 0.04 ENSDART00000099748
nap1l4b
nucleosome assembly protein 1-like 4b
chr12_+_30368145 0.04 ENSDART00000153454
ccdc186
si:ch211-225b10.4
chr15_-_11341635 0.04 ENSDART00000055220
rab30
RAB30, member RAS oncogene family
chr7_-_31794476 0.03 ENSDART00000142385
nap1l4b
nucleosome assembly protein 1-like 4b
chr1_-_21287724 0.03 ENSDART00000193900
npy1r
neuropeptide Y receptor Y1
chr6_-_10320676 0.03 ENSDART00000151247
scn1lab
sodium channel, voltage-gated, type I like, alpha b
chr8_-_979735 0.03 ENSDART00000149612
znf366
zinc finger protein 366
chr17_-_1705013 0.03 ENSDART00000182864
CABZ01086293.1

chr1_+_44826367 0.02 ENSDART00000146962
STX3
zgc:165520
chr5_+_37087583 0.02 ENSDART00000049900
tagln2
transgelin 2
chr6_-_39764995 0.02 ENSDART00000085277
pfkmb
phosphofructokinase, muscle b
chr5_-_67721368 0.02 ENSDART00000134386
arhgap31
Rho GTPase activating protein 31
chr7_-_19146925 0.02 ENSDART00000142924
ENSDART00000009695
kirrel1a
kirre like nephrin family adhesion molecule 1a
chr24_+_39211288 0.02 ENSDART00000061540
im:7160594
im:7160594
chr18_+_27926839 0.02 ENSDART00000191835
hipk3b
homeodomain interacting protein kinase 3b
chr6_-_39765546 0.02 ENSDART00000185767
pfkmb
phosphofructokinase, muscle b
chr6_-_8498908 0.02 ENSDART00000149222
pglyrp2
peptidoglycan recognition protein 2
chr16_-_39195318 0.02 ENSDART00000058546
ebag9
estrogen receptor binding site associated, antigen, 9
chr23_+_24272421 0.02 ENSDART00000029974
clcnk
chloride channel K
chr5_-_63218919 0.01 ENSDART00000149979
tecta
tectorin alpha
chr8_-_44004135 0.01 ENSDART00000136269
rimbp2
RIMS binding protein 2
chr5_-_33959868 0.01 ENSDART00000143652
zgc:63972
zgc:63972
chr5_-_41838354 0.01 ENSDART00000146793
si:dkey-65b12.6
si:dkey-65b12.6
chr7_+_31871830 0.01 ENSDART00000139899
mybpc3
myosin binding protein C, cardiac
chr1_+_19332837 0.01 ENSDART00000078594
tyrp1b
tyrosinase-related protein 1b
chr10_+_41668483 0.01 ENSDART00000127073
lrrc75bb
leucine rich repeat containing 75Bb
chr8_-_42238543 0.01 ENSDART00000062697
gfra2a
GDNF family receptor alpha 2a
chr16_-_11859309 0.01 ENSDART00000145754
cxcr3.1
chemokine (C-X-C motif) receptor 3, tandem duplicate 1
chr15_-_21239416 0.01 ENSDART00000155787
A2ML1 (1 of many)
si:dkey-105h12.2
chr16_-_16761164 0.01 ENSDART00000135872
si:dkey-27n14.1
si:dkey-27n14.1
chr11_+_1409622 0.01 ENSDART00000157042
ppp1r3db
protein phosphatase 1, regulatory subunit 3Db
chr3_-_22212764 0.01 ENSDART00000155490
maptb
microtubule-associated protein tau b
chr1_+_44826593 0.00 ENSDART00000162200
STX3
zgc:165520
chr18_-_2433011 0.00 ENSDART00000181922
ENSDART00000193276
CR769778.1

chr21_-_22724980 0.00 ENSDART00000035469
c1qa
complement component 1, q subcomponent, A chain
chr8_+_20825987 0.00 ENSDART00000133309
si:ch211-133l5.4
si:ch211-133l5.4
chr20_+_35086242 0.00 ENSDART00000114262
cdc42bpab
CDC42 binding protein kinase alpha (DMPK-like) b
chr5_-_3839285 0.00 ENSDART00000122292
mlxipl
MLX interacting protein like
chr10_-_29892486 0.00 ENSDART00000099983
bsx
brain-specific homeobox
chr6_-_21189295 0.00 ENSDART00000137136
obsl1a
obscurin-like 1a
chr10_+_7563755 0.00 ENSDART00000165877
purg
purine-rich element binding protein G
chr3_-_46817838 0.00 ENSDART00000028610
elavl3
ELAV like neuron-specific RNA binding protein 3
chr25_-_31898552 0.00 ENSDART00000156128
si:ch73-330k17.3
si:ch73-330k17.3

Network of associatons between targets according to the STRING database.

First level regulatory network of nr4a2b

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.1 0.3 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 0.2 GO:1990575 mitochondrial ornithine transport(GO:0000066) mitochondrial L-ornithine transmembrane transport(GO:1990575)
0.0 0.5 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 0.2 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.2 GO:0071423 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422) malate transmembrane transport(GO:0071423)
0.0 0.2 GO:0032475 otolith formation(GO:0032475)
0.0 0.5 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.3 GO:0045444 fat cell differentiation(GO:0045444)
0.0 0.1 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.0 0.1 GO:0051196 regulation of glycolytic process(GO:0006110) regulation of nucleotide catabolic process(GO:0030811) regulation of cofactor metabolic process(GO:0051193) regulation of coenzyme metabolic process(GO:0051196)
0.0 0.3 GO:0061055 myotome development(GO:0061055)
0.0 0.1 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.1 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.1 GO:2000650 negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.0 0.8 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 0.6 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.2 GO:2000223 regulation of BMP signaling pathway involved in heart jogging(GO:2000223)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0005592 collagen type XI trimer(GO:0005592)
0.1 0.9 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 0.2 GO:0098890 extrinsic component of postsynaptic membrane(GO:0098890)
0.0 0.4 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.2 GO:0035517 PR-DUB complex(GO:0035517)
0.0 0.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.6 GO:0008305 integrin complex(GO:0008305)
0.0 0.1 GO:0005964 phosphorylase kinase complex(GO:0005964)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.1 0.9 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.3 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.2 GO:0015131 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) malate transmembrane transporter activity(GO:0015140)
0.0 0.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.5 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.3 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.2 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.2 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.1 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0043914 NADPH:sulfur oxidoreductase activity(GO:0043914)
0.0 0.1 GO:0034416 bisphosphoglycerate phosphatase activity(GO:0034416)
0.0 0.0 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 0.6 GO:0005178 integrin binding(GO:0005178)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.2 PID ALK2 PATHWAY ALK2 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.0 0.5 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.2 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.1 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)